{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T13:51:55Z","timestamp":1768312315309,"version":"3.49.0"},"reference-count":65,"publisher":"Impact Journals, LLC","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,7,22]]},"DOI":"10.18632\/aging.103505","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T16:27:36Z","timestamp":1595435256000},"page":"14019-14036","source":"Crossref","is-referenced-by-count":10,"title":["Metformin administration during pregnancy attenuated the long-term maternal metabolic and cognitive impairments in a mouse model of gestational diabetes"],"prefix":"10.18632","volume":"12","author":[{"given":"Yalan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, China"},{"name":"Department of Obstetrics, The First People's Hospital of Yunnan Province, Kunming, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Li","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, China"},{"name":"Liggins Institute, University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip N.","family":"Baker","sequence":"additional","affiliation":[{"name":"College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"2746471","DOI":"10.1155\/2017\/2746471","article-title":"Scientific evidence for different options for GDM screening and management: controversies and review of the literature.","volume":"201","author":"Berghella","year":"2017","journal-title":"Biomed Res Int"},{"key":"2","doi-asserted-by":"publisher","first-page":"125","DOI":"10.4103\/0366-6999.147858","article-title":"Comparing the diagnostic criteria for gestational diabetes mellitus of world health organization 2013 with 1999 in chinese population.","volume":"12","author":"Gan","year":"2015","journal-title":"Chin Med J (Engl)"},{"key":"3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1159\/000371628","article-title":"Gestational diabetes mellitus and macrosomia: a literature review.","volume":"6","author":"Zhang","year":"2015","journal-title":"Ann Nutr Metab"},{"key":"4","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1590\/s0004-27302008000600008","article-title":"Gestational diabetes and pre-eclampsia: common antecedents?","volume":"5","author":"Schmidt","year":"2008","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"5","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1136\/jim-2016-000120.99","article-title":"ID: 57: Pre-gestational diabetes and preeclampsia in bangladeshi patients: a retrospective study.","volume":"6","author":"Uddin","year":"2016","journal-title":"J Investig Med"},{"key":"6","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1503\/cmaj.080012","article-title":"Risk of development of diabetes mellitus after diagnosis of gestational diabetes.","volume":"17","author":"Hux","year":"2008","journal-title":"CMAJ"},{"key":"7","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1210\/er.2007-0034","article-title":"Cognitive dysfunction and diabetes mellitus.","volume":"2","author":"Seaquist","year":"2008","journal-title":"Endocr Rev"},{"key":"8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000323188","article-title":"Factors associated with cognitive decline in elderly diabetics.","volume":"1","author":"Takahisa","year":"2011","journal-title":"Dement Geriatr Cogn Dis Extra"},{"key":"9","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1210\/jc.2018-01315","article-title":"Cognitive dysfunction in type 1 diabetes mellitus.","volume":"10","author":"Narkiewicz","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"10","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1111\/dom.13210","article-title":"Sustained high-fat diet modulates inflammation, insulin signalling and cognition in mice and a modified xenin peptide ameliorates neuropathology in a chronic high-fat model.","volume":"2","author":"McClean","year":"2018","journal-title":"Diabetes Obes Metab"},{"key":"11","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13041-016-0223-5","article-title":"Metabonomic profiles delineate potential role of glutamate-glutamine cycle in db\/db mice with diabetes-associated cognitive decline.","volume":"9","author":"Gao","year":"2016","journal-title":"Mol Brain"},{"key":"12","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1095\/biolreprod65.6.1718","article-title":"Estrogen and progesterone metabolites and follicle-stimulating hormone in the aged macaque female.","volume":"6","author":"Lasley","year":"2001","journal-title":"Biol Reprod"},{"key":"13","doi-asserted-by":"publisher","first-page":"2883","DOI":"10.2337\/db10-0752","article-title":"Diabetic retinopathy and cognitive decline in older people with type 2 diabetes: the edinburgh type 2 diabetes study.","volume":"5","author":"Price","year":"2010","journal-title":"Diabetes"},{"key":"14","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.regg.2009.12.005","article-title":"[Aging and ovariectomy cause a decrease in brain glucose consumption in vivo in wistar rats].","volume":"4","author":"Vi\u00f1a","year":"2010","journal-title":"Rev Esp Geriatr Gerontol"},{"key":"15","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.lfs.2010.03.003","article-title":"Female exhibited severe cognitive impairment in type 2 diabetes mellitus mice.","volume":"8","author":"Horiuchi","year":"2010","journal-title":"Life Sci"},{"key":"16","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.neulet.2016.02.057","article-title":"Effects of treatment with estrogen and progesterone on the methamphetamine-induced cognitive impairment in ovariectomized rats.","volume":"61","author":"Sheibani","year":"2016","journal-title":"Neurosci Lett"},{"key":"17","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3389\/fnins.2016.00517","article-title":"Benefits of hormone therapy estrogens depend on estrogen type: 17\u03b2-estradiol and conjugated equine estrogens have differential effects on cognitive, anxiety-like, and depressive-like behaviors and increase tryptophan hydroxylase-2 mRNA levels in dorsal raphe nucleus subregions.","volume":"1","author":"Bimonte-Nelson","year":"2016","journal-title":"Front Neurosci"},{"key":"18","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1038\/sj.npp.1301042","article-title":"Estrogen treatment effects on anticholinergic-induced cognitive dysfunction in normal postmenopausal women.","volume":"3","author":"Newhouse","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"19","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1152\/physrev.00036.2014","article-title":"Estrogen effects on cognitive and synaptic health over the lifecourse.","volume":"9","author":"Morrison","year":"2015","journal-title":"Physiol Rev"},{"key":"20","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/0306-4530(92)90007-t","article-title":"Effects of estrogen on memory function in surgically menopausal women.","volume":"1","author":"Sherwin","year":"1992","journal-title":"Psychoneuroendocrinology"},{"key":"21","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.2337\/diacare.26.8.2318","article-title":"Impaired fasting glucose and impaired glucose tolerance in women with prior gestational diabetes are associated with a different cardiovascular profile.","volume":"2","author":"Ja\u00f1ez","year":"2003","journal-title":"Diabetes Care"},{"key":"22","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1172\/JCI24531","article-title":"Gestational diabetes mellitus.","volume":"11","author":"Xiang","year":"2005","journal-title":"J Clin Invest"},{"key":"23","doi-asserted-by":"publisher","first-page":"1674S","DOI":"10.1093\/jn\/133.5.1674S","article-title":"Gestational diabetes and insulin resistance: role in short- and long-term implications for mother and fetus.","volume":"13","author":"King","year":"2003","journal-title":"J Nutr"},{"key":"24","doi-asserted-by":"publisher","first-page":"6654","DOI":"10.1002\/jcp.27406","article-title":"miR-335-5p induces insulin resistance and pancreatic islet \u03b2-cell secretion in gestational diabetes mellitus mice through VASH1-mediated TGF-\u03b2 signaling pathway.","volume":"23","author":"Qin","year":"2019","journal-title":"J Cell Physiol"},{"key":"25","doi-asserted-by":"publisher","first-page":"e0179647","DOI":"10.1371\/journal.pone.0179647","article-title":"Gestational diabetes mellitus and risk of type 2 diabetes 10 years after the index pregnancy in Sri Lankan women-a community based retrospective cohort study.","volume":"1","author":"Wickremasinghe","year":"2017","journal-title":"PLoS One"},{"key":"26","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.metabol.2015.10.015","article-title":"Testosterone deprivation has neither additive nor synergistic effects with obesity on the cognitive impairment in orchiectomized and\/or obese male rats.","volume":"6","author":"Chattipakorn","year":"2016","journal-title":"Metabolism"},{"key":"27","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1037\/0735-7044.119.5.1389","article-title":"Memory impairment in obese zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity.","volume":"11","author":"McEwen","year":"2005","journal-title":"Behav Neurosci"},{"key":"28","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1002\/hipo.20470","article-title":"Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats.","volume":"1","author":"Mattson","year":"2008","journal-title":"Hippocampus"},{"key":"29","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00221-013-3409-4","article-title":"Hyperinsulinemia in rats causes impairment of spatial memory and learning with defects in hippocampal synaptic plasticity by involvement of postsynaptic mechanisms.","volume":"22","author":"Biessels","year":"2013","journal-title":"Exp Brain Res"},{"key":"30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2008.08.024","article-title":"Strain-specific differences in cell proliferation and differentiation in the dentate gyrus of C57BL\/6N and C3H\/HeN mice fed a high fat diet.","volume":"124","author":"Seong","year":"2008","journal-title":"Brain Res"},{"key":"31","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1172\/JCI59903","article-title":"Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.","volume":"12","author":"Wolf","year":"2012","journal-title":"J Clin Invest"},{"key":"32","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ejphar.2013.08.008","article-title":"Insulin, cognition, and dementia.","volume":"71","author":"Craft","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"33","doi-asserted-by":"publisher","first-page":"3262","DOI":"10.18632\/aging.101978","article-title":"Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice.","volume":"1","author":"Yang","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"34","doi-asserted-by":"publisher","first-page":"10454","DOI":"10.18632\/aging.102469","article-title":"Abnormal gut microbiota composition contributes to the development of type 2 diabetes mellitus in db\/db mice.","volume":"1","author":"Yang","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"35","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1095\/biolreprod42.3.458","article-title":"Arachidonic acid inhibits luteinizing hormone-stimulated progesterone production in hen granulosa cells.","volume":"4","author":"Tilly","year":"1990","journal-title":"Biol Reprod"},{"key":"36","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.molmet.2019.03.012","article-title":"Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth.","volume":"2","author":"Vegiopoulos","year":"2019","journal-title":"Mol Metab"},{"key":"37","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1263\/jbb.91.71","article-title":"Pentanoic acid, a novel protein synthesis stimulant for chinese hamster ovary (CHO) cells.","volume":"9","author":"Hwang","year":"2001","journal-title":"J Biosci Bioeng"},{"key":"38","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1210\/er.2009-0006","article-title":"Ovarian aging: mechanisms and clinical consequences.","volume":"3","author":"Fauser","year":"2009","journal-title":"Endocr Rev"},{"key":"39","doi-asserted-by":"publisher","first-page":"47898","DOI":"10.1074\/jbc.M408149200","article-title":"AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells.","volume":"27","author":"Cohen","year":"2004","journal-title":"J Biol Chem"},{"key":"40","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/j.1749-6632.2011.06285.x","article-title":"Diabetes, cancer, and metformin: connections of metabolism and cell proliferation.","volume":"124","author":"LeRoith","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"41","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.bbadis.2017.10.014","article-title":"Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK.","volume":"186","author":"Piwkowska","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"42","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.diabres.2012.02.023","article-title":"Downregulation of chemerin and alleviation of endoplasmic reticulum stress by metformin in adipose tissue of rats.","volume":"9","author":"Zhang","year":"2012","journal-title":"Diabetes Res Clin Pract"},{"key":"43","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/nature15766","article-title":"Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.","volume":"52","author":"Voigt","year":"2015","journal-title":"Nature"},{"key":"44","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1080\/14767058.2016.1228061","article-title":"Metformin - a potentially effective drug for gestational diabetes mellitus: a systematic review and meta-analysis.","volume":"3","author":"Yang","year":"2017","journal-title":"J Matern Fetal Neonatal Med"},{"key":"45","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1093\/humupd\/dmv025","article-title":"Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis.","volume":"2","author":"Teede","year":"2015","journal-title":"Hum Reprod Update"},{"key":"46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2337\/diacare.13.1.1","article-title":"Effect of metformin on carbohydrate and lipoprotein metabolism in NIDDM patients.","volume":"1","author":"Reaven","year":"1990","journal-title":"Diabetes Care"},{"key":"47","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3389\/fnagi.2018.00227","article-title":"Evaluation of Metformin on Cognitive Improvement in Patients With Non-dementia Vascular Cognitive Impairment and Abnormal Glucose Metabolism.","volume":"1","author":"Cheng","year":"2018","journal-title":"Front Aging Neurosci"},{"key":"48","doi-asserted-by":"publisher","first-page":"751","DOI":"10.2337\/dc16-2001","article-title":"Insulin Resistance Predicts Cognitive Decline: An 11-Year Follow-up of a Nationally Representative Adult Population Sample.","volume":"4","author":"Jula","year":"2017","journal-title":"Diabetes care"},{"key":"49","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1146\/annurev-nutr-071812-161148","article-title":"AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels.","volume":"3","author":"Hardie","year":"2014","journal-title":"Annu Rev Nutr"},{"key":"50","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.","volume":"45","author":"Auwerx","year":"2009","journal-title":"Nature"},{"key":"51","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.bbi.2017.12.009","article-title":"Metformin treatment prevents amyloid plaque deposition and memory impairment in APP\/PS1 mice.","volume":"6","author":"Xuan","year":"2018","journal-title":"Brain Behav Immun"},{"key":"52","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s11357-019-00146-3","article-title":"Metformin and cognition from the perspectives of sex, age, and disease.","volume":"4","author":"Yang","year":"2020","journal-title":"Geroscience"},{"key":"53","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.stemcr.2015.10.014","article-title":"Metformin acts on two different molecular pathways to enhance adult neural precursor proliferation\/self-renewal and differentiation.","volume":"5","author":"Wang","year":"2015","journal-title":"Stem Cell Reports"},{"key":"54","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.stem.2012.03.016","article-title":"Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.","volume":"1","author":"Miller","year":"2012","journal-title":"Cell Stem Cell"},{"key":"55","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.stem.2012.06.003","article-title":"An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation.","volume":"1","author":"Lim","year":"2012","journal-title":"Cell Stem Cell"},{"key":"56","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1124\/mol.117.109512","article-title":"Activation of AMPK\/mTORC1-mediated autophagy by metformin reverses Clk1 deficiency-sensitized dopaminergic neuronal death.","volume":"9","author":"Zhen","year":"2017","journal-title":"Mol Pharmacol"},{"key":"57","doi-asserted-by":"publisher","first-page":"46","DOI":"10.4161\/15548627.2014.984271","article-title":"Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway.","volume":"1","author":"Lee","year":"2015","journal-title":"Autophagy"},{"key":"58","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s12035-014-8866-7","article-title":"Chronic metformin preconditioning provides neuroprotection via suppression of NF-\u03baB-mediated inflammatory pathway in rats with permanent cerebral ischemia.","volume":"5","author":"Yu","year":"2015","journal-title":"Mol Neurobiol"},{"key":"59","doi-asserted-by":"publisher","first-page":"949","DOI":"10.14336\/AD.2019.0120","article-title":"Metformin alters locomotor and cognitive function and brain metabolism in normoglycemic mice.","volume":"1","author":"Yang","year":"2019","journal-title":"Aging Dis"},{"key":"60","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1002\/jnr.24050","article-title":"The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes.","volume":"9","author":"Dringen","year":"2017","journal-title":"J Neurosci Res"},{"key":"61","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1007\/s11064-015-1733-8","article-title":"The antidiabetic drug metformin stimulates glycolytic lactate production in cultured primary rat astrocytes.","volume":"4","author":"Dringen","year":"2017","journal-title":"Neurochem Res"},{"key":"62","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1042\/CS20110386","article-title":"Cellular and molecular mechanisms of metformin: an overview.","volume":"12","author":"Andreelli","year":"2012","journal-title":"Clin Sci (Lond)"},{"key":"63","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1097\/FPC.0b013e3283559b22","article-title":"Metformin pathways: pharmacokinetics and pharmacodynamics.","volume":"2","author":"Klein","year":"2012","journal-title":"Pharmacogenet Genomics"},{"key":"64","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.metabol.2018.03.025","article-title":"Gestational diabetes mellitus: multi-disciplinary treatment approaches.","volume":"8","author":"Goulis","year":"2018","journal-title":"Metabolism"},{"key":"65","unstructured":"Team. (2018). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria."}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T20:48:55Z","timestamp":1599079735000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,22]]},"references-count":65,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2020,7,31]]}},"alternative-id":["103505","32697764"],"URL":"https:\/\/doi.org\/10.18632\/aging.103505","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,22]]}}}