{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:05:58Z","timestamp":1770750358199,"version":"3.50.0"},"reference-count":54,"publisher":"Impact Journals, LLC","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,8,15]]},"DOI":"10.18632\/aging.103776","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T22:10:43Z","timestamp":1597702243000},"page":"15682-15704","source":"Crossref","is-referenced-by-count":43,"title":["Vascular, inflammatory and metabolic risk factors in relation to dementia in Parkinson\u2019s disease patients with type 2 diabetes mellitus"],"prefix":"10.18632","volume":"12","author":[{"given":"Ting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feilan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenze","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzhen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanlin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongfang","family":"Que","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peihua","family":"Cao","sequence":"additional","affiliation":[{"name":"Clinical Research Center, ZhuJiang Hospital of Southern Medical University, Guangzhou, Guangdong, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinxia","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Duke-NUS Medical School, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Duke-NUS Medical School, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linting","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Puning People\u2019s Hospital, Puning, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiurong","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guiping People\u2019s Hospital, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piu","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori A.","family":"Yenari","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eng-King","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Duke-NUS Medical School, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2020,8,15]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"e1654","DOI":"10.1212\/WNL.0000000000005475","article-title":"Diabetes mellitus and Parkinson disease.","volume":"9","author":"Politis","year":"2018","journal-title":"Neurology"},{"key":"2","doi-asserted-by":"publisher","first-page":"S106","DOI":"10.1016\/j.parkreldis.2015.09.048","article-title":"Biomarkers in Parkinson\u2019s disease: advances and strategies.","volume":"2","author":"Uitti","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"key":"3","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s00415-019-09197-0","article-title":"Subjective cognitive decline and progression to dementia in Parkinson\u2019s disease: a long-term follow-up study.","volume":"26","author":"Barroso","year":"2019","journal-title":"J Neurol"},{"key":"4","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1002\/ana.25564","article-title":"Associations between cerebrovascular risk factors and Parkinson disease.","volume":"8","author":"Navi","year":"2019","journal-title":"Ann Neurol"},{"key":"5","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1111\/ene.13551","article-title":"Vascular risk factors and depression in Parkinson\u2019s disease.","volume":"2","author":"Shang","year":"2018","journal-title":"Eur J Neurol"},{"key":"6","doi-asserted-by":"publisher","first-page":"51","DOI":"10.14336\/AD.2017.0416","article-title":"Trefoil factor 3, cholinesterase and homocysteine: potential predictors for Parkinson\u2019s disease dementia and vascular Parkinsonism dementia in advanced stage.","volume":"9","author":"Liang","year":"2018","journal-title":"Aging Dis"},{"key":"7","doi-asserted-by":"publisher","first-page":"847","DOI":"10.14336\/AD.2018.0814","article-title":"The metabolic activity of caudate and prefrontal cortex negatively correlates with the severity of idiopathic Parkinson\u2019s disease.","volume":"1","author":"Meng","year":"2019","journal-title":"Aging Dis"},{"key":"8","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.2337\/dc08-0479","article-title":"Diabetes in patients with idiopathic Parkinson\u2019s disease.","volume":"3","author":"Meier","year":"2008","journal-title":"Diabetes Care"},{"key":"9","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1161\/01.STR.0000217384.03237.9c","article-title":"Reduced risk factors for vascular disorders in Parkinson disease patients: a case-control study.","volume":"3","author":"Girotti","year":"2006","journal-title":"Stroke"},{"key":"10","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.18632\/aging.100968","article-title":"Deep biomarkers of human aging: application of deep neural networks to biomarker development.","volume":"8","author":"Zhavoronkov","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"11","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/mds.27492","article-title":"Baseline predictors for progression 4 years after Parkinson\u2019s disease diagnosis in the de novo Parkinson cohort (DeNoPa).","volume":"3","author":"Trenkwalder","year":"2019","journal-title":"Mov Disord"},{"key":"12","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/ene.13797","article-title":"Modifiable vascular risk factors, white matter disease and cognition in early Parkinson\u2019s disease.","volume":"2","author":"McMillan","year":"2019","journal-title":"Eur J Neurol"},{"key":"13","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s40035-019-0151-2","article-title":"Cognitive decline is related to high blood glucose levels in older Chinese adults with the ApoE \u03b53\/\u03b53 genotype.","volume":"8","author":"Li","year":"2019","journal-title":"Transl Neurodegener"},{"key":"14","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.parkreldis.2014.02.016","article-title":"Diabetes is associated with postural and cognitive domains in Parkinson\u2019s disease. Results from a single-center study.","volume":"2","author":"Ceravolo","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"key":"15","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12916-017-0869-6","article-title":"Towards the concept of disease-modifier in post-stroke or vascular cognitive impairment: a consensus report.","volume":"1","author":"Guekht","year":"2017","journal-title":"BMC Med"},{"key":"16","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12916-016-0676-5","article-title":"Post-mortem assessment in vascular dementia: advances and aspirations.","volume":"1","author":"K\u00f6vari","year":"2016","journal-title":"BMC Med"},{"key":"17","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1016\/S0140-6736(15)00463-8","article-title":"Vascular dementia.","volume":"38","author":"Thomas","year":"2015","journal-title":"Lancet"},{"key":"18","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1007\/s00415-018-8838-3","article-title":"Exploring the relationship between motor impairment, vascular burden and cognition in Parkinson\u2019s disease.","volume":"26","author":"Kostic","year":"2018","journal-title":"J Neurol"},{"key":"19","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.nbd.2014.03.019","article-title":"System-based approaches to decode the molecular links in Parkinson\u2019s disease and diabetes.","volume":"7","author":"Potashkin","year":"2014","journal-title":"Neurobiol Dis"},{"key":"20","doi-asserted-by":"publisher","first-page":"374","DOI":"10.14336\/AD.2017.0706","article-title":"Pro- and anti-inflammatory effects of high cholesterol diet on aged brain.","volume":"9","author":"Xiao","year":"2018","journal-title":"Aging Dis"},{"key":"21","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1016\/j.jalz.2018.06.2857","article-title":"Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults.","volume":"1","author":"Popp","year":"2018","journal-title":"Alzheimers Dement"},{"key":"22","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1097\/MOL.0000000000000449","article-title":"Hyperlipidemia and cardiovascular disease with focus on familial hypercholesterolemia.","volume":"2","author":"Bogsrud","year":"2017","journal-title":"Curr Opin Lipidol"},{"key":"23","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1750-3639.2012.00628.x","article-title":"Vascular degeneration in Parkinson\u2019s disease.","volume":"2","author":"Nicholson","year":"2013","journal-title":"Brain Pathol"},{"key":"24","doi-asserted-by":"publisher","first-page":"834","DOI":"10.14336\/AD.2019.0304","article-title":"Plasma lipoprotein-associated phospholipase A2 and superoxide dismutase are independent predicators of cognitive impairment in cerebral small vessel disease patients: diagnosis and assessment.","volume":"1","author":"Sun","year":"2019","journal-title":"Aging Dis"},{"key":"25","doi-asserted-by":"publisher","first-page":"488","DOI":"10.3389\/fncel.2018.00488","article-title":"Microglia in neurological diseases: a road map to brain-disease dependent-inflammatory response.","volume":"1","author":"Boza-Serrano","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"26","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.pneurobio.2017.12.003","article-title":"Functional dissection of astrocyte-secreted proteins: implications in brain health and diseases.","volume":"16","author":"Suk","year":"2018","journal-title":"Prog Neurobiol"},{"key":"27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/mds.27836","article-title":"Understanding the links between cardiovascular disease and Parkinson\u2019s disease.","volume":"3","author":"Marras","year":"2020","journal-title":"Mov Disord"},{"key":"28","first-page":"2957","article-title":"The expression features of serum cystatin C and homocysteine of Parkinson\u2019s disease with mild cognitive dysfunction.","volume":"1","author":"Xie","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"29","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/jnc.13425","article-title":"Iron neurochemistry in Alzheimer\u2019s disease and Parkinson\u2019s disease: targets for therapeutics.","volume":"13","author":"Bush","year":"2016","journal-title":"J Neurochem"},{"key":"30","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1111\/ene.13728","article-title":"European association of nuclear medicine and European academy of neurology recommendations for the use of brainF-fluorodeoxyglucose positron emission tomography in neurodegenerative cognitive impairment and dementia: delphi consensus.","volume":"2","author":"Boccardi","year":"2018","journal-title":"Eur J Neurol"},{"key":"31","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1002\/mds.26698","article-title":"Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson\u2019s disease.","volume":"3","author":"Grosset","year":"2016","journal-title":"Mov Disord"},{"key":"32","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nrn.2018.13","article-title":"Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics.","volume":"1","author":"Akassoglou","year":"2018","journal-title":"Nat Rev Neurosci"},{"key":"33","doi-asserted-by":"publisher","first-page":"676","DOI":"10.14336\/AD.2019.0315","article-title":"A microcirculatory theory of aging.","volume":"1","author":"Jin","year":"2019","journal-title":"Aging Dis"},{"key":"34","doi-asserted-by":"publisher","first-page":"237","DOI":"10.14336\/AD.2015.1030","article-title":"Higher plasma LDL-cholesterol is associated with preserved executive and fine motor functions in Parkinson\u2019s disease.","volume":"7","author":"Huang","year":"2016","journal-title":"Aging Dis"},{"key":"35","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40035-018-0110-3","article-title":"The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms.","volume":"7","author":"Berlau","year":"2018","journal-title":"Transl Neurodegener"},{"key":"36","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease.","volume":"3","author":"Gasser","year":"2015","journal-title":"Mov Disord"},{"key":"37","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1016\/S0140-6736(17)30058-2","article-title":"Type 2 diabetes.","volume":"38","author":"Davies","year":"2017","journal-title":"Lancet"},{"key":"38","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1055\/s-2008-1041419","article-title":"Drug treatment of hyperkinetic movement disorders.","volume":"7","author":"Fahn","year":"1987","journal-title":"Semin Neurol"},{"key":"39","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1002\/mds.21596","article-title":"The metric properties of a novel non-motor symptoms scale for Parkinson\u2019s disease: results from an international pilot study.","volume":"2","author":"Forbes","year":"2007","journal-title":"Mov Disord"},{"key":"40","doi-asserted-by":"publisher","first-page":"789","DOI":"10.3233\/JAD-161042","article-title":"Cross-cultural applicability of the montreal cognitive assessment (MoCA): a systematic review.","volume":"5","author":"Shaikh","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"41","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.1002\/mds.21844","article-title":"Diagnostic procedures for Parkinson\u2019s disease dementia: recommendations from the movement disorder society task force.","volume":"2","author":"Levy","year":"2007","journal-title":"Mov Disord"},{"key":"42","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1212\/wnl.55.11.1609","article-title":"Population norms for the MMSE in the very old: estimates based on longitudinal data. Mini-mental state examination.","volume":"5","author":"Huppert","year":"2000","journal-title":"Neurology"},{"key":"43","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1177\/0890117116671537","article-title":"Identification of undiagnosed hyperlipidemia: do work site screening programs work?","volume":"3","author":"Legorreta","year":"2018","journal-title":"Am J Health Promot"},{"key":"44","first-page":"390","article-title":"[Chinese guidelines on prevention and treatment of dyslipidemia in adults].","volume":"3","author":"Joint Committee for Developing Chinese guidelines on Prevention and Treatment of Dyslipidemia in Adults","year":"2007","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"45","doi-asserted-by":"publisher","first-page":"e285","DOI":"10.1016\/j.jacc.2018.11.003","article-title":"2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of blood cholesterol: a report of the American college of cardiology\/American heart association task force on clinical practice guidelines.","volume":"7","author":"Hlatky","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"46","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.3390\/nu11122885","article-title":"Threshold-effect association of dietary cholesterol intake with dyslipidemia in Chinese adults: results from the China health and nutrition survey in 2015.","volume":"1","author":"Wang","year":"2019","journal-title":"Nutrients"},{"key":"47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5551\/jat.9.1","article-title":"Report of the Japan atherosclerosis society (JAS) guideline for diagnosis and treatment of hyperlipidemia in Japanese adults.","volume":"9","author":"Sasaki","year":"2002","journal-title":"J Atheroscler Thromb"},{"key":"48","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1007\/s12325-018-0717-x","article-title":"Safety and efficacy of high versus standard starting doses of insulin glargine in overweight and obese Chinese individuals with type 2 diabetes mellitus inadequately controlled on oral antidiabetic medications (beyond VII): study protocol for a randomized controlled trial.","volume":"3","author":"Cui","year":"2018","journal-title":"Adv Ther"},{"key":"49","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.remn.2018.12.001","article-title":"Association between white matter lesions and the cerebral glucose metabolism in patients with cognitive impairment.","volume":"3","author":"Kim","year":"2019","journal-title":"Rev Esp Med Nucl Imagen Mol"},{"key":"50","doi-asserted-by":"publisher","first-page":"e018288","DOI":"10.1136\/bmjopen-2017-018288","article-title":"Dementia prevalence in a population at high vascular risk: the trinidad national survey of ageing and cognition.","volume":"8","author":"Stewart","year":"2018","journal-title":"BMJ Open"},{"key":"51","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.parkreldis.2019.07.005","article-title":"Third ventricular width assessed by transcranial ultrasound correlates with cognitive performance in Parkinson\u2019s disease.","volume":"6","author":"Berg","year":"2019","journal-title":"Parkinsonism Relat Disord"},{"key":"52","doi-asserted-by":"publisher","first-page":"e025274","DOI":"10.1136\/bmjopen-2018-025274","article-title":"Risk of dementia after Parkinson\u2019s disease in Taiwan: a population-based retrospective cohort study using national health insurance claims.","volume":"9","author":"Hu","year":"2019","journal-title":"BMJ Open"},{"key":"53","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1097\/WAD.0000000000000122","article-title":"Prevalence of cognitive impairment without dementia and dementia in trememb\u00e9, Brazil.","volume":"3","author":"Sp\u00edndola","year":"2016","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"54","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1111\/dme.13380","article-title":"Older people with type 2 diabetes, including those with chronic kidney disease or dementia, are commonly overtreated with sulfonylurea or insulin therapies.","volume":"3","author":"Khunti","year":"2017","journal-title":"Diabet Med"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T13:23:55Z","timestamp":1602249835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,15]]},"references-count":54,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2020,8,15]]}},"alternative-id":["103776","32805719"],"URL":"https:\/\/doi.org\/10.18632\/aging.103776","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,15]]}}}