{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:15:54Z","timestamp":1771877754782,"version":"3.50.1"},"reference-count":30,"publisher":"Impact Journals, LLC","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,4,30]]},"DOI":"10.18632\/aging.202641","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T16:21:54Z","timestamp":1614615714000},"page":"11026-11042","source":"Crossref","is-referenced-by-count":6,"title":["Calycosin stimulates the proliferation of endothelial cells, but not breast cancer cells, via a feedback loop involving RP11-65M17.3, BRIP1 and ER\u03b1"],"prefix":"10.18632","volume":"13","author":[{"given":"Yong","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Tumor Immunology and Microenvironmental Regulation of Guangxi, Guilin Medical University, Guilin 541004, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tumor Immunology and Microenvironmental Regulation of Guangxi, Guilin Medical University, Guilin 541004, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyue","family":"Hou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tumor Immunology and Microenvironmental Regulation of Guangxi, Guilin Medical University, Guilin 541004, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Physiology, Guilin Medical University, Guilin 541004, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tumor Immunology and Microenvironmental Regulation of Guangxi, Guilin Medical University, Guilin 541004, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianyao","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tumor Immunology and Microenvironmental Regulation of Guangxi, Guilin Medical University, Guilin 541004, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, First Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tumor Immunology and Microenvironmental Regulation of Guangxi, Guilin Medical University, Guilin 541004, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"10179","DOI":"10.1038\/srep10179","article-title":"A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome.","volume":"5","author":"Lam","year":"2015","journal-title":"Sci Rep"},{"key":"2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0010-7824(95)00258-8","article-title":"The third age, the third world and the third millennium.","volume":"5","author":"Diczfalusy","year":"1996","journal-title":"Contraception"},{"key":"3","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1080\/13697137.2017.1291780","article-title":"Cardiovascular disease in women, is it different to men? the role of sex hormones.","volume":"2","author":"Vitale","year":"2017","journal-title":"Climacteric"},{"key":"4","doi-asserted-by":"publisher","first-page":"H2822","DOI":"10.1152\/ajpheart.00129.2008","article-title":"Estradiol accelerates endothelial healing through the retrograde commitment of uninjured endothelium.","volume":"29","author":"Laurell","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"5","doi-asserted-by":"publisher","first-page":"10318","DOI":"10.1038\/s41598-017-10442-7","article-title":"Estradiol regulates txnip and prevents intermittent hypoxia-induced vascular injury.","volume":"7","author":"Li","year":"2017","journal-title":"Sci Rep"},{"key":"6","doi-asserted-by":"publisher","first-page":"S51","DOI":"10.3816\/cbc.2006.s.004","article-title":"Current status of combined hormone replacement therapy in clinical practice.","volume":"6","author":"Hill","year":"2006","journal-title":"Clin Breast Cancer"},{"key":"7","doi-asserted-by":"publisher","first-page":"480","DOI":"10.3945\/ajcn.2009.28203","article-title":"Effect of oral isoflavone supplementation on vascular endothelial function in postmenopausal women: a meta-analysis of randomized placebo-controlled trials.","volume":"9","author":"Hui","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"8","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1016\/j.biopha.2018.08.100","article-title":"Phytoestrogens and breast cancer:anticancer activities of isoflavones, lignans, coumestans, stilbenes and their analogs and derivatives.","volume":"10","author":"Maier","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"9","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1158\/0008-5472.CAN-05-2067","article-title":"Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breast.","volume":"6","author":"Cline","year":"2006","journal-title":"Cancer Res"},{"key":"10","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1002\/mc.22531","article-title":"Differential ability of formononetin to stimulate proliferation of endothelial cells and breast cancer cells via a feedback loop involving MicroRNA-375, RASD1, and ER\u03b1.","volume":"5","author":"Huang","year":"2018","journal-title":"Mol Carcinog"},{"key":"11","doi-asserted-by":"publisher","first-page":"e11822","DOI":"10.1371\/journal.pone.0011822","article-title":"Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC.","volume":"5","author":"Lee","year":"2010","journal-title":"PLoS One"},{"key":"12","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.canlet.2011.04.022","article-title":"Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1\/2 activationand","volume":"30","author":"Zhou","year":"2011","journal-title":"Cancer Lett"},{"key":"13","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.semcdb.2014.05.015","article-title":"Functional interactions among microRNAs and long noncoding RNAs.","volume":"3","author":"Gorospe","year":"2014","journal-title":"Semin Cell Dev Biol"},{"key":"14","doi-asserted-by":"publisher","first-page":"891","DOI":"10.2147\/CMAR.S151120","article-title":"Expression profile analysis of long noncoding RNA in ER-positive subtype breast cancer using microarray technique and bioinformatics.","volume":"9","author":"Lu","year":"2017","journal-title":"Cancer Manag Res"},{"key":"15","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.mce.2013.06.021","article-title":"Hormone-regulated transcriptomes: lessons learned from estrogen signaling pathways in breast cancer cells.","volume":"38","author":"Kraus","year":"2014","journal-title":"Mol Cell Endocrinol"},{"key":"16","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s10549-017-4403-5","article-title":"Functional importance of PP2A regulatory subunit loss in breast cancer.","volume":"16","author":"Verrills","year":"2017","journal-title":"Breast Cancer Res Treat"},{"key":"17","doi-asserted-by":"publisher","first-page":"253","DOI":"10.2217\/fon.10.191","article-title":"Hereditary breast cancer and the BRCA1-associated FANCJ\/BACH1\/BRIP1.","volume":"7","author":"Guillemette","year":"2011","journal-title":"Future Oncol"},{"key":"18","doi-asserted-by":"publisher","first-page":"e229","DOI":"10.1016\/S1470-2045(12)70558-2","article-title":"Protein phosphatase 2A: a target for anticancer therapy.","volume":"1","author":"Neviani","year":"2013","journal-title":"Lancet Oncol"},{"key":"19","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1196\/annals.1365.031","article-title":"Hormone replacement therapy and cardioprotection: what is good and what is bad for the cardiovascular system?","volume":"109","author":"Fini","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"20","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/j.bcp.2013.09.024","article-title":"Estrogen, vascular estrogen receptor and hormone therapy in postmenopausal vascular disease.","volume":"8","author":"Khalil","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"21","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1742-7843.2006.pto_277.x","article-title":"The risk of breast, endometrial and ovarian cancer in users of hormonal preparations.","volume":"9","author":"Bernstein","year":"2006","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"22","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S1875-5364(16)30024-3","article-title":"Bidirectional regulation of angiogenesis by phytoestrogens through estrogen receptor-mediated signaling networks.","volume":"1","author":"Zhu","year":"2016","journal-title":"Chin J Nat Med"},{"key":"23","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.jsbmb.2012.12.010","article-title":"Interactions of isoflavones and other plant derived estrogens with estrogen receptors for prevention and treatment of breast cancer-considerations concerning related efficacy and safety.","volume":"13","author":"Jacquot","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"key":"24","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/s13046-018-0908-y","article-title":"HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK\/ERK and PI3K\/AKT signaling pathways.","volume":"3","author":"Tu","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"key":"25","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1615\/JEnvironPatholToxicolOncol.2018028386","article-title":"Mitogen-activated protein kinase (MAPK): new insights in breast cancer.","volume":"3","author":"Tian","year":"2019","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"26","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.canlet.2019.04.031","article-title":"A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K\/AKT\/mTOR and Ras\/Raf\/MEK\/ERK signaling pathways.","volume":"45","author":"Duan","year":"2019","journal-title":"Cancer Lett"},{"key":"27","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1093\/carcin\/bgt356","article-title":"Beta-naphthoflavone (DB06732) mediates estrogen receptor-positive breast cancer cell cycle arrest through AhR-dependent regulation of PI3K\/AKT and MAPK\/ERK signaling.","volume":"3","author":"Tischkau","year":"2014","journal-title":"Carcinogenesis"},{"key":"28","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/s12967-017-1370-x","article-title":"Comprehensive molecular biomarker identification in breast cancer brain metastases.","volume":"1","author":"Al-Qahtani","year":"2017","journal-title":"J Transl Med"},{"key":"29","doi-asserted-by":"publisher","first-page":"e91245","DOI":"10.1371\/journal.pone.0091245","article-title":"Calycosin suppresses breast cancer cell growth via ER\u03b2-dependent regulation of IGF-1R, p38 MAPK and PI3K\/Akt pathways.","volume":"9","author":"Tian","year":"2014","journal-title":"PLoS One"},{"key":"30","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1002\/med.21442","article-title":"Therapeutic Targeting of Poly(ADP-Ribose) Polymerase-1 (PARP1) in Cancer: Current Developments, Therapeutic Strategies, and Future Opportunities.","volume":"3","author":"Mishra","year":"2017","journal-title":"Med Res Rev"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T16:57:02Z","timestamp":1620320222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,4,30]]}},"alternative-id":["202641","33647882"],"URL":"https:\/\/doi.org\/10.18632\/aging.202641","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,1]]}}}