{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T20:08:05Z","timestamp":1769198885003,"version":"3.49.0"},"reference-count":31,"publisher":"Impact Journals, LLC","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,4,15]]},"DOI":"10.18632\/aging.202779","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T06:22:00Z","timestamp":1616826120000},"page":"10175-10186","source":"Crossref","is-referenced-by-count":3,"title":["Regulation of PINX1 expression ameliorates lipopolysaccharide-induced lung injury and alleviates cell senescence during the convalescent phase through affecting the telomerase activity"],"prefix":"10.18632","volume":"13","author":[{"given":"Shujing","family":"Li","sequence":"first","affiliation":[{"name":"Rehabilitation Medicine Department, Qingdao Hospital of Traditional Chinese Medicine (Hiser Hospital), Qingdao 266033, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Qingdao Hospital of Traditional Chinese Medicine (Hiser Hospital), Qingdao 266033, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyang","family":"Yu","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Qingdao Hospital of Traditional Chinese Medicine (Hiser Hospital), Qingdao 266033, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongqing","family":"Song","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Qingdao Hospital of Traditional Chinese Medicine (Hiser Hospital), Qingdao 266033, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1001\/jama.2016.0291","article-title":"Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries.","volume":"31","author":"Thompson","year":"2016","journal-title":"JAMA"},{"key":"2","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.3389\/fphar.2019.01613","article-title":"Protective effect of piceatannol against acute lung injury through protecting the integrity of air-blood barrier and modulating the TLR4\/NF-\u03baB signaling pathway activation.","volume":"1","author":"Shen","year":"2020","journal-title":"Front Pharmacol"},{"key":"3","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3892\/mmr.2019.10278","article-title":"Synergistic protection of matrine and lycopene against lipopolysaccharide induced acute lung injury in mice.","volume":"2","author":"Liu","year":"2019","journal-title":"Mol Med Rep"},{"key":"4","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3389\/fphar.2017.00120","article-title":"Protective effects of dioscin against lipopolysaccharide-induced acute lung injury through inhibition of oxidative stress and inflammation.","volume":"8","author":"Peng","year":"2017","journal-title":"Front Pharmacol"},{"key":"5","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1080\/15384101.2018.1509635","article-title":"MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting inflammation and apoptosis through modulating TLR4\/MyD88\/NF-\u03baB pathway.","volume":"1","author":"Luo","year":"2018","journal-title":"Cell Cycle"},{"key":"6","doi-asserted-by":"publisher","first-page":"109868","DOI":"10.1016\/j.biopha.2020.109868","article-title":"Ruscogenin alleviates LPS-induced pulmonary endothelial cell apoptosis by suppressing TLR4 signaling.","volume":"12","author":"Kou","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/08941939.2019.1680777","article-title":"Dipeptidyl peptidase-4 (DPP-4) inhibitor saxagliptin alleviates lipopolysaccharide-induced acute lung injury via regulating the Nrf-2\/HO-1 and NF- \u03ba B pathways.","volume":"1","author":"Jin","year":"2019","journal-title":"J Invest Surg"},{"key":"8","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1111\/j.1651-2227.2010.01720.x","article-title":"Telomere length in relation to insulin resistance, inflammation and obesity among Arab youth.","volume":"9","author":"Huang","year":"2010","journal-title":"Acta Paediatr"},{"key":"9","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3390\/jcm8050711","article-title":"Effects of inflammation and depression on telomere length in young adults in the United States.","volume":"8","author":"Lee","year":"2019","journal-title":"J Clin Med"},{"key":"10","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.bjhh.2017.02.007","article-title":"Telomere length correlates with disease severity and inflammation in sickle cell disease.","volume":"3","author":"Saad","year":"2017","journal-title":"Rev Bras Hematol Hemoter"},{"key":"11","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1093\/ijnp\/pyx001","article-title":"Telomere length, oxidative stress, inflammation and BDNF levels in siblings of patients with bipolar disorder: implications for accelerated cellular aging.","volume":"2","author":"Rosa","year":"2017","journal-title":"Int J Neuropsychopharmacol"},{"key":"12","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.4049\/jimmunol.1700414","article-title":"PINX1 and TERT are required for TNF-\u03b1-induced airway smooth muscle chemokine gene expression.","volume":"20","author":"Knox","year":"2018","journal-title":"J Immunol"},{"key":"13","doi-asserted-by":"publisher","first-page":"8861","DOI":"10.1074\/jbc.RA118.006615","article-title":"Telomerase reverse transcriptase ameliorates lung fibrosis by protecting alveolar epithelial cells against senescence.","volume":"29","author":"Phan","year":"2019","journal-title":"J Biol Chem"},{"key":"14","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.12659\/MSM.914114","article-title":"Allicin improves lung injury induced by sepsis via regulation of the toll-like receptor 4 (TLR4)\/myeloid differentiation primary response 88 (MYD88)\/nuclear factor kappa B (NF-\u03baB) pathway.","volume":"2","author":"Zang","year":"2019","journal-title":"Med Sci Monit"},{"key":"15","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3892\/etm.2019.7551","article-title":"miR-206 regulates alveolar type II epithelial cell Cx43 expression in sepsis-induced acute lung injury.","volume":"1","author":"Zhang","year":"2019","journal-title":"Exp Ther Med"},{"key":"16","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1002\/cphy.c100068","article-title":"Oxidants and redox signaling in acute lung injury.","volume":"1","author":"Ward","year":"2011","journal-title":"Compr Physiol"},{"key":"17","doi-asserted-by":"publisher","first-page":"759","DOI":"10.3892\/etm.2017.4534","article-title":"Salvianolic acid B attenuates lipopolysaccharide-induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation.","volume":"1","author":"Liu","year":"2017","journal-title":"Exp Ther Med"},{"key":"18","doi-asserted-by":"publisher","first-page":"L217","DOI":"10.1152\/ajplung.00311.2013","article-title":"The mercurial nature of neutrophils: still an enigma in ARDS?","volume":"30","author":"Chambers","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"19","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.3390\/ijms20051082","article-title":"Protein S is protective in acute lung injury by inhibiting cell apoptosis.","volume":"2","author":"Gabazza","year":"2019","journal-title":"Int J Mol Sci"},{"key":"20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.freeradbiomed.2018.06.009","article-title":"Apigenin C-glycosides of Microcos paniculata protects lipopolysaccharide induced apoptosis and inflammation in acute lung injury through TLR4 signaling pathway.","volume":"12","author":"Guo","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"21","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.taap.2015.04.004","article-title":"Effects of acteoside on lipopolysaccharide-induced inflammation in acute lung injury via regulation of NF-\u03baB pathwayand","volume":"28","author":"Shumin","year":"2015","journal-title":"Toxicol Appl Pharmacol"},{"key":"22","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s00281-016-0560-6","article-title":"Key mechanisms governing resolution of lung inflammation.","volume":"3","author":"Rossi","year":"2016","journal-title":"Semin Immunopathol"},{"key":"23","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1126\/science.aah6752","article-title":"TZAP: A telomere-associated protein involved in telomere length control.","volume":"35","author":"Lazzerini Denchi","year":"2017","journal-title":"Science"},{"key":"24","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1146\/annurev.bi.65.070196.002005","article-title":"Telomere length regulation.","volume":"6","author":"Greider","year":"1996","journal-title":"Annu Rev Biochem"},{"key":"25","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s00412-006-0067-3","article-title":"Telomere length homeostasis.","volume":"11","author":"Lingner","year":"2006","journal-title":"Chromosoma"},{"key":"26","doi-asserted-by":"publisher","first-page":"H251","DOI":"10.1152\/ajpheart.00197.2013","article-title":"Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries.","volume":"30","author":"Donato","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"27","doi-asserted-by":"publisher","first-page":"e5747","DOI":"10.1590\/1414-431x20165747","article-title":"The anesthetic agent sevoflurane attenuates pulmonary acute lung injury by modulating apoptotic pathways.","volume":"5","author":"Yang","year":"2017","journal-title":"Braz J Med Biol Res"},{"key":"28","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1097\/SHK.0b013e31824ddc81","article-title":"Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis.","volume":"3","author":"Wang","year":"2012","journal-title":"Shock"},{"key":"29","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1080\/01902148.2017.1321064","article-title":"Gene expression of the concentration-sensitive sodium channel is suppressed in lipopolysaccharide-induced acute lung injury in mice.","volume":"4","author":"Hidaka","year":"2017","journal-title":"Exp Lung Res"},{"key":"30","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.4049\/jimmunol.1203147","article-title":"Overexpression of CREM\u03b1 in T cells aggravates lipopolysaccharide-induced acute lung injury.","volume":"19","author":"Martin","year":"2013","journal-title":"J Immunol"},{"key":"31","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1097\/00003246-200002000-00033","article-title":"Lidocaine attenuates acute lung injury induced by a combination of phospholipase A2 and trypsin.","volume":"2","author":"Obara","year":"2000","journal-title":"Crit Care Med"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T16:55:45Z","timestamp":1620320145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,26]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,4,15]]}},"alternative-id":["202779","33819185"],"URL":"https:\/\/doi.org\/10.18632\/aging.202779","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,26]]}}}