{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T19:15:35Z","timestamp":1781118935257,"version":"3.54.1"},"reference-count":40,"publisher":"Impact Journals, LLC","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,3,15]]},"DOI":"10.18632\/aging.202537","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T12:59:52Z","timestamp":1613566792000},"page":"6782-6803","source":"Crossref","is-referenced-by-count":13,"title":["The role of CDX2 in renal tubular lesions during diabetic kidney disease"],"prefix":"10.18632","volume":"13","author":[{"given":"Huiming","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, Guizhou, China"},{"name":"Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, Guizhou, China"},{"name":"Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Guizhou Medical University, Guiyang 550025, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luqun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, Guizhou, China"},{"name":"Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, Guizhou, China"},{"name":"Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, Guizhou, China"},{"name":"Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, Guizhou, China"},{"name":"Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, Guizhou, China"},{"name":"Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, Guizhou, China"},{"name":"Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, Guizhou, China"},{"name":"Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, Guizhou, China"},{"name":"Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, Guizhou, China"},{"name":"Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, Guizhou, China"},{"name":"Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, Guizhou, China"},{"name":"Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, Guizhou, China"},{"name":"Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, Guizhou, China"},{"name":"Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.2215\/CJN.11491116","article-title":"Diabetic kidney disease: challenges, progress, and possibilities.","volume":"1","author":"Tuttle","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"2","doi-asserted-by":"publisher","first-page":"4647685","DOI":"10.1155\/2016\/4647685","article-title":"Urinary markers of tubular injury in early diabetic nephropathy.","volume":"201","author":"Tamir","year":"2016","journal-title":"Int J Nephrol"},{"key":"3","doi-asserted-by":"publisher","first-page":"iv60","DOI":"10.1093\/ndt\/gfv264","article-title":"New developments concerning the proximal tubule in diabetic nephropathy:models and mechanisms.","volume":"3","author":"Ryan","year":"2015","journal-title":"Nephrol Dial Transplant"},{"key":"4","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1002\/cbin.10433","article-title":"Interleukin-13 promotes expression of alix to compromise renal tubular epithelial barrier function.","volume":"3","author":"Tong","year":"2015","journal-title":"Cell Biol Int"},{"key":"5","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1002\/jcb.25372","article-title":"Ketamine increases permeability and alters epithelial phenotype of renal distal tubular cells via a GSK-3\u03b2-dependent mechanism.","volume":"11","author":"Lee","year":"2016","journal-title":"J Cell Biochem"},{"key":"6","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.molmed.2012.07.006","article-title":"Gastric intestinal metaplasia revisited: function and regulation of CDX2.","volume":"1","author":"Almeida","year":"2012","journal-title":"Trends Mol Med"},{"key":"7","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/cas.13462","article-title":"Helicobacter pylori induces caudal-type homeobox protein 2 and cyclooxygenase 2 expression by modulating microRNAs in esophageal epithelial cells.","volume":"10","author":"Wang","year":"2018","journal-title":"Cancer Sci"},{"key":"8","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.canlet.2016.10.040","article-title":"The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton.","volume":"38","author":"Gross","year":"2017","journal-title":"Cancer Lett"},{"key":"9","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/1756-9966-31-98","article-title":"Prognostic significance of Cdx2 immunohistochemical expression in gastric cancer: a meta-analysis of published literatures.","volume":"3","author":"Xie","year":"2012","journal-title":"J Exp Clin Cancer Res"},{"key":"10","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.bbadis.2019.01.003","article-title":"Down-regulated expression of LINC00518 prevents epithelial cell growth and metastasis in breast cancer through the inhibition of CDX2 methylation and the Wnt signaling pathway.","volume":"186","author":"Li","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"11","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/cdd.2017.14","article-title":"AMPK improves gut epithelial differentiation and barrier function via regulating Cdx2 expression.","volume":"2","author":"Zhu","year":"2017","journal-title":"Cell Death Differ"},{"key":"12","doi-asserted-by":"publisher","first-page":"5231","DOI":"10.3892\/mmr.2015.4114","article-title":"Nuclear transcription factor CDX2 inhibits gastric cancer-cell growth and reverses epithelial-to-mesenchymal transitionand","volume":"1","author":"Chen","year":"2015","journal-title":"Mol Med Rep"},{"key":"13","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00018-016-2391-y","article-title":"Role of CFTR in epithelial physiology.","volume":"7","author":"Gray","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"14","doi-asserted-by":"publisher","first-page":"5233","DOI":"10.1038\/s41598-017-05435-5","article-title":"Defective CFTR leads to aberrant \u03b2-catenin activation and kidney fibrosis.","volume":"7","author":"Chan","year":"2017","journal-title":"Sci Rep"},{"key":"15","doi-asserted-by":"publisher","first-page":"2732","DOI":"10.1111\/jcmm.13189","article-title":"LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with \u03b2-catenin.","volume":"2","author":"Lv","year":"2017","journal-title":"J Cell Mol Med"},{"key":"16","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/nm.3901","article-title":"Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease.","volume":"2","author":"Nieto","year":"2015","journal-title":"Nat Med"},{"key":"17","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.canlet.2013.12.029","article-title":"MUC1 drives epithelial-mesenchymal transition in renal carcinoma through Wnt\/\u03b2-catenin pathway and interaction with SNAIL promoter.","volume":"34","author":"Leroy","year":"2014","journal-title":"Cancer Lett"},{"key":"18","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1111\/jcmm.13446","article-title":"FHL2 promotes tubular epithelial-to-mesenchymal transition through modulating \u03b2-catenin signalling.","volume":"2","author":"He","year":"2018","journal-title":"J Cell Mol Med"},{"key":"19","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1042\/BJ20120693","article-title":"Transcriptional networks driving enhancer function in the CFTR gene.","volume":"44","author":"Harris","year":"2012","journal-title":"Biochem J"},{"key":"20","doi-asserted-by":"publisher","first-page":"2724","DOI":"10.1093\/hmg\/ddv032","article-title":"CHD6 regulates the topological arrangement of the CFTR locus.","volume":"2","author":"Walsh","year":"2015","journal-title":"Hum Mol Genet"},{"key":"21","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.tem.2016.06.004","article-title":"Partial epithelial-to-mesenchymal transition and other new mechanisms of kidney fibrosis.","volume":"2","author":"Kalluri","year":"2016","journal-title":"Trends Endocrinol Metab"},{"key":"22","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.ebiom.2018.04.023","article-title":"Runt-related transcription factor 1 (RUNX1) promotes TGF-\u03b2-induced renal tubular epithelial-to-mesenchymal transition (EMT) and renal fibrosis through the PI3K subunit p110\u03b4.","volume":"3","author":"Wang","year":"2018","journal-title":"EBioMedicine"},{"key":"23","doi-asserted-by":"publisher","first-page":"593","DOI":"10.4161\/cbt.3.7.913","article-title":"The role of cdx proteins in intestinal development and cancer.","volume":"3","author":"Lynch","year":"2004","journal-title":"Cancer Biol Ther"},{"key":"24","doi-asserted-by":"publisher","first-page":"15229","DOI":"10.1016\/S0021-9258(17)36596-1","article-title":"Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium.","volume":"26","author":"Kazenwadel","year":"1994","journal-title":"J Biol Chem"},{"key":"25","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/sj.bjc.6690068","article-title":"Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas.","volume":"7","author":"Yuasa","year":"1999","journal-title":"Br J Cancer"},{"key":"26","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/s0092-8674(00)81279-9","article-title":"Cell adhesion: the molecular basis of tissue architecture and morphogenesis.","volume":"8","author":"Gumbiner","year":"1996","journal-title":"Cell"},{"key":"27","doi-asserted-by":"publisher","first-page":"F20","DOI":"10.1152\/ajprenal.00052.2005","article-title":"Tight junction biology and kidney dysfunction.","volume":"29","author":"Ward","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"28","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00109-003-0517-9","article-title":"The role of epithelial-to-mesenchymal transition in renal fibrosis.","volume":"8","author":"Kalluri","year":"2004","journal-title":"J Mol Med (Berl)"},{"key":"29","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.pharmthera.2017.08.009","article-title":"EMT: mechanisms and therapeutic implications.","volume":"18","author":"Singh","year":"2018","journal-title":"Pharmacol Ther"},{"key":"30","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1038\/nm.3902","article-title":"Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis.","volume":"2","author":"Kalluri","year":"2015","journal-title":"Nat Med"},{"key":"31","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1172\/JCI121987","article-title":"PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.","volume":"12","author":"Han","year":"2019","journal-title":"J Clin Invest"},{"key":"32","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/S2213-2600(13)70025-0","article-title":"Management of comorbidities in older patients with cystic fibrosis.","volume":"1","author":"Bell","year":"2013","journal-title":"Lancet Respir Med"},{"key":"33","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/\u03b2-catenin signaling, disease, and emerging therapeutic modalities.","volume":"16","author":"Clevers","year":"2017","journal-title":"Cell"},{"key":"34","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.phrs.2019.03.022","article-title":"Protective or deleterious role of Wnt\/beta-catenin signaling in diabetic nephropathy: an unresolved issue.","volume":"14","author":"Liu","year":"2019","journal-title":"Pharmacol Res"},{"key":"35","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1038\/srep01878","article-title":"Kidney tubular \u03b2-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication.","volume":"3","author":"Liu","year":"2013","journal-title":"Sci Rep"},{"key":"36","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/\u03b2-catenin signaling and disease.","volume":"14","author":"Nusse","year":"2012","journal-title":"Cell"},{"key":"37","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/j.celrep.2014.07.040","article-title":"Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction.","volume":"8","author":"Ishitani","year":"2014","journal-title":"Cell Rep"},{"key":"38","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.devcel.2008.02.006","article-title":"Wnt\/beta-catenin signaling: turning the switch.","volume":"1","author":"Cadigan","year":"2008","journal-title":"Dev Cell"},{"key":"39","doi-asserted-by":"publisher","first-page":"L1170","DOI":"10.1152\/ajplung.00363.2016","article-title":"A sequence upstream of canonical PDZ-binding motif within CFTR COOH-terminus enhances NHERF1 interaction.","volume":"31","author":"Milewski","year":"2016","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"40","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1093\/ndt\/gfw333","article-title":"Snail and kidney fibrosis.","volume":"3","author":"Hertig","year":"2017","journal-title":"Nephrol Dial Transplant"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T16:21:25Z","timestamp":1617726085000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,3,15]]}},"alternative-id":["202537","33621200"],"URL":"https:\/\/doi.org\/10.18632\/aging.202537","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,17]]}}}