{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:52:42Z","timestamp":1777099962030,"version":"3.51.4"},"reference-count":62,"publisher":"Impact Journals, LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,1,15]]},"DOI":"10.18632\/aging.202171","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T15:27:45Z","timestamp":1607009265000},"page":"646-674","source":"Crossref","is-referenced-by-count":11,"title":["MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role"],"prefix":"10.18632","volume":"13","author":[{"given":"Yi-Jing","family":"Hsiao","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Hsin","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsuan-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Statistical Science, Academia Sinica, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin-Chen","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Chin","family":"Chiu","sequence":"additional","affiliation":[{"name":"Inservice Master Program in Life Sciences, College of Life Sciences, National Chung-Hsing University, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Cheng","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gee-Chen","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ju","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Academia Sinica, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Statistical Science, Academia Sinica, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ju","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Academia Sinica, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan-Chyr","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"},{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy J.W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, National Chung-Hsing University, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Liang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan"},{"name":"Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan"},{"name":"Centers for Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020.","volume":"7","author":"Jemal","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"2","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.jtho.2017.04.011","article-title":"The IASLC lung cancer staging project: external validation of the revision of the TNM stage groupings in the Eighth edition of the TNM classification of lung cancer.","volume":"1","author":"Rami-Porta","year":"2017","journal-title":"J Thorac Oncol"},{"key":"3","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12885-020-6621-1","article-title":"Clinicopathological variables influencing overall survival, recurrence and post-recurrence survival in resected stage I non-small-cell lung cancer.","volume":"2","author":"Li","year":"2020","journal-title":"BMC Cancer"},{"key":"4","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1097\/JTO.0b013e31807ec803","article-title":"The IASLC Lung Cancer Staging Project: proposals for the revision of the N descriptors in the forthcoming seventh edition of the TNM classification for lung cancer.","volume":"2","author":"Vansteenkiste","year":"2007","journal-title":"J Thorac Oncol"},{"key":"5","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.cell.2006.11.001","article-title":"Cancer metastasis: building a framework.","volume":"12","author":"Massagu\u00e9","year":"2006","journal-title":"Cell"},{"key":"6","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/PAP.0000000000000219","article-title":"Paget\u2019s \u201dseed and soil\u201c theory of cancer metastasis: an idea whose time has come.","volume":"2","author":"Al-Nabet","year":"2019","journal-title":"Adv Anat Pathol"},{"key":"7","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1158\/1078-0432.CCR-17-1347","article-title":"FAM198B is associated with prolonged survival and inhibits metastasis in lung adenocarcinoma via blockage of ERK-mediated MMP-1 expression.","volume":"2","author":"Wu","year":"2018","journal-title":"Clin Cancer Res"},{"key":"8","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1164\/rccm.201312-2256OC","article-title":"Shisa3 is associated with prolonged survival through promoting \u03b2-catenin degradation in lung cancer.","volume":"19","author":"Chen","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"9","doi-asserted-by":"publisher","first-page":"44417","DOI":"10.18632\/oncotarget.10088","article-title":"SPANXA suppresses EMT by inhibiting c-JUN\/SNAI2 signaling in lung adenocarcinoma.","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"10","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1101\/gad.324657.119","article-title":"MITF-the first 25 years.","volume":"3","author":"Arnheiter","year":"2019","journal-title":"Genes Dev"},{"key":"11","doi-asserted-by":"publisher","first-page":"e1002757","DOI":"10.1371\/journal.pgen.1002757","article-title":"A regulatory loop involving PAX6, MITF, and Wnt signaling controls retinal pigment epithelium development.","volume":"8","author":"Arnheiter","year":"2012","journal-title":"PLoS Genet"},{"key":"12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature03664","article-title":"Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in Malignant melanoma.","volume":"43","author":"Li","year":"2005","journal-title":"Nature"},{"key":"13","doi-asserted-by":"publisher","first-page":"3426","DOI":"10.1101\/gad.406406","article-title":"Mitf regulation of Dia1 controls melanoma proliferation and invasiveness.","volume":"2","author":"Goding","year":"2006","journal-title":"Genes Dev"},{"key":"14","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1111\/exd.12724","article-title":"Microphthalmia-associated transcription factor expression levels in melanoma cells contribute to cell invasion and proliferation.","volume":"2","author":"Ondru\u0161ov\u00e1","year":"2015","journal-title":"Exp Dermatol"},{"key":"15","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1172\/JCI94295","article-title":"SMAD signaling promotes melanoma metastasis independently of phenotype switching.","volume":"12","author":"Sommer","year":"2019","journal-title":"J Clin Invest"},{"key":"16","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1007\/s00018-014-1791-0","article-title":"MITF in melanoma: mechanisms behind its expression and activity.","volume":"7","author":"Czyz","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"17","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ijcard.2015.05.108","article-title":"FHL2 switches MITF from activator to repressor of erbin expression during cardiac hypertrophy.","volume":"19","author":"Tshori","year":"2015","journal-title":"Int J Cardiol"},{"key":"18","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/s0092-8674(02)00762-6","article-title":"Bcl2 regulation by the melanocyte master regulator mitf modulates lineage survival and melanoma cell viability.","volume":"10","author":"Korsmeyer","year":"2002","journal-title":"Cell"},{"key":"19","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.ccr.2004.10.014","article-title":"Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF.","volume":"6","author":"Fisher","year":"2004","journal-title":"Cancer Cell"},{"key":"20","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/nature03269","article-title":"Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression.","volume":"43","author":"Goding","year":"2005","journal-title":"Nature"},{"key":"21","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/onc.2016.178","article-title":"Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools.","volume":"3","author":"Lipchick","year":"2017","journal-title":"Oncogene"},{"key":"22","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1038\/onc.2010.612","article-title":"Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma.","volume":"3","author":"Davidson","year":"2011","journal-title":"Oncogene"},{"key":"23","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1111\/j.1755-148X.2008.00505.x","article-title":"Novel MITF targets identified using a two-step DNA microarray strategy.","volume":"2","author":"Steingrimsson","year":"2008","journal-title":"Pigment Cell Melanoma Res"},{"key":"24","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1101\/gr.166231.113","article-title":"Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition.","volume":"2","author":"Khavari","year":"2014","journal-title":"Genome Res"},{"key":"25","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1158\/1541-7786.MCR-12-0189","article-title":"A novel function of YWHAZ\/\u03b2-catenin axis in promoting epithelial-mesenchymal transition and lung cancer metastasis.","volume":"1","author":"Chen","year":"2012","journal-title":"Mol Cancer Res"},{"key":"26","doi-asserted-by":"publisher","first-page":"9227","DOI":"10.1038\/s41598-018-27521-y","article-title":"Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets.","volume":"8","author":"Gy\u0151rffy","year":"2018","journal-title":"Sci Rep"},{"key":"27","first-page":"7083","article-title":"A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction.","volume":"6","author":"Quigley","year":"2002","journal-title":"Cancer Res"},{"key":"28","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.","volume":"10","author":"Mesirov","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"29","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.","volume":"3","author":"Patterson","year":"2003","journal-title":"Nat Genet"},{"key":"30","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.7717\/peerj-cs.67","article-title":"OncoLnc: linking TCGA survival data to mRNAs, miRNAs, and lncRNAs.","volume":"2","author":"Anaya","year":"2016","journal-title":"PeerJ Comput Sci"},{"key":"31","doi-asserted-by":"publisher","first-page":"eaan2507","DOI":"10.1126\/science.aan2507","article-title":"A pathology atlas of the human cancer transcriptome.","volume":"35","author":"Oksvold","year":"2017","journal-title":"Science"},{"key":"32","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data.","volume":"2","author":"Goldberg","year":"2012","journal-title":"Cancer Discov"},{"key":"33","doi-asserted-by":"publisher","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal.","volume":"6","author":"Schultz","year":"2013","journal-title":"Sci Signal"},{"key":"34","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.cell.2020.06.012","article-title":"Proteogenomics of non-smoking lung cancer in east Asia delineates molecular signatures of pathogenesis and progression.","volume":"18","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"35","doi-asserted-by":"publisher","first-page":"e1007093","DOI":"10.1371\/journal.pgen.1007093","article-title":"MITF - a controls branching morphogenesis and nephron endowment.","volume":"1","author":"Druilhe","year":"2017","journal-title":"PLoS Genet"},{"key":"36","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1083\/jcb.201209135","article-title":"Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes.","volume":"20","author":"Puertollano","year":"2013","journal-title":"J Cell Biol"},{"key":"37","doi-asserted-by":"publisher","first-page":"E8668","DOI":"10.1073\/pnas.1810498115","article-title":"BRAF\/MAPK and GSK3 signaling converges to control MITF nuclear export.","volume":"11","author":"Filippakopoulos","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"38","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s10585-014-9665-2","article-title":"Annexin A1 in primary tumors promotes melanoma dissemination.","volume":"3","author":"Papon","year":"2014","journal-title":"Clin Exp Metastasis"},{"key":"39","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/1756-9966-31-70","article-title":"Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients.","volume":"3","author":"Min","year":"2012","journal-title":"J Exp Clin Cancer Res"},{"key":"40","doi-asserted-by":"publisher","first-page":"4287","DOI":"10.2147\/CMAR.S174409","article-title":"Identification of genes and analysis of prognostic values in nonsmoking females with non-small cell lung carcinoma by bioinformatics analyses.","volume":"1","author":"Lin","year":"2018","journal-title":"Cancer Manag Res"},{"key":"41","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.7314\/apjcp.2015.16.7.2719","article-title":"Identification of ANXA1 as a lymphatic metastasis and poor prognostic factor in pancreatic ductal adenocarcinoma.","volume":"1","author":"Zheng","year":"2015","journal-title":"Asian Pac J Cancer Prev"},{"key":"42","doi-asserted-by":"publisher","first-page":"3858","DOI":"10.3892\/mmr.2016.5022","article-title":"Knockdown of ANXA1 suppresses the biological behavior of human NSCLC cells in vitro.","volume":"1","author":"Zhang","year":"2016","journal-title":"Mol Med Rep"},{"key":"43","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.molmed.2019.02.004","article-title":"annexin-A1 - a blessing or a curse in cancer?","volume":"2","author":"Lim","year":"2019","journal-title":"Trends Mol Med"},{"key":"44","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.2147\/OTT.S202271","article-title":"Advancements of annexin A1 in inflammation and tumorigenesis.","volume":"1","author":"Fu","year":"2019","journal-title":"Onco Targets Ther"},{"key":"45","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.lungcan.2009.06.011","article-title":"Restoration of leukotriene B(4)-12-hydroxydehydrogenase\/15- oxo-prostaglandin 13-reductase (LTBDH\/PGR) expression inhibits lung cancer growth in vitro and in vivo.","volume":"6","author":"Tai","year":"2010","journal-title":"Lung Cancer"},{"key":"46","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.smim.2017.09.005","article-title":"The yin and yang of leukotriene Bmediated inflammation in cancer.","volume":"3","author":"Haribabu","year":"2017","journal-title":"Semin Immunol"},{"key":"47","doi-asserted-by":"publisher","first-page":"8755","DOI":"10.1038\/ncomms9755","article-title":"MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment.","volume":"6","author":"Davidson","year":"2015","journal-title":"Nat Commun"},{"key":"48","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1126\/science.aad0501","article-title":"Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.","volume":"35","author":"Lin","year":"2016","journal-title":"Science"},{"key":"49","doi-asserted-by":"publisher","first-page":"14013","DOI":"10.1074\/jbc.c000113200","article-title":"Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a.","volume":"27","author":"Shibahara","year":"2000","journal-title":"J Biol Chem"},{"key":"50","doi-asserted-by":"publisher","first-page":"8914","DOI":"10.1128\/MCB.02299-05","article-title":"The microphthalmia-associated transcription factor mitf interacts with beta-catenin to determine target gene expression.","volume":"2","author":"Hecht","year":"2006","journal-title":"Mol Cell Biol"},{"key":"51","doi-asserted-by":"publisher","first-page":"E420","DOI":"10.1073\/pnas.1424576112","article-title":"MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells.","volume":"11","author":"De Robertis","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"52","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.ydbio.2006.06.037","article-title":"Frizzled7 mediates canonical Wnt signaling in neural crest induction.","volume":"29","author":"Wheeler","year":"2006","journal-title":"Dev Biol"},{"key":"53","doi-asserted-by":"publisher","first-page":"e1346","DOI":"10.1038\/cddis.2014.302","article-title":"FZD7 drives in vitro aggressiveness in stem-a subtype of ovarian cancer via regulation of non-canonical Wnt\/PCP pathway.","volume":"5","author":"Huang","year":"2014","journal-title":"Cell Death Dis"},{"key":"54","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1158\/0008-5472.CAN-07-2491","article-title":"In vivo switching of human melanoma cells between proliferative and invasive states.","volume":"6","author":"Dummer","year":"2008","journal-title":"Cancer Res"},{"key":"55","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ccr.2010.11.009","article-title":"HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.","volume":"1","author":"Dresselaer","year":"2011","journal-title":"Cancer Cell"},{"key":"56","doi-asserted-by":"publisher","first-page":"5368","DOI":"10.18632\/aging.102112","article-title":"Downregulation of microRNA-218 is cardioprotective against cardiac fibrosis and cardiac function impairment in myocardial infarction by binding to MITF.","volume":"1","author":"Qian","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"57","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/labinvest.2017.9","article-title":"The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology.","volume":"9","author":"Fisher","year":"2017","journal-title":"Lab Invest"},{"key":"58","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1056\/NEJMoa1103782","article-title":"Improved survival with vemurafenib in melanoma with BRAF V600E mutation.","volume":"36","author":"Lebbe","year":"2011","journal-title":"N Engl J Med"},{"key":"59","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.ccell.2018.03.017","article-title":"Multi-stage differentiation defines melanoma subtypes with differential vulnerability to drug-induced iron-dependent oxidative stress.","volume":"3","author":"Palaskas","year":"2018","journal-title":"Cancer Cell"},{"key":"60","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1165\/ajrcmb.17.3.2837","article-title":"Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line.","volume":"1","author":"Wu","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"61","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nature02370","article-title":"A resource for large-scale RNA-interference-based screens in mammals.","volume":"42","author":"Cleary","year":"2004","journal-title":"Nature"},{"key":"62","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.gene.2004.12.002","article-title":"Genomic analysis of the microphthalmia locus and identification of the MITF-J\/Mitf-J isoform.","volume":"34","author":"Fisher","year":"2005","journal-title":"Gene"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T16:01:30Z","timestamp":1617724890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,3]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,15]]}},"alternative-id":["202171","33293474"],"URL":"https:\/\/doi.org\/10.18632\/aging.202171","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,3]]}}}