{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:04:27Z","timestamp":1791875067186,"version":"4.3.4"},"reference-count":92,"publisher":"Impact Journals, LLC","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,2,15]]},"DOI":"10.18632\/aging.202353","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T18:55:33Z","timestamp":1611341733000},"page":"3843-3865","source":"Crossref","is-referenced-by-count":19,"title":["Cell lineage-specific methylome and genome alterations in gout"],"prefix":"10.18632","volume":"13","author":[{"given":"Chia-Chun","family":"Tseng","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ting","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Chun","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan"},{"name":"Division of General Internal Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Chen","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory Diagnosis of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeng-Hsien","family":"Yen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"},{"name":"Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan"},{"name":"Department of Biological Science and Technology, National Chiao-Tung University, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Jen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Health and Leisure Studies, National University of Kaohsiung, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2021,1,20]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s42358-019-0067-7","article-title":"Gender-specific risk factors for gout: a systematic review of cohort studies.","volume":"5","author":"Roddy","year":"2019","journal-title":"Adv Rheumatol"},{"key":"2","doi-asserted-by":"publisher","first-page":"16767","DOI":"10.1038\/s41598-018-35175-z","article-title":"Effect of fenofibrate on uric acid level in patients with gout.","volume":"8","author":"Kim","year":"2018","journal-title":"Sci Rep"},{"key":"3","doi-asserted-by":"publisher","first-page":"5470739","DOI":"10.1155\/2020\/5470739","article-title":"Diabetes mellitus is associated with a lower risk of gout: a meta-analysis of observational studies.","volume":"202","author":"Ma","year":"2020","journal-title":"J Diabetes Res"},{"key":"4","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3389\/fmed.2020.00166","article-title":"Autoinflammatory mechanisms in crystal-induced arthritis.","volume":"7","author":"Sfriso","year":"2020","journal-title":"Front Med (Lausanne)"},{"key":"5","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3389\/fimmu.2019.00070","article-title":"Secretion of IL-1\u03b2 from monocytes in gout is redox independent.","volume":"1","author":"Mullen","year":"2019","journal-title":"Front Immunol"},{"key":"6","doi-asserted-by":"publisher","first-page":"54","DOI":"10.7861\/clinmedicine.17-1-54","article-title":"Gout - a guide for the general and acute physicians.","volume":"1","author":"Doherty","year":"2017","journal-title":"Clin Med (Lond)"},{"key":"7","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1097\/BOR.0000000000000571","article-title":"Genetic advances in gout: potential applications in clinical practice.","volume":"3","author":"Dalbeth","year":"2019","journal-title":"Curr Opin Rheumatol"},{"key":"8","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1136\/annrheumdis-2019-215521","article-title":"Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.","volume":"7","author":"Shirahama","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"9","first-page":"1","article-title":"One year in review 2018: gout.","volume":"3","author":"Oliviero","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"10","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1136\/annrheumdis-2017-212288","article-title":"Relationship between serum urate concentration and clinically evident incident gout: an individual participant data analysis.","volume":"7","author":"Merriman","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"11","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1186\/s13075-019-2027-3","article-title":"IL1 inhibition in gout-where are we a decade on?","volume":"2","author":"So","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"12","doi-asserted-by":"publisher","first-page":"4981","DOI":"10.1038\/s41598-019-41434-4","article-title":"Integrative genome-wide association studies of eQTL and GWAS data for gout disease susceptibility.","volume":"9","author":"Lee","year":"2019","journal-title":"Sci Rep"},{"key":"13","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1136\/annrheumdis-2014-206191","article-title":"Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes.","volume":"7","author":"Abe","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"14","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1093\/humupd\/dmz017","article-title":"Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health.","volume":"2","author":"Nixon","year":"2019","journal-title":"Hum Reprod Update"},{"key":"15","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3389\/fgene.2019.00471","article-title":"Paternal tobacco smoke correlated to offspring asthma and prenatal epigenetic programming.","volume":"1","author":"Yang","year":"2019","journal-title":"Front Genet"},{"key":"16","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1042\/CS20200031","article-title":"DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-\u03baB pathway.","volume":"13","author":"Li","year":"2020","journal-title":"Clin Sci (Lond)"},{"key":"17","doi-asserted-by":"publisher","first-page":"390","DOI":"10.3389\/fcell.2019.00390","article-title":"Methylomic changes of autophagy-related genes by Legionella effector Lpg2936 in infected macrophages.","volume":"7","author":"Khalil","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"18","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/JLB.3HI0518-193R","article-title":"Frontline science: reprogramming COX-2, 5-LOX, and CYP4A-mediated arachidonic acid metabolism in macrophages by salidroside alleviates gouty arthritis.","volume":"10","author":"Zhou","year":"2019","journal-title":"J Leukoc Biol"},{"key":"19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/JIR.S129027","article-title":"Epigenetics of chronic inflammatory diseases.","volume":"1","author":"Stylianou","year":"2018","journal-title":"J Inflamm Res"},{"key":"20","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1038\/s41592-018-0213-x","article-title":"Identification of differentially methylated cell types in epigenome-wide association studies.","volume":"1","author":"Teschendorff","year":"2018","journal-title":"Nat Methods"},{"key":"21","doi-asserted-by":"publisher","first-page":"e133","DOI":"10.3346\/jkms.2020.35.e133","article-title":"Seasonal variations and associated factors of gout attacks: a prospective multicenter study in Korea.","volume":"3","author":"Lee","year":"2020","journal-title":"J Korean Med Sci"},{"key":"22","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1186\/s12859-017-1870-y","article-title":"Usability of human infinium MethylationEPIC BeadChip for mouse DNA methylation studies.","volume":"1","author":"Jagodic","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"23","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3892\/etm.2018.6134","article-title":"Identification of differential modules in ankylosing spondylitis using systemic module inference and the attract method.","volume":"1","author":"Zhang","year":"2018","journal-title":"Exp Ther Med"},{"key":"24","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nrrheum.2017.155","article-title":"Inflammation in gout: mechanisms and therapeutic targets.","volume":"1","author":"Martinon","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"25","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00011-016-1008-0","article-title":"Macrophage-derived IL-1\u03b2 enhances monosodium urate crystal-triggered NET formation.","volume":"6","author":"Rada","year":"2017","journal-title":"Inflamm Res"},{"key":"26","doi-asserted-by":"publisher","first-page":"3348","DOI":"10.3390\/ijms20133348","article-title":"VDAC1 and the TSPO: expression, interactions, and associated functions in health and disease states.","volume":"2","author":"Mizrachi","year":"2019","journal-title":"Int J Mol Sci"},{"key":"27","doi-asserted-by":"publisher","first-page":"4184","DOI":"10.3390\/ijms21114184","article-title":"NLRP3 inflammasome activation in adipose tissues and its implications on metabolic diseases.","volume":"2","author":"Cheng","year":"2020","journal-title":"Int J Mol Sci"},{"key":"28","doi-asserted-by":"publisher","first-page":"9084730","DOI":"10.1155\/2020\/9084730","article-title":"Increased expression of BIRC2, BIRC3, and BIRC5 from the IAP family in mesenchymal stem cells of the umbilical cord wharton\u2019s jelly (WJSC) in younger women giving birth naturally.","volume":"202","author":"Kocki","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"29","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.celrep.2017.06.073","article-title":"XIAP loss triggers RIPK3- and caspase-8-driven IL-1\u03b2 activation and cell death as a consequence of TLR-MyD88-induced cIAP1-TRAF2 degradation.","volume":"2","author":"D\u2019Silva","year":"2017","journal-title":"Cell Rep"},{"key":"30","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/jcb.27322","article-title":"Liver kinase B1 overexpression controls mycobacterial infection in macrophages via FOXO1\/Wnt5a signaling.","volume":"12","author":"Wang","year":"2019","journal-title":"J Cell Biochem"},{"key":"31","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1189\/jlb.4MR0716-330R","article-title":"Bacterial secretion systems and regulation of inflammasome activation.","volume":"10","author":"Lien","year":"2017","journal-title":"J Leukoc Biol"},{"key":"32","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1177\/1947601910376079","article-title":"PRKC-\u03b6 expression promotes the aggressive phenotype of human prostate cancer cells and is a novel target for therapeutic intervention.","volume":"1","author":"Risk","year":"2010","journal-title":"Genes Cancer"},{"key":"33","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1111\/bph.14695","article-title":"Inhibitors of DAG metabolism suppress CCR2 signalling in human monocytes.","volume":"17","author":"Fountain","year":"2019","journal-title":"Br J Pharmacol"},{"key":"34","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1007\/s10753-018-0834-3","article-title":"CIDEC is involved in LPS-induced inflammation and apoptosis in renal tubular epithelial cells.","volume":"4","author":"Gan","year":"2018","journal-title":"Inflammation"},{"key":"35","doi-asserted-by":"publisher","first-page":"eaaw0638","DOI":"10.1126\/scitranslmed.aaw0638","article-title":"Apoptosis of hematopoietic progenitor-derived adipose tissue-resident macrophages contributes to insulin resistance after myocardial infarction.","volume":"1","author":"Chattopadhyay","year":"2020","journal-title":"Sci Transl Med"},{"key":"36","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3390\/genes11040409","article-title":"Replication stress, DNA damage, inflammatory cytokines and innate immune response.","volume":"1","author":"Lopez","year":"2020","journal-title":"Genes (Basel)"},{"key":"37","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.bbagrm.2018.10.019","article-title":"EP300-HDAC1-SWI\/SNF functional unit defines transcription of some DNA repair enzymes during differentiation of human macrophages.","volume":"186","author":"Robaszkiewicz","year":"2019","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"key":"38","doi-asserted-by":"publisher","first-page":"D989","DOI":"10.1093\/nar\/gky942","article-title":"EWASdb: epigenome-wide association study database.","volume":"4","author":"Lei","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"39","doi-asserted-by":"publisher","first-page":"e0227728","DOI":"10.1371\/journal.pone.0227728","article-title":"Associations between high blood pressure and DNA methylation.","volume":"1","author":"Relton","year":"2020","journal-title":"PLoS One"},{"key":"40","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s13073-018-0519-4","article-title":"Characterization of cross-tissue genetic-epigenetic effects and their patterns in schizophrenia.","volume":"1","author":"Liu","year":"2018","journal-title":"Genome Med"},{"key":"41","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.ygeno.2019.05.007","article-title":"Nucleotide distance influences co-methylation between nearby CpG sites.","volume":"11","author":"Cocozza","year":"2020","journal-title":"Genomics"},{"key":"42","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.stemcr.2018.07.003","article-title":"High-resolution single-cell DNA methylation measurements reveal epigenetically distinct hematopoietic stem cell subpopulations.","volume":"1","author":"Hirst","year":"2018","journal-title":"Stem Cell Reports"},{"key":"43","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12859-015-0568-2","article-title":"coMET: visualisation of regional epigenome-wide association scan results and DNA co-methylation patterns.","volume":"1","author":"Bell","year":"2015","journal-title":"BMC Bioinformatics"},{"key":"44","unstructured":"Mallona, Auss\u00f3, Diez-Villanueva, Moreno, Peinado. Modular dynamics of DNA co-methylation networks exposes the functional organization of colon cancer cells' genome. bioRxiv. 2020. [Epub ahead of print]. https:\/\/www.biorxiv.org\/content\/10.1101\/428730v1."},{"key":"45","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3892\/br.2019.1233","article-title":"Unveiling the gene regulatory landscape in diseases through the identification of DNase I-hypersensitive sites.","volume":"1","author":"Chen","year":"2019","journal-title":"Biomed Rep"},{"key":"46","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1101\/gad.335794.119","article-title":"Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation.","volume":"3","author":"Hetzer","year":"2020","journal-title":"Genes Dev"},{"key":"47","doi-asserted-by":"publisher","first-page":"eaaj2239","DOI":"10.1126\/science.aaj2239","article-title":"Impact of cytosine methylation on DNA binding specificities of human transcription factors.","volume":"35","author":"Popov","year":"2017","journal-title":"Science"},{"key":"48","doi-asserted-by":"publisher","first-page":"D252","DOI":"10.1093\/nar\/gkx1106","article-title":"HOCOMOCO: towards a complete collection of transcription factor binding models for human and mouse via large-scale ChIP-seq analysis.","volume":"4","author":"Makeev","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"49","doi-asserted-by":"publisher","first-page":"D180","DOI":"10.1093\/nar\/gkz945","article-title":"ReMap 2020: a database of regulatory regions from an integrative analysis of human and arabidopsis DNA-binding sequencing experiments.","volume":"4","author":"Ballester","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15226\/2475-4676\/3\/3\/00144","article-title":"Gout - Practicable Interdisciplinary Insights for the Clinician on a Surgeon\u2019s Perspective.","volume":"3","author":"Schmidt","year":"2018","journal-title":"J Rheumatol Arthritic Dis"},{"key":"51","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1007\/s10067-017-3969-y","article-title":"Clinical characteristics associated with subcutaneous tophi formation in Chinese gout patients: a retrospective study.","volume":"3","author":"Li","year":"2018","journal-title":"Clin Rheumatol"},{"key":"52","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1002\/art.40422","article-title":"Twin DNA methylation profiling reveals flare-dependent interferon signature and B cell promoter hypermethylation in systemic lupus erythematosus.","volume":"7","author":"Jacobsen","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"53","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1136\/gutjnl-2016-312742","article-title":"Suppression of interferon-mediated anti-HBV response by single CpG methylation in the 5'-UTR of TRIM22.","volume":"6","author":"Park","year":"2018","journal-title":"Gut"},{"key":"54","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/s41580-019-0159-6","article-title":"The diverse roles of DNA methylation in mammalian development and disease.","volume":"2","author":"Bourc\u2019his","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"55","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3892\/mco.2019.1800","article-title":"Methylation and ovarian cancer: can DNA methylation be of diagnostic use?","volume":"1","author":"H\u00f8gdall","year":"2019","journal-title":"Mol Clin Oncol"},{"key":"56","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1158\/0008-5472.CAN-19-3339","article-title":"Induction of DNMT3B by PGE2 and IL6 at distant metastatic sites promotes epigenetic modification and breast cancer colonization.","volume":"8","author":"Huang","year":"2020","journal-title":"Cancer Res"},{"key":"57","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1038\/s41467-020-16989-w","article-title":"Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development.","volume":"1","author":"Yamada","year":"2020","journal-title":"Nat Commun"},{"key":"58","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1007\/s00394-019-02018-0","article-title":"Adolescent caffeine consumption and mammographic breast density in premenopausal women.","volume":"5","author":"Tamimi","year":"2020","journal-title":"Eur J Nutr"},{"key":"59","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s13075-018-1629-5","article-title":"Mediation analysis to understand genetic relationships between habitual coffee intake and gout.","volume":"2","author":"Dalbeth","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"60","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.3945\/ajcn.117.155648","article-title":"DHA-rich n-3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study.","volume":"10","author":"Palmblad","year":"2017","journal-title":"Am J Clin Nutr"},{"key":"61","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1038\/s41598-018-19252-x","article-title":"Omega-3-carboxylic acids provide efficacious anti-inflammatory activity in models of crystal-mediated inflammation.","volume":"8","author":"Miner","year":"2018","journal-title":"Sci Rep"},{"key":"62","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.3390\/nu11081843","article-title":"Dietary patterns are associated with leukocyte LINE-1 methylation in women: a cross-sectional study in Southern Italy.","volume":"1","author":"Agodi","year":"2019","journal-title":"Nutrients"},{"key":"63","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.3390\/nu11122955","article-title":"Dietary interventions for gout and effect on cardiovascular risk factors: a systematic review.","volume":"1","author":"Gerritsen","year":"2019","journal-title":"Nutrients"},{"key":"64","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1038\/s41467-019-11058-3","article-title":"The nasal methylome as a biomarker of asthma and airway inflammation in children.","volume":"1","author":"DeMeo","year":"2019","journal-title":"Nat Commun"},{"key":"65","doi-asserted-by":"publisher","first-page":"67005","DOI":"10.1289\/EHP6345","article-title":"Cadmium, smoking, and human blood DNA methylation profiles in adults from the strong heart study.","volume":"12","author":"Tellez-Plaza","year":"2020","journal-title":"Environ Health Perspect"},{"key":"66","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1111\/acer.14168","article-title":"Epigenome-wide DNA methylation association analysis identified novel loci in peripheral cells for alcohol consumption among European American male veterans.","volume":"4","author":"Gelernter","year":"2019","journal-title":"Alcohol Clin Exp Res"},{"key":"67","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s13148-017-0401-z","article-title":"DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding.","volume":"9","author":"Zou","year":"2017","journal-title":"Clin Epigenetics"},{"key":"68","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.1007\/s10067-020-05090-8","article-title":"Gout: a disease involved with complicated immunoinflammatory responses: a narrative review.","volume":"3","author":"Guo","year":"2020","journal-title":"Clin Rheumatol"},{"key":"69","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1136\/annrheumdis-2017-212454","article-title":"Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk.","volume":"7","author":"Petretto","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"70","doi-asserted-by":"publisher","first-page":"7233","DOI":"10.1038\/s41598-019-43829-9","article-title":"Tissue-specific genes as an underutilized resource in drug discovery.","volume":"9","author":"Hammar","year":"2019","journal-title":"Sci Rep"},{"key":"71","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.jaut.2018.09.007","article-title":"Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: identifying DNA methylation signatures associated with interferon-related genes based on ethnicity and SLEDAI.","volume":"9","author":"Lyn-Cook","year":"2019","journal-title":"J Autoimmun"},{"key":"72","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13073-018-0575-9","article-title":"Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins.","volume":"1","author":"Worthington","year":"2018","journal-title":"Genome Med"},{"key":"73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/gigascience\/gix110","article-title":"Taiwan biobank: making cross-database convergence possible in the big data era.","volume":"7","author":"Chen","year":"2018","journal-title":"Gigascience"},{"key":"74","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13148-019-0647-8","article-title":"SOX2 promoter hypermethylation in non-smoking Taiwanese adults residing in air pollution areas.","volume":"1","author":"Liaw","year":"2019","journal-title":"Clin Epigenetics"},{"key":"75","doi-asserted-by":"publisher","first-page":"56389","DOI":"10.18632\/oncotarget.16916","article-title":"Urine miR-21-5p as a potential non-invasive biomarker for gastric cancer.","volume":"8","author":"Lin","year":"2017","journal-title":"Oncotarget"},{"key":"76","doi-asserted-by":"publisher","first-page":"e43657","DOI":"10.7554\/eLife.43657","article-title":"An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome.","volume":"8","author":"Davey Smith","year":"2019","journal-title":"Elife"},{"key":"77","doi-asserted-by":"publisher","first-page":"13184","DOI":"10.1038\/s41598-018-31282-z","article-title":"Genetics of serum urate concentrations and gout in a high-risk population, patients with chronic kidney disease.","volume":"8","author":"Schultheiss","year":"2018","journal-title":"Sci Rep"},{"key":"78","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/s13075-017-1390-1","article-title":"Performance of gout definitions for genetic epidemiological studies: analysis of UK biobank.","volume":"1","author":"Dalbeth","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"79","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13148-017-0333-7","article-title":"Validation of the MethylationEPIC BeadChip for fresh-frozen and formalin-fixed paraffin-embedded tumours.","volume":"9","author":"Car\u00e9n","year":"2017","journal-title":"Clin Epigenetics"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1093\/cdn\/nzz037.FS11-06-19","article-title":"Differences in DNA Methylation Patterns Between Vegans and Non-vegetarians in the AHS-2 Cohort (FS11-06-19).","volume":"3","author":"Fraser","year":"2019","journal-title":"Curr Dev Nutr"},{"key":"81","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1093\/hmg\/ddx395","article-title":"Location matters: distinct DNA methylation patterns in GABAergic interneuronal populations from separate microcircuits within the human hippocampus.","volume":"2","author":"Benes","year":"2018","journal-title":"Hum Mol Genet"},{"key":"82","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/s41431-018-0291-3","article-title":"Skewed X-inactivation is common in the general female population.","volume":"2","author":"Kie\u0142basa","year":"2019","journal-title":"Eur J Hum Genet"},{"key":"83","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1080\/15592294.2019.1700003","article-title":"Correlation of infinium HumanMethylation450K and MethylationEPIC BeadChip arrays in cartilage.","volume":"1","author":"Reynard","year":"2020","journal-title":"Epigenetics"},{"key":"84","doi-asserted-by":"publisher","first-page":"3487","DOI":"10.18632\/aging.101992","article-title":"Investigation of bidirectional longitudinal associations between advanced epigenetic age and peripheral biomarkers of inflammation and metabolic syndrome.","volume":"1","author":"Wolf","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"85","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13148-019-0664-7","article-title":"Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk.","volume":"1","author":"Jones","year":"2019","journal-title":"Clin Epigenetics"},{"key":"86","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1136\/annrheumdis-2019-215442","article-title":"T cell receptor \u03b2 repertoires as novel diagnostic markers for systemic lupus erythematosus and rheumatoid arthritis.","volume":"7","author":"Yang","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"87","doi-asserted-by":"publisher","first-page":"5147","DOI":"10.3892\/ol.2018.9237","article-title":"Integrated bioinformatic analysis of microarray data reveals shared gene signature between MDS and AML.","volume":"1","author":"Li","year":"2018","journal-title":"Oncol Lett"},{"key":"88","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1136\/annrheumdis-2018-214379","article-title":"Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity.","volume":"7","author":"Repa","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"89","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.ajhg.2019.03.025","article-title":"Cell-type heterogeneity in adipose tissue is associated with complex traits and reveals disease-relevant cell-specific eQTLs.","volume":"10","author":"Small","year":"2019","journal-title":"Am J Hum Genet"},{"key":"90","doi-asserted-by":"publisher","first-page":"eaav7188","DOI":"10.1126\/science.aav7188","article-title":"Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.","volume":"36","author":"International Multiple Sclerosis Genetics Consortium","year":"2019","journal-title":"Science"},{"key":"91","doi-asserted-by":"publisher","first-page":"W158","DOI":"10.1093\/nar\/gkz348","article-title":"WashU epigenome browser update 2019.","volume":"4","author":"Wang","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"92","doi-asserted-by":"publisher","first-page":"D682","DOI":"10.1093\/nar\/gkz966","article-title":"Ensembl 2020.","volume":"4","author":"Boddu","year":"2020","journal-title":"Nucleic Acids Res"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T16:12:46Z","timestamp":1617725566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,20]]},"references-count":92,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2,15]]}},"alternative-id":["202353","33493135"],"URL":"https:\/\/doi.org\/10.18632\/aging.202353","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,20]]}}}