{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:45:50Z","timestamp":1792017950453,"version":"4.4.0"},"reference-count":16,"publisher":"Impact Journals, LLC","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,12,31]]},"DOI":"10.18632\/aging.202321","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T02:37:35Z","timestamp":1608691055000},"page":"24481-24483","source":"Crossref","is-referenced-by-count":20,"title":["The Ercc<i>1<\/i>-\/\u0394 mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions"],"prefix":"10.18632","volume":"12","author":[{"given":"Alec","family":"Wong","sequence":"first","affiliation":[{"name":"Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tra","family":"Kieu","sequence":"additional","affiliation":[{"name":"Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Robbins","sequence":"additional","affiliation":[{"name":"Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.exger.2015.01.045","article-title":"Comparison of mice with accelerated aging caused by distinct mechanisms.","volume":"6","author":"Niedernhofer","year":"2015","journal-title":"Exp Gerontol"},{"key":"2","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1038\/nature05456","article-title":"A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.","volume":"44","author":"van der Horst","year":"2006","journal-title":"Nature"},{"key":"3","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1111\/j.1474-9726.2012.00828.x","article-title":"The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner.","volume":"1","author":"Wang","year":"2012","journal-title":"Aging Cell"},{"key":"4","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1146\/annurev-biochem-062917-012239","article-title":"Nuclear genomic instability and aging.","volume":"8","author":"Robbins","year":"2018","journal-title":"Annu Rev Biochem"},{"key":"5","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.redox.2018.04.007","article-title":"Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.","volume":"1","author":"Pope-Varsalona","year":"2018","journal-title":"Redox Biol"},{"key":"6","doi-asserted-by":"publisher","first-page":"e13094","DOI":"10.1111\/acel.13094","article-title":"Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice.","volume":"1","author":"Niedernhofer","year":"2020","journal-title":"Aging Cell"},{"key":"7","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/ng1382","article-title":"BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.","volume":"3","author":"van Deursen","year":"2004","journal-title":"Nat Genet"},{"key":"8","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.","volume":"53","author":"van Deursen","year":"2016","journal-title":"Nature"},{"key":"9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ebiom.2017.04.013","article-title":"Cellular senescence: a translational perspective.","volume":"2","author":"Tchkonia","year":"2017","journal-title":"EBioMedicine"},{"key":"10","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1172\/JCI22475","article-title":"Ink4a\/Arf expression is a biomarker of aging.","volume":"11","author":"Sharpless","year":"2004","journal-title":"J Clin Invest"},{"key":"11","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1172\/JCI64098","article-title":"Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.","volume":"12","author":"Kirkland","year":"2013","journal-title":"J Clin Invest"},{"key":"12","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1474-9726.2009.00481.x","article-title":"DNA damage response and cellular senescence in tissues of aging mice.","volume":"8","author":"von Zglinicki","year":"2009","journal-title":"Aging Cell"},{"key":"13","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression.","volume":"5","author":"Campisi","year":"2010","journal-title":"Annu Rev Pathol"},{"key":"14","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/s41467-017-00314-z","article-title":"Identification of HSP90 inhibitors as a novel class of senolytics.","volume":"8","author":"Bukata","year":"2017","journal-title":"Nat Commun"},{"key":"15","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ebiom.2018.09.015","article-title":"Fisetin is a senotherapeutic that extends health and lifespan.","volume":"3","author":"Kato","year":"2018","journal-title":"EBioMedicine"},{"key":"16","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/acel.12344","article-title":"The achilles\u2019 heel of senescent cells: from transcriptome to senolytic drugs.","volume":"1","author":"Miller","year":"2015","journal-title":"Aging Cell"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T15:52:27Z","timestamp":1617724347000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,22]]},"references-count":16,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2020,12,31]]}},"alternative-id":["202321","33353886"],"URL":"https:\/\/doi.org\/10.18632\/aging.202321","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,22]]}}}