{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:02:24Z","timestamp":1791511344770,"version":"4.3.4"},"reference-count":53,"publisher":"Impact Journals, LLC","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,4,30]]},"DOI":"10.18632\/aging.202807","type":"journal-article","created":{"date-parts":[[2021,4,4]],"date-time":"2021-04-04T09:06:57Z","timestamp":1617527217000},"page":"11234-11256","source":"Crossref","is-referenced-by-count":41,"title":["Ischemic-hypoxic preconditioning enhances the mitochondrial function recovery of transplanted olfactory mucosa mesenchymal stem cells via miR-181a signaling in ischemic stroke"],"prefix":"10.18632","volume":"13","author":[{"given":"Yi","family":"Zhuo","sequence":"first","affiliation":[{"name":"The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha 410006, Hunan, P.R. China"},{"name":"Hunan Provincical Key Laboratory of Neurorestoratology, The Second Affiliated Hospital Hunan Normal University, Changsha 410003, Hunan, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Hunan Provincical Key Laboratory of Neurorestoratology, The Second Affiliated Hospital Hunan Normal University, Changsha 410003, Hunan, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshui","family":"Li","sequence":"additional","affiliation":[{"name":"The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha 410006, Hunan, P.R. China"},{"name":"Hunan Provincical Key Laboratory of Neurorestoratology, The Second Affiliated Hospital Hunan Normal University, Changsha 410003, Hunan, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha 410006, Hunan, P.R. China"},{"name":"Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha 410008, Hunan, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Duan","sequence":"additional","affiliation":[{"name":"Hunan Provincical Key Laboratory of Neurorestoratology, The Second Affiliated Hospital Hunan Normal University, Changsha 410003, Hunan, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lite","family":"Ge","sequence":"additional","affiliation":[{"name":"The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha 410006, Hunan, P.R. China"},{"name":"Hunan Provincical Key Laboratory of Neurorestoratology, The Second Affiliated Hospital Hunan Normal University, Changsha 410003, Hunan, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha 410008, Hunan, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha 410008, Hunan, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha 410008, Hunan, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lu","sequence":"additional","affiliation":[{"name":"The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha 410006, Hunan, P.R. China"},{"name":"Hunan Provincical Key Laboratory of Neurorestoratology, The Second Affiliated Hospital Hunan Normal University, Changsha 410003, Hunan, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2021,4,4]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.1161\/STROKEAHA.119.025732","article-title":"Stroke mechanisms in symptomatic intracranial atherosclerotic disease: classification and clinical implications.","volume":"5","author":"Leung","year":"2019","journal-title":"Stroke"},{"key":"2","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1161\/STROKEAHA.118.020711","article-title":"Improving microcirculatory reperfusion reduces parenchymal oxygen radical formation and provides neuroprotection.","volume":"4","author":"Dalkara","year":"2018","journal-title":"Stroke"},{"key":"3","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1161\/STROKEAHA.118.023837","article-title":"Location of neutrophils in different compartments of the damaged mouse brain after severe ischemia\/reperfusion.","volume":"5","author":"Planas","year":"2019","journal-title":"Stroke"},{"key":"4","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3389\/fncel.2019.00101","article-title":"Homer1a attenuates endoplasmic reticulum stress-induced mitochondrial stress after ischemic reperfusion injury by inhibiting the PERK pathway.","volume":"1","author":"Fei","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"5","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.neuint.2018.11.015","article-title":"Tetrahydrocurcumin epigenetically mitigates mitochondrial dysfunction in brain vasculature during ischemic stroke.","volume":"12","author":"Tyagi","year":"2019","journal-title":"Neurochem Int"},{"key":"6","doi-asserted-by":"publisher","first-page":"44682","DOI":"10.18632\/oncotarget.17967","article-title":"Ginkgolide K attenuates neuronal injury after ischemic stroke by inhibiting mitochondrial fission and GSK-3\u03b2-dependent increases in mitochondrial membrane permeability.","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"7","doi-asserted-by":"publisher","first-page":"10931","DOI":"10.18632\/aging.103307","article-title":"Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia\/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1\u03b1.","volume":"1","author":"Hu","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"8","doi-asserted-by":"publisher","first-page":"112051","DOI":"10.1016\/j.jep.2019.112051","article-title":"Neuroprotective effect of glycosides in Buyang Huanwu Decoction on pyroptosis following cerebral ischemia-reperfusion injury in rats.","volume":"24","author":"Liu","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.2176\/nmc.oa.2019-0186","article-title":"Early transplantation of human cranial bone-derived mesenchymal stem cells enhances functional recovery in ischemic stroke model rats.","volume":"6","author":"Kurisu","year":"2020","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"10","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3389\/fneur.2019.00211","article-title":"Mesenchymal stem cell-derived extracellular vesicle therapy for stroke: challenges and progress.","volume":"1","author":"Kim","year":"2019","journal-title":"Front Neurol"},{"key":"11","doi-asserted-by":"publisher","first-page":"1243659","DOI":"10.1155\/2016\/1243659","article-title":"Secretome of olfactory mucosa mesenchymal stem cell, a multiple potential stem cell.","volume":"201","author":"Lu","year":"2016","journal-title":"Stem Cells Int"},{"key":"12","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1089\/scd.2010.0420","article-title":"Nasal septum-derived multipotent progenitors: a potent source for stem cell-based regenerative medicine.","volume":"2","author":"Soleimani","year":"2011","journal-title":"Stem Cells Dev"},{"key":"13","doi-asserted-by":"publisher","first-page":"e74330","DOI":"10.1371\/journal.pone.0074330","article-title":"Age-related characteristics of multipotent human nasal inferior turbinate-derived mesenchymal stem cells.","volume":"8","author":"Sun","year":"2013","journal-title":"PLoS One"},{"key":"14","doi-asserted-by":"publisher","first-page":"e100219","DOI":"10.1371\/journal.pone.0100219","article-title":"Characteristics of mesenchymal stem cells originating from the bilateral inferior turbinate in humans with nasal septal deviation.","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"key":"15","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1177\/0963689717720291","article-title":"Hypoxic culture promotes dopaminergic-neuronal differentiation of nasal olfactory mucosa mesenchymal stem cells via upregulation of hypoxia-inducible factor-1\u03b1.","volume":"2","author":"Xie","year":"2017","journal-title":"Cell Transplant"},{"key":"16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.expneurol.2014.11.007","article-title":"Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia.","volume":"26","author":"Giffard","year":"2015","journal-title":"Exp Neurol"},{"key":"17","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.mcn.2017.05.004","article-title":"Inhibition of miR-181a protects female mice from transient focal cerebral ischemia by targeting astrocyte estrogen receptor-\u03b1.","volume":"8","author":"Giffard","year":"2017","journal-title":"Mol Cell Neurosci"},{"key":"18","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1139\/bcb-2019-0253","article-title":"Homogeneity and heterogeneity of biological characteristics in mesenchymal stem cells from human umbilical cords and exfoliated deciduous teeth.","volume":"9","author":"Chen","year":"2020","journal-title":"Biochem Cell Biol"},{"key":"19","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1089\/scd.2009.0267","article-title":"The human nose harbors a niche of olfactory ectomesenchymal stem cells displaying neurogenic and osteogenic properties.","volume":"1","author":"F\u00e9ron","year":"2010","journal-title":"Stem Cells Dev"},{"key":"20","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/humu.22010","article-title":"Genome-wide analysis of familial dysautonomia and kinetin target genes with patient olfactory ecto-mesenchymal stem cells.","volume":"3","author":"Ibrahim","year":"2012","journal-title":"Hum Mutat"},{"key":"21","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1089\/scd.2013.0274","article-title":"Adult human nasal mesenchymal-like stem cells restore cochlear spiral ganglion neurons after experimental lesion.","volume":"2","author":"Goldstein","year":"2014","journal-title":"Stem Cells Dev"},{"key":"22","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1002\/jcp.26931","article-title":"Hypoxic conditioned medium derived from bone marrow mesenchymal stromal cells protects against ischemic stroke in rats.","volume":"23","author":"Shi","year":"2019","journal-title":"J Cell Physiol"},{"key":"23","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s13287-017-0565-7","article-title":"Preconditioning of bone marrow-derived mesenchymal stromal cells by tetramethylpyrazine enhances cell migration and improves functional recovery after focal cerebral ischemia in rats.","volume":"8","author":"Gu","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"24","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1002\/jnr.24025","article-title":"Transplantation with hypoxia-preconditioned mesenchymal stem cells suppresses brain injury caused by cardiac arrest-induced global cerebral ischemia in rats.","volume":"9","author":"Huang","year":"2017","journal-title":"J Neurosci Res"},{"key":"25","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1002\/cbf.3423","article-title":"Hypoxic preconditioning improves the survival and neural effects of transplanted mesenchymal stem cells via CXCL12\/CXCR4 signalling in a rat model of cerebral infarction.","volume":"3","author":"Tang","year":"2019","journal-title":"Cell Biochem Funct"},{"key":"26","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.3390\/ijms18061320","article-title":"Hypoxic preconditioning promotes the bioactivities of mesenchymal stem cells via the HIF-1\u03b1-GRP78-Akt axis.","volume":"1","author":"Lee","year":"2017","journal-title":"Int J Mol Sci"},{"key":"27","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.nbd.2012.03.002","article-title":"Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and neurogenesis after cerebral ischemia in rats.","volume":"4","author":"Yu","year":"2012","journal-title":"Neurobiol Dis"},{"key":"28","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13287-017-0543-0","article-title":"Autophagy mediates the beneficial effect of hypoxic preconditioning on bone marrow mesenchymal stem cells for the therapy of myocardial infarction.","volume":"8","author":"Hu","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-017-0014-9","article-title":"Donor-dependent variation of human umbilical cord blood mesenchymal stem cells in response to hypoxic preconditioning and amelioration of limb ischemia.","volume":"5","author":"Kang","year":"2018","journal-title":"Exp Mol Med"},{"key":"30","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1248\/yakushi.20-00012-7","article-title":"[Development of DDS actively to overcome the blood-brain barrier in the region of ischemic stroke].","volume":"14","author":"Kogure","year":"2020","journal-title":"Yakugaku Zasshi"},{"key":"31","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12883-020-01634-2","article-title":"Blood-brain barrier integrity of stroke patients presenting in an extended time window.","volume":"2","author":"Leigh","year":"2020","journal-title":"BMC Neurol"},{"key":"32","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.stem.2016.08.021","article-title":"Mesenchymal inflammation drives genotoxic stress in hematopoietic stem cells and predicts disease evolution in human pre-leukemia.","volume":"1","author":"Cremers","year":"2016","journal-title":"Cell Stem Cell"},{"key":"33","doi-asserted-by":"publisher","first-page":"S287","DOI":"10.33549\/physiolres.934353","article-title":"Mitochondrial respiration of adipocytes differentiating from human mesenchymal stem cells derived from adipose tissue.","volume":"6","author":"Kuncov\u00e1","year":"2019","journal-title":"Physiol Res"},{"key":"34","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.mvr.2019.01.001","article-title":"Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke.","volume":"12","author":"Yan","year":"2019","journal-title":"Microvasc Res"},{"key":"35","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1161\/STROKEAHA.119.025249","article-title":"Eye opener in stroke.","volume":"5","author":"Borlongan","year":"2019","journal-title":"Stroke"},{"key":"36","doi-asserted-by":"publisher","first-page":"104604","DOI":"10.1016\/j.neuint.2019.104604","article-title":"Neuroprotective potential of azilsartan against cerebral ischemic injury: possible involvement of mitochondrial mechanisms.","volume":"13","author":"Kumar","year":"2020","journal-title":"Neurochem Int"},{"key":"37","doi-asserted-by":"publisher","first-page":"109834","DOI":"10.1016\/j.biopha.2020.109834","article-title":"The protective effect of cordyceps sinensis extract on cerebral ischemic injury via modulating the mitochondrial respiratory chain and inhibiting the mitochondrial apoptotic pathway.","volume":"12","author":"Liu","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"38","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.cell.2015.10.001","article-title":"Mitochondrial ROS signaling in organismal homeostasis.","volume":"16","author":"Horvath","year":"2015","journal-title":"Cell"},{"key":"39","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.cell.2016.10.016","article-title":"Mitochondrial sirtuin network reveals dynamic SIRT3-dependent deacetylation in response to membrane depolarization.","volume":"16","author":"Gygi","year":"2016","journal-title":"Cell"},{"key":"40","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s10495-016-1320-8","article-title":"The regulation of the mitochondrial apoptotic pathway by glucocorticoid receptor in collaboration with Bcl-2 family proteins in developing T cells.","volume":"2","author":"Berki","year":"2017","journal-title":"Apoptosis"},{"key":"41","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1038\/s41467-019-09397-2","article-title":"Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation.","volume":"1","author":"Alnemri","year":"2019","journal-title":"Nat Commun"},{"key":"42","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1074\/mcp.RA119.001808","article-title":"Mitochondrial Oxidative Phosphorylation Complex Regulates NLRP3 Inflammasome Activation and Predicts Patient Survival in Nasopharyngeal Carcinoma.","volume":"1","author":"Chang","year":"2020","journal-title":"Mol Cell Proteomics"},{"key":"43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2019.07.026","article-title":"Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects.","volume":"14","author":"Lin","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"44","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s12012-020-09576-4","article-title":"Involvement of ROS\/NLRP3 inflammasome signaling pathway in doxorubicin-induced cardiotoxicity.","volume":"2","author":"Li","year":"2020","journal-title":"Cardiovasc Toxicol"},{"key":"45","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.3389\/fimmu.2018.02563","article-title":"Inflammasome-independent role of NLRP3 mediates mitochondrial regulation in renal injury.","volume":"9","author":"Moon","year":"2018","journal-title":"Front Immunol"},{"key":"46","doi-asserted-by":"publisher","first-page":"166","DOI":"10.5853\/jos.2016.01368","article-title":"Emerging roles of microRNAs in ischemic stroke: as possible therapeutic agents.","volume":"1","author":"Farzaneh","year":"2017","journal-title":"J Stroke"},{"key":"47","doi-asserted-by":"publisher","first-page":"8354350","DOI":"10.1155\/2018\/8354350","article-title":"Systematic analysis of RNA regulatory network in rat brain after ischemic stroke.","volume":"201","author":"Deng","year":"2018","journal-title":"Biomed Res Int"},{"key":"48","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1002\/glia.22483","article-title":"Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes.","volume":"6","author":"Mattson","year":"2013","journal-title":"Glia"},{"key":"49","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.nbd.2011.09.012","article-title":"miR-181 regulates GRP78 and influences outcome from cerebral ischemiaand","volume":"4","author":"Giffard","year":"2012","journal-title":"Neurobiol Dis"},{"key":"50","doi-asserted-by":"publisher","first-page":"689","DOI":"10.3390\/nu10060689","article-title":"Taurine supplementation alleviates puromycin aminonucleoside damage by modulating endoplasmic reticulum stress and mitochondrial-related apoptosis in rat kidney.","volume":"1","author":"Rezzani","year":"2018","journal-title":"Nutrients"},{"key":"51","doi-asserted-by":"publisher","first-page":"e1602038","DOI":"10.1126\/sciadv.1602038","article-title":"Mitochondrial metabolic regulation by GRP78.","volume":"3","author":"Bose","year":"2017","journal-title":"Sci Adv"},{"key":"52","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.mito.2011.09.001","article-title":"miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes.","volume":"1","author":"Giffard","year":"2012","journal-title":"Mitochondrion"},{"key":"53","doi-asserted-by":"publisher","first-page":"5076","DOI":"10.3390\/ijms16035076","article-title":"Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate.","volume":"1","author":"Ueda","year":"2015","journal-title":"Int J Mol Sci"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T12:57:47Z","timestamp":1620305867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,4]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,4,30]]}},"alternative-id":["202807","33820869"],"URL":"https:\/\/doi.org\/10.18632\/aging.202807","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,4]]}}}