{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:11:37Z","timestamp":1780625497461,"version":"3.54.1"},"reference-count":44,"publisher":"Impact Journals, LLC","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,5,15]]},"DOI":"10.18632\/aging.202926","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T11:41:57Z","timestamp":1619955717000},"page":"12526-12536","source":"Crossref","is-referenced-by-count":5,"title":["RO4929097 regulates RANKL-induced osteoclast formation and LPS-mediated bone resorption"],"prefix":"10.18632","volume":"13","author":[{"given":"Tao","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Baoshan Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congyun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Mang Shi People\u2019s Hospital, Yunnan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Baoshan Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Baoshan Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghua","family":"Hang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2021,5,2]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1177\/1759720X16670154","article-title":"Bone modeling and remodeling: potential as therapeutic targets for the treatment of osteoporosis.","volume":"8","author":"Dempster","year":"2016","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"2","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future.","volume":"37","author":"Hofbauer","year":"2011","journal-title":"Lancet"},{"key":"3","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.joca.2015.10.008","article-title":"Osteoclasts are recruited to the subchondral bone in naturally occurring post-traumatic equine carpal osteoarthritis and may contribute to cartilage degradation.","volume":"2","author":"Laverty","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.bcp.2016.04.010","article-title":"Pharmacological inhibition of cathepsin K: A promising novel approach for postmenopausal osteoporosis therapy.","volume":"11","author":"Chattopadhyay","year":"2016","journal-title":"Biochem Pharmacol"},{"key":"5","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3390\/jfb8040042","article-title":"The Effect of RANKL\/OPG Balance on Reducing Implant Complications.","volume":"8","author":"Yang","year":"2017","journal-title":"J Funct Biomater"},{"key":"6","doi-asserted-by":"publisher","first-page":"e0158365","DOI":"10.1371\/journal.pone.0158365","article-title":"Barriers to Effective Postmenopausal Osteoporosis Treatment: A Qualitative Study of Patients' and Practitioners' Views.","volume":"1","author":"Roux","year":"2016","journal-title":"PLoS One"},{"key":"7","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jsbmb.2013.09.008","article-title":"Prevention and treatment of postmenopausal osteoporosis.","volume":"14","author":"Gallagher","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"key":"8","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1002\/jbmr.5650100706","article-title":"Characterization of MCSF-induced proliferation and subsequent osteoclast formation in murine marrow culture.","volume":"1","author":"Rubin","year":"1995","journal-title":"J Bone Miner Res"},{"key":"9","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/S8756-3282(99)00210-0","article-title":"Osteoblasts\/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor\/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand.","volume":"2","author":"Suda","year":"1999","journal-title":"Bone"},{"key":"10","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1038\/sj.cdd.4401882","article-title":"Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL.","volume":"1","author":"Kim","year":"2006","journal-title":"Cell Death Differ"},{"key":"11","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/cr.2010.159","article-title":"Role of NF-\u03baB in the skeleton.","volume":"2","author":"Novack","year":"2011","journal-title":"Cell Res"},{"key":"12","doi-asserted-by":"publisher","first-page":"E3481","DOI":"10.1073\/pnas.1702367114","article-title":"Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling.","volume":"11","author":"Cohen","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"13","doi-asserted-by":"publisher","first-page":"235","DOI":"10.7150\/ijbs.13814","article-title":"Selective Regulation of MAPK Signaling Mediates RANKL-dependent Osteoclast Differentiation.","volume":"1","author":"Jeong","year":"2016","journal-title":"Int J Biol Sci"},{"key":"14","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1242\/dev.01074","article-title":"Notch signaling: control of cell communication and cell fate.","volume":"13","author":"Lai","year":"2004","journal-title":"Development"},{"key":"15","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s00223-013-9773-z","article-title":"Notch signaling in skeletal stem cells.","volume":"9","author":"Bae","year":"2014","journal-title":"Calcif Tissue Int"},{"key":"16","doi-asserted-by":"publisher","first-page":"R45","DOI":"10.1186\/ar3758","article-title":"Differential regulation of osteoclastogenesis by Notch2\/Delta-like 1 and Notch1\/Jagged1 axes.","volume":"1","author":"Yagita","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"17","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.1002\/jcb.25205","article-title":"Notch signaling promotes osteoclast maturation and resorptive activity.","volume":"11","author":"Hankenson","year":"2015","journal-title":"J Cell Biochem"},{"key":"18","first-page":"7064","article-title":"Notch is activated in RANKL-induced osteoclast differentiation and resorption.","volume":"1","author":"Ren","year":"2008","journal-title":"Front Biosci"},{"key":"19","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.bcp.2014.10.019","article-title":"Myricetin prevents titanium particle-induced osteolysisand inhibits RANKL-induced osteoclastogenesis","volume":"9","author":"Zhu","year":"2015","journal-title":"Biochem Pharmacol"},{"key":"20","doi-asserted-by":"publisher","first-page":"6299","DOI":"10.1016\/j.biomaterials.2014.04.044","article-title":"The effect of metallic magnesium degradation products on osteoclast-induced osteolysis and attenuation of NF-\u03baB and NFATc1 signaling.","volume":"3","author":"Tang","year":"2014","journal-title":"Biomaterials"},{"key":"21","doi-asserted-by":"publisher","first-page":"111857","DOI":"10.1016\/j.yexcr.2020.111857","article-title":"PP121 suppresses RANKL-Induced osteoclast formationand LPS-Induced bone resorption","volume":"38","author":"Zhang","year":"2020","journal-title":"Exp Cell Res"},{"key":"22","doi-asserted-by":"publisher","first-page":"20944","DOI":"10.1002\/jcp.28699","article-title":"LY411575, a potent \u03b3-secretase inhibitor, suppresses osteoclastogenesisand LPS-induced calvarial osteolysis","volume":"23","author":"Zhang","year":"2019","journal-title":"J Cell Physiol"},{"key":"23","doi-asserted-by":"publisher","first-page":"111470","DOI":"10.1016\/j.yexcr.2019.06.015","article-title":"Nirogacestat suppresses RANKL-Induced osteoclast formationand attenuates LPS-Induced bone resorption","volume":"38","author":"Zhang","year":"2019","journal-title":"Exp Cell Res"},{"key":"24","doi-asserted-by":"publisher","first-page":"264","DOI":"10.30802\/AALAS-JAALAS-19-000097","article-title":"Evaluating Intrahepatic and Intraperitoneal Sodium Pentobarbital or Ethanol for Mouse Euthanasia.","volume":"5","author":"Pang","year":"2020","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s40273-014-0231-1","article-title":"A systematic review of cost-effectiveness analyses of drugs for postmenopausal osteoporosis.","volume":"3","author":"Boonen","year":"2015","journal-title":"Pharmacoeconomics"},{"key":"26","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1007\/s00198-015-3164-4","article-title":"Persistence, adherence, and medication-taking behavior in women with postmenopausal osteoporosis receiving denosumab in routine practice in Germany, Austria, Greece, and Belgium: 12-month results from a European non-interventional study.","volume":"2","author":"Fahrleitner-Pammer","year":"2015","journal-title":"Osteoporos Int"},{"key":"27","doi-asserted-by":"publisher","first-page":"3137","DOI":"10.1185\/030079907X242890","article-title":"The impact of osteoporosis medication beliefs and side-effect experiences on non-adherence to oral bisphosphonates.","volume":"2","author":"Weiss","year":"2007","journal-title":"Curr Med Res Opin"},{"key":"28","doi-asserted-by":"publisher","first-page":"279","DOI":"10.7196\/SAMJ.7505","article-title":"The safety of osteoporosis medication.","volume":"10","author":"Pettifor","year":"2014","journal-title":"S Afr Med J"},{"key":"29","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch signaling: cell fate control and signal integration in development.","volume":"28","author":"Lake","year":"1999","journal-title":"Science"},{"key":"30","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nrm2009","article-title":"Notch signalling: a simple pathway becomes complex.","volume":"7","author":"Bray","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"31","doi-asserted-by":"publisher","first-page":"4769","DOI":"10.1128\/MCB.00319-06","article-title":"RBP-Jkappa-dependent notch signaling is dispensable for mouse early embryonic development.","volume":"2","author":"Cohen-Tannoudji","year":"2006","journal-title":"Mol Cell Biol"},{"key":"32","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cellsig.2013.09.021","article-title":"New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of \u03b3-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.","volume":"2","author":"Matherly","year":"2014","journal-title":"Cell Signal"},{"key":"33","doi-asserted-by":"publisher","first-page":"3555","DOI":"10.1158\/0008-5472.CAN-04-3132","article-title":"Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers.","volume":"6","author":"Dang","year":"2005","journal-title":"Cancer Res"},{"key":"34","doi-asserted-by":"publisher","first-page":"7106","DOI":"10.1128\/JVI.77.12.7106-7112.2003","article-title":"Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB\/Akt-dependent pathway.","volume":"7","author":"Krishna","year":"2003","journal-title":"J Virol"},{"key":"35","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1038\/sj.emboj.7600996","article-title":"Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.","volume":"2","author":"Screpanti","year":"2006","journal-title":"EMBO J"},{"key":"36","doi-asserted-by":"publisher","first-page":"6509","DOI":"10.1074\/jbc.M707000200","article-title":"NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells.","volume":"28","author":"Teitelbaum","year":"2008","journal-title":"J Biol Chem"},{"key":"37","doi-asserted-by":"publisher","first-page":"6402","DOI":"10.1128\/MCB.00299-08","article-title":"The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis.","volume":"2","author":"Okabe","year":"2008","journal-title":"Mol Cell Biol"},{"key":"38","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1091\/mbc.e02-07-0404","article-title":"IkappaBalpha and p65 regulate the cytoplasmic shuttling of nuclear corepressors: cross-talk between Notch and NFkappaB pathways.","volume":"1","author":"Bigas","year":"2003","journal-title":"Mol Biol Cell"},{"key":"39","doi-asserted-by":"publisher","first-page":"398","DOI":"10.2174\/138920310791824039","article-title":"Notch signaling proteins: legitimate targets for cancer therapy.","volume":"1","author":"Sarkar","year":"2010","journal-title":"Curr Protein Pept Sci"},{"key":"40","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1172\/JCI90527","article-title":"RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.","volume":"12","author":"Rottapel","year":"2017","journal-title":"J Clin Invest"},{"key":"41","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1136\/annrheumdis-2012-201568","article-title":"Immune complex-induced inhibition of osteoclastogenesis is mediated via activating but not inhibitory Fc\u03b3 receptors on myeloid precursor cells.","volume":"7","author":"van Lent","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"42","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/j.1600-079X.2005.00274.x","article-title":"Melatonin protects against lipopolysaccharide-induced intra-uterine fetal death and growth retardation in mice.","volume":"4","author":"Wei","year":"2006","journal-title":"J Pineal Res"},{"key":"43","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1084\/jem.20030015","article-title":"An essential role of cytosolic phospholipase A2alpha in prostaglandin E2-mediated bone resorption associated with inflammation.","volume":"19","author":"Ito","year":"2003","journal-title":"J Exp Med"},{"key":"44","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1172\/JCI119679","article-title":"Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor.","volume":"10","author":"Teitelbaum","year":"1997","journal-title":"J Clin Invest"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T17:25:31Z","timestamp":1625765131000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,2]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,5,15]]}},"alternative-id":["202926","33934091"],"URL":"https:\/\/doi.org\/10.18632\/aging.202926","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,2]]}}}