{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:35:12Z","timestamp":1757705712198},"reference-count":53,"publisher":"Impact Journals, LLC","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,9,25]]},"DOI":"10.18632\/aging.103856","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T16:27:43Z","timestamp":1601051263000},"page":"18603-18621","source":"Crossref","is-referenced-by-count":7,"title":["Muscle defects due to perturbed somite segmentation contribute to late adult scoliosis"],"prefix":"10.18632","volume":"12","author":[{"given":"Laura","family":"Lleras-Forero","sequence":"first","affiliation":[{"name":"Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, M\u00fcnster, Germany"},{"name":"Hubrecht Institute-KNAW and University Medical Center Utrecht, CT, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elis","family":"Newham","sequence":"additional","affiliation":[{"name":"The School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences, University of Bristol, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Teufel","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Muskuloskelettale Medizin (IMM), Abteilung Knochen- und Skelettforschung, Universit\u00e4tsklinikum M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Developmental Biology, National Institute of Genetics, Mishima, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Muskuloskelettale Medizin (IMM), Abteilung Knochen- und Skelettforschung, Universit\u00e4tsklinikum M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrissy L.","family":"Hammond","sequence":"additional","affiliation":[{"name":"The School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences, University of Bristol, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Knight","sequence":"additional","affiliation":[{"name":"Centre for Craniofacial and Regenerative Biology, King\u00b4s College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schulte-Merker","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, M\u00fcnster, Germany"},{"name":"Hubrecht Institute-KNAW and University Medical Center Utrecht, CT, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"1","first-page":"829","article-title":"[Late myopathies located at the spinal muscles: a cause of acquired lumbar kyphosis in adults].","volume":"5","author":"Arlet","year":"1991","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"2","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1097\/BRS.0000000000000095","article-title":"Thoracic scoliosis prevalence in patients 50 years or older and its relationship with age, sex, and thoracic kyphosis.","volume":"3","author":"Klaber","year":"2014","journal-title":"Spine (Phila Pa 1976)"},{"key":"3","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1097\/00007632-200202150-00012","article-title":"Adult scoliosis: a quantitative radiographic and clinical analysis.","volume":"2","author":"Pagala","year":"2002","journal-title":"Spine (Phila Pa 1976)"},{"key":"4","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.3171\/2010.1.FOCUS09271","article-title":"Adult degenerative scoliosis: evaluation and management.","volume":"2","author":"Lenke","year":"2010","journal-title":"Neurosurg Focus"},{"key":"5","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1097\/01.brs.0000194777.87055.1b","article-title":"A prospective study of de novo scoliosis in a community based cohort.","volume":"3","author":"Takeda","year":"2006","journal-title":"Spine (Phila Pa 1976)"},{"key":"6","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.cell.2011.05.011","article-title":"Vertebrate segmentation: from cyclic gene networks to scoliosis.","volume":"14","author":"Pourqui\u00e9","year":"2011","journal-title":"Cell"},{"key":"7","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/dgd.12655","article-title":"Somite boundary determination in normal and clock-less vertebrate embryos.","volume":"6","author":"Matsui","year":"2020","journal-title":"Dev Growth Differ"},{"key":"8","first-page":"821","article-title":"Diversity of expression of engrailed-like antigens in zebrafish.","volume":"11","author":"Kimmel","year":"1991","journal-title":"Development"},{"key":"9","first-page":"153","article-title":"Mutations affecting somite formation and patterning in the zebrafish, danio rerio.","volume":"12","author":"Odenthal","year":"1996","journal-title":"Development"},{"key":"10","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/0092-8674(94)90008-6","article-title":"Ectopic expression of sonic hedgehog alters dorsal-ventral patterning of somites.","volume":"7","author":"Tabin","year":"1994","journal-title":"Cell"},{"key":"11","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1101\/gad.11.17.2163","article-title":"Notochord induction of zebrafish slow muscle mediated by sonic hedgehog.","volume":"1","author":"Hughes","year":"1997","journal-title":"Genes Dev"},{"key":"12","first-page":"3371","article-title":"Identification of separate slow and fast muscle precursor cells in vivo, prior to somite formation.","volume":"12","author":"Westerfield","year":"1996","journal-title":"Development"},{"key":"13","doi-asserted-by":"publisher","first-page":"4211","DOI":"10.1242\/dev.01958","article-title":"Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish.","volume":"13","author":"Hughes","year":"2005","journal-title":"Development"},{"key":"14","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1242\/dev.151035","article-title":"Making muscle: skeletal myogenesis in vivo and in vitro.","volume":"14","author":"Pourqui\u00e9","year":"2017","journal-title":"Development"},{"key":"15","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/wdev.34","article-title":"Scoliosis and segmentation defects of the vertebrae.","volume":"1","author":"Kusumi","year":"2012","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"16","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1097\/00007632-198902000-00008","volume-title":"Spinal stability and intersegmental muscle forces. A biomechanical model.","volume":"14","author":"Oxland","year":"1989"},{"key":"17","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1007\/s002470050607","article-title":"MRI evaluation of multifidus muscles in adolescent idiopathic scoliosis.","volume":"2","author":"Metreweli","year":"1999","journal-title":"Pediatr Radiol"},{"key":"18","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1748-7161-2-9","article-title":"Trunk rotational strength asymmetry in adolescents with idiopathic scoliosis: an observational study.","volume":"2","author":"Liu","year":"2007","journal-title":"Scoliosis"},{"key":"19","doi-asserted-by":"publisher","first-page":"125","DOI":"10.3121\/cmr.1.2.125","article-title":"Congenital and idiopathic scoliosis: clinical and genetic aspects.","volume":"1","author":"Schowalter","year":"2003","journal-title":"Clin Med Res"},{"key":"20","doi-asserted-by":"publisher","first-page":"29","DOI":"10.11005\/jbm.2014.21.1.29","article-title":"Interaction between muscle and bone.","volume":"2","author":"Kaji","year":"2014","journal-title":"J Bone Metab"},{"key":"21","first-page":"200","article-title":"Muscle imbalance in the aetiology of scoliosis.","volume":"5","author":"Jowett","year":"1976","journal-title":"J Bone Joint Surg Br"},{"key":"22","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.devcel.2017.07.022","article-title":"The proprioceptive system masterminds spinal alignment: insight into the mechanism of scoliosis.","volume":"4","author":"Zelzer","year":"2017","journal-title":"Dev Cell"},{"key":"23","doi-asserted-by":"publisher","first-page":"e33843","DOI":"10.7554\/eLife.33843","article-title":"Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock.","volume":"7","author":"Schulte-Merker","year":"2018","journal-title":"Elife"},{"key":"24","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1242\/bio.20121958","article-title":"fss\/Tbx6 is required for central dermomyotome cell fate in zebrafish.","volume":"1","author":"Devoto","year":"2012","journal-title":"Biol Open"},{"key":"25","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1097\/01.brs.0000160842.43482.cd","article-title":"Adult scoliosis: prevalence, SF-36, and nutritional parameters in an elderly volunteer population.","volume":"3","author":"Farcy","year":"2005","journal-title":"Spine (Phila Pa 1976)"},{"key":"26","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1097\/BRS.0b013e3181e9f120","article-title":"Scoliosis in adults aged forty years and older: prevalence and relationship to age, race, and gender.","volume":"3","author":"Skolasky","year":"2011","journal-title":"Spine (Phila Pa 1976)"},{"key":"27","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/74307","article-title":"Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis.","volume":"2","author":"Turnpenny","year":"2000","journal-title":"Nat Genet"},{"key":"28","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1136\/jmg.40.5.333","article-title":"Novel mutations in DLL3, a somitogenesis gene encoding a ligand for the notch signalling pathway, cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis.","volume":"4","author":"Ellard","year":"2003","journal-title":"J Med Genet"},{"key":"29","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1056\/NEJMoa1406829","article-title":"TBX6 null variants and a common hypomorphic allele in congenital scoliosis.","volume":"37","author":"Yang","year":"2015","journal-title":"N Engl J Med"},{"key":"30","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1086\/421053","article-title":"Mutated MESP2 causes spondylocostal dysostosis in humans.","volume":"7","author":"Turnpenny","year":"2004","journal-title":"Am J Hum Genet"},{"key":"31","doi-asserted-by":"publisher","first-page":"3761","DOI":"10.1093\/hmg\/ddn272","article-title":"Mutation of hairy-and-enhancer-of-split-7 in humans causes spondylocostal dysostosis.","volume":"1","author":"Dunwoodie","year":"2008","journal-title":"Hum Mol Genet"},{"key":"32","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/ejhg.2009.241","article-title":"Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis.","volume":"1","author":"Dunwoodie","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"33","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1086\/498879","article-title":"Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype.","volume":"7","author":"Dunwoodie","year":"2006","journal-title":"Am J Hum Genet"},{"key":"34","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1093\/hmg\/ddu534","article-title":"Compound heterozygous mutations in RIPPLY2 associated with vertebral segmentation defects.","volume":"2","author":"Duncan","year":"2015","journal-title":"Hum Mol Genet"},{"key":"35","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1242\/dev.113431","article-title":"Tbx6, mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish.","volume":"14","author":"Devoto","year":"2015","journal-title":"Development"},{"key":"36","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1097\/00007632-197901000-00003","article-title":"Studies on spinal and peripheral muscles from patients with scoliosis.","volume":"4","author":"Robin","year":"1979","journal-title":"Spine (Phila Pa 1976)"},{"key":"37","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0022-510x(76)90262-8","article-title":"Spinal muscle in scoliosis. Part 2. The proportion and size of type 1 and type 2 skeletal muscle fibres measured using a computer-controlled microscope.","volume":"3","author":"Eccles","year":"1976","journal-title":"J Neurol Sci"},{"key":"38","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1093\/ilar.53.2.161","article-title":"Zebrafish breeding in the laboratory environment.","volume":"5","author":"Clark","year":"2012","journal-title":"ILAR J"},{"key":"39","first-page":"117","article-title":"Adolescent changes in size, build, composition and performance.","volume":"4","author":"Malina","year":"1974","journal-title":"Hum Biol"},{"key":"40","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1038\/s41436-018-0377-x","article-title":"TBX6-associated congenital scoliosis (TACS) as a clinically distinguishable subtype of congenital scoliosis: further evidence supporting the compound inheritance and TBX6 gene dosage model.","volume":"2","author":"Zhao","year":"2019","journal-title":"Genet Med"},{"key":"41","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0022-510x(76)90261-6","article-title":"Spinal muscle in scoliosis. Part 1. Histology and histochemistry.","volume":"3","author":"Zorab","year":"1976","journal-title":"J Neurol Sci"},{"key":"42","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1016\/j.cub.2007.07.039","article-title":"The him gene reveals a balance of inputs controlling muscle differentiation in drosophila.","volume":"1","author":"Taylor","year":"2007","journal-title":"Curr Biol"},{"key":"43","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.ydbio.2015.02.005","article-title":"The myogenic repressor gene holes in muscles is a direct transcriptional target of twist and tinman in the drosophila embryonic mesoderm.","volume":"40","author":"Cripps","year":"2015","journal-title":"Dev Biol"},{"key":"44","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1242\/dev.053181","article-title":"Specificity of notch pathway activation: twist controls the transcriptional output in adult muscle progenitors.","volume":"13","author":"Bray","year":"2010","journal-title":"Development"},{"key":"45","doi-asserted-by":"publisher","first-page":"4158","DOI":"10.1242\/dev.111930","article-title":"Spatial gradients of protein-level time delays set the pace of the traveling segmentation clock waves.","volume":"14","author":"Ozbudak","year":"2014","journal-title":"Development"},{"key":"46","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/gene.20140","article-title":"Dll1 is a downstream target of Tbx6 in the paraxial mesoderm.","volume":"4","author":"Chapman","year":"2005","journal-title":"Genesis"},{"key":"47","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1177\/0023677219869037","article-title":"Zebrafish: housing and husbandry recommendations.","volume":"5","author":"Warner","year":"2020","journal-title":"Lab Anim"},{"key":"48","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/j.1440-169X.2008.01044.x","article-title":"Targeted gene expression by the Gal4-UAS system in zebrafish.","volume":"5","author":"Kawakami","year":"2008","journal-title":"Dev Growth Differ"},{"key":"49","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.1242\/dev.024034","article-title":"Retinoic acid and Cyp26b1 are critical regulators of osteogenesis in the axial skeleton.","volume":"13","author":"Schulte-Merker","year":"2008","journal-title":"Development"},{"key":"50","doi-asserted-by":"crossref","unstructured":"Goody. M HC. Phalloidin staining and Immunohistochemistry of zebrafish Embryos. bio-protocol. 2013; 3. https:\/\/doi.org\/10.21769\/BioProtoc.786.","DOI":"10.21769\/BioProtoc.786"},{"key":"51","doi-asserted-by":"publisher","first-page":"20","DOI":"10.26496\/bjz.2014.63","article-title":"A. De Kegel, B. Van Loo, D. Van Hoorebeke, L. Adriaens, D. Soft tissue discrimination with contrast agents using micro-CT scanning.","volume":"14","author":"Descamps","year":"2014","journal-title":"Belg J Zool"},{"key":"52","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis.","volume":"9","author":"Eliceiri","year":"2012","journal-title":"Nat Methods"},{"key":"53","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/ajpa.23702","article-title":"Nondestructive adult age at death estimation: visualizing cementum annulations in a known age historical human assemblage using synchrotron x-ray microtomography.","volume":"16","author":"Hillson","year":"2019","journal-title":"Am J Phys Anthropol"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T13:52:58Z","timestamp":1602251578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":53,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2020,9,30]]}},"alternative-id":["103856","32979261"],"URL":"https:\/\/doi.org\/10.18632\/aging.103856","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,25]]}}}