{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:12:06Z","timestamp":1770336726715,"version":"3.49.0"},"reference-count":98,"publisher":"Impact Journals, LLC","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,6,11]]},"DOI":"10.18632\/aging.103335","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T23:28:32Z","timestamp":1591918112000},"page":"10022-10034","source":"Crossref","is-referenced-by-count":56,"title":["Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients"],"prefix":"10.18632","volume":"12","author":[{"given":"Haili","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu, China"},{"name":"Department of Neurology, Clinical Medical College of Yangzhou, Dalian Medical University, Yangzhou 225000, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojia","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu, China"},{"name":"Department of Neurology, Clinical Medical College of Yangzhou, Dalian Medical University, Yangzhou 225000, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu, China"},{"name":"Department of Neurology, Clinical Medical College of Yangzhou, Dalian Medical University, Yangzhou 225000, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxia","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu, China"},{"name":"Department of Neurology, Clinical Medical College of Yangzhou, Dalian Medical University, Yangzhou 225000, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingzhu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1056\/NEJMoa2001316","article-title":"Early transmission dynamics in wuhan, China, of novel coronavirus-infected pneumonia.","volume":"38","author":"Wu","year":"2020","journal-title":"N Engl J Med"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1101\/2020.02.07.937862","article-title":"Severe acute respiratory sydrome-related coronavirus: The species and its viruses-a statement of the Coronavirus Study Group.","author":"Poon","year":"2020","journal-title":"bioRxiv"},{"key":"3","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S1473-3099(20)30196-1","article-title":"Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study.","volume":"2","author":"Chen","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.3542150","article-title":"Estimation of the epidemic properties of the 2019 novel coronavirus: A mathematical modeling study.","author":"Hao","year":"2020","journal-title":"bioRxiv"},{"key":"5","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.ijid.2020.03.042","article-title":"Delivery of infection from asymptomatic carriers of COVID-19 in a familial cluster.","volume":"9","author":"Xu","year":"2020","journal-title":"Int J Infect Dis"},{"key":"6","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1056\/NEJMc2001468","article-title":"Transmission of 2019-nCoV infection from an asymptomatic contact in Germany.","volume":"38","author":"Vollmar","year":"2020","journal-title":"N Engl J Med"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3201\/eid2607.200591","article-title":"Severe Acute Respiratory Syndrome Coronavirus 2 Shedding by Travelers, Vietnam, 2020.","volume":"2","author":"Ngu","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"8","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1056\/NEJMc2001737","article-title":"SARS-CoV-2 viral load in upper respiratory specimens of infected patients.","volume":"38","author":"He","year":"2020","journal-title":"N Engl J Med"},{"key":"9","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/S0140-6736(20)30154-9","article-title":"A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.","volume":"39","author":"Chan","year":"2020","journal-title":"Lancet"},{"key":"10","doi-asserted-by":"publisher","first-page":"e201127","DOI":"10.1001\/jamaneurol.2020.1127","article-title":"Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.","author":"Hu","year":"2020","journal-title":"JAMA Neurol"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2008597","article-title":"Neurologic Features in Severe SARS-CoV-2 Infection.","author":"Meziani","year":"2020","journal-title":"N Engl J Med"},{"key":"12","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin.","volume":"57","author":"Luo","year":"2020","journal-title":"Nature"},{"key":"13","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1080\/01652176.2020.1727993","article-title":"Emerging novel coronavirus (2019-nCoV)-current scenario, evolutionary perspective based on genome analysis and recent developments.","volume":"4","author":"Chaicumpa","year":"2020","journal-title":"Vet Q"},{"key":"14","doi-asserted-by":"publisher","first-page":"2000058","DOI":"10.2807\/1560-7917.ES.2020.25.4.2000058","article-title":"Pattern of early human-to-human transmission of wuhan 2019 novel coronavirus (2019-nCoV), december 2019 to january 2020.","volume":"2","author":"Althaus","year":"2020","journal-title":"Euro Surveill"},{"key":"15","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.micinf.2020.01.004","article-title":"Pathogenicity and transmissibility of 2019-nCoV-a quick overview and comparison with other emerging viruses.","volume":"2","author":"Chen","year":"2020","journal-title":"Microbes Infect"},{"key":"16","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019.","volume":"38","author":"Ma","year":"2020","journal-title":"N Engl J Med"},{"key":"17","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/lam.13285","article-title":"2019_nCoV\/SARS-CoV-2: rapid classification of betacoronaviruses and identification of traditional chinese medicine as potential origin of zoonotic coronaviruses.","volume":"7","author":"Zou","year":"2020","journal-title":"Lett Appl Microbiol"},{"key":"18","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.drudis.2020.01.015","article-title":"Recent discovery and development of inhibitors targeting coronaviruses.","volume":"2","author":"Manickam","year":"2020","journal-title":"Drug Discov Today"},{"key":"19","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.idc.2019.07.001","article-title":"Severe acute respiratory syndrome: historical, epidemiologic, and clinical features.","volume":"3","author":"Zumla","year":"2019","journal-title":"Infect Dis Clin North Am"},{"key":"20","doi-asserted-by":"publisher","first-page":"e00127","DOI":"10.1128\/JVI.00127-20","article-title":"Receptor recognition by the novel coronavirus from wuhan: an analysis based on decade-long structural studies of SARS coronavirus.","volume":"9","author":"Li","year":"2020","journal-title":"J Virol"},{"key":"21","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/357420a0","article-title":"Human aminopeptidase N is a receptor for human coronavirus 229E.","volume":"35","author":"Holmes","year":"1992","journal-title":"Nature"},{"key":"22","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1038\/nature02145","article-title":"Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.","volume":"42","author":"Farzan","year":"2003","journal-title":"Nature"},{"key":"23","doi-asserted-by":"publisher","first-page":"19970","DOI":"10.1073\/pnas.0908837106","article-title":"Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor.","volume":"10","author":"Li","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"24","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.virol.2007.04.035","article-title":"The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2.","volume":"36","author":"Farzan","year":"2007","journal-title":"Virology"},{"key":"25","doi-asserted-by":"publisher","first-page":"7202","DOI":"10.1128\/JVI.00854-15","article-title":"Human coronavirus HKU1 spike protein uses o-acetylated sialic acid as an attachment receptor determinant and employs hemagglutinin-esterase protein as a receptor-destroying enzyme.","volume":"8","author":"Sui","year":"2015","journal-title":"J Virol"},{"key":"26","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.virol.2005.11.044","article-title":"Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated.","volume":"34","author":"Perlman","year":"2006","journal-title":"Virology"},{"key":"27","doi-asserted-by":"publisher","first-page":"9220","DOI":"10.1128\/JVI.00676-14","article-title":"Host species restriction of middle east respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4.","volume":"8","author":"Munster","year":"2014","journal-title":"J Virol"},{"key":"28","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in wuhan, China: a descriptive study.","volume":"39","author":"Zhang","year":"2020","journal-title":"Lancet"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1101\/2020.02.06.20020974","article-title":"Clinical characteristics of 2019 novel coronavirus infection in China.","author":"Zeng","year":"2020","journal-title":"medRxiv"},{"key":"30","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in wuhan, China.","volume":"32","author":"Peng","year":"2020","journal-title":"JAMA"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1101\/2020.02.22.20026500","article-title":"Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study.","author":"Hu","year":"2020","journal-title":"medRxiv"},{"key":"32","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1086\/444461","article-title":"Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis.","volume":"4","author":"Jiang","year":"2005","journal-title":"Clin Infect Dis"},{"key":"33","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3201\/eid1002.030638","article-title":"Possible central nervous system infection by SARS coronavirus.","volume":"1","author":"Yuen","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"34","doi-asserted-by":"publisher","first-page":"4030","DOI":"10.4049\/jimmunol.173.6.4030","article-title":"Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice.","volume":"17","author":"Murphy","year":"2004","journal-title":"J Immunol"},{"key":"35","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0882-4010(87)90033-7","article-title":"Experimental demyelination induced by coronavirus JHM (MHV-4): molecular identification of a viral determinant of paralytic disease.","volume":"3","author":"Weiner","year":"1987","journal-title":"Microb Pathog"},{"key":"36","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/305150a0","article-title":"Adoptive transfer of EAE-like lesions from rats with coronavirus-induced demyelinating encephalomyelitis.","volume":"30","author":"ter Meulen","year":"1983","journal-title":"Nature"},{"key":"37","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12974-019-1409-4","article-title":"Cerebrovascular manifestations of herpes simplex virus infection of the central nervous system: a systematic review.","volume":"1","author":"Sellner","year":"2019","journal-title":"J Neuroinflammation"},{"key":"38","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1177\/1941874418758902","article-title":"An unusual etiology of acute spontaneous intracerebral hemorrhage.","volume":"9","author":"Ayodele","year":"2019","journal-title":"Neurohospitalist"},{"key":"39","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1586\/14737175.2015.1134321","article-title":"Clinical management of infectious cerebral vasculitides.","volume":"1","author":"Carod Artal","year":"2016","journal-title":"Expert Rev Neurother"},{"key":"40","doi-asserted-by":"publisher","first-page":"6038146","DOI":"10.1155\/2017\/6038146","article-title":"Intracranial hemorrhage complicating herpes simplex encephalitis on antiviral therapy: a case report and review of the literature.","volume":"201","author":"Lashin","year":"2017","journal-title":"Case Rep Infect Dis"},{"key":"41","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1161\/STROKEAHA.118.021751","article-title":"D-dimer is associated with first-ever intracerebral hemorrhage.","volume":"4","author":"Lind","year":"2018","journal-title":"Stroke"},{"key":"42","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1159\/000366470","article-title":"Potential role of blood biomarkers in the management of nontraumatic intracerebral hemorrhage.","volume":"3","author":"Katan","year":"2014","journal-title":"Cerebrovasc Dis"},{"key":"43","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s00018-009-0152-x","article-title":"Not just angiotensinases: new roles for the angiotensin-converting enzymes.","volume":"6","author":"Turner","year":"2010","journal-title":"Cell Mol Life Sci"},{"key":"44","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1161\/STROKEAHA.119.025514","article-title":"Blood pressure variability predicts poor in-hospital outcome in spontaneous intracerebral hemorrhage.","volume":"5","author":"Petersen","year":"2019","journal-title":"Stroke"},{"key":"45","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in wuhan, China.","volume":"39","author":"Xia","year":"2020","journal-title":"Lancet"},{"key":"46","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in wuhan, China: a retrospective cohort study.","volume":"39","author":"Li","year":"2020","journal-title":"Lancet"},{"key":"47","doi-asserted-by":"crossref","unstructured":"Yao, Cao, Wang, Liu, Luo, Yu, Chen, Hu, Huang. D-dimer as a biomarker for disease severity and mortality in COVID-19 patients: a case control study. PREPRINT (Version 1). Research Square. 2020. https:\/\/www.researchsquare.com\/article\/rs-20850\/v1.","DOI":"10.21203\/rs.3.rs-20850\/v1"},{"key":"48","article-title":"Acute cerebrovascular disease following covid-19: a single center, retrospective, observational study.","author":"Hu","year":"2020","journal-title":"medRxiv"},{"key":"49","doi-asserted-by":"publisher","first-page":"100669","DOI":"10.1016\/j.nmni.2020.100669","article-title":"COVID-19 and intracerebral haemorrhage: causative or coincidental?","volume":"3","author":"Rouhani","year":"2020","journal-title":"New Microbes New Infect"},{"key":"50","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s00281-017-0629-x","article-title":"Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology.","volume":"3","author":"Perlman","year":"2017","journal-title":"Semin Immunopathol"},{"key":"51","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.cca.2019.02.009","article-title":"Determination of serum neutrophil gelatinase-associated lipocalin as a prognostic biomarker of acute spontaneous intracerebral hemorrhage.","volume":"49","author":"Ruan","year":"2019","journal-title":"Clin Chim Acta"},{"key":"52","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.3389\/fimmu.2018.01921","article-title":"Monomeric c-reactive protein and cerebral hemorrhage: from bench to bedside.","volume":"9","author":"Divani","year":"2018","journal-title":"Front Immunol"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-020-00839-0","article-title":"Matrix Metalloproteinases in Acute Intracerebral Hemorrhage.","author":"Divani","year":"2020","journal-title":"Neurotherapeutics"},{"key":"54","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s12975-018-0649-4","article-title":"Neutrophil-to-lymphocyte ratio in acute cerebral hemorrhage: a system review.","volume":"1","author":"Silvestrini","year":"2019","journal-title":"Transl Stroke Res"},{"key":"55","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jns.2016.06.071","article-title":"Role of galectin-3 in plasma as a predictive biomarker of outcome after acute intracerebral hemorrhage.","volume":"36","author":"Dai","year":"2016","journal-title":"J Neurol Sci"},{"key":"56","doi-asserted-by":"publisher","first-page":"e16120","DOI":"10.1097\/MD.0000000000016120","article-title":"Predictive ability of admission neutrophil to lymphocyte ratio on short-term outcome in patients with spontaneous cerebellar hemorrhage.","volume":"9","author":"Xin","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"57","doi-asserted-by":"publisher","first-page":"e651","DOI":"10.1016\/j.wneu.2019.01.143","article-title":"Predictive accuracy of neutrophil-to-lymphocyte ratio on long-term outcome in patients with spontaneous intracerebral hemorrhage.","volume":"12","author":"Yang","year":"2019","journal-title":"World Neurosurg"},{"key":"58","first-page":"113","article-title":"The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) \u2014 China, 2020.","volume":"2","author":"The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team","year":"2020","journal-title":"Chinese Center for Disease Control and Prevention"},{"key":"59","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/S2213-2600(20)30076-X","article-title":"Pathological findings of COVID-19 associated with acute respiratory distress syndrome.","volume":"8","author":"Gao","year":"2020","journal-title":"Lancet Respir Med"},{"key":"60","doi-asserted-by":"publisher","first-page":"535","DOI":"10.18632\/aging.100482","article-title":"Sarcopenia, obesity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mechanism.","volume":"4","author":"Quinn","year":"2012","journal-title":"Aging (Albany NY)"},{"key":"61","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.bbrc.2020.02.071","article-title":"Structure analysis of the receptor binding of 2019-nCoV.","volume":"52","author":"Zhao","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"62","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41368-020-0074-x","article-title":"High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.","volume":"1","author":"Chen","year":"2020","journal-title":"Int J Oral Sci"},{"key":"63","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.2174\/138161207780618911","article-title":"The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases.","volume":"1","author":"Lavoie","year":"2007","journal-title":"Curr Pharm Des"},{"key":"64","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1161\/HYPERTENSIONAHA.114.03743","article-title":"Angiotensin II mediates angiotensin converting enzyme type 2 internalization and degradation through an angiotensin II type I receptor-dependent mechanism.","volume":"6","author":"Filipeanu","year":"2014","journal-title":"Hypertension"},{"key":"65","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/sj.clpt.6100214","article-title":"Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of captopril in women.","volume":"8","author":"Chen","year":"2007","journal-title":"Clin Pharmacol Ther"},{"key":"66","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/nature00786","article-title":"Angiotensin-converting enzyme 2 is an essential regulator of heart function.","volume":"41","author":"Manoukian","year":"2002","journal-title":"Nature"},{"key":"67","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s11684-020-0754-0","article-title":"Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection.","volume":"1","author":"Han","year":"2020","journal-title":"Front Med"},{"key":"68","article-title":"Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov.","author":"Zuo","year":"2020","journal-title":"bioRxiv"},{"key":"69","article-title":"The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes.","author":"Xu","year":"2020","journal-title":"bioRxiv"},{"key":"70","article-title":"Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection.","author":"Lan","year":"2020","journal-title":"bioRxiv"},{"key":"71","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1002\/path.1570","article-title":"Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.","volume":"20","author":"van Goor","year":"2004","journal-title":"J Pathol"},{"key":"72","doi-asserted-by":"publisher","first-page":"R373","DOI":"10.1152\/ajpregu.00292.2006","article-title":"Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system.","volume":"29","author":"Lazartigues","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/ice.2020.146","article-title":"Could COVID-19 represent a negative prognostic factor in patients with stroke?","volume":"202","author":"Gallelli","journal-title":"Infect Control Hosp Epidemiol"},{"key":"74","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s00281-016-0558-0","article-title":"The host immune response in respiratory virus infection: balancing virus clearance and immunopathology.","volume":"3","author":"Braciale","year":"2016","journal-title":"Semin Immunopathol"},{"key":"75","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/nm1267","article-title":"A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.","volume":"1","author":"Liu","year":"2005","journal-title":"Nat Med"},{"key":"76","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/j.1365-2362.2009.02153.x","article-title":"SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS.","volume":"3","author":"Butany","year":"2009","journal-title":"Eur J Clin Invest"},{"key":"77","doi-asserted-by":"publisher","first-page":"3358","DOI":"10.1161\/STROKEAHA.112.667063","article-title":"Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging.","volume":"4","author":"Heistad","year":"2012","journal-title":"Stroke"},{"key":"78","doi-asserted-by":"publisher","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor mas.","volume":"10","author":"Campagnole-Santos","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"79","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/j.1750-3639.2002.tb00450.x","article-title":"Hypertensive cerebral small vessel disease and stroke.","volume":"1","author":"Lammie","year":"2002","journal-title":"Brain Pathol"},{"key":"80","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1046\/j.1440-1681.1999.03081.x","article-title":"Hypertension mechanisms causing stroke.","volume":"2","author":"Johansson","year":"1999","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"81","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1007\/s00125-006-0485-z","article-title":"Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases.","volume":"5","author":"Egleton","year":"2007","journal-title":"Diabetologia"},{"key":"82","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/s0166-2236(00)02004-x","article-title":"Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier.","volume":"2","author":"Davis","year":"2001","journal-title":"Trends Neurosci"},{"key":"83","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.2174\/138161208784705441","article-title":"Diabetes, cognitive function, and the blood-brain barrier.","volume":"1","author":"Huber","year":"2008","journal-title":"Curr Pharm Des"},{"key":"84","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s13365-015-0385-4","article-title":"Multiple strokes associated with herpes simplex virus type-2 infection: case report.","volume":"2","author":"Joshi","year":"2016","journal-title":"J Neurovirol"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.29.014209","article-title":"Orthogonal genome-wide screenings in bat cells identify MTHFD1 as a target of broad antiviral therapy.","author":"Niu","year":"2020","journal-title":"bioRxiv"},{"key":"86","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1038\/s41418-020-0530-3","article-title":"COVID-19 infection: the perspectives on immune responses.","volume":"2","author":"Melino","year":"2020","journal-title":"Cell Death Differ"},{"key":"87","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1159\/000109684","article-title":"Is psychological stress a risk factor for cerebrovascular disease?","volume":"1","author":"Schneck","year":"1997","journal-title":"Neuroepidemiology"},{"key":"88","doi-asserted-by":"publisher","first-page":"e004500","DOI":"10.1161\/CIRCOUTCOMES.117.004500","article-title":"Psychological distress and risk of myocardial infarction and stroke in the 45 and up study.","volume":"1","author":"Mishra","year":"2018","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"89","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1159\/000468126","article-title":"The peripheral and central role of the catecholamines in the mechanisms of anxiety.","volume":"9","author":"Lader","year":"1974","journal-title":"Int Pharmacopsychiatry"},{"key":"90","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1055\/a-0669-9556","article-title":"Catecholamine-induced cardiomyopathy in pheochromocytoma: how to manage a rare complication in a rare disease?","volume":"5","author":"Pacak","year":"2019","journal-title":"Horm Metab Res"},{"key":"91","doi-asserted-by":"publisher","first-page":"e60","DOI":"10.1056\/NEJMc2009787","article-title":"Large-vessel stroke as a presenting feature of covid-19 in the young.","volume":"38","author":"Dangayach","year":"2020","journal-title":"N Engl J Med"},{"key":"92","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1016\/j.jocn.2015.04.020","article-title":"The role of age in intracerebral hemorrhages.","volume":"2","author":"Sander Connolly","year":"2015","journal-title":"J Clin Neurosci"},{"key":"93","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1080\/10739680701641421","article-title":"Age-related alterations in reactivity of cerebral arterioles: role of oxidative stress.","volume":"1","author":"Sun","year":"2008","journal-title":"Microcirculation"},{"key":"94","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1038\/sj.jcbfm.9600491","article-title":"Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain.","volume":"2","author":"Iadecola","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"95","doi-asserted-by":"publisher","first-page":"H1914","DOI":"10.1152\/ajpheart.00300.2009","article-title":"Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging.","volume":"29","author":"Faraci","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"96","doi-asserted-by":"publisher","first-page":"590","DOI":"10.14336\/AD.2017.0430","article-title":"Age-related impairment of vascular structure and functions.","volume":"8","author":"Jin","year":"2017","journal-title":"Aging Dis"},{"key":"97","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3109\/07853890.2011.645498","article-title":"Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease.","volume":"4","author":"van der Loo","year":"2013","journal-title":"Ann Med"},{"key":"98","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3389\/fnagi.2017.00129","article-title":"Brain renin-angiotensin system and microglial polarization: implications for aging and neurodegeneration.","volume":"9","author":"Guerra","year":"2017","journal-title":"Front Aging Neurosci"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T20:25:09Z","timestamp":1599078309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,11]]},"references-count":98,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,6,15]]}},"alternative-id":["103335","32527987"],"URL":"https:\/\/doi.org\/10.18632\/aging.103335","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,11]]}}}