{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T13:13:28Z","timestamp":1768914808638,"version":"3.49.0"},"reference-count":57,"publisher":"Impact Journals, LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,1,15]]},"DOI":"10.18632\/aging.202159","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T08:26:12Z","timestamp":1606465572000},"page":"493-515","source":"Crossref","is-referenced-by-count":28,"title":["Melatonin alleviates angiotensin-II-induced cardiac hypertrophy via activating MICU1 pathway"],"prefix":"10.18632","volume":"13","author":[{"given":"Yi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dachun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houxiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2020,11,26]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1161\/HYPERTENSIONAHA.111.00947","article-title":"Cathepsin K knockout alleviates pressure overload-induced cardiac hypertrophy.","volume":"6","author":"Nair","year":"2013","journal-title":"Hypertension"},{"key":"2","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy.","volume":"9","author":"Minamino","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"3","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1113\/JP271301","article-title":"Mitochondrial dynamics, mitophagy and cardiovascular disease.","volume":"59","author":"Lavandero","year":"2016","journal-title":"J Physiol"},{"key":"4","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.yjmcc.2012.09.002","article-title":"Mitochondria in cardiac hypertrophy and heart failure.","volume":"5","author":"Hoppel","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"5","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.freeradbiomed.2019.01.052","article-title":"Ferritinophagy activation and sideroflexin1-dependent mitochondria iron overload is involved in apelin-13-induced cardiomyocytes hypertrophy.","volume":"13","author":"Chen","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"6","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.cell.2012.10.011","article-title":"MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.","volume":"15","author":"Madesh","year":"2012","journal-title":"Cell"},{"key":"7","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1016\/j.bbabio.2009.05.011","article-title":"The role of Ca(2+) signaling in the coordination of mitochondrial ATP production with cardiac work.","volume":"178","author":"Balaban","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"8","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.bbagen.2012.02.010","article-title":"High glucose-induced Ca2+ overload and oxidative stress contribute to apoptosis of cardiac cells through mitochondrial dependent and independent pathways.","volume":"182","author":"Sitasawad","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"9","doi-asserted-by":"publisher","first-page":"12897","DOI":"10.1038\/ncomms12897","article-title":"PRMT1-mediated methylation of MICU1 determines the UCP2\/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells.","volume":"7","author":"Graier","year":"2016","journal-title":"Nat Commun"},{"key":"10","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/nature09358","article-title":"MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake.","volume":"46","author":"Mootha","year":"2010","journal-title":"Nature"},{"key":"11","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/ng.2851","article-title":"Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.","volume":"4","author":"Whyte","year":"2014","journal-title":"Nat Genet"},{"key":"12","doi-asserted-by":"publisher","first-page":"e2923","DOI":"10.1038\/cddis.2017.280","article-title":"MICU1 protects against myocardial ischemia\/reperfusion injury and its control by the importer receptor Tom70.","volume":"8","author":"Tao","year":"2017","journal-title":"Cell Death Dis"},{"key":"13","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.2337\/db16-1237","article-title":"MICU1 alleviates diabetic cardiomyopathy through mitochondrial Ca-dependent antioxidant response.","volume":"6","author":"Li","year":"2017","journal-title":"Diabetes"},{"key":"14","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling.","volume":"2","author":"Tsuji","year":"2012","journal-title":"Cell Signal"},{"key":"15","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1161\/01.HYP.0000254415.31362.a7","article-title":"Role of oxidative stress in cardiac hypertrophy and remodeling.","volume":"4","author":"Kass","year":"2007","journal-title":"Hypertension"},{"key":"16","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3109\/15376516.2012.666650","article-title":"Oxidative stress and cardiac hypertrophy: a review.","volume":"2","author":"Kumar","year":"2012","journal-title":"Toxicol Mech Methods"},{"key":"17","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.abb.2018.11.007","article-title":"Interplay of N acetyl cysteine and melatonin in regulating oxidative stress-induced cardiac hypertrophic factors and microRNAs.","volume":"66","author":"Murtaza","year":"2019","journal-title":"Arch Biochem Biophys"},{"key":"18","doi-asserted-by":"publisher","first-page":"e99435","DOI":"10.15252\/embj.201899435","article-title":"Akt-mediated phosphorylation of MICU1 regulates mitochondrial Calevels and tumor growth.","volume":"3","author":"Pinton","year":"2019","journal-title":"EMBO J"},{"key":"19","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1080\/01616412.2017.1315864","article-title":"A review of sleep disorders and melatonin.","volume":"3","author":"Yu","year":"2017","journal-title":"Neurol Res"},{"key":"20","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1210\/er.2018-00084","article-title":"Melatonin as a hormone: new physiological and clinical insights.","volume":"3","author":"Amaral","year":"2018","journal-title":"Endocr Rev"},{"key":"21","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.ijcard.2014.04.044","article-title":"The potential usefulness of serum melatonin level to predict heart failure in patients with hypertensive cardiomyopathy.","volume":"17","author":"Reiter","year":"2014","journal-title":"Int J Cardiol"},{"key":"22","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.ijcard.2016.07.056","article-title":"Melatonin is associated with reverse remodeling after cardiac resynchronization therapy in patients with heart failure and ventricular dyssynchrony.","volume":"22","author":"Reiter","year":"2016","journal-title":"Int J Cardiol"},{"key":"23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-079X.2011.00916.x","article-title":"Melatonin as a natural ally against oxidative stress: a physicochemical examination.","volume":"5","author":"Reiter","year":"2011","journal-title":"J Pineal Res"},{"key":"24","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.exger.2014.01.021","article-title":"Mitochondrial homeostasis: the interplay between mitophagy and mitochondrial biogenesis.","volume":"5","author":"Tavernarakis","year":"2014","journal-title":"Exp Gerontol"},{"key":"25","doi-asserted-by":"publisher","first-page":"3449","DOI":"10.1038\/s41467-018-05856-4","article-title":"FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation.","volume":"9","author":"Barrero","year":"2018","journal-title":"Nat Commun"},{"key":"26","doi-asserted-by":"publisher","first-page":"16080","DOI":"10.1038\/cddiscovery.2016.80","article-title":"MICU1 may be a promising intervention target for gut-derived sepsis induced by intra-abdominal hypertension.","volume":"2","author":"Yao","year":"2016","journal-title":"Cell Death Discov"},{"key":"27","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/j.celrep.2019.09.063","article-title":"Dysregulation of mitochondrial Cauptake and sarcolemma repair underlie muscle weakness and wasting in patients and mice lacking MICU1.","volume":"2","author":"Hajn\u00f3czky","year":"2019","journal-title":"Cell Rep"},{"key":"28","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1172\/JCI14190","article-title":"TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II.","volume":"10","author":"Doetschman","year":"2002","journal-title":"J Clin Invest"},{"key":"29","doi-asserted-by":"publisher","first-page":"172549","DOI":"10.1016\/j.ejphar.2019.172549","article-title":"Klotho inhibits angiotensin II-induced cardiac hypertrophy, fibrosis, and dysfunction in mice through suppression of transforming growth factor-\u03b21 signaling pathway.","volume":"85","author":"Li","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"30","doi-asserted-by":"publisher","first-page":"595","DOI":"10.5483\/BMBRep.2019.52.10.206","article-title":"Endothelial-specific deletion of ets-1 attenuates angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transition.","volume":"5","author":"Ye","year":"2019","journal-title":"BMB Rep"},{"key":"31","doi-asserted-by":"publisher","first-page":"H186","DOI":"10.1152\/ajpheart.00531.2018","article-title":"The nuclear receptor ROR\u03b1 protects against angiotensin II-induced cardiac hypertrophy and heart failure.","volume":"31","author":"Jensen","year":"2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"32","doi-asserted-by":"publisher","first-page":"e12579","DOI":"10.1111\/jpi.12579","article-title":"Melatonin differentially regulates pathological and physiological cardiac hypertrophy: crucial role of circadian nuclear receptor ROR\u03b1 signaling.","volume":"6","author":"Pu","year":"2019","journal-title":"J Pineal Res"},{"key":"33","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1093\/eurheartj\/ehw138","article-title":"SIRT4 accelerates ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity.","volume":"3","author":"Liu","year":"2017","journal-title":"Eur Heart J"},{"key":"34","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.yjmcc.2020.05.009","article-title":"Nuclear-mitochondrial communication involving miR-181c plays an important role in cardiac dysfunction during obesity.","volume":"14","author":"Das","year":"2020","journal-title":"J Mol Cell Cardiol"},{"key":"35","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1161\/CIRCULATIONAHA.109.906818","article-title":"Oxidative stress regulates left ventricular PDE5 expression in the failing heart.","volume":"12","author":"Chen","year":"2010","journal-title":"Circulation"},{"key":"36","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.freeradbiomed.2018.09.019","article-title":"Targeting mitochondrial dysfunction and oxidative stress in heart failure: challenges and opportunities.","volume":"12","author":"Ferreira","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"37","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.1093\/eurheartj\/ehv305","article-title":"Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications.","volume":"3","author":"Daiber","year":"2015","journal-title":"Eur Heart J"},{"key":"38","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1161\/CIRCRESAHA.110.232306","article-title":"Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and galphaq overexpression-induced heart failure.","volume":"10","author":"Rabinovitch","year":"2011","journal-title":"Circ Res"},{"key":"39","doi-asserted-by":"publisher","first-page":"5470457","DOI":"10.1155\/2016\/5470457","article-title":"The role of mitochondrial functional proteins in ROS production in ischemic heart diseases.","volume":"201","author":"Yang","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"40","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1161\/CIRCULATIONAHA.114.010686","article-title":"Carabin protects against cardiac hypertrophy by blocking calcineurin, ras, and Ca2+\/calmodulin-dependent protein kinase II signaling.","volume":"13","author":"Delom\u00e9nie","year":"2015","journal-title":"Circulation"},{"key":"41","doi-asserted-by":"publisher","first-page":"2634976","DOI":"10.1155\/2016\/2634976","article-title":"Role of histone demethylases in cardiomyocytes induced to hypertrophy.","volume":"201","author":"Lizcano","year":"2016","journal-title":"Biomed Res Int"},{"key":"42","doi-asserted-by":"publisher","first-page":"11432","DOI":"10.1038\/ncomms11432","article-title":"Suppressor of IKK\u025b is an essential negative regulator of pathological cardiac hypertrophy.","volume":"7","author":"Yang","year":"2016","journal-title":"Nat Commun"},{"key":"43","first-page":"169","article-title":"Angiotensin converting enzyme inhibition and dihydropyridine calcium channel blockade in the treatment of left ventricular hypertrophy in arterial hypertension.","volume":"5","author":"Devereux","year":"2002","journal-title":"Minerva Cardioangiol"},{"key":"44","doi-asserted-by":"publisher","first-page":"II42","DOI":"10.1161\/01.hyp.11.3_pt_2.ii42","article-title":"Side effects of calcium channel blockers.","volume":"1","author":"Russell","year":"1988","journal-title":"Hypertension"},{"key":"45","doi-asserted-by":"publisher","first-page":"e28","DOI":"10.1097\/PTS.0000000000000244","article-title":"Measuring patients\u2019 knowledge about adverse effects of angiotensin-converting enzyme inhibitors.","volume":"1","author":"Kostic","year":"2019","journal-title":"J Patient Saf"},{"key":"46","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/jpi.12267","article-title":"Melatonin: an ancient molecule that makes oxygen metabolically tolerable.","volume":"5","author":"Reiter","year":"2015","journal-title":"J Pineal Res"},{"key":"47","doi-asserted-by":"publisher","first-page":"5080798","DOI":"10.1155\/2019\/5080798","article-title":"Melatonin and docosahexaenoic acid decrease proliferation of PNT1A prostate benign cells via modulation of mitochondrial bioenergetics and ROS production.","volume":"201","author":"G\u00f3es","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"48","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1161\/CIRCULATIONAHA.107.670588","article-title":"Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease.","volume":"11","author":"Kelly","year":"2007","journal-title":"Circulation"},{"key":"49","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1002\/jcp.24015","article-title":"The protective role of peroxisome proliferator-activated receptor \u03b3 coactivator-1\u03b1 in hyperthyroid cardiac hypertrophy.","volume":"22","author":"Zhang","year":"2012","journal-title":"J Cell Physiol"},{"key":"50","doi-asserted-by":"publisher","first-page":"R1017","DOI":"10.1152\/ajpregu.00032.2017","article-title":"Improved skeletal muscle Caregulation in vivo following contractions in mice overexpressing PGC-1\u03b1.","volume":"31","author":"Kano","year":"2017","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"51","doi-asserted-by":"publisher","first-page":"e12371","DOI":"10.1111\/jpi.12371","article-title":"Melatonin attenuates postmyocardial infarction injury via increasing Tom70 expression.","volume":"6","author":"Gao","year":"2017","journal-title":"J Pineal Res"},{"key":"52","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1093\/ajh\/hpaa024","article-title":"Cinnamaldehyde ameliorates vascular dysfunction in diabetic mice by activating Nrf2.","volume":"3","author":"Yang","year":"2020","journal-title":"Am J Hypertens"},{"key":"53","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1161\/CIRCRESAHA.116.303356","article-title":"Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress.","volume":"11","author":"Sadoshima","year":"2015","journal-title":"Circ Res"},{"key":"54","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s00395-013-0373-x","article-title":"Notch1 cardioprotection in myocardial ischemia\/reperfusion involves reduction of oxidative\/nitrative stress.","volume":"10","author":"Tao","year":"2013","journal-title":"Basic Res Cardiol"},{"key":"55","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1111\/jcmm.12242","article-title":"Overexpression of microRNA-99a attenuates heart remodelling and improves cardiac performance after myocardial infarction.","volume":"1","author":"Xu","year":"2014","journal-title":"J Cell Mol Med"},{"key":"56","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.2337\/db12-1025","article-title":"Glucagon-like peptide-1 protects against cardiac microvascular injury in diabetes via a cAMP\/PKA\/Rho-dependent mechanism.","volume":"6","author":"Cao","year":"2013","journal-title":"Diabetes"},{"key":"57","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1085\/jgp.200709926","article-title":"Antibody-based validation of CNS ion channel drug targets.","volume":"13","author":"Trimmer","year":"2008","journal-title":"J Gen Physiol"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T16:01:05Z","timestamp":1617724865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,26]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,15]]}},"alternative-id":["202159","33259334"],"URL":"https:\/\/doi.org\/10.18632\/aging.202159","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,26]]}}}