{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T03:35:52Z","timestamp":1777088152528,"version":"3.51.4"},"reference-count":51,"publisher":"Impact Journals, LLC","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,4,15]]},"DOI":"10.18632\/aging.202708","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T08:21:42Z","timestamp":1616142102000},"page":"9646-9664","source":"Crossref","is-referenced-by-count":36,"title":["BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice"],"prefix":"10.18632","volume":"13","author":[{"given":"Yan","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China"},{"name":"The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China"},{"name":"The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianying","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China"},{"name":"The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China"},{"name":"The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China"},{"name":"The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China"},{"name":"The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China"},{"name":"The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China"},{"name":"The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingsheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China"},{"name":"The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China"},{"name":"The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochun","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China"},{"name":"The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China"},{"name":"The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daozhang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China"},{"name":"The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nrrheum.2014.44","article-title":"The individual and socioeconomic impact of osteoarthritis.","volume":"1","author":"Callander","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"2","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis.","volume":"39","author":"Bierma-Zeinstra","year":"2019","journal-title":"Lancet"},{"key":"3","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.3390\/cells8111305","article-title":"Articular Cartilage Regeneration in Osteoarthritis.","volume":"8","author":"Grigolo","year":"2019","journal-title":"Cells"},{"key":"4","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1002\/art.25002","article-title":"Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.","volume":"6","author":"Thompson","year":"2009","journal-title":"Arthritis Rheum"},{"key":"5","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.1111\/febs.15178","article-title":"Forkhead box C1 promotes the pathology of osteoarthritis by upregulating \u03b2-catenin in synovial fibroblasts.","volume":"28","author":"Yin","year":"2020","journal-title":"FEBS J"},{"key":"6","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/nature03369","article-title":"Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.","volume":"43","author":"Morris","year":"2005","journal-title":"Nature"},{"key":"7","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1002\/jor.21348","article-title":"Oxidative stress induces senescence in chondrocytes.","volume":"2","author":"Angele","year":"2011","journal-title":"J Orthop Res"},{"key":"8","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/s1063-4584(03)00150-x","article-title":"The role of reactive oxygen species in homeostasis and degradation of cartilage.","volume":"1","author":"Pujol","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"9","doi-asserted-by":"publisher","first-page":"706","DOI":"10.3389\/fphys.2018.00706","article-title":"Role of the inflammation-autophagy-senescence integrative network in osteoarthritis.","volume":"9","author":"Caram\u00e9s","year":"2018","journal-title":"Front Physiol"},{"key":"10","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/nm.4324","article-title":"Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.","volume":"2","author":"Elisseeff","year":"2017","journal-title":"Nat Med"},{"key":"11","doi-asserted-by":"publisher","first-page":"e12771","DOI":"10.1111\/acel.12771","article-title":"Expression of p16is a biomarker of chondrocyte aging but does not cause osteoarthritis.","volume":"1","author":"Sharpless","year":"2018","journal-title":"Aging Cell"},{"key":"12","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.arr.2017.07.004","article-title":"Aging and osteoarthritis: Central role of the extracellular matrix.","volume":"4","author":"Mozafari","year":"2017","journal-title":"Ageing Res Rev"},{"key":"13","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nrrheum.2016.65","article-title":"Ageing and the pathogenesis of osteoarthritis.","volume":"1","author":"Diekman","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"14","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/acel.12562","article-title":"Cellular senescence in osteoarthritis pathology.","volume":"1","author":"Rai","year":"2017","journal-title":"Aging Cell"},{"key":"15","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13287-019-1193-1","article-title":"Intraarticular senescent chondrocytes impair the cartilage regeneration capacity of mesenchymal stem cells.","volume":"1","author":"Wu","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"16","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1002\/art.10554","article-title":"Apoptosis and cellular vitality: issues in osteoarthritic cartilage degeneration.","volume":"4","author":"Kim","year":"2002","journal-title":"Arthritis Rheum"},{"key":"17","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1007\/s10495-007-0137-x","article-title":"Interleukin-1beta enhances the effect of serum deprivation on rat annular cell apoptosis.","volume":"1","author":"Dai","year":"2007","journal-title":"Apoptosis"},{"key":"18","doi-asserted-by":"publisher","first-page":"e222","DOI":"10.1111\/sms.12290","article-title":"Physical activity ameliorates cartilage degeneration in a rat model of aging: a study on lubricin expression.","volume":"2","author":"Mobasheri","year":"2015","journal-title":"Scand J Med Sci Sports"},{"key":"19","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s00167-010-1215-0","article-title":"Characterization of apoptosis in articular cartilage derived from the knee joints of patients with osteoarthritis.","volume":"1","author":"Martinez","year":"2011","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"20","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.mad.2004.11.008","article-title":"Dinstinct ROS and biochemical profiles in cells undergoing DNA damage-induced senescence and apoptosis.","volume":"12","author":"Hwang","year":"2005","journal-title":"Mech Ageing Dev"},{"key":"21","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1042\/0264-6021:3470543","article-title":"Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts.","volume":"34","author":"Merrett","year":"2000","journal-title":"Biochem J"},{"key":"22","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.cell.2013.10.019","article-title":"Programmed cell senescence during mammalian embryonic development.","volume":"15","author":"Serrano","year":"2013","journal-title":"Cell"},{"key":"23","doi-asserted-by":"publisher","first-page":"16005","DOI":"10.1038\/boneres.2016.5","article-title":"The biological function of type I receptors of bone morphogenetic protein in bone.","volume":"4","author":"Jiang","year":"2016","journal-title":"Bone Res"},{"key":"24","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1038\/sj.gt.3302298","article-title":"Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery.","volume":"1","author":"Li","year":"2004","journal-title":"Gene Ther"},{"key":"25","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.joca.2013.01.011","article-title":"Association study of candidate genes for the progression of hand osteoarthritis.","volume":"2","author":"Meulenbelt","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"26","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1007\/s12013-014-0102-6","article-title":"Association between single nucleotide polymorphisms of asporin (ASPN) and BMP5 with the risk of knee osteoarthritis in a Chinese Han population.","volume":"7","author":"Qian","year":"2014","journal-title":"Cell Biochem Biophys"},{"key":"27","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3109\/08977191003752296","article-title":"BMP5 activates multiple signaling pathways and promotes chondrogenic differentiation in the ATDC5 growth plate model.","volume":"2","author":"Loughlin","year":"2010","journal-title":"Growth Factors"},{"key":"28","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.1038\/sj.onc.1207386","article-title":"Bone morphogenetic protein-5, -6 and -7 inhibit growth and induce apoptosis in human myeloma cells.","volume":"2","author":"Borset","year":"2004","journal-title":"Oncogene"},{"key":"29","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1016\/j.biocel.2013.08.018","article-title":"The NF-\u03baB signalling pathway in osteoarthritis.","volume":"4","author":"Papavassiliou","year":"2013","journal-title":"Int J Biochem Cell Biol"},{"key":"30","doi-asserted-by":"publisher","first-page":"759","DOI":"10.3892\/mmr.2018.9712","article-title":"Mechanisms shaping the role of ERK1\/2 in cellular senescence (review).","volume":"1","author":"Huang","year":"2019","journal-title":"Mol Med Rep"},{"key":"31","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1002\/stem.2533","article-title":"Bmp5 regulates neural crest cell survival and proliferation via two different signaling pathways.","volume":"3","author":"Cheng","year":"2017","journal-title":"Stem Cells"},{"key":"32","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1039\/c6bm00068a","article-title":"Articular cartilage: from formation to tissue engineering.","volume":"4","author":"Weder","year":"2016","journal-title":"Biomater Sci"},{"key":"33","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s11420-011-9250-z","article-title":"Articular cartilage degradation in osteoarthritis.","volume":"8","author":"Goldring","year":"2012","journal-title":"HSS J"},{"key":"34","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/j.1749-6632.2009.05240.x","article-title":"Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis.","volume":"119","author":"Goldring","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"35","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/art.24151","article-title":"Effect of interleukin-1beta on osteogenic protein 1-induced signaling in adult human articular chondrocytes.","volume":"6","author":"Chubinskaya","year":"2009","journal-title":"Arthritis Rheum"},{"key":"36","doi-asserted-by":"publisher","first-page":"969","DOI":"10.3390\/cells8090969","article-title":"TGF\u03b2\/BMP signaling pathway in cartilage homeostasis.","volume":"8","author":"van Caam","year":"2019","journal-title":"Cells"},{"key":"37","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/s41598-018-36500-2","article-title":"Identification of chondrocyte genes and signaling pathways in response to acute joint inflammation.","volume":"9","author":"Lu","year":"2019","journal-title":"Sci Rep"},{"key":"38","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.yexcr.2017.05.018","article-title":"Engineered cartilage regeneration from adipose tissue derived-mesenchymal stem cells: a morphomolecular study on osteoblast, chondrocyte and apoptosis evaluation.","volume":"35","author":"Musumeci","year":"2017","journal-title":"Exp Cell Res"},{"key":"39","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1089\/ten.TEB.2017.0083","article-title":"Mesenchymal stem cell-based cartilage regeneration approach and cell senescence: can we manipulate cell aging and function?","volume":"2","author":"Musumeci","year":"2017","journal-title":"Tissue Eng Part B Rev"},{"key":"40","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/biof.139","article-title":"New insights on the roles of BMP signaling in bone-a review of recent mouse genetic studies.","volume":"3","author":"Mishina","year":"2011","journal-title":"Biofactors"},{"key":"41","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1016\/j.yexcr.2011.06.001","article-title":"Bone morphogenetic protein -4 and -5 in pancreatic cancer\u2014novel bidirectional players.","volume":"31","author":"Kallioniemi","year":"2011","journal-title":"Exp Cell Res"},{"key":"42","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nature13193","article-title":"The role of senescent cells in ageing.","volume":"50","author":"van Deursen","year":"2014","journal-title":"Nature"},{"key":"43","doi-asserted-by":"publisher","first-page":"26035","DOI":"10.3390\/ijms161125943","article-title":"Chondrocyte apoptosis in the pathogenesis of osteoarthritis.","volume":"1","author":"Kim","year":"2015","journal-title":"Int J Mol Sci"},{"key":"44","doi-asserted-by":"publisher","first-page":"5683","DOI":"10.1038\/sj.onc.1209569","article-title":"Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage.","volume":"2","author":"Zhivotovsky","year":"2006","journal-title":"Oncogene"},{"key":"45","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.15252\/embr.201439245","article-title":"Senescence and apoptosis: dueling or complementary cell fates?","volume":"1","author":"van Deursen","year":"2014","journal-title":"EMBO Rep"},{"key":"46","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1242\/jcs.01651","article-title":"Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway.","volume":"11","author":"Toussaint","year":"2005","journal-title":"J Cell Sci"},{"key":"47","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1038\/sj.onc.1206366","article-title":"Caspase inhibition switches doxorubicin-induced apoptosis to senescence.","volume":"2","author":"Mirkin","year":"2003","journal-title":"Oncogene"},{"key":"48","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1016\/j.joca.2010.08.014","article-title":"Mechanical impact induces cartilage degradation via mitogen activated protein kinases.","volume":"1","author":"Martin","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"49","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/978-1-4939-1619-1_2","article-title":"Primary murine growth plate and articular chondrocyte isolation and cell culture.","volume":"122","author":"O\u2019Keefe","year":"2015","journal-title":"Methods Mol Biol"},{"key":"50","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/978-1-4939-1619-1_12","article-title":"Mouse models of osteoarthritis: surgical model of posttraumatic osteoarthritis induced by destabilization of the medial meniscus.","volume":"122","author":"Goldring","year":"2015","journal-title":"Methods Mol Biol"},{"key":"51","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse.","volume":"1","author":"Little","year":"2010","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T16:53:17Z","timestamp":1620319997000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,19]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,4,15]]}},"alternative-id":["202708","33744859"],"URL":"https:\/\/doi.org\/10.18632\/aging.202708","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,19]]}}}