{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:51:15Z","timestamp":1761598275840},"reference-count":50,"publisher":"Impact Journals, LLC","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,12,15]]},"DOI":"10.18632\/aging.103940","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T22:03:11Z","timestamp":1605564191000},"page":"23739-23760","source":"Crossref","is-referenced-by-count":11,"title":["Red light exaggerated sepsis-induced learning impairments and anxiety-like behaviors"],"prefix":"10.18632","volume":"12","author":[{"given":"Bing","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiying","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiancheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nrneurol.2012.183","article-title":"Sepsis-associated encephalopathy.","volume":"8","author":"Young","year":"2012","journal-title":"Nat Rev Neurol"},{"key":"2","doi-asserted-by":"publisher","first-page":"E1083","DOI":"10.1503\/cmaj.180454","article-title":"Sepsis-associated encephalopathy.","volume":"19","author":"Witte","year":"2018","journal-title":"CMAJ"},{"key":"3","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.neuint.2011.01.004","article-title":"Septic encephalopathy: inflammation in man and mouse.","volume":"5","author":"Alexander","year":"2011","journal-title":"Neurochem Int"},{"key":"4","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1038\/jcbfm.2011.48","article-title":"Neuro-oxidative-nitrosative stress in sepsis.","volume":"3","author":"Bailey","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"key":"5","doi-asserted-by":"publisher","first-page":"50","DOI":"10.2174\/138920012798356970","article-title":"Morphofunctional aspects of the blood-brain barrier.","volume":"1","author":"Ribatti","year":"2012","journal-title":"Curr Drug Metab"},{"key":"6","doi-asserted-by":"publisher","first-page":"828","DOI":"10.3760\/cma.j.issn.0366-6999.2012.05.018","article-title":"Epidemiological features and risk factors of sepsis-associated encephalopathy in intensive care unit patients: 2008-2011.","volume":"12","author":"Yao","year":"2012","journal-title":"Chin Med J (Engl)"},{"key":"7","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.pharmthera.2015.11.012","article-title":"Gut microbiome in health and disease: linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases.","volume":"15","author":"Kanthasamy","year":"2016","journal-title":"Pharmacol Ther"},{"key":"8","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1172\/JCI76304","article-title":"Gut\/brain axis and the microbiota.","volume":"12","author":"Gupta","year":"2015","journal-title":"J Clin Invest"},{"key":"9","doi-asserted-by":"publisher","first-page":"e03236","DOI":"10.1128\/mBio.03236-19","article-title":"Respiratory viral infection alters the gut microbiota by inducing inappetence.","volume":"1","author":"Tregoning","year":"2020","journal-title":"mBio"},{"key":"10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1146\/annurev-neuro-072116-031347","article-title":"The microbiome and host behavior.","volume":"4","author":"Hsiao","year":"2017","journal-title":"Annu Rev Neurosci"},{"key":"11","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41575-018-0061-2","article-title":"You are what you eat: diet, health and the gut microbiota.","volume":"1","author":"Elinav","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"12","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nrmicro2974","article-title":"The gut microbiota\u2014masters of host development and physiology.","volume":"1","author":"B\u00e4ckhed","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"13","doi-asserted-by":"publisher","first-page":"6152","DOI":"10.2174\/1381612822666160907093807","article-title":"The gut-brain axis, including the microbiome, leaky gut and bacterial translocation: mechanisms and pathophysiological role in Alzheimer\u2019s disease.","volume":"2","author":"Carvalho","year":"2016","journal-title":"Curr Pharm Des"},{"key":"14","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1073\/pnas.1010529108","article-title":"Normal gut microbiota modulates brain development and behavior.","volume":"10","author":"Pettersson","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"15","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.psyneuen.2014.01.014","article-title":"Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats.","volume":"4","author":"Rabot","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"16","doi-asserted-by":"publisher","first-page":"11258","DOI":"10.1096\/fj.201802188R","article-title":"The gut microbiome alters immunophenotype and survival from sepsis.","volume":"3","author":"Coopersmith","year":"2019","journal-title":"FASEB J"},{"key":"17","doi-asserted-by":"publisher","first-page":"16050","DOI":"10.1073\/pnas.1102999108","article-title":"Ingestion of lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.","volume":"10","author":"Cryan","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"18","doi-asserted-by":"publisher","first-page":"18","DOI":"10.21307\/ane-2017-033","article-title":"Energy-dense diet triggers changes in gut microbiota, reorganization of gut-brain vagal communication and increases body fat accumulation.","volume":"7","author":"Czaja","year":"2017","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"19","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1111\/j.1365-2982.2011.01796.x","article-title":"The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication.","volume":"2","author":"Kunze","year":"2011","journal-title":"Neurogastroenterol Motil"},{"key":"20","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1038\/nn.2179","article-title":"The acute light-induction of sleep is mediated by OPN4-based photoreception.","volume":"1","author":"Foster","year":"2008","journal-title":"Nat Neurosci"},{"key":"21","doi-asserted-by":"publisher","first-page":"e1002482","DOI":"10.1371\/journal.pbio.1002482","article-title":"Melanopsin regulates both sleep-promoting and arousal-promoting responses to light.","volume":"1","author":"Peirson","year":"2016","journal-title":"PLoS Biol"},{"key":"22","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1210\/jc.2004-0957","article-title":"High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light.","volume":"9","author":"Wirz-Justice","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"23","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1212\/WNL.0000000000003761","article-title":"Clinical implications of the melanopsin-based non-image-forming visual system.","volume":"8","author":"Provencio","year":"2017","journal-title":"Neurology"},{"key":"24","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1126\/science.1069609","article-title":"Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity.","volume":"29","author":"Yau","year":"2002","journal-title":"Science"},{"key":"25","doi-asserted-by":"publisher","first-page":"2788","DOI":"10.1093\/cercor\/bhm007","article-title":"Wavelength-dependent modulation of brain responses to a working memory task by daytime light exposure.","volume":"1","author":"Maquet","year":"2007","journal-title":"Cereb Cortex"},{"key":"26","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.tics.2009.07.004","article-title":"Light as a modulator of cognitive brain function.","volume":"1","author":"Dijk","year":"2009","journal-title":"Trends Cogn Sci"},{"key":"27","doi-asserted-by":"publisher","first-page":"e1247","DOI":"10.1371\/journal.pone.0001247","article-title":"Brain responses to violet, blue, and green monochromatic light exposures in humans: prominent role of blue light and the brainstem.","volume":"2","author":"Dijk","year":"2007","journal-title":"PLoS One"},{"key":"28","doi-asserted-by":"publisher","first-page":"e2000111","DOI":"10.1371\/journal.pbio.2000111","article-title":"Alerting or Somnogenic Light: Pick Your Color.","volume":"1","author":"Hubbard","year":"2016","journal-title":"PLoS Biol"},{"key":"29","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.biopsych.2013.11.029","article-title":"Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain.","volume":"7","author":"Godbout","year":"2014","journal-title":"Biol Psychiatry"},{"key":"30","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1126\/science.1175202","article-title":"Identification of splenic reservoir monocytes and their deployment to inflammatory sites.","volume":"32","author":"Libby","year":"2009","journal-title":"Science"},{"key":"31","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.tins.2013.01.005","article-title":"Gut-brain axis: how the microbiome influences anxiety and depression.","volume":"3","author":"McVey Neufeld","year":"2013","journal-title":"Trends Neurosci"},{"key":"32","doi-asserted-by":"publisher","first-page":"G168","DOI":"10.1152\/ajpgi.00190.2011","article-title":"Linkage of gut microbiome with cognition in hepatic encephalopathy.","volume":"30","author":"Gillevet","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"33","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1136\/gut.2009.202515","article-title":"Bacterial infection causes stress-induced memory dysfunction in mice.","volume":"6","author":"Sherman","year":"2011","journal-title":"Gut"},{"key":"34","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.copbio.2017.08.004","article-title":"Intestinal lactobacillus in health and disease, a driver or just along for the ride?","volume":"4","author":"Marco","year":"2018","journal-title":"Curr Opin Biotechnol"},{"key":"35","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.neuroscience.2015.05.016","article-title":"Relationships between diet-related changes in the gut microbiome and cognitive flexibility.","volume":"30","author":"Bermudez","year":"2015","journal-title":"Neuroscience"},{"key":"36","doi-asserted-by":"publisher","first-page":"4907","DOI":"10.1038\/s41598-018-23261-1","article-title":"Microbiome-metabolome signatures in mice genetically prone to develop dementia, fed a normal or fatty diet.","volume":"8","author":"Iozzo","year":"2018","journal-title":"Sci Rep"},{"key":"37","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3389\/fnagi.2017.00298","article-title":"Age drives distortion of brain metabolic, vascular and cognitive functions, and the gut microbiome.","volume":"9","author":"Lin","year":"2017","journal-title":"Front Aging Neurosci"},{"key":"38","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nn.4476","article-title":"Interactions between the microbiota, immune and nervous systems in health and disease.","volume":"2","author":"Hsiao","year":"2017","journal-title":"Nat Neurosci"},{"key":"39","doi-asserted-by":"publisher","first-page":"eaau6085","DOI":"10.1126\/sciimmunol.aau6085","article-title":"Structure and function of the immune system in the spleen.","volume":"4","author":"Eisenbarth","year":"2019","journal-title":"Sci Immunol"},{"key":"40","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41586-020-2235-7","article-title":"Brain control of humoral immune responses amenable to behavioural modulation.","volume":"58","author":"Qi","year":"2020","journal-title":"Nature"},{"key":"41","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/d41586-020-01168-0","article-title":"Brain-spleen connection aids antibody production.","volume":"58","author":"Russo","year":"2020","journal-title":"Nature"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-019-01092-z","article-title":"Splenic NKG2D confers resilience versus susceptibility in mice after chronic social defeat stress: beneficial effects of (R)-ketamine.","author":"Hashimoto","year":"2019","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"43","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/s41398-020-00878-3","article-title":"A key role of the subdiaphragmatic vagus nerve in the depression-like phenotype and abnormal composition of gut microbiota in mice after lipopolysaccharide administration.","volume":"1","author":"Hashimoto","year":"2020","journal-title":"Transl Psychiatry"},{"key":"44","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/joim.12104","article-title":"HMGB1 mediates splenomegaly and expansion of splenic CD11b+ ly-6C(high) inflammatory monocytes in murine sepsis survivors.","volume":"27","author":"Pavlov","year":"2013","journal-title":"J Intern Med"},{"key":"45","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1002\/jnr.21661","article-title":"The spleen contributes to stroke-induced neurodegeneration.","volume":"8","author":"Pennypacker","year":"2008","journal-title":"J Neurosci Res"},{"key":"46","doi-asserted-by":"publisher","first-page":"3535","DOI":"10.4049\/jimmunol.181.5.3535","article-title":"Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels.","volume":"18","author":"Yang","year":"2008","journal-title":"J Immunol"},{"key":"47","doi-asserted-by":"publisher","first-page":"13081","DOI":"10.1523\/JNEUROSCI.5734-12.2013","article-title":"Nocturnal light exposure impairs affective responses in a wavelength-dependent manner.","volume":"3","author":"Nelson","year":"2013","journal-title":"J Neurosci"},{"key":"48","doi-asserted-by":"publisher","first-page":"e779","DOI":"10.1097\/CCM.0000000000003190","article-title":"Blue light enhances bacterial clearance and reduces organ injury during sepsis.","volume":"4","author":"Rosengart","year":"2018","journal-title":"Crit Care Med"},{"key":"49","doi-asserted-by":"publisher","first-page":"e16231","DOI":"10.1038\/lsa.2016.231","article-title":"Red light at intensities above 10 lx alters sleep-wake behavior in mice.","volume":"6","author":"Huang","year":"2017","journal-title":"Light Sci Appl"},{"key":"50","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1016\/j.neuropharm.2011.12.022","article-title":"The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide.","volume":"6","author":"Hayes","year":"2012","journal-title":"Neuropharmacology"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T15:47:43Z","timestamp":1617724063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,10]]},"references-count":50,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2020,12,15]]}},"alternative-id":["103940","33197883"],"URL":"https:\/\/doi.org\/10.18632\/aging.103940","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,10]]}}}