{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:28:24Z","timestamp":1782289704473,"version":"3.54.5"},"reference-count":44,"publisher":"Impact Journals, LLC","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,4,30]]},"DOI":"10.18632\/aging.202865","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T19:43:02Z","timestamp":1618861382000},"page":"11705-11726","source":"Crossref","is-referenced-by-count":14,"title":["Selenomethionine protects hematopoietic stem\/progenitor cells against cobalt nanoparticles by stimulating antioxidant actions and DNA repair functions"],"prefix":"10.18632","volume":"13","author":[{"given":"Wenfeng","family":"Zhu","sequence":"first","affiliation":[{"name":"Orthopaedic Laboratory, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China"},{"name":"Department of Orthopaedics, The Sixth Affiliated Hospital of Nantong University, Yancheng, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yake","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weinan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Orthopaedic Laboratory, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Orthopaedic Laboratory, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hua","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, Jiangsu Province, China"},{"name":"Department of Orthopaedics, The Sixth Affiliated Hospital of Nantong University, Yancheng, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanjian","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Sixth Affiliated Hospital of Nantong University, Yancheng, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3109\/17435390.2013.796538","article-title":"Cytotoxicity and morphological transforming potential of cobalt nanoparticles, microparticles and ions in Balb\/3T3 mouse fibroblasts: anmodel.","volume":"8","author":"Di Gioacchino","year":"2014","journal-title":"Nanotoxicology"},{"key":"2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1093\/mutage\/gen024","article-title":"Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes","volume":"2","author":"Migliore","year":"2008","journal-title":"Mutagenesis"},{"key":"3","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s12012-018-9498-3","article-title":"Cobalt administration causes reduced contractility with parallel increases in TRPC6 and TRPM7 transporter protein expression in adult rat hearts.","volume":"1","author":"Currie","year":"2019","journal-title":"Cardiovasc Toxicol"},{"key":"4","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1302\/2046-3758.510.BJR-2016-0016.R1","article-title":"Cytotoxicity and genotoxicity in liver cells induced by cobalt nanoparticles and ions.","volume":"5","author":"Yang","year":"2016","journal-title":"Bone Joint Res"},{"key":"5","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.taap.2019.03.003","article-title":"Comparison of the neurotoxicity associated with cobalt nanoparticles and cobalt chloride in Wistar rats.","volume":"36","author":"Li","year":"2019","journal-title":"Toxicol Appl Pharmacol"},{"key":"6","doi-asserted-by":"publisher","first-page":"4413","DOI":"10.3892\/mmr.2017.7309","article-title":"Melatonin counteracts cobalt nanoparticle-induced cytotoxicity and genotoxicity by deactivating reactive oxygen species-dependent mechanisms in the NRK cell line.","volume":"1","author":"Liu","year":"2017","journal-title":"Mol Med Rep"},{"key":"7","doi-asserted-by":"publisher","first-page":"905","DOI":"10.3109\/17435390.2014.991430","article-title":"Importance of the HIF pathway in cobalt nanoparticle-induced cytotoxicity and inflammation in human macrophages.","volume":"9","author":"Tetley","year":"2015","journal-title":"Nanotoxicology"},{"key":"8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41467-017-02425-z","article-title":"Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.","volume":"9","author":"Messina","year":"2018","journal-title":"Nat Commun"},{"key":"9","doi-asserted-by":"publisher","first-page":"D780","DOI":"10.1093\/nar\/gky1020","article-title":"Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans.","volume":"4","author":"Corcoran","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1182\/blood-2018-02-831065","article-title":"Aged murine hematopoietic stem cells drive aging-associated immune remodeling.","volume":"13","author":"Schirmbeck","year":"2018","journal-title":"Blood"},{"key":"11","first-page":"1829","article-title":"Hematopoietic stem cells: cancer involvement and myeloid leukemia.","volume":"1","author":"Fu","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.tox.2009.05.017","article-title":"Toxicity of antimony trioxide nanoparticles on human hematopoietic progenitor cells and comparison to cell lines.","volume":"26","author":"Cocco","year":"2009","journal-title":"Toxicology"},{"key":"13","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1101\/gad.334383.119","article-title":"Mixed ubiquitin chains regulate DNA repair.","volume":"3","author":"Pagano","year":"2019","journal-title":"Genes Dev"},{"key":"14","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nrm.2016.58","article-title":"Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers.","volume":"1","author":"Mailand","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"15","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.cell.2007.09.041","article-title":"RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.","volume":"13","author":"Chen","year":"2007","journal-title":"Cell"},{"key":"16","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s00204-010-0595-8","article-title":"Selenium: a double-edged sword for defense and offence in cancer.","volume":"8","author":"Chovanec","year":"2010","journal-title":"Arch Toxicol"},{"key":"17","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00204-009-0505-0","article-title":"evaluation of selenium genotoxic, cytotoxic, and protective effects: a review.","volume":"8","author":"Laffon","year":"2010","journal-title":"Arch Toxicol"},{"key":"18","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3109\/10715762.2011.647009","article-title":"Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells.","volume":"4","author":"Rachidi","year":"2012","journal-title":"Free Radic Res"},{"key":"19","doi-asserted-by":"publisher","first-page":"5895439","DOI":"10.1155\/2018\/5895439","article-title":"Age-dependent protective effect of selenium against UVA irradiation in primary human keratinocytes and the associated DNA repair signature.","volume":"201","author":"Rachidi","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"20","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1186\/1556-276X-9-589","article-title":"Differential protein expression of Caco-2 cells treated with selenium nanoparticles compared with sodium selenite and selenomethionine.","volume":"9","author":"Wang","year":"2014","journal-title":"Nanoscale Res Lett"},{"key":"21","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/nsmb1295","article-title":"E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages.","volume":"1","author":"Klevit","year":"2007","journal-title":"Nat Struct Mol Biol"},{"key":"22","doi-asserted-by":"publisher","first-page":"5005","DOI":"10.1038\/onc.2012.522","article-title":"BRCA1 targets G2\/M cell cycle proteins for ubiquitination and proteasomal degradation.","volume":"3","author":"Yarden","year":"2013","journal-title":"Oncogene"},{"key":"23","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1101\/gad.1309505","article-title":"BRCA1\/BARD1 inhibition of mRNA 3\u2019 processing involves targeted degradation of RNA polymerase II.","volume":"1","author":"Manley","year":"2005","journal-title":"Genes Dev"},{"key":"24","doi-asserted-by":"publisher","first-page":"8564","DOI":"10.1016\/j.biomaterials.2013.07.073","article-title":"Consequences of exposure to peri-articular injections of micro- and nano-particulate cobalt-chromium alloy.","volume":"3","author":"Ingham","year":"2013","journal-title":"Biomaterials"},{"key":"25","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.cbi.2014.11.016","article-title":"Toxicity of cobalt oxide nanoparticles to normal cells; anandstudy.","volume":"22","author":"Roy","year":"2015","journal-title":"Chem Biol Interact"},{"key":"26","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.1021\/es304226h","article-title":"Selenomethionine protects against neuronal degeneration by methylmercury in the developing rat cerebrum.","volume":"4","author":"Watanabe","year":"2013","journal-title":"Environ Sci Technol"},{"key":"27","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1007\/s12011-011-9057-2","article-title":"Metabolism of L-selenomethionine and selenite by probiotic bacteria:andstudies.","volume":"14","author":"Fawcett","year":"2011","journal-title":"Biol Trace Elem Res"},{"key":"28","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/s0278-6915(02)00043-1","article-title":"Interference by toxic metal ions with zinc-dependent proteins involved in maintaining genomic stability.","volume":"4","author":"B\u00fcrkle","year":"2002","journal-title":"Food Chem Toxicol"},{"key":"29","doi-asserted-by":"publisher","first-page":"13238","DOI":"10.1021\/ja404653q","article-title":"Allosterically tunable, DNA-based switches triggered by heavy metals.","volume":"13","author":"Ricci","year":"2013","journal-title":"J Am Chem Soc"},{"key":"30","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s12011-016-0858-1","article-title":"Cardioprotective effect of selenium against cyclophosphamide-induced cardiotoxicity in rats.","volume":"17","author":"Ayhanci","year":"2017","journal-title":"Biol Trace Elem Res"},{"key":"31","first-page":"899","article-title":"Selenium protection from DNA damage involves a Ref1\/p53\/Brca1 protein complex.","volume":"2","author":"Smith","year":"2006","journal-title":"Anticancer Res"},{"key":"32","doi-asserted-by":"publisher","first-page":"14548","DOI":"10.1073\/pnas.212319799","article-title":"Selenomethionine regulation of p53 by a ref1-dependent redox mechanism.","volume":"9","author":"Smith","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"33","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.1038\/sj.onc.1208549","article-title":"Roles of thioredoxin reductase 1 and APE\/Ref-1 in the control of basal p53 stability and activity.","volume":"2","author":"Hainaut","year":"2005","journal-title":"Oncogene"},{"key":"34","doi-asserted-by":"publisher","first-page":"33010","DOI":"10.1074\/jbc.M110.137406","article-title":"Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.","volume":"28","author":"Cheng","year":"2010","journal-title":"J Biol Chem"},{"key":"35","doi-asserted-by":"publisher","first-page":"3663","DOI":"10.1038\/sj.onc.1205468","article-title":"Selenomethionine induction of DNA repair response in human fibroblasts.","volume":"2","author":"Smith","year":"2002","journal-title":"Oncogene"},{"key":"36","doi-asserted-by":"publisher","first-page":"a026070","DOI":"10.1101\/cshperspect.a026070","article-title":"P53 in the DNA-damage-repair process.","volume":"6","author":"Schumacher","year":"2016","journal-title":"Cold Spring Harb Perspect Med"},{"key":"37","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.celrep.2014.07.025","article-title":"BRCA1 is a histone-H2A-specific ubiquitin ligase.","volume":"8","author":"Hiom","year":"2014","journal-title":"Cell Rep"},{"key":"38","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1038\/sj.emboj.7600196","article-title":"HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.","volume":"2","author":"Huang","year":"2004","journal-title":"EMBO J"},{"key":"39","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1182\/blood-2004-07-2958","article-title":"Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.","volume":"10","author":"Semenza","year":"2005","journal-title":"Blood"},{"key":"40","doi-asserted-by":"publisher","first-page":"411","DOI":"10.5483\/bmbrep.2014.47.7.104","article-title":"Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1\u03b1 and suppresses the malignant characteristics of prostate cancer cells.","volume":"4","author":"Sytkowski","year":"2014","journal-title":"BMB Rep"},{"key":"41","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1093\/carcin\/bgn032","article-title":"Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells.","volume":"2","author":"Ha","year":"2008","journal-title":"Carcinogenesis"},{"key":"42","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1038\/onc.2014.229","article-title":"K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks.","volume":"3","author":"Shao","year":"2015","journal-title":"Oncogene"},{"key":"43","doi-asserted-by":"publisher","first-page":"eaar8133","DOI":"10.1126\/scisignal.aar8133","article-title":"K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair.","volume":"1","author":"Wei","year":"2018","journal-title":"Sci Signal"},{"key":"44","doi-asserted-by":"publisher","first-page":"10371","DOI":"10.1093\/nar\/gkt820","article-title":"Pre-activation of the genome integrity checkpoint increases DNA damage tolerance.","volume":"4","author":"Chabes","year":"2013","journal-title":"Nucleic Acids Res"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T16:59:37Z","timestamp":1620320377000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,19]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,4,30]]}},"alternative-id":["202865","33875618"],"URL":"https:\/\/doi.org\/10.18632\/aging.202865","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,19]]}}}