{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:33:37Z","timestamp":1793118817493,"version":"4.5.0"},"reference-count":57,"publisher":"Impact Journals, LLC","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,5,15]]},"DOI":"10.18632\/aging.202936","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T15:46:47Z","timestamp":1619538407000},"page":"12587-12606","source":"Crossref","is-referenced-by-count":19,"title":["Neural presbycusis at ultra-high frequency in aged common marmosets and rhesus monkeys"],"prefix":"10.18632","volume":"13","author":[{"given":"Zhuoer","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"},{"name":"Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"},{"name":"Shanghai Key Laboratory of Translation Medicine on Ear and Nose Disease, Shanghai 200011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhe","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"},{"name":"Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"},{"name":"Shanghai Key Laboratory of Translation Medicine on Ear and Nose Disease, Shanghai 200011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neng","family":"Gong","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, P.R. China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, P.R. China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"},{"name":"Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"},{"name":"Shanghai Key Laboratory of Translation Medicine on Ear and Nose Disease, Shanghai 200011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"},{"name":"Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"},{"name":"Shanghai Key Laboratory of Translation Medicine on Ear and Nose Disease, Shanghai 200011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"},{"name":"Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"},{"name":"Shanghai Key Laboratory of Translation Medicine on Ear and Nose Disease, Shanghai 200011, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1121\/1.397467","article-title":"Comments on \u201cspeech understanding and aging\u201d.","volume":"8","author":"Kirby","year":"1989","journal-title":"J Acoust Soc Am"},{"key":"2","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/S0140-6736(05)67423-5","article-title":"Presbycusis.","volume":"36","author":"Mills","year":"2005","journal-title":"Lancet"},{"key":"3","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1111\/j.1532-5415.2005.53152.x","article-title":"Change in sensory functioning predicts change in cognitive functioning: results from a 6-year follow-up in the maastricht aging study.","volume":"5","author":"Jolles","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"4","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1186\/s13287-019-1437-0","article-title":"Age-related transcriptome changes in Sox2+ supporting cells in the mouse cochlea.","volume":"1","author":"Chai","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"5","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.cger.2018.01.001","article-title":"Hearing loss in the elderly.","volume":"3","author":"McKinnon","year":"2018","journal-title":"Clin Geriatr Med"},{"key":"6","doi-asserted-by":"publisher","first-page":"101364","DOI":"10.1016\/j.redox.2019.101364","article-title":"The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways.","volume":"2","author":"Kong","year":"2020","journal-title":"Redox Biol"},{"key":"7","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1007\/s00018-019-03291-2","article-title":"Knockdown of Foxg1 in supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse cochlea.","volume":"7","author":"Zhang","year":"2020","journal-title":"Cell Mol Life Sci"},{"key":"8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/00034894931020S101","article-title":"Cochlear pathology in presbycusis.","volume":"10","author":"Gacek","year":"1993","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"9","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.exger.2010.12.003","article-title":"Pathogenesis of presbycusis in animal models: a review.","volume":"4","author":"Troiani","year":"2011","journal-title":"Exp Gerontol"},{"key":"10","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.heares.2015.04.014","article-title":"Cochlear neuropathy in human presbycusis: confocal analysis of hidden hearing loss in post-mortem tissue.","volume":"32","author":"Liberman","year":"2015","journal-title":"Hear Res"},{"key":"11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41421-018-0076-4","article-title":"A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells.","volume":"5","author":"Zhong","year":"2019","journal-title":"Cell Discov"},{"key":"12","doi-asserted-by":"publisher","first-page":"eaav7803","DOI":"10.1126\/sciadv.aav7803","article-title":"Critical role of spectrin in hearing development and deafness.","volume":"5","author":"He","year":"2019","journal-title":"Sci Adv"},{"key":"13","doi-asserted-by":"publisher","first-page":"927","DOI":"10.12688\/f1000research.11310.1","article-title":"Noise-induced and age-related hearing loss: new perspectives and potential therapies.","volume":"6","author":"Liberman","year":"2017","journal-title":"F1000Res"},{"key":"14","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1093\/ilar.52.1.54","article-title":"The marmoset as a model of aging and age-related diseases.","volume":"5","author":"Ziegler","year":"2011","journal-title":"ILAR J"},{"key":"15","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.1749-6632.2010.05609.x","article-title":"Animal models of reproductive aging: what can they tell us?","volume":"120","author":"Austad","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"16","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nature25164","article-title":"Treatment of autosomal dominant hearing loss bydelivery of genome editing agents.","volume":"55","author":"Yang","year":"2018","journal-title":"Nature"},{"key":"17","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1089\/hum.2016.053","article-title":"Identification of adeno-associated viral vectors that target neonatal and adult mammalian inner ear cell subtypes.","volume":"2","author":"Chen","year":"2016","journal-title":"Hum Gene Ther"},{"key":"18","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/s41434-020-0124-1","article-title":"Adeno-associated virus vector enables safe and efficient Cas9 activation in neonatal and adult Cas9 knockin murine cochleae.","volume":"2","author":"Wu","year":"2020","journal-title":"Gene Ther"},{"key":"19","doi-asserted-by":"publisher","first-page":"107999","DOI":"10.1016\/j.heares.2020.107999","article-title":"Characterization of promoters for adeno-associated virus mediated efficient Cas9 activation in adult Cas9 knock-in murine cochleae.","volume":"39","author":"Wu","year":"2020","journal-title":"Hear Res"},{"key":"20","doi-asserted-by":"publisher","first-page":"9409846","DOI":"10.1155\/2016\/9409846","article-title":"Adenovirus vectors target several cell subtypes of mammalian inner ear","volume":"201","author":"Chen","year":"2016","journal-title":"Neural Plast"},{"key":"21","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1002\/ajp.22281","article-title":"Why primate models matter.","volume":"7","author":"Voytko","year":"2014","journal-title":"Am J Primatol"},{"key":"22","doi-asserted-by":"publisher","first-page":"R60","DOI":"10.1186\/gb-2005-6-7-r60","article-title":"Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human.","volume":"6","author":"Iadonato","year":"2005","journal-title":"Genome Biol"},{"key":"23","doi-asserted-by":"publisher","first-page":"e55092","DOI":"10.1371\/journal.pone.0055092","article-title":"Age-related hearing loss in rhesus monkeys is correlated with cochlear histopathologies.","volume":"8","author":"Recanzone","year":"2013","journal-title":"PLoS One"},{"key":"24","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1002\/dneu.22458","article-title":"The common marmoset: an overview of its natural history, ecology and behavior.","volume":"7","author":"Souto","year":"2017","journal-title":"Dev Neurobiol"},{"key":"25","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1159\/000500500","article-title":"Critique of pure marmoset.","volume":"9","author":"Preuss","year":"2019","journal-title":"Brain Behav Evol"},{"key":"26","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1037\/\/0735-7044.97.4.602","article-title":"Demonstration of presbycusis across repeated measures in a nonhuman primate species.","volume":"9","author":"Miller","year":"1983","journal-title":"Behav Neurosci"},{"key":"27","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/s0378-5955(00)00025-3","article-title":"Age-related changes in auditory function of rhesus monkeys (Macaca mulatta).","volume":"14","author":"Fowler","year":"2000","journal-title":"Hear Res"},{"key":"28","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/s0378-5955(98)00201-9","article-title":"Age-related changes in the brainstem auditory evoked potentials of the marmoset.","volume":"12","author":"Tanioka","year":"1999","journal-title":"Hear Res"},{"key":"29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.heares.2016.07.006","article-title":"Frequency discrimination in the common marmoset (Callithrix jacchus).","volume":"34","author":"Wang","year":"2016","journal-title":"Hear Res"},{"key":"30","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/febs.15341","article-title":"The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development.","volume":"28","author":"Ogawa","year":"2021","journal-title":"FEBS J"},{"key":"31","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1177\/019459988910000105","article-title":"Is there a conductive type of presbycusis?","volume":"10","author":"Schuknecht","year":"1989","journal-title":"Otolaryngol Head Neck Surg"},{"key":"32","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0378-5955(90)90002-7","article-title":"Age-related changes in auditory potentials of Mongolian gerbil.","volume":"4","author":"Kulish","year":"1990","journal-title":"Hear Res"},{"key":"33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0378-5955(03)00365-4","article-title":"Age-related hearing loss and the ahl locus in mice.","volume":"18","author":"Johnson","year":"2004","journal-title":"Hear Res"},{"key":"34","first-page":"15","article-title":"On renaming auditory neuropathy as auditory dys-synchrony.","volume":"1","author":"Rose","year":"2001","journal-title":"Audiol Today"},{"key":"35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/108471380500900102","article-title":"Auditory neuropathy\/dys-synchrony and its perceptual consequences.","volume":"9","author":"Rance","year":"2005","journal-title":"Trends Amplif"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Gordon-Salant, Frisina, Popper, Fay. The Aging Auditory System. 2010. https:\/\/doi.org\/10.1007\/978-1-4419-0993-0.","DOI":"10.1007\/978-1-4419-0993-0"},{"key":"37","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1152\/jn.00663.2014","article-title":"Age-related changes of auditory brainstem responses in nonhuman primates.","volume":"11","author":"Recanzone","year":"2015","journal-title":"J Neurophysiol"},{"key":"38","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/0378-5955(95)00065-c","article-title":"Distortion product otoacoustic emissions in rhesus (Macaca mulatta) monkey ears: normative findings.","volume":"8","author":"Fredrickson","year":"1995","journal-title":"Hear Res"},{"key":"39","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3109\/00206090009073055","article-title":"Immittance and otoacoustic emissions in rhesus monkeys and humans.","volume":"3","author":"Laughlin","year":"2000","journal-title":"Audiology"},{"key":"40","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0378-5955(95)00120-1","article-title":"Distortion product otoacoustic emissions in Macaca mulatta and humans.","volume":"8","author":"Hecox","year":"1995","journal-title":"Hear Res"},{"key":"41","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.heares.2008.05.006","article-title":"Distortion-product otoacoustic emissions in the common marmoset (Callithrix jacchus): parameter optimization.","volume":"24","author":"Ratnam","year":"2008","journal-title":"Hear Res"},{"key":"42","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.heares.2011.07.004","article-title":"Reliability of distortion-product otoacoustic emissions in the common marmoset (Callithrix jacchus).","volume":"28","author":"Ratnam","year":"2011","journal-title":"Hear Res"},{"key":"43","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/s0378-5955(03)00302-2","article-title":"Microtubule-associated protein 2 (MAP2) expression during synaptic plasticity in the Guinea pig cochlea.","volume":"18","author":"Puel","year":"2003","journal-title":"Hear Res"},{"key":"44","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/s0378-5955(97)00026-9","article-title":"Age-related changes in GFAP-immunoreactive astrocytes in the rat ventral cochlear nucleus.","volume":"10","author":"Romand","year":"1997","journal-title":"Hear Res"},{"key":"45","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1023\/a:1014374717773","article-title":"Surviving apoptosis.","volume":"7","author":"Villalobos","year":"2002","journal-title":"Apoptosis"},{"key":"46","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neulet.2010.05.023","article-title":"Caspase-3 activation in the Guinea pig cochlea exposed to salicylate.","volume":"47","author":"Xie","year":"2010","journal-title":"Neurosci Lett"},{"key":"47","doi-asserted-by":"publisher","first-page":"1759091415573985","DOI":"10.1177\/1759091415573985","article-title":"Caspase-mediated apoptosis in the cochleae contributes to the early onset of hearing loss in A\/J mice.","volume":"7","author":"Han","year":"2015","journal-title":"ASN Neuro"},{"key":"48","doi-asserted-by":"publisher","first-page":"14795","DOI":"10.1523\/JNEUROSCI.3393-10.2010","article-title":"Hierarchical and serial processing in the spatial auditory cortical pathway is degraded by natural aging.","volume":"3","author":"Recanzone","year":"2010","journal-title":"J Neurosci"},{"key":"49","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.heares.2010.03.084","article-title":"Spatial and temporal processing of single auditory cortical neurons and populations of neurons in the macaque monkey.","volume":"27","author":"Juarez-Salinas","year":"2011","journal-title":"Hear Res"},{"key":"50","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.heares.2010.01.006","article-title":"Auditory function in rhesus monkeys: effects of aging and caloric restriction in the Wisconsin monkeys five years later.","volume":"26","author":"Weindruch","year":"2010","journal-title":"Hear Res"},{"key":"51","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/s0378-5955(02)00335-0","article-title":"Effects of caloric restriction and aging on the auditory function of rhesus monkeys (Macaca mulatta): the university of Wisconsin study.","volume":"16","author":"Kemnitz","year":"2002","journal-title":"Hear Res"},{"key":"52","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.heares.2011.02.001","article-title":"Measurement of absolute auditory thresholds in the common marmoset (Callithrix jacchus).","volume":"27","author":"Wang","year":"2011","journal-title":"Hear Res"},{"key":"53","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/s0168-5597(96)96015-3","article-title":"Brain-stem auditory evoked potentials in the common marmoset (Callithrix jacchus).","volume":"10","author":"Tokuriki","year":"1997","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"54","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.heares.2015.02.009","article-title":"Synaptopathy in the noise-exposed and aging cochlea: primary neural degeneration in acquired sensorineural hearing loss.","volume":"33","author":"Liberman","year":"2015","journal-title":"Hear Res"},{"key":"55","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1111\/febs.13324","article-title":"Age-related changes in mitochondrial antioxidant enzyme Trx2 and TXNIP-Trx2-ASK1 signal pathways in the auditory cortex of a mimetic aging rat model: changes to Trx2 in the auditory cortex.","volume":"28","author":"Kong","year":"2015","journal-title":"FEBS J"},{"key":"56","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.bbrc.2014.09.118","article-title":"Mitochondrial DNA common deletion increases susceptibility to noise-induced hearing loss in a mimetic aging rat model.","volume":"45","author":"Kong","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"57","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s10522-012-9388-1","article-title":"Life span of common marmoset (Callithrix jacchus) at CLEA Japan breeding colony.","volume":"1","author":"Kitajima","year":"2012","journal-title":"Biogerontology"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T17:25:52Z","timestamp":1625765152000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.202936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,27]]},"references-count":57,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,5,15]]}},"alternative-id":["202936","33909598"],"URL":"https:\/\/doi.org\/10.18632\/aging.202936","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,27]]}}}