{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T01:24:57Z","timestamp":1787707497550,"version":"build-2784847793"},"reference-count":44,"publisher":"Impact Journals, LLC","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,7,31]]},"DOI":"10.18632\/aging.203283","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T01:56:40Z","timestamp":1627610200000},"page":"18340-18359","source":"Crossref","is-referenced-by-count":10,"title":["CircSPIDR acts as a tumour suppressor in cervical adenocarcinoma by sponging miR-431-5p and regulating SORCS1 and CUBN expression"],"prefix":"10.18632","volume":"13","author":[{"given":"Junfen","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology, Women\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Women\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang, China"},{"name":"Center of Uterine Cancer Diagnosis & Therapy of Zhejiang Province, Hangzhou 310006, Zhejiang, China"},{"name":"Zhejiang University Cancer Center, Hangzhou 310006, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.","volume":"6","author":"Jemal","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"2","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3322\/caac.21338","article-title":"Cancer statistics in China, 2015.","volume":"6","author":"He","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020.","volume":"7","author":"Jemal","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"4","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nbt.2890","article-title":"Detecting and characterizing circular RNAs.","volume":"3","author":"Sharpless","year":"2014","journal-title":"Nat Biotechnol"},{"key":"5","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.molcel.2014.08.019","article-title":"circRNA biogenesis competes with pre-mRNA splicing.","volume":"5","author":"Kadener","year":"2014","journal-title":"Mol Cell"},{"key":"6","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency.","volume":"49","author":"Landthaler","year":"2013","journal-title":"Nature"},{"key":"7","doi-asserted-by":"publisher","first-page":"e1478","DOI":"10.1002\/wrna.1478","article-title":"A 360\u00b0 view of circular RNAs: From biogenesis to functions.","volume":"9","author":"Wilusz","year":"2018","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"8","doi-asserted-by":"publisher","first-page":"12060","DOI":"10.1038\/ncomms12060","article-title":"Comprehensive identification of internal structure and alternative splicing events in circular RNAs.","volume":"7","author":"Zhao","year":"2016","journal-title":"Nat Commun"},{"key":"9","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.cell.2016.03.020","article-title":"Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations.","volume":"16","author":"Pandolfi","year":"2016","journal-title":"Cell"},{"key":"10","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1261\/rna.047126.114","article-title":"Circular RNAs: diversity of form and function.","volume":"2","author":"Parker","year":"2014","journal-title":"RNA"},{"key":"11","doi-asserted-by":"publisher","first-page":"109462","DOI":"10.1016\/j.biopha.2019.109462","article-title":"Downregulation of CircRNA CDR1as specifically triggered low-dose Diosbulbin-B induced gastric cancer cell death by regulating miR-7-5p\/REG\u03b3 axis.","volume":"12","author":"Xue","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"12","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/1759-7714.13274","article-title":"CircRNA CDR1as knockdown inhibits progression of non-small-cell lung cancer by regulating miR-219a-5p\/SOX5 axis.","volume":"1","author":"Liu","year":"2020","journal-title":"Thorac Cancer"},{"key":"13","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1002\/1878-0261.12523","article-title":"Circular RNA Cdr1as sensitizes bladder cancer to cisplatin by upregulating APAF1 expression through miR-1270 inhibition.","volume":"1","author":"Gu","year":"2019","journal-title":"Mol Oncol"},{"key":"14","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12943-019-0969-3","article-title":"Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression.","volume":"1","author":"Sun","year":"2019","journal-title":"Mol Cancer"},{"key":"15","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12943-019-1056-5","article-title":"A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1.","volume":"1","author":"Zhang","year":"2019","journal-title":"Mol Cancer"},{"key":"16","doi-asserted-by":"publisher","first-page":"4317","DOI":"10.1038\/s41467-019-11777-7","article-title":"Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS\/VEGF-A axis.","volume":"1","author":"Ibetti","year":"2019","journal-title":"Nat Commun"},{"key":"17","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.molcel.2017.02.017","article-title":"Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis.","volume":"6","author":"Bozzoni","year":"2017","journal-title":"Mol Cell"},{"key":"18","doi-asserted-by":"publisher","first-page":"3843","DOI":"10.1038\/s41388-019-0699-4","article-title":"Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma.","volume":"3","author":"Bozzoni","year":"2019","journal-title":"Oncogene"},{"key":"19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.molcel.2017.02.021","article-title":"Translation of CircRNAs.","volume":"6","author":"Dittmar","year":"2017","journal-title":"Mol Cell"},{"key":"20","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12943-017-0663-2","article-title":"CircRNA: functions and properties of a novel potential biomarker for cancer.","volume":"1","author":"Wu","year":"2017","journal-title":"Mol Cancer"},{"key":"21","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s12943-018-0888-8","article-title":"CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer.","volume":"1","author":"Cao","year":"2018","journal-title":"Mol Cancer"},{"key":"22","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.biopha.2018.08.030","article-title":"Circular RNA hsa_circ_0052112 promotes cell migration and invasion by acting as sponge for miR-125a-5p in breast cancer.","volume":"10","author":"Tang","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"23","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.omtn.2020.10.026","article-title":"circEYA1 Functions as a Sponge of miR-582-3p to Suppress Cervical Adenocarcinoma Tumorigenesis via Upregulating CXCL14.","volume":"2","author":"Lu","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"24","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges.","volume":"49","author":"Kjems","year":"2013","journal-title":"Nature"},{"key":"25","doi-asserted-by":"publisher","first-page":"16584","DOI":"10.1038\/s41598-020-73523-0","article-title":"Transcriptome analysis uncovers the diagnostic value of miR-192-5p\/HNF1A-AS1\/VIL1 panel in cervical adenocarcinoma.","volume":"1","author":"Lu","year":"2020","journal-title":"Sci Rep"},{"key":"26","doi-asserted-by":"publisher","first-page":"eaam8526","DOI":"10.1126\/science.aam8526","article-title":"Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.","volume":"35","author":"Plass","year":"2017","journal-title":"Science"},{"key":"27","doi-asserted-by":"publisher","first-page":"11215","DOI":"10.1038\/ncomms11215","article-title":"Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs.","volume":"7","author":"Huang","year":"2016","journal-title":"Nat Commun"},{"key":"28","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nrm.2015.32","article-title":"The biogenesis and emerging roles of circular RNAs.","volume":"1","author":"Chen","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"29","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.2147\/OTT.S131597","article-title":"Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7.","volume":"1","author":"Xu","year":"2017","journal-title":"Onco Targets Ther"},{"key":"30","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/s12935-019-0959-y","article-title":"Circular RNA CDR1as sponges miR-7-5p to enhance E2F3 stability and promote the growth of nasopharyngeal carcinoma.","volume":"1","author":"Wu","year":"2019","journal-title":"Cancer Cell Int"},{"key":"31","doi-asserted-by":"publisher","first-page":"e0158347","DOI":"10.1371\/journal.pone.0158347","article-title":"The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression.","volume":"1","author":"Zhu","year":"2016","journal-title":"PLoS One"},{"key":"32","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12943-019-1007-1","article-title":"Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression.","volume":"1","author":"Fan","year":"2019","journal-title":"Mol Cancer"},{"key":"33","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/s41419-019-2027-x","article-title":"Circ-Spidr enhances axon regeneration after peripheral nerve injury.","volume":"1","author":"Yu","year":"2019","journal-title":"Cell Death Dis"},{"key":"34","doi-asserted-by":"publisher","first-page":"10275","DOI":"10.2147\/CMAR.S226828","article-title":"ATG3, a Target of miR-431-5p, Promotes Proliferation and Invasion of Colon Cancer via Promoting Autophagy.","volume":"1","author":"Liu","year":"2019","journal-title":"Cancer Manag Res"},{"key":"35","doi-asserted-by":"publisher","first-page":"BSR20181804","DOI":"10.1042\/BSR20181804","article-title":"FBXL19-AS1 exerts oncogenic function by sponging miR-431-5p to regulate RAF1 expression in lung cancer.","volume":"3","author":"Zhao","year":"2019","journal-title":"Biosci Rep"},{"key":"36","doi-asserted-by":"publisher","first-page":"10300","DOI":"10.26355\/eurrev_201912_19668","article-title":"Circ_0001742 promotes tongue squamous cell carcinoma progression via miR-431-5p\/ATF3 axis.","volume":"2","author":"Zeng","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"37","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1006\/bbrc.1999.1822","article-title":"Identification and characterization of SorCS, a third member of a novel receptor family.","volume":"26","author":"Hermans-Borgmeyer","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"38","doi-asserted-by":"publisher","first-page":"e44810","DOI":"10.15252\/embr.201744810","article-title":"SORCS1 and SORCS3 control energy balance and orexigenic peptide production.","volume":"1","author":"Willnow","year":"2018","journal-title":"EMBO Rep"},{"key":"39","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/ng1796","article-title":"Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.","volume":"3","author":"Stoehr","year":"2006","journal-title":"Nat Genet"},{"key":"40","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.2337\/db06-1677","article-title":"SORCS1: a novel human type 2 diabetes susceptibility gene suggested by the mouse.","volume":"5","author":"Rotter","year":"2007","journal-title":"Diabetes"},{"key":"41","doi-asserted-by":"publisher","first-page":"539","DOI":"10.2337\/db09-0653","article-title":"A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose.","volume":"5","author":"Cox","year":"2010","journal-title":"Diabetes"},{"key":"42","doi-asserted-by":"publisher","first-page":"119","DOI":"10.4149\/neo_2019_190221N146","article-title":"Decreased expression of SorCS1 in colorectal cancer: An independent predictor of poor prognosis.","volume":"6","author":"Huang","year":"2020","journal-title":"Neoplasma"},{"key":"43","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/6831","article-title":"Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1.","volume":"2","author":"Krahe","year":"1999","journal-title":"Nat Genet"},{"key":"44","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12885-016-3030-6","article-title":"A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma.","volume":"1","author":"Uhl\u00e9n","year":"2017","journal-title":"BMC Cancer"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T19:15:35Z","timestamp":1628190935000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":44,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2021,7,31]]}},"alternative-id":["203283","34326275"],"URL":"https:\/\/doi.org\/10.18632\/aging.203283","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,29]]}}}