{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:59:34Z","timestamp":1788026374840,"version":"build-2784847793"},"reference-count":18,"publisher":"Impact Journals, LLC","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,4,15]]},"DOI":"10.18632\/aging.202916","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T23:02:10Z","timestamp":1617404530000},"page":"9433-9454","source":"Crossref","is-referenced-by-count":21,"title":["Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3\u00d7Tg-AD mice model of Alzheimer's disease"],"prefix":"10.18632","volume":"13","author":[{"given":"Hugo","family":"Ferreira","sequence":"first","affiliation":[{"name":"University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Institute for Nuclear Sciences Applied to Health (ICNAS), Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Martins","sequence":"additional","affiliation":[{"name":"University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Institute for Nuclear Sciences Applied to Health (ICNAS), Coimbra, Portugal"},{"name":"University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine (FMUC), Coimbra, Portugal"},{"name":"University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, Portugal"},{"name":"University of Coimbra, Clinical Academic Center of Coimbra (CACC), Faculty of Medicine (FMUC), Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula I.","family":"Moreira","sequence":"additional","affiliation":[{"name":"University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, Portugal"},{"name":"University of Coimbra, Clinical Academic Center of Coimbra (CACC), Faculty of Medicine (FMUC), Coimbra, Portugal"},{"name":"University of Coimbra, Laboratory of Physiology, Faculty of Medicine (FMUC), Coimbra, Portugal"},{"name":"University of Coimbra, Center for Neuroscience and Cell Biology (CNC), Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio Francisco","family":"Ambr\u00f3sio","sequence":"additional","affiliation":[{"name":"University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine (FMUC), Coimbra, Portugal"},{"name":"University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, Portugal"},{"name":"University of Coimbra, Clinical Academic Center of Coimbra (CACC), Faculty of Medicine (FMUC), Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[{"name":"University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Institute for Nuclear Sciences Applied to Health (ICNAS), Coimbra, Portugal"},{"name":"University of Coimbra, Clinical Academic Center of Coimbra (CACC), Faculty of Medicine (FMUC), Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Serranho","sequence":"additional","affiliation":[{"name":"University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Institute for Nuclear Sciences Applied to Health (ICNAS), Coimbra, Portugal"},{"name":"Universidade Aberta, Department of Sciences and Technology, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Bernardes","sequence":"additional","affiliation":[{"name":"University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Institute for Nuclear Sciences Applied to Health (ICNAS), Coimbra, Portugal"},{"name":"University of Coimbra, Clinical Academic Center of Coimbra (CACC), Faculty of Medicine (FMUC), Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2021,4,2]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.1364\/BOE.8.003248","article-title":"Twenty-five years of optical coherence tomography: the paradigm shift in sensitivity and speed provided by Fourier domain OCT [Invited].","volume":"8","author":"Wojtkowski","year":"2017","journal-title":"Biomed Opt Express"},{"key":"2","doi-asserted-by":"publisher","first-page":"e67265","DOI":"10.1371\/journal.pone.0067265","article-title":"Retinal Thickness Normative Data in Wild-Type Mice Using Customized Miniature SD-OCT.","volume":"8","author":"Chalam","year":"2013","journal-title":"PLoS One"},{"key":"3","doi-asserted-by":"publisher","first-page":"e0218826","DOI":"10.1371\/journal.pone.0218826","article-title":"Retinal texture biomarkers may help to discriminate between Alzheimer\u2019s, Parkinson\u2019s, and healthy controls.","volume":"1","author":"Bernardes","year":"2019","journal-title":"PLoS One"},{"key":"4","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nrneurol.2012.227","article-title":"The retina as a window to the brain-from eye research to CNS disorders.","volume":"9","author":"Schwartz","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"5","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/978-3-319-75402-4_46","article-title":"Impact of MCT1 Haploinsufficiency on the Mouse Retina.","volume":"107","author":"Philp","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"6","doi-asserted-by":"publisher","first-page":"dmm031005","DOI":"10.1242\/dmm.031005","article-title":"Hamartoma-like lesions in the mouse retina: an animal model ofhamartoma tumour syndrome.","volume":"1","author":"Schuurmans","year":"2018","journal-title":"Dis Model Mech"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Ronneberger, Fischer, Brox. U-net: Convolutional networks for biomedical image segmentation. In: Navab N., Hornegger J., Wells W., Frangi A. (eds) Medical Image Computing and Computer-Assisted Intervention - MICCAI 2015. MICCAI 2015. Lecture Notes in Computer Science, vol 9351: p. 234\u201341. Springer, Cham. https:\/\/doi.org\/10.1007\/978-3-319-24574-4_28.","DOI":"10.1007\/978-3-319-24574-4_28"},{"key":"8","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.1364\/BOE.8.003627","article-title":"ReLayNet: retinal layer and fluid segmentation of macular optical coherence tomography using fully convolutional networks.","volume":"8","author":"Navab","year":"2017","journal-title":"Biomed Opt Express"},{"key":"9","doi-asserted-by":"publisher","first-page":"e111203","DOI":"10.1371\/journal.pone.0111203","article-title":"Retinal thickness measurement obtained with spectral domain optical coherence tomography assisted optical biopsy accurately correlates withhistology.","volume":"9","author":"Chalam","year":"2014","journal-title":"PLoS One"},{"key":"10","doi-asserted-by":"publisher","first-page":"e96494","DOI":"10.1371\/journal.pone.0096494","article-title":"Spectral-domain optical coherence tomography of the rodent eye: highlighting layers of the outer retina using signal averaging and comparison with histology.","volume":"9","author":"Bemelmans","year":"2014","journal-title":"PLoS One"},{"key":"11","doi-asserted-by":"publisher","first-page":"16685","DOI":"10.1038\/s41598-019-53082-9","article-title":"Longitudinal OCT and OCTA monitoring reveals accelerated regression of hyaloid vessels in retinal degeneration 10 (rd10) mice.","volume":"9","author":"Yao","year":"2019","journal-title":"Sci Rep"},{"key":"12","doi-asserted-by":"publisher","first-page":"655","DOI":"10.3233\/JAD-160823","article-title":"Investigations into Retinal Pathology in the Early Stages of a Mouse Model of Alzheimer\u2019s Disease.","volume":"5","author":"Casson","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"13","doi-asserted-by":"publisher","first-page":"7912","DOI":"10.1038\/s41598-020-64827-2","article-title":"Multimodal Coherent Imaging of Retinal Biomarkers of Alzheimer\u2019s Disease in a Mouse Model.","volume":"1","author":"Wax","year":"2020","journal-title":"Sci Rep"},{"key":"14","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.clineuro.2011.02.014","article-title":"Retinal thickness in patients with mild cognitive impairment and Alzheimer\u2019s disease.","volume":"11","author":"Neudorfer","year":"2011","journal-title":"Clin Neurol Neurosurg"},{"key":"15","doi-asserted-by":"publisher","first-page":"5953","DOI":"10.1167\/iovs.13-12046","article-title":"Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer\u2019s disease using spectral-domain optical coherence tomography.","volume":"5","author":"Staurenghi","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"16","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/eye.2014.51","article-title":"Reliability and validity of Cirrus and Spectralis optical coherence tomography for detecting retinal atrophy in Alzheimer\u2019s disease.","volume":"2","author":"Pablo","year":"2014","journal-title":"Eye (Lond)"},{"key":"17","doi-asserted-by":"publisher","first-page":"015006","DOI":"10.1117\/1.NPh.7.1.015006","article-title":"Retinal analysis of a mouse model of Alzheimer\u2019s disease with multicontrast optical coherence tomography.","volume":"7","author":"Baumann","year":"2020","journal-title":"Neurophotonics"},{"key":"18","doi-asserted-by":"publisher","first-page":"16345","DOI":"10.1038\/s41598-018-34577-3","article-title":"Usefulness of peripapillary nerve fiber layer thickness assessed by optical coherence tomography as a biomarker for Alzheimer\u2019s disease.","volume":"8","author":"Abdelnour","year":"2018","journal-title":"Sci Rep"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T16:52:06Z","timestamp":1620319926000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,2]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,4,15]]}},"alternative-id":["202916","33799308"],"URL":"https:\/\/doi.org\/10.18632\/aging.202916","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,2]]}}}