{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:23:12Z","timestamp":1773656592625,"version":"3.50.1"},"reference-count":52,"publisher":"Impact Journals, LLC","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,4,30]]},"DOI":"10.18632\/aging.202437","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T12:41:29Z","timestamp":1612183289000},"page":"11010-11025","source":"Crossref","is-referenced-by-count":20,"title":["Obacunone protects retinal pigment epithelium cells from ultra-violet radiation-induced oxidative injury"],"prefix":"10.18632","volume":"13","author":[{"given":"Da-Rui","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Huaian NO.1 People's Hospital of Nanjing Medical University, Huaian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Ming","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Huaian NO.1 People's Hospital of Nanjing Medical University, Huaian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Huaian NO.1 People's Hospital of Nanjing Medical University, Huaian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Huaian NO.1 People's Hospital of Nanjing Medical University, Huaian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/path.4266","article-title":"Mechanisms of age-related macular degeneration and therapeutic opportunities.","volume":"23","author":"Ye","year":"2014","journal-title":"J Pathol"},{"key":"2","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/s0039-6257(00)00140-5","article-title":"The role of oxidative stress in the pathogenesis of age-related macular degeneration.","volume":"4","author":"Boulton","year":"2000","journal-title":"Surv Ophthalmol"},{"key":"3","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1056\/NEJMra0801537","article-title":"Age-related macular degeneration.","volume":"35","author":"Miller","year":"2008","journal-title":"N Engl J Med"},{"key":"4","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/0039-6257(88)90174-9","article-title":"Solar radiation and age-related macular degeneration.","volume":"3","author":"Young","year":"1988","journal-title":"Surv Ophthalmol"},{"key":"5","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1097\/ICL.0b013e31821cbcc9","article-title":"Ultraviolet radiation as a risk factor for cataract and macular degeneration.","volume":"3","author":"Roberts","year":"2011","journal-title":"Eye Contact Lens"},{"key":"6","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/ICL.0b013e31821fbd3e","article-title":"A review: role of ultraviolet radiation in age-related macular degeneration.","volume":"3","author":"Balaiya","year":"2011","journal-title":"Eye Contact Lens"},{"key":"7","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.exer.2013.09.003","article-title":"Retinal pigment epithelium development, plasticity, and tissue homeostasis.","volume":"12","author":"Levine","year":"2014","journal-title":"Exp Eye Res"},{"key":"8","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.exer.2013.07.009","article-title":"The retinal pigment epithelium: an important player of retinal disorders and regeneration.","volume":"12","author":"Chiba","year":"2014","journal-title":"Exp Eye Res"},{"key":"9","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.mam.2012.04.005","article-title":"Understanding age-related macular degeneration (AMD): relationships between the photoreceptor\/retinal pigment epithelium\/Bruch\u2019s membrane\/choriocapillaris complex.","volume":"3","author":"Lutty","year":"2012","journal-title":"Mol Aspects Med"},{"key":"10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1023\/a:1022419606629","article-title":"Aging of cultured retinal pigment epithelial cells: oxidative reactions, lipofuscin formation and blue light damage.","volume":"10","author":"Brunk","year":"2003","journal-title":"Doc Ophthalmol"},{"key":"11","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/s0014-4835(03)00023-x","article-title":"Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration.","volume":"7","author":"Godley","year":"2003","journal-title":"Exp Eye Res"},{"key":"12","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1038\/s41433-018-0044-0","article-title":"What do we know about the macular pigment in AMD: the past, the present, and the future.","volume":"3","author":"Bernstein","year":"2018","journal-title":"Eye (Lond)"},{"key":"13","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s10495-008-0179-8","article-title":"MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells.","volume":"1","author":"Schorderet","year":"2008","journal-title":"Apoptosis"},{"key":"14","doi-asserted-by":"publisher","first-page":"10355","DOI":"10.3390\/ijms140510355","article-title":"Ultraviolet (UV) and hydrogen peroxide activate ceramide-ER stress-AMPK signaling axis to promote retinal pigment epithelium (RPE) cell apoptosis.","volume":"1","author":"Jiang","year":"2013","journal-title":"Int J Mol Sci"},{"key":"15","doi-asserted-by":"publisher","first-page":"60123","DOI":"10.18632\/oncotarget.11164","article-title":"SC79 protects retinal pigment epithelium cells from UV radiation via activating Akt-Nrf2 signaling.","volume":"7","author":"Jiang","year":"2016","journal-title":"Oncotarget"},{"key":"16","doi-asserted-by":"publisher","first-page":"13186","DOI":"10.18632\/oncotarget.14489","article-title":"miRNA-141 attenuates UV-induced oxidative stress via activating Keap1-Nrf2 signaling in human retinal pigment epithelium cells and retinal ganglion cells.","volume":"8","author":"Wu","year":"2017","journal-title":"Oncotarget"},{"key":"17","doi-asserted-by":"publisher","first-page":"89793","DOI":"10.18632\/oncotarget.21131","article-title":"MIND4-17 protects retinal pigment epithelium cells and retinal ganglion cells from UV.","volume":"8","author":"Huang","year":"2017","journal-title":"Oncotarget"},{"key":"18","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.bbrc.2017.04.128","article-title":"The novel cyclophilin D inhibitor compound 19 protects retinal pigment epithelium cells and retinal ganglion cells from UV radiation.","volume":"48","author":"Song","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"19","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.freeradbiomed.2018.02.001","article-title":"Activation of Nrf2 by Ginsenoside Rh3 protects retinal pigment epithelium cells and retinal ganglion cells from UV.","volume":"11","author":"Cao","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"20","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3892\/mmr.2011.582","article-title":"EGCG protects against UVB-induced apoptosis via oxidative stress and the JNK1\/c-Jun pathway in ARPE19 cells.","volume":"5","author":"Jiang","year":"2012","journal-title":"Mol Med Rep"},{"key":"21","doi-asserted-by":"publisher","first-page":"25525","DOI":"10.1038\/srep25525","article-title":"3H-1,2-dithiole-3-thione protects retinal pigment epithelium cells against Ultra-violet radiation via activation of Akt-mTORC1-dependent Nrf2-HO-1 signaling.","volume":"6","author":"Cao","year":"2016","journal-title":"Sci Rep"},{"key":"22","doi-asserted-by":"publisher","first-page":"246","DOI":"10.4161\/auto.5432","article-title":"Is mitochondrial generation of reactive oxygen species a trigger for autophagy?","volume":"4","author":"Gibson","year":"2008","journal-title":"Autophagy"},{"key":"23","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1159\/000213257","article-title":"Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited.","volume":"3","author":"Davies","year":"1991","journal-title":"Gerontology"},{"key":"24","first-page":"2267","article-title":"Bioactive compounds in green tea leaves attenuate the injury of retinal ganglion RGC-5 cells induced by H2O2 and ultraviolet radiation.","volume":"2","author":"Du","year":"2015","journal-title":"Pak J Pharm Sci"},{"key":"25","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.tiv.2012.12.001","article-title":"Reactive oxygen species-induced cytotoxic effects of zinc oxide nanoparticles in rat retinal ganglion cells.","volume":"2","author":"Cui","year":"2013","journal-title":"Toxicol In Vitro"},{"key":"26","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.bbrc.2018.05.003","article-title":"PF-06409577 activates AMPK signaling to protect retinal pigment epithelium cells from UV radiation.","volume":"50","author":"Wang","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"27","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.pharep.2016.12.011","article-title":"The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment.","volume":"6","author":"Baer-Dubowska","year":"2017","journal-title":"Pharmacol Rep"},{"key":"28","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.redox.2016.10.003","article-title":"Nrf2 mediates redox adaptations to exercise.","volume":"1","author":"Traustad\u00f3ttir","year":"2016","journal-title":"Redox Biol"},{"key":"29","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.freeradbiomed.2015.05.036","article-title":"Oxidative stress response and Nrf2 signaling in aging.","volume":"8","author":"Forman","year":"2015","journal-title":"Free Radic Biol Med"},{"key":"30","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.mce.2014.12.013","article-title":"The Keap1-Nrf2-antioxidant response element pathway: a review of its regulation by melatonin and the proteasome.","volume":"40","author":"Reiter","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"31","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1007\/s13238-016-0297-y","article-title":"Obacunone activates the Nrf2-dependent antioxidant responses.","volume":"7","author":"Xu","year":"2016","journal-title":"Protein Cell"},{"key":"32","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1002\/jcb.26248","article-title":"Obacunone causes sustained expression of MKP-1 thus inactivating p38 MAPK to suppress pro-inflammatory mediators through intracellular MIF.","volume":"11","author":"Qi","year":"2018","journal-title":"J Cell Biochem"},{"key":"33","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1016\/j.fct.2011.04.014","article-title":"Obacunone and obacunone glucoside inhibit human colon cancer (SW480) cells by the induction of apoptosis.","volume":"4","author":"Patil","year":"2011","journal-title":"Food Chem Toxicol"},{"key":"34","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.bbrc.2011.06.055","article-title":"Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet.","volume":"41","author":"Sato","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"35","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1007\/s12272-010-0818-9","article-title":"Neuroprotective effects of constituents of the root bark of Dictamnus dasycarpus in mouse hippocampal cells.","volume":"3","author":"An","year":"2010","journal-title":"Arch Pharm Res"},{"key":"36","doi-asserted-by":"publisher","first-page":"7204","DOI":"10.1002\/jcp.29619","article-title":"The Nrf2 activator MIND4-17 protects retinal ganglion cells from high glucose-induced oxidative injury.","volume":"23","author":"Jiang","year":"2020","journal-title":"J Cell Physiol"},{"key":"37","doi-asserted-by":"publisher","first-page":"103447","DOI":"10.1016\/j.jprot.2019.103447","article-title":"Identification of the perturbed metabolic pathways associating with prostate cancer cells and anticancer affects of obacunone.","volume":"20","author":"Wang","year":"2019","journal-title":"J Proteomics"},{"key":"38","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.bbrc.2019.03.201","article-title":"Obacunone attenuates high glucose-induced oxidative damage in NRK-52E cells by inhibiting the activity of GSK-3\u03b2.","volume":"51","author":"Peng","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"39","doi-asserted-by":"publisher","first-page":"4668","DOI":"10.1038\/s41598-019-41111-6","article-title":"Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress.","volume":"9","author":"Sweeney","year":"2019","journal-title":"Sci Rep"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1080\/10495398.2019.1654485","article-title":"Efficiency of CellROX deep redand CellROX orangefluorescent probes in identifying reactive oxygen species in sperm samples from high and low fertility bulls.","author":"de S\u00e1 Filho","year":"2019","journal-title":"Anim Biotechnol"},{"key":"41","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.exer.2015.07.007","article-title":"Beneficial protective effect of pramipexole on light-induced retinal damage in mice.","volume":"13","author":"Nakamura","year":"2015","journal-title":"Exp Eye Res"},{"key":"42","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.vph.2014.01.006","article-title":"Endothelial nitric oxide synthase activation through obacunone-dependent arginase inhibition restored impaired endothelial function in ApoE-null mice.","volume":"6","author":"Ryoo","year":"2014","journal-title":"Vascul Pharmacol"},{"key":"43","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.freeradbiomed.2014.01.025","article-title":"Salvianolic acid a protects RPE cells against oxidative stress through activation of Nrf2\/HO-1 signaling.","volume":"6","author":"Yao","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"44","doi-asserted-by":"publisher","first-page":"31085","DOI":"10.18632\/oncotarget.5044","article-title":"Focal adhesion kinase overexpression and its impact on human osteosarcoma.","volume":"6","author":"Sun","year":"2015","journal-title":"Oncotarget"},{"key":"45","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.yexcr.2014.12.017","article-title":"C6 ceramide dramatically enhances docetaxel-induced growth inhibition and apoptosis in cultured breast cancer cells: a mechanism study.","volume":"33","author":"Cao","year":"2015","journal-title":"Exp Cell Res"},{"key":"46","doi-asserted-by":"publisher","first-page":"28935","DOI":"10.18632\/oncotarget.7898","article-title":"Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cells.","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"47","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s11064-013-0968-5","article-title":"Oxygen glucose deprivation (OGD)\/re-oxygenation-induced in vitro neuronal cell death involves mitochondrial cyclophilin-D\/P53 signaling axis.","volume":"3","author":"Gao","year":"2013","journal-title":"Neurochem Res"},{"key":"48","first-page":"1406","article-title":"Lenticular mitoprotection. Part A: Monitoring mitochondrial depolarization with JC-1 and artifactual fluorescence by the glycogen synthase kinase-3\u03b2 inhibitor, SB216763.","volume":"1","author":"Cammarata","year":"2013","journal-title":"Mol Vis"},{"key":"49","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.bbrc.2018.01.168","article-title":"CC-223 inhibits human head and neck squamous cell carcinoma cell growth.","volume":"49","author":"Li","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"50","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.cellsig.2011.01.014","article-title":"Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway.","volume":"2","author":"Yang","year":"2011","journal-title":"Cell Signal"},{"key":"51","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.bbrc.2019.05.171","article-title":"Targeting cullin 3 by miR-601 activates Nrf2 signaling to protect retinal pigment epithelium cells from hydrogen peroxide.","volume":"51","author":"Jiang","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"52","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12964-018-0294-2","article-title":"Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide.","volume":"1","author":"Di","year":"2018","journal-title":"Cell Commun Signal"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T16:57:00Z","timestamp":1620320220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,4,30]]}},"alternative-id":["202437","33535179"],"URL":"https:\/\/doi.org\/10.18632\/aging.202437","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,1]]}}}