{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:58:42Z","timestamp":1778806722967,"version":"3.51.4"},"reference-count":42,"publisher":"Impact Journals, LLC","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,4,30]]},"DOI":"10.18632\/aging.202890","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T16:54:59Z","timestamp":1620320099000},"page":"11889-11906","source":"Crossref","is-referenced-by-count":7,"title":["Integrated metabolomics and transcriptomics reveal the anti-aging effect of melanin from Sepiella maindroni ink (MSMI) on D-galactose-induced aging mice"],"prefix":"10.18632","volume":"13","author":[{"given":"Yueyue","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ministry of Education, Ningbo University, Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ministry of Education, Ningbo University, Ningbo 315211, China"},{"name":"Collaborative Innovation Center for Zhejiang Marine High-Efficiency and Healthy Aquaculture, Ningbo University, Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ministry of Education, Ningbo University, Ningbo 315211, China"},{"name":"Collaborative Innovation Center for Zhejiang Marine High-Efficiency and Healthy Aquaculture, Ningbo University, Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changkao","family":"Mu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ministry of Education, Ningbo University, Ningbo 315211, China"},{"name":"Collaborative Innovation Center for Zhejiang Marine High-Efficiency and Healthy Aquaculture, Ningbo University, Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronghua","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Applied Marine Biotechnology, Ministry of Education, Ningbo University, Ningbo 315211, China"},{"name":"Collaborative Innovation Center for Zhejiang Marine High-Efficiency and Healthy Aquaculture, Ningbo University, Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"7780","DOI":"10.18632\/aging.102286","article-title":"Sulfated polysaccharide ofink targets Akt and overcomes resistance to the FGFR inhibitor AZD4547 in bladder cancer.","volume":"1","author":"Zhan","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"2","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/bcpt.12748","article-title":"Pharmacological Properties of Melanin and its Function in Health.","volume":"12","author":"Haseeb","year":"2017","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"3","doi-asserted-by":"publisher","first-page":"42129","DOI":"10.1038\/srep42129","article-title":"Bioproduction, characterization, anticancer and antioxidant activities of extracellular melanin pigment produced by newly isolated microbial cell factories Streptomyces glaucescens NEAE-H.","volume":"7","author":"El-Ewasy","year":"2017","journal-title":"Sci Rep"},{"key":"4","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s12866-017-1058-7","article-title":"Effects of melanin from Sepiella Maindroni ink (MSMI) on the intestinal Microbiome of mice.","volume":"1","author":"Li","year":"2017","journal-title":"BMC Microbiol"},{"key":"5","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.16333\/j.1001-6880.2015.09.027","article-title":"Antioxidant Effects of Melanin from Sepiella maindroni on Subacute Aged Model Mice.","volume":"2","author":"Song","year":"2015","journal-title":"Natural Product Research & Development"},{"key":"6","doi-asserted-by":"publisher","first-page":"5616","DOI":"10.1021\/acs.jafc.0c00291","article-title":"Changes in microRNAs Expression Profile of Mimetic Aging Mice Treated with Melanin fromInk.","volume":"6","author":"Li","year":"2020","journal-title":"J Agric Food Chem"},{"key":"7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1532-5415.1980.tb00115.x","article-title":"Human neurologic function and the aging process.","volume":"2","author":"Potvin","year":"1980","journal-title":"J Am Geriatr Soc"},{"key":"8","doi-asserted-by":"publisher","first-page":"7800","DOI":"10.1021\/jf402224w","article-title":"Antiaging effects of astaxanthin-rich alga Haematococcus pluvialis on fruit flies under oxidative stress.","volume":"6","author":"Chen","year":"2013","journal-title":"J Agric Food Chem"},{"key":"9","doi-asserted-by":"publisher","first-page":"e0132088","DOI":"10.1371\/journal.pone.0132088","article-title":"Gene Transcriptional and Metabolic Profile Changes in Mimetic Aging Mice Induced by D-Galactose.","volume":"1","author":"Song","year":"2015","journal-title":"PLoS One"},{"key":"10","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.jbiosc.2012.12.007","article-title":"Current metabolomics: practical applications.","volume":"11","author":"Fukusaki","year":"2013","journal-title":"J Biosci Bioeng"},{"key":"11","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nmeth704","article-title":"A custom microarray platform for analysis of microRNA gene expression.","volume":"1","author":"Hammond","year":"2004","journal-title":"Nat Methods"},{"key":"12","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.freeradbiomed.2017.05.008","article-title":"Aging-associated metabolic disorder induces Nox2 activation and oxidative damage of endothelial function.","volume":"10","author":"Li","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"13","first-page":"168","article-title":"Correlation of Erythrocyte Sorbitol Concentration and Kidney Injury in Diabetic Rats.","volume":"1","author":"Jia","year":"2013","journal-title":"Food & Drug"},{"key":"14","doi-asserted-by":"publisher","first-page":"1418593","DOI":"10.1080\/20010001.2017.1418593","article-title":"Exendin-4 protects mice from D-galactose-induced hepatic and pancreatic dysfunction.","volume":"8","author":"Badavi","year":"2017","journal-title":"Pathobiol Aging Age Relat Dis"},{"key":"15","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s00391-007-0484-9","article-title":"Advanced glycation end products, diabetes and ageing.","volume":"4","author":"Simm","year":"2007","journal-title":"Z Gerontol Geriatr"},{"key":"16","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s12013-007-0025-6","article-title":"PCK1 and PCK2 as candidate diabetes and obesity genes.","volume":"4","author":"Forest","year":"2007","journal-title":"Cell Biochem Biophys"},{"key":"17","doi-asserted-by":"publisher","first-page":"9151","DOI":"10.1073\/pnas.91.19.9151","article-title":"Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus.","volume":"9","author":"Bosch","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"18","doi-asserted-by":"publisher","first-page":"152","DOI":"10.21037\/hbsn.2019.09.03","article-title":"Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease.","volume":"9","author":"Chiang","year":"2020","journal-title":"Hepatobiliary Surg Nutr"},{"key":"19","first-page":"135","article-title":"Cholesterol 7 alpha-hydroxylase.","volume":"1","author":"Mitropoulos","year":"1977","journal-title":"J Lipid Res"},{"key":"20","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s10545-017-0076-9","article-title":"Functional characterisation of peroxisomal \u03b2-oxidation disorders in fibroblasts using lipidomics.","volume":"4","author":"Vaz","year":"2018","journal-title":"J Inherit Metab Dis"},{"key":"21","doi-asserted-by":"publisher","first-page":"4731","DOI":"10.1242\/dev.02659","article-title":"Cytoplasmic activated protein kinase Akt regulates lipid-droplet accumulation in Drosophila nurse cells.","volume":"13","author":"Wilson","year":"2006","journal-title":"Development"},{"key":"22","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1038\/35073608","article-title":"Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10.","volume":"41","author":"Saltiel","year":"2001","journal-title":"Nature"},{"key":"23","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1194\/jlr.M052977","article-title":"Hepatic insulin resistance in ob\/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.","volume":"5","author":"Farese","year":"2015","journal-title":"J Lipid Res"},{"key":"24","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.2337\/db10-0245","article-title":"Acute stimulation of white adipocyte respiration by PKA-induced lipolysis.","volume":"5","author":"Collins","year":"2010","journal-title":"Diabetes"},{"key":"25","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1677\/JME-08-0004","article-title":"Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice.","volume":"4","author":"Friedman","year":"2008","journal-title":"J Mol Endocrinol"},{"key":"26","doi-asserted-by":"publisher","first-page":"3659","DOI":"10.1128\/MCB.01584-12","article-title":"Insulin inhibits lipolysis in adipocytes via the evolutionarily conserved mTORC1-Egr1-ATGL-mediated pathway.","volume":"3","author":"Kandror","year":"2013","journal-title":"Mol Cell Biol"},{"key":"27","doi-asserted-by":"publisher","first-page":"268","DOI":"10.20517\/2394-5079.2017.36","article-title":"Role of early growth response 1 in liver metabolism and liver cancer.","volume":"3","author":"Zhang","year":"2017","journal-title":"Hepatoma Res"},{"key":"28","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1023\/a:1022417102206","article-title":"Establishment of the mimetic aging effect in mice caused by D-galactose.","volume":"4","author":"Wu","year":"2003","journal-title":"Biogerontology"},{"key":"29","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1007\/s10545-006-0382-0","article-title":"Classical galactosaemia revisited.","volume":"2","author":"Bosch","year":"2006","journal-title":"J Inherit Metab Dis"},{"key":"30","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s10522-004-2570-3","article-title":"D-galactose-caused life shortening in Drosophila melanogaster and Musca domestica is associated with oxidative stress.","volume":"5","author":"Liu","year":"2004","journal-title":"Biogerontology"},{"key":"31","doi-asserted-by":"publisher","first-page":"e0148230","DOI":"10.1371\/journal.pone.0148230","article-title":"The Genetic Architecture of Murine Glutathione Transferases.","volume":"1","author":"Mulligan","year":"2016","journal-title":"PLoS One"},{"key":"32","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3967\/bes2017.083","article-title":"Antioxidant and Anti-aging Activities of Silybum Marianum Protein Hydrolysate in Mice Treated with D-galactose.","volume":"3","author":"Zhou","year":"2017","journal-title":"Biomed Environ Sci"},{"key":"33","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/s0047-6374(99)00022-6","article-title":"Advanced glycation in D-galactose induced mouse aging model.","volume":"10","author":"Li","year":"1999","journal-title":"Mech Ageing Dev"},{"key":"34","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.1271\/bbb.60311","article-title":"Suppression of AGE precursor formation following unilateral ureteral obstruction in mouse kidneys by transgenic expression of alpha-dicarbonyl\/L-xylulose reductase.","volume":"7","author":"Nakagawa","year":"2006","journal-title":"Biosci Biotechnol Biochem"},{"key":"35","first-page":"7","article-title":"Scavenging effects of two sepia melanins on glycosylation end products in aging mice.","volume":"3","author":"Li","year":"2019","journal-title":"Journal of Ningbo University(Natural Science & Engineering Edition)"},{"key":"36","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1099\/jgv.0.001149","article-title":"Better together: the role of IFIT protein-protein interactions in the antiviral response.","volume":"9","author":"Sweeney","year":"2018","journal-title":"J Gen Virol"},{"key":"37","doi-asserted-by":"publisher","first-page":"6338","DOI":"10.1128\/MCB.25.15.6338-6345.2005","article-title":"ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus.","volume":"2","author":"Knobeloch","year":"2005","journal-title":"Mol Cell Biol"},{"key":"38","doi-asserted-by":"publisher","first-page":"e0133190","DOI":"10.1371\/journal.pone.0133190","article-title":"The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication.","volume":"1","author":"Michiels","year":"2015","journal-title":"PLoS One"},{"key":"39","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0166-3542(91)90037-r","article-title":"Selective antiviral activity of synthetic soluble L-tyrosine and L-dopa melanins against human immunodeficiency virus","volume":"1","author":"Zhou","year":"1991","journal-title":"Antiviral Res"},{"key":"40","first-page":"28","article-title":"Research on the extraction method of the melanin from Sepiella maindroni ink.","volume":"3","author":"Song","year":"2015","journal-title":"Journal of Biology"},{"key":"41","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method.","volume":"3","author":"Livak","year":"2008","journal-title":"Nat Protoc"},{"key":"42","doi-asserted-by":"publisher","first-page":"105231","DOI":"10.1016\/j.envint.2019.105231","article-title":"Integration of metabolomics and transcriptomics reveals short-chain chlorinated paraffin-induced hepatotoxicity in male Sprague-Dawley rat.","volume":"13","author":"Chen","year":"2019","journal-title":"Environ Int"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T17:00:23Z","timestamp":1620320423000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,21]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,4,30]]}},"alternative-id":["202890","33952720"],"URL":"https:\/\/doi.org\/10.18632\/aging.202890","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,21]]}}}