{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:59:00Z","timestamp":1784077140076,"version":"3.55.0"},"reference-count":51,"publisher":"Impact Journals, LLC","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,12,31]]},"DOI":"10.18632\/aging.202404","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T00:12:49Z","timestamp":1608768769000},"page":"24836-24852","source":"Crossref","is-referenced-by-count":14,"title":["miR-106b suppresses pathological retinal angiogenesis"],"prefix":"10.18632","volume":"12","author":[{"given":"Catherine","family":"M\u00e9nard","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal H1T 2M4, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel M.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal H1T 2M4, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Dejda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal H1T 2M4, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Miloudi","sequence":"additional","affiliation":[{"name":"Department of Neurology-Neurosurgery, McGill University, Montreal H3A 2B4, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Binet","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal H1T 2M4, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Crespo-Garcia","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal H1T 2M4, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia","family":"Parinot","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal H1T 2M4, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Pilon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal H1T 2M4, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Juneau","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal H1T 2M4, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth MMA","family":"Andriessen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal H1T 2M4, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Mawambo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal H1T 2M4, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Paul","family":"SanGiovanni","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Arizona, Tucson, AZ 85719, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"De Guire","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal H1T 2M4, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemyslaw","family":"Sapieha","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal H1T 2M4, Quebec, Canada"},{"name":"Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal H1T 2M4, Quebec, Canada"},{"name":"Department of Neurology-Neurosurgery, McGill University, Montreal H3A 2B4, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"ORSF5","DOI":"10.1167\/iovs.13-12789","article-title":"The prevalence of age-related eye diseases and visual impairment in aging: current estimates.","volume":"5","author":"Klein","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ajo.2012.10.018","article-title":"Age-related macular degeneration revisited\u2014piecing the puzzle: the LXIX Edward Jackson memorial lecture.","volume":"15","author":"Miller","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"3","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.mam.2012.04.004","article-title":"Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics.","volume":"3","author":"Gorin","year":"2012","journal-title":"Mol Aspects Med"},{"key":"4","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1001\/archopht.122.4.564","article-title":"Prevalence of age-related macular degeneration in the United States.","volume":"12","author":"Kempen","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"5","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1001\/archopht.122.4.552","article-title":"The prevalence of diabetic retinopathy among adults in the United States.","volume":"12","author":"Hamman","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"6","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/sj.eye.6701879","article-title":"The prevalence of low vision and blindness in Canada.","volume":"2","author":"Bassett","year":"2006","journal-title":"Eye (Lond)"},{"key":"7","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.ophtha.2008.10.006","article-title":"Photoreceptor layer thinning over drusen in eyes with age-related macular degeneration imaged in vivo with spectral-domain optical coherence tomography.","volume":"11","author":"Toth","year":"2009","journal-title":"Ophthalmology"},{"key":"8","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1136\/bjo.2007.119685","article-title":"Microperimetry and fundus autofluorescence in patients with early age-related macular degeneration.","volume":"9","author":"Pilotto","year":"2007","journal-title":"Br J Ophthalmol"},{"key":"9","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1136\/bjo.60.5.324","article-title":"Ageing and degeneration in the macular region: a clinico-pathological study.","volume":"6","author":"Sarks","year":"1976","journal-title":"Br J Ophthalmol"},{"key":"10","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.preteyeres.2017.06.002","article-title":"On phagocytes and macular degeneration.","volume":"6","author":"Sennlaub","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2013.12.004","article-title":"Nature and nurture- genes and environment- predict onset and progression of macular degeneration.","volume":"4","author":"Seddon","year":"2014","journal-title":"Prog Retin Eye Res"},{"key":"12","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1056\/NEJMoa062655","article-title":"Ranibizumab versus verteporfin for neovascular age-related macular degeneration.","volume":"35","author":"Schneider","year":"2006","journal-title":"N Engl J Med"},{"key":"13","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1056\/NEJMoa054481","article-title":"Ranibizumab for neovascular age-related macular degeneration.","volume":"35","author":"Kim","year":"2006","journal-title":"N Engl J Med"},{"key":"14","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1185\/03007995.2011.585394","article-title":"A systematic review of the efficacy and safety outcomes of anti-VEGF agents used for treating neovascular age-related macular degeneration: comparison of ranibizumab and bevacizumab.","volume":"2","author":"Mitchell","year":"2011","journal-title":"Curr Med Res Opin"},{"key":"15","doi-asserted-by":"publisher","first-page":"81","DOI":"10.18240\/ijo.2017.01.14","article-title":"Six-year outcomes in neovascular age-related macular degeneration with ranibizumab.","volume":"1","author":"MacDonald","year":"2017","journal-title":"Int J Ophthalmol"},{"key":"16","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1038\/eye.2015.159","article-title":"Defining response to anti-VEGF therapies in neovascular AMD.","volume":"2","author":"Sivaprasad","year":"2015","journal-title":"Eye (Lond)"},{"key":"17","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1096\/fj.00-0598fje","article-title":"Nonvascular role for VEGF: VEGFR-1, 2 activity is critical for neural retinal development.","volume":"1","author":"Smith","year":"2001","journal-title":"FASEB J"},{"key":"18","doi-asserted-by":"publisher","first-page":"e3554","DOI":"10.1371\/journal.pone.0003554","article-title":"Endogenous VEGF is required for visual function: evidence for a survival role on m\u00fcller cells and photoreceptors.","volume":"3","author":"D\u2019Amore","year":"2008","journal-title":"PLoS One"},{"key":"19","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ophtha.2013.08.015","article-title":"Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials.","volume":"12","author":"Martin","year":"2014","journal-title":"Ophthalmology"},{"key":"20","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.ophtha.2014.11.007","article-title":"Growth of geographic atrophy in the comparison of age-related macular degeneration treatments trials.","volume":"12","author":"Martin","year":"2015","journal-title":"Ophthalmology"},{"key":"21","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1016\/j.ophtha.2008.03.021","article-title":"Inflammation, complement factor h, and age-related macular degeneration: the multi-ethnic study of atherosclerosis.","volume":"11","author":"Sharrett","year":"2008","journal-title":"Ophthalmology"},{"key":"22","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.neuron.2012.06.018","article-title":"Mechanisms of age-related macular degeneration.","volume":"7","author":"Fowler","year":"2012","journal-title":"Neuron"},{"key":"23","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s13105-010-0050-6","article-title":"Biological functions of microRNAs: a review.","volume":"6","author":"Zhang","year":"2011","journal-title":"J Physiol Biochem"},{"key":"24","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nature07242","article-title":"The impact of microRNAs on protein output.","volume":"45","author":"Bartel","year":"2008","journal-title":"Nature"},{"key":"25","doi-asserted-by":"publisher","first-page":"19171","DOI":"10.18632\/oncotarget.8280","article-title":"MicroRNA signatures in vitreous humour and plasma of patients with exudative AMD.","volume":"7","author":"Sapieha","year":"2016","journal-title":"Oncotarget"},{"key":"26","doi-asserted-by":"publisher","first-page":"12163","DOI":"10.1073\/pnas.1508426112","article-title":"Endothelial microRNA-150 is an intrinsic suppressor of pathologic ocular neovascularization.","volume":"11","author":"Chen","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"27","doi-asserted-by":"publisher","first-page":"23264","DOI":"10.1074\/jbc.M115.646950","article-title":"Single and compound knock-outs of MicroRNA (miRNA)-155 and its angiogenic gene target CCN1 in mice alter vascular and neovascular growth in the retina via resident microglia.","volume":"29","author":"Chaqour","year":"2015","journal-title":"J Biol Chem"},{"key":"28","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1038\/mt.2008.104","article-title":"MicroRNAs regulate ocular neovascularization.","volume":"1","author":"Campochiaro","year":"2008","journal-title":"Mol Ther"},{"key":"29","first-page":"1057","article-title":"Evaluation of circulating miRNAs in wet age-related macular degeneration.","volume":"2","author":"Tamer","year":"2014","journal-title":"Mol Vis"},{"key":"30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s40291-016-0234-z","article-title":"An eye on age-related macular degeneration: the role of MicroRNAs in disease pathology.","volume":"2","author":"Weber","year":"2017","journal-title":"Mol Diagn Ther"},{"key":"31","doi-asserted-by":"publisher","first-page":"3770","DOI":"10.1073\/pnas.1500008112","article-title":"Synchronous down-modulation of miR-17 family members is an early causative event in the retinal angiogenic switch.","volume":"11","author":"Passetti","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"32","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1038\/nprot.2013.135","article-title":"Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice.","volume":"8","author":"Noel","year":"2013","journal-title":"Nat Protoc"},{"key":"33","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.cell.2008.04.001","article-title":"miRiad roles for the miR-17-92 cluster in development and disease.","volume":"13","author":"Mendell","year":"2008","journal-title":"Cell"},{"key":"34","doi-asserted-by":"publisher","first-page":"e333","DOI":"10.1038\/cddis.2012.74","article-title":"Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis.","volume":"3","author":"Samali","year":"2012","journal-title":"Cell Death Dis"},{"key":"35","first-page":"101","article-title":"Oxygen-induced retinopathy in the mouse.","volume":"3","author":"D\u2019Amore","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"36","doi-asserted-by":"publisher","first-page":"535","DOI":"10.2119\/molmed.2010.00070","article-title":"Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization.","volume":"1","author":"Kaarniranta","year":"2010","journal-title":"Mol Med"},{"key":"37","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/16729","article-title":"Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase.","volume":"39","author":"Ron","year":"1999","journal-title":"Nature"},{"key":"38","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.cmet.2015.07.010","article-title":"ER stress and angiogenesis.","volume":"2","author":"Sapieha","year":"2015","journal-title":"Cell Metab"},{"key":"39","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1210\/me.2016-1056","article-title":"miR-204 targets PERK and regulates UPR signaling and \u03b2-cell apoptosis.","volume":"3","author":"Shalev","year":"2016","journal-title":"Mol Endocrinol"},{"key":"40","doi-asserted-by":"publisher","first-page":"C243","DOI":"10.1152\/ajpcell.00293.2016","article-title":"Regulation of the unfolded protein response by noncoding RNA.","volume":"31","author":"Chevet","year":"2017","journal-title":"Am J Physiol Cell Physiol"},{"key":"41","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1126\/science.1174381","article-title":"MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice.","volume":"32","author":"Tjwa","year":"2009","journal-title":"Science"},{"key":"42","doi-asserted-by":"publisher","first-page":"4944","DOI":"10.1182\/blood-2010-01-264812","article-title":"Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells.","volume":"11","author":"Dimmeler","year":"2010","journal-title":"Blood"},{"key":"43","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12944-016-0216-5","article-title":"MiR-106b exhibits an anti-angiogenic function by inhibiting STAT3 expression in endothelial cells.","volume":"1","author":"Ma","year":"2016","journal-title":"Lipids Health Dis"},{"key":"44","doi-asserted-by":"publisher","first-page":"CD011346","DOI":"10.1002\/14651858.CD011346.pub2","article-title":"Aflibercept for neovascular age-related macular degeneration.","volume":"2","author":"Nguyen","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"45","doi-asserted-by":"publisher","first-page":"e0218282","DOI":"10.1371\/journal.pone.0218282","article-title":"MicroRNA expression profile in retina and choroid in oxygen-induced retinopathy model.","volume":"1","author":"Chemtob","year":"2019","journal-title":"PLoS One"},{"key":"46","doi-asserted-by":"publisher","first-page":"478","DOI":"10.3389\/fgene.2019.00478","article-title":"The potential for microRNA therapeutics and clinical research.","volume":"1","author":"Kocerha","year":"2019","journal-title":"Front Genet"},{"key":"47","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1172\/JCI42142","article-title":"Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life.","volume":"12","author":"Chemtob","year":"2010","journal-title":"J Clin Invest"},{"key":"48","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1167\/iovs.10-5176","article-title":"The mouse retina as an angiogenesis model.","volume":"5","author":"Smith","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"49","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s10456-009-9155-3","article-title":"Computer-aided quantification of retinal neovascularization.","volume":"1","author":"Smith","year":"2009","journal-title":"Angiogenesis"},{"key":"50","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.cmet.2013.02.003","article-title":"Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1\u03b1 degradation of netrin-1.","volume":"1","author":"Joyal","year":"2013","journal-title":"Cell Metab"},{"key":"51","doi-asserted-by":"publisher","first-page":"e69552","DOI":"10.1371\/journal.pone.0069552","article-title":"Choroid sprouting assay: an ex vivo model of microvascular angiogenesis.","volume":"8","author":"Smith","year":"2013","journal-title":"PLoS One"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T15:54:46Z","timestamp":1617724486000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,23]]},"references-count":51,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2020,12,31]]}},"alternative-id":["202404","33361521"],"URL":"https:\/\/doi.org\/10.18632\/aging.202404","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,23]]}}}