{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:31:43Z","timestamp":1772548303166,"version":"3.50.1"},"reference-count":75,"publisher":"Impact Journals, LLC","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,12,31]]},"DOI":"10.18632\/aging.202367","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T00:15:19Z","timestamp":1608768919000},"page":"24778-24797","source":"Crossref","is-referenced-by-count":11,"title":["L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis"],"prefix":"10.18632","volume":"12","author":[{"given":"Yassine","family":"Ouhaddi","sequence":"first","affiliation":[{"name":"Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), and Department of Medicine, University of Montreal, Montreal, QC H2X 0A9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Najar","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), and Department of Medicine, University of Montreal, Montreal, QC H2X 0A9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Par\u00e9","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), and Department of Medicine, University of Montreal, Montreal, QC H2X 0A9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Lussier","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Clinical Science, University of Montreal, Saint-Hyacinthe, QC, J2S 2M2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Urade","sequence":"additional","affiliation":[{"name":"Isotope Science Center, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Benderdour","sequence":"additional","affiliation":[{"name":"Research Centre, Sacr\u00e9-Coeur Hospital, University of Montreal, Montreal, QC H4J 1C5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), and Department of Medicine, University of Montreal, Montreal, QC H2X 0A9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanne","family":"Martel-Pelletier","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), and Department of Medicine, University of Montreal, Montreal, QC H2X 0A9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Fahmi","sequence":"additional","affiliation":[{"name":"Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), and Department of Medicine, University of Montreal, Montreal, QC H2X 0A9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"1","first-page":"172","article-title":"Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project.","volume":"3","author":"Hochberg","year":"2007","journal-title":"J Rheumatol"},{"key":"2","doi-asserted-by":"publisher","first-page":"16072","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis.","volume":"2","author":"Pelletier","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"3","doi-asserted-by":"publisher","first-page":"98","DOI":"10.2174\/1573397113666170807122312","article-title":"Novel insights into the pathogenesis of osteoarthritis.","volume":"1","author":"Sch\u00f6nfeld","year":"2018","journal-title":"Curr Rheumatol Rev"},{"key":"4","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/nature03369","article-title":"Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.","volume":"43","author":"Morris","year":"2005","journal-title":"Nature"},{"key":"5","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1002\/art.25002","article-title":"Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.","volume":"6","author":"Thompson","year":"2009","journal-title":"Arthritis Rheum"},{"key":"6","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1172\/JCI10564","article-title":"Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice.","volume":"10","author":"DeGennaro","year":"2001","journal-title":"J Clin Invest"},{"key":"7","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1093\/rheumatology\/keh197","article-title":"Chondrogenesis of expanded adult human articular chondrocytes is enhanced by specific prostaglandins.","volume":"4","author":"Martin","year":"2004","journal-title":"Rheumatology (Oxford)"},{"key":"8","doi-asserted-by":"publisher","first-page":"e0153162","DOI":"10.1371\/journal.pone.0153162","article-title":"The role of prostaglandins and COX-enzymes in chondrogenic differentiation of ATDC5 progenitor cells.","volume":"1","author":"Welting","year":"2016","journal-title":"PLoS One"},{"key":"9","doi-asserted-by":"publisher","first-page":"22399","DOI":"10.1074\/jbc.M314118200","article-title":"15-deoxy-delta12,14-prostaglandin J2 inhibits bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts.","volume":"27","author":"Malaise","year":"2004","journal-title":"J Biol Chem"},{"key":"10","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.1002\/art.23958","article-title":"Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2.","volume":"5","author":"Fahmi","year":"2008","journal-title":"Arthritis Rheum"},{"key":"11","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1016\/j.yexcr.2010.08.009","article-title":"Expression of TREM-1 is inhibited by PGD2 and PGJ2 in macrophages.","volume":"31","author":"Sadikot","year":"2010","journal-title":"Exp Cell Res"},{"key":"12","doi-asserted-by":"publisher","first-page":"4943","DOI":"10.4049\/jimmunol.170.10.4943","article-title":"Prostaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive th cells.","volume":"17","author":"Trottein","year":"2003","journal-title":"J Immunol"},{"key":"13","doi-asserted-by":"publisher","first-page":"783","DOI":"10.4049\/jimmunol.180.2.783","article-title":"Prostaglandin D2 inhibits the production of IFN-gamma by invariant NK T cells: consequences in the control of B16 melanoma.","volume":"18","author":"Trottein","year":"2008","journal-title":"J Immunol"},{"key":"14","doi-asserted-by":"publisher","first-page":"8202","DOI":"10.1096\/fj.201802817R","article-title":"Epithelial cell-derived prostaglandin Dinhibits chronic allergic lung inflammation in mice.","volume":"3","author":"Murata","year":"2019","journal-title":"FASEB J"},{"key":"15","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1158\/0008-5472.CAN-13-2792","article-title":"Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice.","volume":"7","author":"Murata","year":"2014","journal-title":"Cancer Res"},{"key":"16","doi-asserted-by":"publisher","first-page":"3822","DOI":"10.4049\/jimmunol.172.6.3822","article-title":"Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses.","volume":"17","author":"Trottein","year":"2004","journal-title":"J Immunol"},{"key":"17","doi-asserted-by":"publisher","first-page":"5179","DOI":"10.1073\/pnas.0507175103","article-title":"Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity.","volume":"10","author":"Gilroy","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"18","doi-asserted-by":"publisher","first-page":"20009","DOI":"10.1073\/pnas.0805171105","article-title":"Role of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis","volume":"10","author":"Sessa","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"19","doi-asserted-by":"publisher","first-page":"5205","DOI":"10.1073\/pnas.1218091110","article-title":"Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement.","volume":"11","author":"Ozaki","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"20","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.3390\/ijms19072012","article-title":"Implications of angiogenesis involvement in arthritis.","volume":"1","author":"Tang","year":"2018","journal-title":"Int J Mol Sci"},{"key":"21","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/s0090-6980(02)00042-4","article-title":"Lipocalin-type and hematopoietic prostaglandin D synthases as a novel example of functional convergence.","volume":"6","author":"Eguchi","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"22","first-page":"12410","article-title":"Purification and characterization of rat brain prostaglandin D synthetase.","volume":"26","author":"Hayaishi","year":"1985","journal-title":"J Biol Chem"},{"key":"23","doi-asserted-by":"publisher","first-page":"14689","DOI":"10.1073\/pnas.94.26.14689","article-title":"Expression of lipocalin-type prostaglandin D synthase (beta-trace) in human heart and its accumulation in the coronary circulation of angina patients.","volume":"9","author":"Hayaishi","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"24","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1097\/IAE.0b013e3181631975","article-title":"Lipocalin-like prostaglandin D synthase in subretinal fluid of detached retinas in humans.","volume":"2","author":"Killer","year":"2008","journal-title":"Retina"},{"key":"25","first-page":"371","article-title":"Mast cells contain spleen-type prostaglandin D synthetase.","volume":"26","author":"Hayaishi","year":"1990","journal-title":"J Biol Chem"},{"key":"26","doi-asserted-by":"publisher","first-page":"40511","DOI":"10.1074\/jbc.M007688200","article-title":"Transcriptional activation of the human hematopoietic prostaglandin D synthase gene in megakaryoblastic cells. Roles of the oct-1 element in the 5'-flanking region and the AP-2 element in the untranslated exon 1.","volume":"27","author":"Urade","year":"2000","journal-title":"J Biol Chem"},{"key":"27","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.4049\/jimmunol.164.5.2277","article-title":"Cutting edge: differential production of prostaglandin D2 by human helper T cell subsets.","volume":"16","author":"Nagata","year":"2000","journal-title":"J Immunol"},{"key":"28","doi-asserted-by":"publisher","first-page":"R146","DOI":"10.1186\/ar2581","article-title":"Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage.","volume":"1","author":"Fahmi","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"29","doi-asserted-by":"publisher","first-page":"877","DOI":"10.3899\/jrheum.120738","article-title":"Expression of peroxisome proliferator-activated receptors \u03b1, \u03b2, \u03b3, and H- and l-prostaglandin D synthase during osteoarthritis in the spontaneous hartley Guinea pig and experimental dog models.","volume":"4","author":"Fahmi","year":"2013","journal-title":"J Rheumatol"},{"key":"30","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse.","volume":"1","author":"Little","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"31","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1002\/art.41297","article-title":"Role of lipocalin-type prostaglandin D synthase in experimental osteoarthritis.","volume":"7","author":"Fahmi","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"32","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1002\/art.40160","article-title":"Exacerbation of aging-associated and instability-induced murine osteoarthritis with deletion of D prostanoid receptor 1, a prostaglandin Dreceptor.","volume":"6","author":"Fahmi","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"33","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1136\/ard.2010.142018","article-title":"Weight loss as treatment for knee osteoarthritis symptoms in obese patients: 1-year results from a randomised controlled trial.","volume":"7","author":"Christensen","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"34","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1002\/acr.23608","article-title":"Intentional weight loss in overweight and obese patients with knee osteoarthritis: is more better?","volume":"7","author":"Loeser","year":"2018","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"35","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1002\/art.33332","article-title":"Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise.","volume":"6","author":"Guilak","year":"2012","journal-title":"Arthritis Rheum"},{"key":"36","doi-asserted-by":"publisher","first-page":"3220","DOI":"10.1002\/art.34533","article-title":"Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice.","volume":"6","author":"Guilak","year":"2012","journal-title":"Arthritis Rheum"},{"key":"37","doi-asserted-by":"publisher","first-page":"R198","DOI":"10.1186\/ar3529","article-title":"High-fat diet accelerates progression of osteoarthritis after meniscal\/ligamentous injury.","volume":"1","author":"Zuscik","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"38","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.berh.2011.11.013","article-title":"Biomechanical factors in osteoarthritis.","volume":"2","author":"Guilak","year":"2011","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"39","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1136\/annrheumdis-2011-200372","article-title":"Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases.","volume":"7","author":"Young","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"40","doi-asserted-by":"publisher","first-page":"345838","DOI":"10.1155\/2009\/345838","article-title":"Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage\u2014mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production.","volume":"200","author":"Moilanen","year":"2009","journal-title":"Mediators Inflamm"},{"key":"41","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1007\/s11033-009-9911-x","article-title":"Leptin plays a catabolic role on articular cartilage.","volume":"3","author":"Wu","year":"2010","journal-title":"Mol Biol Rep"},{"key":"42","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1002\/art.24854","article-title":"Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis.","volume":"6","author":"Guilak","year":"2009","journal-title":"Arthritis Rheum"},{"key":"43","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/j.joca.2012.05.002","article-title":"Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage.","volume":"2","author":"Mastbergen","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"key":"44","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/j.joca.2019.08.003","article-title":"The role of leptin and adiponectin as mediators in the relationship between adiposity and hand and knee osteoarthritis.","volume":"2","author":"Kloppenburg","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"45","doi-asserted-by":"publisher","first-page":"29946","DOI":"10.1074\/jbc.M502927200","article-title":"Accelerated glucose intolerance, nephropathy, and atherosclerosis in prostaglandin D2 synthase knock-out mice.","volume":"28","author":"Urade","year":"2005","journal-title":"J Biol Chem"},{"key":"46","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1002\/art.30656","article-title":"Prostaglandin D2 regulates joint inflammation and destruction in murine collagen-induced arthritis.","volume":"6","author":"Ferr\u00e1ndiz","year":"2012","journal-title":"Arthritis Rheum"},{"key":"47","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1172\/JCI9652","article-title":"15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats.","volume":"10","author":"Sano","year":"2000","journal-title":"J Clin Invest"},{"key":"48","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1002\/art.39561","article-title":"Suppressive effects of insulin on tumor necrosis factor-dependent early osteoarthritic changes associated with obesity and type 2 diabetes mellitus.","volume":"6","author":"Mooney","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"49","doi-asserted-by":"publisher","first-page":"e0183693","DOI":"10.1371\/journal.pone.0183693","article-title":"Obesity-associated metabolic syndrome spontaneously induces infiltration of pro-inflammatory macrophage in synovium and promotes osteoarthritis.","volume":"1","author":"Prasadam","year":"2017","journal-title":"PLoS One"},{"key":"50","doi-asserted-by":"publisher","first-page":"3564","DOI":"10.1002\/art.34637","article-title":"Leptin exacerbates collagen-induced arthritis via enhancement of Th17 cell response.","volume":"6","author":"Lu","year":"2012","journal-title":"Arthritis Rheum"},{"key":"51","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1136\/annrheumdis-2012-202685","article-title":"The relationship between longitudinal serum leptin measures and measures of magnetic resonance imaging-assessed knee joint damage in a population of mid-life women.","volume":"7","author":"Jiang","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"52","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1359\/jbmr.080228","article-title":"Prostaglandin D2 receptors control osteoclastogenesis and the activity of human osteoclasts.","volume":"2","author":"de Brum-Fernandes","year":"2008","journal-title":"J Bone Miner Res"},{"key":"53","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.bone.2013.12.011","article-title":"Prostaglandin D(2) induces apoptosis of human osteoclasts through ERK1\/2 and Akt signaling pathways.","volume":"6","author":"de Brum-Fernandes","year":"2014","journal-title":"Bone"},{"key":"54","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1016\/0006-291x(89)92238-9","article-title":"Prostaglandin D2 stimulates calcification of human osteoblastic cells.","volume":"15","author":"Kawamura","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"55","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1007\/BF00571334","article-title":"Effect of prostaglandin D2 on the femoral bone mineral density in ovariectomized rats.","volume":"5","author":"Tamaki","year":"1993","journal-title":"Calcif Tissue Int"},{"key":"56","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1210\/er.2017-00226","article-title":"Effects of leptin on the skeleton.","volume":"3","author":"Cornish","year":"2018","journal-title":"Endocr Rev"},{"key":"57","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1073\/pnas.96.2.726","article-title":"Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice.","volume":"9","author":"Hayaishi","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"58","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.neuroscience.2008.07.017","article-title":"Different effects of spinally applied prostaglandin D2 on responses of dorsal horn neurons with knee input in normal rats and in rats with acute knee inflammation.","volume":"15","author":"Schaible","year":"2008","journal-title":"Neuroscience"},{"key":"59","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/1471-2474-9-163","article-title":"The association of BMI and knee pain among persons with radiographic knee osteoarthritis: a cross-sectional study.","volume":"9","author":"Wilder","year":"2008","journal-title":"BMC Musculoskelet Disord"},{"key":"60","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1172\/JCI36785","article-title":"Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents.","volume":"11","author":"Mao","year":"2009","journal-title":"J Clin Invest"},{"key":"61","doi-asserted-by":"publisher","first-page":"13076","DOI":"10.1073\/pnas.0903524106","article-title":"Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation.","volume":"10","author":"Kishioka","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"62","doi-asserted-by":"publisher","first-page":"e135446","DOI":"10.1172\/jci.insight.135446","article-title":"Angiogenesis stimulated by elevated PDGF-BB in subchondral bone contributes to osteoarthritis development.","volume":"5","author":"Wan","year":"2020","journal-title":"JCI Insight"},{"key":"63","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1136\/annrheumdis-2015-207923","article-title":"Halofuginone attenuates osteoarthritis by inhibition of TGF-\u03b2 activity and H-type vessel formation in subchondral bone.","volume":"7","author":"Ding","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"64","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.bone.2011.11.030","article-title":"Elevated cross-talk between subchondral bone and cartilage in osteoarthritic joints.","volume":"5","author":"Wang","year":"2012","journal-title":"Bone"},{"key":"65","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.exger.2009.07.001","article-title":"Age-related increase of prostaglandin D(2) synthase concentration and glycation in ovine cerebrospinal fluid.","volume":"4","author":"Preston","year":"2009","journal-title":"Exp Gerontol"},{"key":"66","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/s0090-6980(97)00062-2","article-title":"Prostaglandin D synthase concentration in cerebrospinal fluid and serum of patients with neurological disorders.","volume":"5","author":"Diamandis","year":"1997","journal-title":"Prostaglandins"},{"key":"67","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1097\/IJG.0b013e31826a7dea","article-title":"Lipocalin-like prostaglandin D synthase (L-PGDS) concentration in aqueous humour in patients with open-angle glaucoma.","volume":"2","author":"Jaggi","year":"2014","journal-title":"J Glaucoma"},{"key":"68","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1291\/hypres.31.1931","article-title":"Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects.","volume":"3","author":"Sasaguri","year":"2008","journal-title":"Hypertens Res"},{"key":"69","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3892\/ijmm.2011.694","article-title":"Single impact trauma in human early-stage osteoarthritic cartilage: implication of prostaglandin D2 but no additive effect of IL-1\u03b2 on cell survival.","volume":"2","author":"Brenner","year":"2011","journal-title":"Int J Mol Med"},{"key":"70","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1538\/expanim.61.59","article-title":"Differential age-related bone architecture changes between female and male STR\/ort mice.","volume":"6","author":"Takaso","year":"2012","journal-title":"Exp Anim"},{"key":"71","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s13075-015-0747-6","article-title":"On the predictive utility of animal models of osteoarthritis.","volume":"1","author":"Little","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"72","doi-asserted-by":"publisher","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research.","volume":"8","author":"Altman","year":"2010","journal-title":"PLoS Biol"},{"key":"73","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.joca.2011.04.011","article-title":"Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee.","volume":"1","author":"Olson","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"74","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1016\/j.joca.2017.07.001","article-title":"Deletion of 12\/15-lipoxygenase accelerates the development of aging-associated and instability-induced osteoarthritis.","volume":"2","author":"Fahmi","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"75","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw.","volume":"5","author":"Yaksh","year":"1994","journal-title":"J Neurosci Methods"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T15:54:31Z","timestamp":1617724471000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,23]]},"references-count":75,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2020,12,31]]}},"alternative-id":["202367","33361529"],"URL":"https:\/\/doi.org\/10.18632\/aging.202367","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,23]]}}}