{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T19:13:12Z","timestamp":1778785992680,"version":"3.51.4"},"reference-count":37,"publisher":"Impact Journals, LLC","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,12,31]]},"DOI":"10.18632\/aging.104172","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T00:52:28Z","timestamp":1605919948000},"page":"25643-25657","source":"Crossref","is-referenced-by-count":10,"title":["Neurofilament degradation is involved in laparotomy-induced cognitive dysfunction in aged rats"],"prefix":"10.18632","volume":"12","author":[{"given":"Yiyun","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taotao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengqian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Sixth People\u2019s Hospital East Campus Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, North Minzu University, Yinchuan, Ningxia 750021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinning","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aihua","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aizhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1097\/ALN.0b013e31828ce55d","article-title":"Effects of anesthetic isoflurane and desflurane on human cerebrospinal fluid A\u03b2 and \u03c4 level.","volume":"11","author":"Xie","year":"2013","journal-title":"Anesthesiology"},{"key":"2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.bbr.2017.09.004","article-title":"Hypoxia-inducible factor-1\u03b1 is involved in isoflurane-induced blood-brain barrier disruption in aged rats model of POCD.","volume":"33","author":"Guo","year":"2018","journal-title":"Behav Brain Res"},{"key":"3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12871-017-0408-1","article-title":"Influence of the postoperative inflammatory response on cognitive decline in elderly patients undergoing on-pump cardiac surgery: a controlled, prospective observational study.","volume":"1","author":"Gal","year":"2017","journal-title":"BMC Anesthesiol"},{"key":"4","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.bbrc.2013.08.003","article-title":"Activation of the canonical nuclear factor-\u03baB pathway is involved in isoflurane-induced hippocampal interleukin-1\u03b2 elevation and the resultant cognitive deficits in aged rats.","volume":"43","author":"Guo","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"5","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1146\/annurev-immunol-032713-120240","article-title":"Microglia development and function.","volume":"3","author":"McGavern","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"6","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/aps.2016.162","article-title":"Regulation of microglial activation in stroke.","volume":"3","author":"Liu","year":"2017","journal-title":"Acta Pharmacol Sin"},{"key":"7","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1038\/ng.3916","article-title":"Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer\u2019s disease.","volume":"4","author":"Heilmann-Heimbach","year":"2017","journal-title":"Nat Genet"},{"key":"8","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nri3705","article-title":"Innate immune activation in neurodegenerative disease.","volume":"1","author":"Latz","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"9","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/1742-2094-11-98","article-title":"Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.","volume":"1","author":"O\u2019Banion","year":"2014","journal-title":"J Neuroinflammation"},{"key":"10","doi-asserted-by":"publisher","first-page":"14641","DOI":"10.1523\/JNEUROSCI.2173-12.2012","article-title":"Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats.","volume":"3","author":"Maier","year":"2012","journal-title":"J Neurosci"},{"key":"11","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.bbrc.2014.04.153","article-title":"Prophylactic angiotensin type 1 receptor antagonism confers neuroprotection in an aged rat model of postoperative cognitive dysfunction.","volume":"44","author":"Guo","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"12","doi-asserted-by":"publisher","first-page":"10006","DOI":"10.1523\/JNEUROSCI.2580-06.2006","article-title":"Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS.","volume":"2","author":"Nixon","year":"2006","journal-title":"J Neurosci"},{"key":"13","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1172\/JCI38003","article-title":"Dysfunctions of neuronal and glial intermediate filaments in disease.","volume":"11","author":"Messing","year":"2009","journal-title":"J Clin Invest"},{"key":"14","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1093\/hmg\/11.23.2837","article-title":"Charcot-marie-tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport.","volume":"1","author":"Miller","year":"2002","journal-title":"Hum Mol Genet"},{"key":"15","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1093\/hmg\/ddh236","article-title":"Phenotypic analysis of neurofilament light gene mutations linked to charcot-marie-tooth disease in cell culture models.","volume":"1","author":"Liem","year":"2004","journal-title":"Hum Mol Genet"},{"key":"16","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1001\/jamaneurol.2016.6117","article-title":"Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease.","volume":"7","author":"Blennow","year":"2017","journal-title":"JAMA Neurol"},{"key":"17","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1212\/WNL.0000000000004645","article-title":"Serum neurofilament light is sensitive to active cerebral small vessel disease.","volume":"8","author":"Ropele","year":"2017","journal-title":"Neurology"},{"key":"18","doi-asserted-by":"publisher","first-page":"17368","DOI":"10.1038\/s41598-018-35766-w","article-title":"Levels of plasma neurofilament light chain and cognitive function in patients with Alzheimer or Parkinson disease.","volume":"8","author":"Fuh","year":"2018","journal-title":"Sci Rep"},{"key":"19","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13195-018-0367-x","article-title":"Neurofilament light as a blood biomarker for neurodegeneration in down syndrome.","volume":"1","author":"Zetterberg","year":"2018","journal-title":"Alzheimers Res Ther"},{"key":"20","doi-asserted-by":"publisher","first-page":"778","DOI":"10.3389\/fneur.2018.00778","article-title":"The importance of inter-species variation in traumatic brain injury-induced alterations of microglial-axonal interactions.","volume":"9","author":"Lafrenaye","year":"2018","journal-title":"Front Neurol"},{"key":"21","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.neulet.2005.06.003","article-title":"Inhibition of histone deacetylation by trichostatin a intensifies the transcriptions of neuronal c-fos and c-jun genes after kainate stimulation.","volume":"38","author":"Yoneda","year":"2005","journal-title":"Neurosci Lett"},{"key":"22","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1002\/jnr.23221","article-title":"Histone deacetylase inhibitors suppress immune activation in primary mouse microglia.","volume":"9","author":"Boddeke","year":"2013","journal-title":"J Neurosci Res"},{"key":"23","doi-asserted-by":"publisher","first-page":"146493","DOI":"10.1155\/2011\/146493","article-title":"Beyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substrates.","volume":"201","author":"Yang","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"24","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.semcdb.2019.05.004","article-title":"Microglia-mediated neuroinflammation in neurodegenerative diseases.","volume":"9","author":"Dheen","year":"2019","journal-title":"Semin Cell Dev Biol"},{"key":"25","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/nan.12445","article-title":"Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study.","volume":"4","author":"Sousa","year":"2018","journal-title":"Neuropathol Appl Neurobiol"},{"key":"26","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.bbr.2017.05.066","article-title":"Astrocyte-derived CCL2 participates in surgery-induced cognitive dysfunction and neuroinflammation via evoking microglia activation.","volume":"33","author":"Qian","year":"2017","journal-title":"Behav Brain Res"},{"key":"27","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain.","volume":"9","author":"Kelley","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"28","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer\u2019s disease.","volume":"16","author":"Amit","year":"2017","journal-title":"Cell"},{"key":"29","doi-asserted-by":"publisher","first-page":"3132","DOI":"10.1111\/j.1460-9568.2008.06296.x","article-title":"Dual modulation of synaptic transmission in the nucleus tractus solitarius by prostaglandin E2 synthesized downstream of IL-1beta.","volume":"2","author":"Am\u00e9d\u00e9e","year":"2008","journal-title":"Eur J Neurosci"},{"key":"30","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/j.1749-6632.2001.tb05827.x","article-title":"Cytokine-induced sickness behavior: mechanisms and implications.","volume":"93","author":"Dantzer","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"31","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.mcn.2008.06.009","article-title":"Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice.","volume":"3","author":"Carri\u00f3n","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"32","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13024-019-0318-4","article-title":"The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders.","volume":"1","author":"Opal","year":"2019","journal-title":"Mol Neurodegener"},{"key":"33","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/s0006-8993(00)02899-7","article-title":"Electrophysiological properties of axons in mice lacking neurofilament subunit genes: disparity between conduction velocity and axon diameter in absence of NF-H.","volume":"88","author":"Padjen","year":"2000","journal-title":"Brain Res"},{"key":"34","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12974-017-0805-x","article-title":"Microglia-derived IL-1\u03b2 contributes to axon development disorders and synaptic deficit through p38-MAPK signal pathway in septic neonatal rats.","volume":"1","author":"Deng","year":"2017","journal-title":"J Neuroinflammation"},{"key":"35","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.jbiotec.2007.06.024","article-title":"Collagen biomaterial doped with colominic acid for cell culture applications with regard to peripheral nerve repair.","volume":"13","author":"Scheper","year":"2007","journal-title":"J Biotechnol"},{"key":"36","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/j.biomaterials.2011.10.069","article-title":"The role of microstructured and interconnected pore channels in a collagen-based nerve guide on axonal regeneration in peripheral nerves.","volume":"3","author":"Eummelen","year":"2012","journal-title":"Biomaterials"},{"key":"37","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.neulet.2014.12.018","article-title":"Isoflurane anesthesia results in reversible ultrastructure and occludin tight junction protein expression changes in hippocampal blood-brain barrier in aged rats.","volume":"58","author":"Guo","year":"2015","journal-title":"Neurosci Lett"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.104172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T11:57:46Z","timestamp":1617710266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.104172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,24]]},"references-count":37,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2020,12,31]]}},"alternative-id":["104172","33232265"],"URL":"https:\/\/doi.org\/10.18632\/aging.104172","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.2.24620\/v1","asserted-by":"object"}]},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,24]]}}}