{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:43:49Z","timestamp":1790621029682,"version":"4.1.0"},"reference-count":42,"publisher":"Impact Journals, LLC","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,2,15]]},"DOI":"10.18632\/aging.202371","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T07:27:08Z","timestamp":1610263628000},"page":"4045-4062","source":"Crossref","is-referenced-by-count":52,"title":["ALKBH5-mediated m6A demethylation of FOXM1 mRNA promotes progression of uveal melanoma"],"prefix":"10.18632","volume":"13","author":[{"given":"Lili","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayang","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoxuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxiang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2021,1,10]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/eye.2016.275","article-title":"Uveal melanoma: relatively rare but deadly cancer.","volume":"3","author":"Shields","year":"2017","journal-title":"Eye (Lond)"},{"key":"2","doi-asserted-by":"publisher","first-page":"279","DOI":"10.2147\/OPTH.S89591","article-title":"Uveal melanoma: epidemiology, etiology, and treatment of primary disease.","volume":"1","author":"Carvajal","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"3","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1136\/bjophthalmol-2016-309034","article-title":"Metastatic disease from uveal melanoma: treatment options and future prospects.","volume":"10","author":"Nathan","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"4","doi-asserted-by":"publisher","first-page":"8076","DOI":"10.1200\/JCO.2005.02.6534","article-title":"Variates of survival in metastatic uveal melanoma.","volume":"2","author":"Chapman","year":"2005","journal-title":"J Clin Oncol"},{"key":"5","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.4143\/crt.2017.171","article-title":"Prognostic factors and decision tree for long-term survival in metastatic uveal melanoma.","volume":"5","author":"Dias","year":"2018","journal-title":"Cancer Res Treat"},{"key":"6","doi-asserted-by":"publisher","first-page":"147","DOI":"10.2147\/TACG.S69210","article-title":"The genetics of uveal melanoma: current insights.","volume":"9","author":"H\u00f6iom","year":"2016","journal-title":"Appl Clin Genet"},{"key":"7","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ccell.2017.07.003","article-title":"Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.","volume":"3","author":"Kimes","year":"2017","journal-title":"Cancer Cell"},{"key":"8","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1111\/cge.13136","article-title":"Genetic and epigenetic insights into uveal melanoma.","volume":"9","author":"Herwig-Carl","year":"2018","journal-title":"Clin Genet"},{"key":"9","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1167\/iovs.14-15250","article-title":"Skewed expression of the genes encoding epigenetic modifiers in high-risk uveal melanoma.","volume":"5","author":"Jager","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10","doi-asserted-by":"publisher","first-page":"16011","DOI":"10.1002\/jcp.28259","article-title":"Ras-ERK1\/2 signaling promotes the development of uveal melanoma by downregulating H3K14ac.","volume":"23","author":"Yin","year":"2019","journal-title":"J Cell Physiol"},{"key":"11","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.tig.2019.12.007","article-title":"Molecular mechanisms driving mRNA degradation by mA modification.","volume":"3","author":"Kim","year":"2020","journal-title":"Trends Genet"},{"key":"12","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.tig.2019.10.011","article-title":"The biogenesis and precise control of RNA mA methylation.","volume":"3","author":"Chen","year":"2020","journal-title":"Trends Genet"},{"key":"13","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s13045-019-0805-7","article-title":"The interplay between mA RNA methylation and noncoding RNA in cancer.","volume":"1","author":"Sun","year":"2019","journal-title":"J Hematol Oncol"},{"key":"14","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s12943-019-1088-x","article-title":"mA modification suppresses ocular melanoma through modulating HINT2 mRNA translation.","volume":"1","author":"Fan","year":"2019","journal-title":"Mol Cancer"},{"key":"15","doi-asserted-by":"publisher","first-page":"7107","DOI":"10.1002\/jcp.29608","article-title":"RNA mA methylation regulates uveal melanoma cell proliferation, migration, and invasion by targeting c-Met.","volume":"23","author":"Yan","year":"2020","journal-title":"J Cell Physiol"},{"key":"16","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.3389\/fimmu.2019.01713","article-title":"Microenvironmental regulation of tumor progression and therapeutic response in brain metastasis.","volume":"1","author":"Sevenich","year":"2019","journal-title":"Front Immunol"},{"key":"17","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1084\/jem.20181827","article-title":"Context-dependent EMT programs in cancer metastasis.","volume":"21","author":"Kang","year":"2019","journal-title":"J Exp Med"},{"key":"18","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1038\/s41467-019-09865-9","article-title":"RNA mA methylation regulates the epithelial mesenchymal transition of cancer cells and translation of snail.","volume":"1","author":"Wang","year":"2019","journal-title":"Nat Commun"},{"key":"19","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s12943-019-1065-4","article-title":"METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer.","volume":"1","author":"Zhao","year":"2019","journal-title":"Mol Cancer"},{"key":"20","doi-asserted-by":"publisher","first-page":"BSR20180532","DOI":"10.1042\/BSR20180532","article-title":"Abnormally expressed JunB transactivated by IL-6\/STAT3 signaling promotes uveal melanoma aggressiveness via epithelial-mesenchymal transition.","volume":"3","author":"Li","year":"2018","journal-title":"Biosci Rep"},{"key":"21","doi-asserted-by":"publisher","first-page":"544","DOI":"10.4161\/cbt.28157","article-title":"Effects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells.","volume":"1","author":"Li","year":"2014","journal-title":"Cancer Biol Ther"},{"key":"22","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1016\/j.celrep.2018.07.041","article-title":"Enhancer activity requires CBP\/P300 bromodomain-dependent histone H3K27 acetylation.","volume":"2","author":"Gascoigne","year":"2018","journal-title":"Cell Rep"},{"key":"23","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.ccell.2017.02.013","article-title":"mA demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program.","volume":"3","author":"Huang","year":"2017","journal-title":"Cancer Cell"},{"key":"24","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.bbrc.2019.10.145","article-title":"ALKBH5-mA-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia.","volume":"52","author":"Ji","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"25","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.7150\/thno.31868","article-title":"The mA demethylase ALKBH5 controls trophoblast invasion at the maternal-fetal interface by regulating the stability of CYR61 mRNA.","volume":"9","author":"Tian","year":"2019","journal-title":"Theranostics"},{"key":"26","doi-asserted-by":"publisher","first-page":"E325","DOI":"10.1073\/pnas.1717794115","article-title":"ALKBH5-dependent mA demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells.","volume":"11","author":"Yan","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"27","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.semcancer.2014.07.008","article-title":"FOXM1: a key oncofoetal transcription factor in health and disease.","volume":"2","author":"Lam","year":"2014","journal-title":"Semin Cancer Biol"},{"key":"28","doi-asserted-by":"publisher","first-page":"144348","DOI":"10.1016\/j.gene.2020.144348","article-title":"N-methyladenosine ALKBH5 promotes non-small cell lung cancer progress by regulating TIMP3 stability.","volume":"73","author":"Chen","year":"2020","journal-title":"Gene"},{"key":"29","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s13105-019-00690-8","article-title":"ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1.","volume":"7","author":"Zhao","year":"2019","journal-title":"J Physiol Biochem"},{"key":"30","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/s13046-019-1159-2","article-title":"ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2.","volume":"3","author":"Hu","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"31","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1007\/s12253-019-00737-7","article-title":"ALKBH5 holds prognostic values and inhibits the metastasis of colon cancer.","volume":"2","author":"Feng","year":"2020","journal-title":"Pathol Oncol Res"},{"key":"32","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12943-019-1128-6","article-title":"mA demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling.","volume":"1","author":"Shimamoto","year":"2020","journal-title":"Mol Cancer"},{"key":"33","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1159\/000491915","article-title":"ALKBH5 inhibits pancreatic cancer motility by decreasing long non-coding RNA KCNK15-AS1 methylation.","volume":"4","author":"Miao","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"34","doi-asserted-by":"publisher","first-page":"E2047","DOI":"10.1073\/pnas.1602883113","article-title":"Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m\u2076A-demethylation of NANOG mRNA.","volume":"11","author":"Semenza","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"35","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.molcel.2016.06.038","article-title":"Diverse activities of histone acylations connect metabolism to chromatin function.","volume":"6","author":"Workman","year":"2016","journal-title":"Mol Cell"},{"key":"36","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.sbi.2018.10.001","article-title":"Beyond histone acetylation-writing and erasing histone acylations.","volume":"5","author":"Li","year":"2018","journal-title":"Curr Opin Struct Biol"},{"key":"37","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.semcancer.2017.08.009","article-title":"FoxM1: repurposing an oncogene as a biomarker.","volume":"5","author":"Nag","year":"2018","journal-title":"Semin Cancer Biol"},{"key":"38","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1158\/0008-5472.CAN-11-3102","article-title":"A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis.","volume":"7","author":"Xie","year":"2012","journal-title":"Cancer Res"},{"key":"39","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.canlet.2013.07.004","article-title":"FOXM1 promotes the epithelial to mesenchymal transition by stimulating the transcription of slug in human breast cancer.","volume":"34","author":"Tan","year":"2013","journal-title":"Cancer Lett"},{"key":"40","doi-asserted-by":"publisher","first-page":"186","DOI":"10.7150\/ijbs.10634","article-title":"FOXM1 promotes lung adenocarcinoma invasion and metastasis by upregulating SNAIL.","volume":"1","author":"Du","year":"2015","journal-title":"Int J Biol Sci"},{"key":"41","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1158\/1078-0432.CCR-16-0226","article-title":"Anthelmintic niclosamide disrupts the interplay of p65 and FOXM1\/\u03b2-catenin and eradicates leukemia stem cells in chronic myelogenous leukemia.","volume":"2","author":"Pan","year":"2017","journal-title":"Clin Cancer Res"},{"key":"42","doi-asserted-by":"publisher","first-page":"668","DOI":"10.15252\/embj.201592810","article-title":"Wnt-induced deubiquitination FoxM1 ensures nucleus \u03b2-catenin transactivation.","volume":"3","author":"Huang","year":"2016","journal-title":"EMBO J"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T12:13:24Z","timestamp":1617711204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,10]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2,15]]}},"alternative-id":["202371","33428593"],"URL":"https:\/\/doi.org\/10.18632\/aging.202371","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,10]]}}}