{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:02:56Z","timestamp":1789653776957,"version":"4.0.0"},"reference-count":36,"publisher":"Impact Journals, LLC","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,6,10]]},"DOI":"10.18632\/aging.103326","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T21:06:37Z","timestamp":1591909597000},"page":"11100-11115","source":"Crossref","is-referenced-by-count":17,"title":["ANXA7 promotes the cell cycle, proliferation and cell adhesion-mediated drug resistance of multiple myeloma cells by up-regulating CDC5L"],"prefix":"10.18632","volume":"12","author":[{"given":"Haiyan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology, The Affiliated Hospital of Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated Hospital of Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuou","family":"Sha","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated Hospital of Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated Hospital of Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lemin","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated Hospital of Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated Hospital of Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated Hospital of Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated Hospital of Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated Hospital of Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"v155","DOI":"10.1093\/annonc\/mdq178","article-title":"Multiple myeloma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up.","volume":"2","author":"Dreyling","year":"2010","journal-title":"Ann Oncol"},{"key":"2","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1002\/ajh.24300","article-title":"TAK-228 (formerly MLN0128), an investigational oral dual TORC1\/2 inhibitor: A phase I dose escalation study in patients with relapsed or refractory multiple myeloma, non-Hodgkin lymphoma, or Waldenstr\u00f6m's macroglobulinemia.","volume":"9","author":"Wolf","year":"2016","journal-title":"Am J Hem"},{"key":"3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21387","article-title":"Cancer statistics, 2017.","volume":"6","author":"Jemal","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"4","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/s1083-8791(00)70037-1","article-title":"Treatment of primary resistant or relapsed multiple myeloma with high-dose chemoradiotherapy, hematopoietic stem cell rescue, and granulocyte-macrophage colony-stimulating factor.","volume":"6","author":"Lazarus","year":"2000","journal-title":"Biol Blood Marrow Transplant"},{"key":"5","first-page":"S303","article-title":"Outcomes of Patients with Multiple Myeloma (MM) after Allogeneic Transplantation (allo-HCT) Failure in the Biologically Targeted Drugs Era: Prolonged Survival Outcomes and Salvage Therapy Analysis.","volume":"5","author":"Corradini","year":"2016","journal-title":"Bone Marrow Transplantation"},{"key":"6","doi-asserted-by":"publisher","first-page":"S54","DOI":"10.1016\/j.clml.2015.07.651","article-title":"Pharmacogenomics of Bortezomib in Multiple Myeloma Patients Reveals that the Ubiquitin Ligase SCF-Skp2 Promotes Drug Resistance.","volume":"1","author":"Malek","year":"2015","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cca.2013.04.018","article-title":"Potential role of annexin A7 in cancers.","volume":"42","author":"Sun","year":"2013","journal-title":"Clin Chim Acta"},{"key":"8","doi-asserted-by":"publisher","first-page":"9836","DOI":"10.3892\/ol.2018.8576","article-title":"Annexin A7 expression is downregulated in late-stage gastric cancer and is negatively correlated with the differentiation grade and apoptosis rate.","volume":"1","author":"Zhang","year":"2018","journal-title":"Oncol Lett"},{"key":"9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12964-018-0234-1","article-title":"High co-expression of the SDF1\/CXCR4 axis in hepatocarcinoma cells is regulated by AnnexinA7 in vitro and in vivo.","volume":"1","author":"Tang","year":"2018","journal-title":"Cell Commun Signal"},{"key":"10","first-page":"31","article-title":"Effect of Annexin A7 on Expression of Adhesion Molecules and Biological Behavior in Mouse Hepatocarcinoma Hca-P Cells.","volume":"2","author":"Tang","year":"2018","journal-title":"Journal of Chinese Oncology"},{"key":"11","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.biopha.2013.10.011","article-title":"Annexin A7 and its binding protein galectin-3 influence mouse hepatocellular carcinoma cell line in vitro.","volume":"6","author":"Tang","year":"2014","journal-title":"Biomed Pharmacother"},{"key":"12","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s11010-016-2934-4","article-title":"Effect of annexin A7 suppression on the apoptosis of gastric cancer cells.","volume":"42","author":"Zhang","year":"2017","journal-title":"Mol Cell Biochem"},{"key":"13","doi-asserted-by":"publisher","first-page":"527","DOI":"10.3233\/CBM-181651","article-title":"AnnexinA7 down-regulation might suppress the proliferation and metastasis of human hepatocellular carcinoma cells via MAPK\/ ERK pathway.","volume":"2","author":"Li","year":"2018","journal-title":"Cancer Biomark"},{"key":"14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.canlet.2017.12.008","article-title":"SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis.","volume":"41","author":"Miao","year":"2018","journal-title":"Cancer Lett"},{"key":"15","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s10620-015-3937-9","article-title":"Expression and clinical role of Cdc5L as a novel cell cycle protein in hepatocellular carcinoma.","volume":"6","author":"Tao","year":"2016","journal-title":"Dig Dis Sci"},{"key":"16","doi-asserted-by":"publisher","first-page":"4093","DOI":"10.1007\/s13277-015-4088-5","article-title":"Expression of CDC5L is associated with tumor progression in gliomas.","volume":"3","author":"Wang","year":"2016","journal-title":"Tumour Biol"},{"key":"17","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/nrm1661","article-title":"Annexins: linking Ca2+ signalling to membrane dynamics.","volume":"6","author":"Moss","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"18","doi-asserted-by":"publisher","first-page":"527","DOI":"10.14670\/HH-25.527","article-title":"Annexins as disease modifiers.","volume":"2","author":"Moss","year":"2010","journal-title":"Histol Histopathol"},{"key":"19","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1002\/ijc.23008","article-title":"ANXA7 expression represents hormone-relevant tumor suppression in different cancers.","volume":"12","author":"Bubendorf","year":"2007","journal-title":"Int J Cancer"},{"key":"20","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/jso.21046","article-title":"The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer.","volume":"9","author":"Hsiao","year":"2008","journal-title":"J Surg Oncol"},{"key":"21","first-page":"6","article-title":"Study the relationship between the expression of Annexin A7 and CT of nasopharyngeal carcinoma.","volume":"2","author":"Liang","year":"2011","journal-title":"J Chin Clin Med Imaging"},{"key":"22","doi-asserted-by":"publisher","first-page":"4247","DOI":"10.1021\/pr800152u","article-title":"Proteome analysis of membrane fractions in colorectal carcinomas by using 2D-DIGE saturation labeling.","volume":"7","author":"Casal","year":"2008","journal-title":"J Proteome Res"},{"key":"23","first-page":"603","article-title":"Expression of annexin A7 in human uterine cervical squamous carcinomas and normal tissues.","volume":"4","author":"Li","year":"2010","journal-title":"Acta Anatomica Sinica"},{"key":"24","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.canlet.2004.01.018","article-title":"Significant allelic loss of ANX7region (10q21) in hormone receptor negative breast carcinomas.","volume":"21","author":"Srivastava","year":"2004","journal-title":"Cancer Lett"},{"key":"25","doi-asserted-by":"publisher","first-page":"778","DOI":"10.3390\/ijms18040778","article-title":"Prp19 arrests cell cycle via Cdc5L in hepatocellular carcinoma cells.","volume":"1","author":"Shen","year":"2017","journal-title":"Int J Mol Sci"},{"key":"26","doi-asserted-by":"publisher","first-page":"353","DOI":"10.7150\/jca.32850","article-title":"Depletion of CDC5L inhibits bladder cancer tumorigenesis.","volume":"1","author":"Yao","year":"2020","journal-title":"J Cancer"},{"key":"27","first-page":"610","article-title":"Telomerase activity and telomere length in acute and chronic leukemia, pre- and post-ex vivo culture.","volume":"6","author":"Moore","year":"2000","journal-title":"Cancer Res"},{"key":"28","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/onc.2008.385","article-title":"Bortezomib overcomes cell-adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma.","volume":"2","author":"Nagai","year":"2009","journal-title":"Oncogene"},{"key":"29","doi-asserted-by":"publisher","first-page":"S111","DOI":"10.1517\/14712598.2013.799131","article-title":"Preclinical models of multiple myeloma: a critical appraisal.","volume":"1","author":"Engelhardt","year":"2013","journal-title":"Expert Opin Biol Ther"},{"key":"30","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/bjh.12226","article-title":"Potent in vitro and in vivo activity of sorafenib in multiple myeloma: induction of cell death, CD138-downregulation and inhibition of migration through actin depolymerization.","volume":"16","author":"Engelhardt","year":"2013","journal-title":"Br J Haematol"},{"key":"31","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.semcancer.2013.08.011","article-title":"The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell Malignancies: insight into disease biology and new targeted therapies.","volume":"2","author":"Gribben","year":"2014","journal-title":"Semin Cancer Biol"},{"key":"32","doi-asserted-by":"publisher","first-page":"3250","DOI":"10.1182\/blood-2014-02-558007","article-title":"Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model.","volume":"12","author":"Ready","year":"2014","journal-title":"Blood"},{"key":"33","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2174\/1568009023334033","article-title":"Integrins as novel drug targets for overcoming innate drug resistance.","volume":"2","author":"Damiano","year":"2002","journal-title":"Curr Cancer Drug Targets"},{"key":"34","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.celrep.2015.06.059","article-title":"CXCR4 regulates extra-medullary myeloma through epithelial-mesenchymal-transition-like transcriptional activation.","volume":"1","author":"Manier","year":"2015","journal-title":"Cell Rep"},{"key":"35","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1186\/s12885-019-6446-y","article-title":"Elucidating the expression and function of numbl during cell adhesion-mediated drug resistance (CAM-DR) in multiple myeloma (MM).","volume":"1","author":"Wang","year":"2019","journal-title":"BMC Cancer"},{"key":"36","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/bjh.14807","article-title":"CXCL12 and CXCR7 are relevant targets to reverse cell adhesion-mediated drug resistance in multiple myeloma.","volume":"17","author":"Engelhardt","year":"2017","journal-title":"Br J Haematol"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T20:27:17Z","timestamp":1599078437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,10]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,6,15]]}},"alternative-id":["103326","32526706"],"URL":"https:\/\/doi.org\/10.18632\/aging.103326","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,10]]}}}