{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T09:08:41Z","timestamp":1772183321774,"version":"3.50.1"},"reference-count":92,"publisher":"Impact Journals, LLC","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,2,15]]},"DOI":"10.18632\/aging.202299","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T12:27:46Z","timestamp":1610281666000},"page":"3573-3587","source":"Crossref","is-referenced-by-count":35,"title":["Late-onset epilepsy and subsequent increased risk of dementia"],"prefix":"10.18632","volume":"13","author":[{"given":"Zhi-Ren","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Computer Science and Information Engineering, Asia University, Taichung, Taiwan"},{"name":"Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan"},{"name":"Taichung City Smart Transportation Big Data Research Center, Taichung, Taiwan"},{"name":"Pervasive Artificial Intelligence Research (PAIR) Labs, Hsinchu, Taiwan"},{"name":"Biomdcare Corporation, New Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biomdcare Corporation, New Taipei, Taiwan"},{"name":"Program for Aging, China Medical University, Taichung, Taiwan"},{"name":"Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan"},{"name":"Institute of Electrical Control Engineering, Department of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Hung","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Neurology, China Medical University Hospital, and School of Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao-Ching","family":"Peng","sequence":"additional","affiliation":[{"name":"Biomdcare Corporation, New Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor C.","family":"Kok","sequence":"additional","affiliation":[{"name":"Disease Informatics Research Group, Asia University, Taichung, Taiwan"},{"name":"Department of Internal Medicine, Kuang Tien General Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gao Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital, Affiliated Hospital of Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao A.","family":"Hsiung","sequence":"additional","affiliation":[{"name":"Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Yi.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2021,1,10]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","article-title":"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the global burden of disease study 2010.","volume":"38","author":"Ackerman","year":"2012","journal-title":"Lancet"},{"key":"2","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the global burden of disease study 2010.","volume":"38","author":"Aggarwal","year":"2012","journal-title":"Lancet"},{"key":"3","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/s0022-510x(97)00289-x","article-title":"Treatable and reversible dementias: an update.","volume":"15","author":"Amaducci","year":"1998","journal-title":"J Neurol Sci"},{"key":"4","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12868-018-0465-5","article-title":"Neurovascular dysfunction in vascular dementia, Alzheimer\u2019s and atherosclerosis.","volume":"1","author":"Francis","year":"2018","journal-title":"BMC Neurosci"},{"key":"5","unstructured":"Alzheimer's Disease International. World Alzheimer's Report 2009. http:\/\/www.alz.co.uk\/research\/files\/WorldAlzheimerReport-ExecutiveSummary.pdf."},{"key":"6","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1001\/jama.288.12.1475","article-title":"Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study.","volume":"28","author":"DeKosky","year":"2002","journal-title":"JAMA"},{"key":"7","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3275\/8105","article-title":"Apathy: a separate syndrome from depression in dementia? a critical review.","volume":"2","author":"Forstmeier","year":"2012","journal-title":"Aging Clin Exp Res"},{"key":"8","doi-asserted-by":"publisher","first-page":"CD003260","DOI":"10.1002\/14651858.CD003260.pub2","article-title":"Cognitive training and cognitive rehabilitation for mild to moderate Alzheimer\u2019s disease and vascular dementia.","volume":"201","author":"Woods","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"9","unstructured":"Alzheimer\u2019s Society. What is dementia? https:\/\/www.alzheimers.org.uk\/about-dementia\/types-dementia\/what-dementia."},{"key":"10","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.bcp.2013.12.024","article-title":"Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers.","volume":"8","author":"Mayeux","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"11","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer\u2019s disease: genes, proteins, and therapy.","volume":"8","author":"Selkoe","year":"2001","journal-title":"Physiol Rev"},{"key":"12","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/nature02621","article-title":"Pathways towards and away from Alzheimer\u2019s disease.","volume":"43","author":"Mattson","year":"2004","journal-title":"Nature"},{"key":"13","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nrn2168","article-title":"Intracellular amyloid-beta in Alzheimer\u2019s disease.","volume":"8","author":"Oddo","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"14","doi-asserted-by":"publisher","first-page":"S499","DOI":"10.3233\/JAD-2010-100504","article-title":"Amyloid-beta and mitochondria in aging and Alzheimer\u2019s disease: implications for synaptic damage and cognitive decline.","volume":"2","author":"Shirendeb","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.neuropharm.2013.07.004","article-title":"Therapeutics of Alzheimer\u2019s disease: past, present and future.","volume":"7","author":"Mahdi","year":"2014","journal-title":"Neuropharmacology"},{"key":"16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jns.2004.09.004","article-title":"Vascular pathologies and cognition in a population-based cohort of elderly people.","volume":"22","author":"Ince","year":"2004","journal-title":"J Neurol Sci"},{"key":"17","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3233\/JAD-160527","article-title":"Stroke, vascular dementia, and Alzheimer\u2019s disease: molecular links.","volume":"5","author":"Reddy","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"18","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1159\/000119103","article-title":"Epilepsy and dementia in the elderly.","volume":"2","author":"Constans","year":"2008","journal-title":"Dement Geriatr Cogn Disord"},{"key":"19","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1212\/wnl.46.3.727","article-title":"Dementia and adult-onset unprovoked seizures.","volume":"4","author":"Rocca","year":"1996","journal-title":"Neurology"},{"key":"20","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1093\/ageing\/afv061","article-title":"Incidence of stroke and seizure in Alzheimer\u2019s disease dementia.","volume":"4","author":"Arrighi","year":"2015","journal-title":"Age Ageing"},{"key":"21","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.eplepsyres.2015.05.009","article-title":"Incidence and risk of seizures in Alzheimer\u2019s disease: a nationwide population-based cohort study.","volume":"11","author":"Wang","year":"2015","journal-title":"Epilepsy Res"},{"key":"22","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1684\/epd.2010.0290","article-title":"Seizures in Alzheimer\u2019s disease: a retrospective study of a cohort of outpatients.","volume":"1","author":"Prencipe","year":"2010","journal-title":"Epileptic Disord"},{"key":"23","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/epi.12045","article-title":"Seizures in patients with Alzheimer\u2019s disease or vascular dementia: a population-based nested case-control analysis.","volume":"5","author":"Meier","year":"2013","journal-title":"Epilepsia"},{"key":"24","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1001\/archneurol.2009.130","article-title":"Seizures in Alzheimer disease: who, when, and how common?","volume":"6","author":"Stern","year":"2009","journal-title":"Arch Neurol"},{"key":"25","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1093\/brain\/awy022","article-title":"Cognition and dementia in older patients with epilepsy.","volume":"14","author":"Husain","year":"2018","journal-title":"Brain"},{"key":"26","doi-asserted-by":"publisher","first-page":"S36","DOI":"10.1093\/ije\/20.supplement_2.s36","article-title":"Medical history and the risk of Alzheimer's disease: a collaborative re-analysis of case-control studies.","volume":"2","author":"Soininen","year":"1991","journal-title":"Int J Epidemiol"},{"key":"27","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1093\/oxfordjournals.aje.a117597","article-title":"Risk of dementia in patients with Parkinson\u2019s disease, epilepsy, and severe head trauma: a register-based follow-up study.","volume":"14","author":"Hofman","year":"1995","journal-title":"Am J Epidemiol"},{"key":"28","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1111\/j.1528-1167.2011.03044.x","article-title":"A prospective case control study of psychiatric disorders in adults with epilepsy and intellectual disability.","volume":"5","author":"Kerr","year":"2011","journal-title":"Epilepsia"},{"key":"29","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jns.2006.11.004","article-title":"Epilepsy and antiepileptic drug use in elderly people as risk factors for dementia.","volume":"25","author":"Rockwood","year":"2007","journal-title":"J Neurol Sci"},{"key":"30","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3233\/JAD-181194","article-title":"Is there an association between antiepileptic drug use and dementia risk? a case-control study.","volume":"6","author":"Kostev","year":"2019","journal-title":"J Alzheimers Dis"},{"key":"31","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1111\/epi.13744","article-title":"The association between dementia and epilepsy: a systematic review and meta-analysis.","volume":"5","author":"Holroyd-Leduc","year":"2017","journal-title":"Epilepsia"},{"key":"32","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1755-5949.2011.00251.x","article-title":"Seizures and epilepsy in Alzheimer\u2019s disease.","volume":"1","author":"Scarmeas","year":"2012","journal-title":"CNS Neurosci Ther"},{"key":"33","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1528-1167.2011.03033.x","article-title":"Inflammation in epilepsy: clinical observations.","volume":"5","author":"Crino","year":"2011","journal-title":"Epilepsia"},{"key":"34","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1111\/j.1528-1157.2000.tb01549.x","article-title":"Seizure-induced neuronal necrosis: implications for programmed cell death mechanisms.","volume":"4","author":"Cai","year":"2000","journal-title":"Epilepsia"},{"key":"35","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/s1474-4422(02)00073-x","article-title":"Is epilepsy a progressive disorder? prospects for new therapeutic approaches in temporal-lobe epilepsy.","volume":"1","author":"Sutula","year":"2002","journal-title":"Lancet Neurol"},{"key":"36","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nrneurol.2010.178","article-title":"The role of inflammation in epilepsy.","volume":"7","author":"Baram","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"37","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.bbi.2008.03.009","article-title":"The role of cytokines in the pathophysiology of epilepsy.","volume":"2","author":"Ravizza","year":"2008","journal-title":"Brain Behav Immun"},{"key":"38","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1016\/j.bbi.2011.03.018","article-title":"IL-1 receptor\/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures.","volume":"2","author":"Bartfai","year":"2011","journal-title":"Brain Behav Immun"},{"key":"39","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.expneurol.2011.09.033","article-title":"Epilepsy and brain inflammation.","volume":"24","author":"Pittman","year":"2013","journal-title":"Exp Neurol"},{"key":"40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1535-7597.2005.05101.x","article-title":"Inflammation and epilepsy.","volume":"5","author":"Vezzani","year":"2005","journal-title":"Epilepsy Curr"},{"key":"41","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1042\/BST0350421","article-title":"Apoptosis signalling pathways in seizure-induced neuronal death and epilepsy.","volume":"3","author":"Henshall","year":"2007","journal-title":"Biochem Soc Trans"},{"key":"42","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1528-1167.2010.02909.x","article-title":"A perfect storm: converging paths of epilepsy and Alzheimer\u2019s dementia intersect in the hippocampal formation.","volume":"5","author":"Noebels","year":"2011","journal-title":"Epilepsia"},{"key":"43","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","article-title":"Mechanisms underlying inflammation in neurodegeneration.","volume":"14","author":"Gage","year":"2010","journal-title":"Cell"},{"key":"44","doi-asserted-by":"publisher","first-page":"e0225363","DOI":"10.1371\/journal.pone.0225363","article-title":"Long-term ambient hydrocarbons exposure and incidence of ischemic stroke.","volume":"1","author":"Hsu","year":"2019","journal-title":"PLoS One"},{"key":"45","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.2174\/1567205017666200103112443","article-title":"Long-term exposure to ambient hydrocarbons increases dementia risk in people aged 50 years and above in Taiwan.","volume":"1","author":"Hsu","year":"2019","journal-title":"Curr Alzheimer Res"},{"key":"46","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1385\/IR:21:2-3:159","article-title":"Focal inflammation in the brain: role in Alzheimer\u2019s disease.","volume":"2","author":"Yu","year":"2000","journal-title":"Immunol Res"},{"key":"47","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/s0197-4580(00)00124-x","article-title":"Inflammation and Alzheimer\u2019s disease.","volume":"2","author":"Griffin","year":"2000","journal-title":"Neurobiol Aging"},{"key":"48","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2174\/1568010023344670","article-title":"Cytokines in dementias.","volume":"1","author":"Tarkowski","year":"2002","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"49","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/S0278-5846(03)00124-6","article-title":"Inflammatory processes in Alzheimer\u2019s disease.","volume":"2","author":"McGeer","year":"2003","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"50","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1196\/annals.1332.007","article-title":"Inflammation and the degenerative diseases of aging.","volume":"103","author":"McGeer","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"51","doi-asserted-by":"publisher","first-page":"247","DOI":"10.2174\/1568010053586237","article-title":"Mechanisms of cell signaling and inflammation in Alzheimer\u2019s disease.","volume":"4","author":"Masliah","year":"2005","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"52","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1038\/nm1484","article-title":"Inflammation in Alzheimer disease: driving force, bystander or beneficial response?","volume":"1","author":"Wyss-Coray","year":"2006","journal-title":"Nat Med"},{"key":"53","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1007\/s12272-010-1006-7","article-title":"Inflammation and Alzheimer\u2019s disease.","volume":"3","author":"Hong","year":"2010","journal-title":"Arch Pharm Res"},{"key":"54","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1001\/archneur.61.5.668","article-title":"Inflammatory proteins in plasma and the risk of dementia: the rotterdam study.","volume":"6","author":"Breteler","year":"2004","journal-title":"Arch Neurol"},{"key":"55","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jneuroim.2006.11.017","article-title":"Inflammatory processes in Alzheimer\u2019s disease.","volume":"18","author":"O\u2019Banion","year":"2007","journal-title":"J Neuroimmunol"},{"key":"56","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1742-2094-8-26","article-title":"Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer\u2019s disease.","volume":"8","author":"Grammas","year":"2011","journal-title":"J Neuroinflammation"},{"key":"57","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1080\/1521654031000153049","article-title":"A role for NOX NADPH oxidases in Alzheimer\u2019s disease and other types of dementia?","volume":"5","author":"Krause","year":"2003","journal-title":"IUBMB Life"},{"key":"58","doi-asserted-by":"publisher","first-page":"4329","DOI":"10.1111\/j.1582-4934.2009.00889.x","article-title":"Neuronal death in Alzheimer\u2019s disease and therapeutic opportunities.","volume":"1","author":"Thome","year":"2009","journal-title":"J Cell Mol Med"},{"key":"59","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/s0074-7742(08)60665-0","article-title":"The cytoskeleton and neurotransmitter receptors.","volume":"3","author":"Harris","year":"1996","journal-title":"Int Rev Neurobiol"},{"key":"60","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s12017-009-8076-z","article-title":"Epileptic seizures in AD patients.","volume":"1","author":"Larner","year":"2010","journal-title":"Neuromolecular Med"},{"key":"61","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/nn.2583","article-title":"Amyloid-beta-induced neuronal dysfunction in Alzheimer\u2019s disease: from synapses toward neural networks.","volume":"1","author":"Mucke","year":"2010","journal-title":"Nat Neurosci"},{"key":"62","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s12017-009-8100-3","article-title":"Alzheimer\u2019s disease and neuronal network activity.","volume":"1","author":"Mattson","year":"2010","journal-title":"Neuromolecular Med"},{"key":"63","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s12017-009-8107-9","article-title":"Adverse stress, hippocampal networks, and Alzheimer\u2019s disease.","volume":"1","author":"Mattson","year":"2010","journal-title":"Neuromolecular Med"},{"key":"64","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1002\/ana.24230","article-title":"Tau reduction prevents disease in a mouse model of dravet syndrome.","volume":"7","author":"Mucke","year":"2014","journal-title":"Ann Neurol"},{"key":"65","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.nbd.2011.12.005","article-title":"Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models.","volume":"4","author":"Hovens","year":"2012","journal-title":"Neurobiol Dis"},{"key":"66","unstructured":"National Health Insurance Research Database (NHIRD). Introduction to the National Health Insurance Research Database [cited Aug 13, 2018]. http:\/\/nhird.nhri.org.tw\/en\/index.html."},{"key":"67","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1056\/NEJMsb1609216","article-title":"Real-world evidence - what is it and what can it tell us?","volume":"37","author":"Woodcock","year":"2016","journal-title":"N Engl J Med"},{"key":"68","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1111\/j.1528-1167.2005.00344.x","article-title":"Somatic comorbidity of epilepsy in the general population in Canada.","volume":"4","author":"Wiebe","year":"2005","journal-title":"Epilepsia"},{"key":"69","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1111\/j.1528-1167.2007.01222.x","article-title":"Psychiatric comorbidity in epilepsy: a population-based analysis.","volume":"4","author":"Wiebe","year":"2007","journal-title":"Epilepsia"},{"key":"70","doi-asserted-by":"publisher","first-page":"48385","DOI":"10.18632\/oncotarget.16801","article-title":"The effects of herbal medicine on epilepsy.","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"71","first-page":"30","article-title":"Epilepsy in older adults. Common morbidities influence development, treatment strategies, and expected outcomes.","volume":"6","author":"Rowan","year":"2005","journal-title":"Geriatrics"},{"key":"72","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.4103\/0972-2327.128645","article-title":"Epilepsy in the elderly: special considerations and challenges.","volume":"1","author":"Acharya","year":"2014","journal-title":"Ann Indian Acad Neurol"},{"key":"73","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1136\/bmj.331.7528.1317","article-title":"Epilepsy in elderly people.","volume":"33","author":"Kwan","year":"2005","journal-title":"BMJ"},{"key":"74","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/j.1600-0404.1999.tb00674.x","article-title":"Late epileptic seizures after cerebral infarction.","volume":"9","author":"Obeid","year":"1999","journal-title":"Acta Neurol Scand"},{"key":"75","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1111\/j.1528-1167.2012.03637.x","article-title":"Blood-brain barrier dysfunction and epilepsy: pathophysiologic role and therapeutic approaches.","volume":"5","author":"Janigro","year":"2012","journal-title":"Epilepsia"},{"key":"76","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.semcdb.2014.10.003","article-title":"Blood-brain barrier dysfunction, seizures and epilepsy.","volume":"3","author":"Gorter","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"77","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1007\/s10571-015-0278-3","article-title":"Long-term treatment with losartan attenuates seizure activity and neuronal damage without affecting behavioral changes in a model of co-morbid hypertension and epilepsy.","volume":"3","author":"Stoynev","year":"2016","journal-title":"Cell Mol Neurobiol"},{"key":"78","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.eplepsyres.2004.03.008","article-title":"Cardiorespiratory findings in sudden unexplained\/unexpected death in epilepsy (SUDEP).","volume":"5","author":"Finsterer","year":"2004","journal-title":"Epilepsy Res"},{"key":"79","doi-asserted-by":"publisher","first-page":"107175","DOI":"10.1016\/j.yebeh.2020.107175","article-title":"Epilepsy and chronic obstructive pulmonary disease among U.S. Adults: national health interview survey 2013, 2015, and 2017.","volume":"11","author":"Croft","year":"2020","journal-title":"Epilepsy Behav"},{"key":"80","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/978-1-4939-3816-2_27","article-title":"Animal models of posttraumatic seizures and epilepsy.","volume":"146","author":"Hayes","year":"2016","journal-title":"Methods Mol Biol"},{"key":"81","doi-asserted-by":"publisher","first-page":"re12","DOI":"10.1126\/stke.3562006re12","article-title":"Molecular signaling mechanisms underlying epileptogenesis.","volume":"200","author":"Leonard","year":"2006","journal-title":"Sci STKE"},{"key":"82","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/S1474-4422(16)00112-5","article-title":"Advances in the development of biomarkers for epilepsy.","volume":"1","author":"Sisodiya","year":"2016","journal-title":"Lancet Neurol"},{"key":"83","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.yebeh.2014.01.013","article-title":"Posttraumatic epilepsy - disease or comorbidity?","volume":"3","author":"Bolkvadze","year":"2014","journal-title":"Epilepsy Behav"},{"key":"84","doi-asserted-by":"publisher","first-page":"613","DOI":"10.14670\/HH-16.613","article-title":"Neuronal and mixed neuronal glial tumors associated to epilepsy. A heterogeneous and related group of tumours.","volume":"1","author":"Ram\u00f3n y Cajal","year":"2001","journal-title":"Histol Histopathol"},{"key":"85","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1080\/02688690701594817","article-title":"The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours.","volume":"2","author":"Park","year":"2007","journal-title":"Br J Neurosurg"},{"key":"86","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.3171\/2009.3.JNS081350","article-title":"Seizure outcome of epilepsy surgery in focal epilepsies associated with temporomesial glioneuronal tumors: lesionectomy compared with tailored resection.","volume":"11","author":"Calbucci","year":"2009","journal-title":"J Neurosurg"},{"key":"87","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3171\/2009.8.PEDS09368","article-title":"Seizure control outcomes after resection of dysembryoplastic neuroepithelial tumor in 50 patients.","volume":"5","author":"Barbaro","year":"2010","journal-title":"J Neurosurg Pediatr"},{"key":"88","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1001\/jamaneurol.2016.5042","article-title":"Association of depression and treated depression with epilepsy and seizure outcomes: a multicohort analysis.","volume":"7","author":"Wiebe","year":"2017","journal-title":"JAMA Neurol"},{"key":"89","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.tins.2013.11.002","article-title":"Inflammatory pathways of seizure disorders.","volume":"3","author":"Janigro","year":"2014","journal-title":"Trends Neurosci"},{"key":"90","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1001\/jamaneurol.2014.188","article-title":"Population-level evidence for an autoimmune etiology of epilepsy.","volume":"7","author":"Mandl","year":"2014","journal-title":"JAMA Neurol"},{"key":"91","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1684\/j.1950-6945.2006.tb00199.x","article-title":"Epilepsy and neurodegenerative diseases in adults: a clinical review.","volume":"8","author":"Vercueil","year":"2006","journal-title":"Epileptic Disorders"},{"key":"92","doi-asserted-by":"publisher","first-page":"3745631","DOI":"10.1155\/2016\/3745631","article-title":"Parkinson\u2019s disease and cryptogenic epilepsy.","volume":"201","author":"Di Rocco","year":"2016","journal-title":"Case Rep Neurol Med"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T04:01:46Z","timestamp":1724299306000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,10]]},"references-count":92,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2,15]]}},"alternative-id":["202299","33429365"],"URL":"https:\/\/doi.org\/10.18632\/aging.202299","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,10]]}}}