{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:30Z","timestamp":1791229470585,"version":"4.1.0"},"reference-count":25,"publisher":"Impact Journals, LLC","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,8,31]]},"DOI":"10.18632\/aging.203416","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T16:08:43Z","timestamp":1630944523000},"page":"20359-20371","source":"Crossref","is-referenced-by-count":13,"title":["LncRNA GACAT1 targeting miRNA-149 regulates the molecular mechanism of proliferation, apoptosis and autophagy of oral squamous cell carcinoma cells"],"prefix":"10.18632","volume":"13","author":[{"given":"Jingxin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Hainan Province People\u2019s Hospital, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xubin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Hainan Province People\u2019s Hospital, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangbin","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Hainan Province People\u2019s Hospital, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hainan Province People\u2019s Hospital, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Hainan Province People\u2019s Hospital, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Hunan Province People\u2019s Hospital, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2021.05.020","article-title":"Characterization and clinicopathological significance of circulating tumour cells in patients with oral squamous cell carcinoma.","author":"Lam","year":"2021","journal-title":"Int J Oral Maxillofac Surg"},{"key":"2","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.archoralbio.2015.11.017","article-title":"Oral squamous cell carcinoma: Key clinical questions, biomarker discovery, and the role of proteomics.","volume":"6","author":"Pennington","year":"2016","journal-title":"Arch Oral Biol"},{"key":"3","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3389\/fgene.2012.00287","article-title":"Bioinformatics of Cancer ncRNA in High Throughput Sequencing: Present State and Challenges.","volume":"3","author":"Passetti","year":"2012","journal-title":"Front Genet"},{"key":"4","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.bbrc.2014.11.056","article-title":"Syndecan-1 responsive microRNA-126 and 149 regulate cell proliferation in prostate cancer.","volume":"45","author":"Konishi","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"5","doi-asserted-by":"publisher","first-page":"4718","DOI":"10.1111\/febs.13012","article-title":"Methylation-regulated miR-149 modulates chemoresistance by targeting GlcNAcN-deacetylase\/N-sulfotransferase-1 in human breast cancer.","volume":"28","author":"Ma","year":"2014","journal-title":"FEBS J"},{"key":"6","article-title":"The effects of miR-149 gene expression on the growth of oral squamous cell carcinoma.","author":"Stomatology","year":"2019","journal-title":"Hebei Medical Journal"},{"key":"7","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1016\/j.ygeno.2021.02.002","article-title":"Predicting lncRNA-miRNA interactions based on interactome network and graphlet interaction.","volume":"11","author":"Liu","year":"2021","journal-title":"Genomics"},{"key":"8","doi-asserted-by":"publisher","first-page":"345605","DOI":"10.1155\/2014\/345605","article-title":"An Integrated analysis of miRNA, lncRNA, and mRNA expression profiles.","volume":"201","author":"Chen","year":"2014","journal-title":"Biomed Res Int"},{"key":"9","doi-asserted-by":"publisher","first-page":"7933","DOI":"10.1002\/jcp.29448","article-title":"lncRNA MIAT promotes esophageal squamous cell carcinoma progression by regulating miR-1301-3p\/INCENP axis and interacting with SOX2.","volume":"23","author":"Cui","year":"2020","journal-title":"J Cell Physiol"},{"key":"10","doi-asserted-by":"crossref","first-page":"8048","DOI":"10.1039\/C8RA10030F","article-title":"Long non-coding RNA GACAT1 alleviates doxorubicin and vincristine resistance through a PTEN\/AKT\/mTOR\/S6K1 regulatory pathway in gastric cancer.","volume":"9","author":"Wang","year":"2019","journal-title":"RSC Advances"},{"key":"11","doi-asserted-by":"publisher","first-page":"3715","DOI":"10.7150\/jca.27546","article-title":"LncRNA GACAT1 Promotes Gastric Cancer Cell Growth, Invasion And Migration By Regulating MiR-149-mediated Of ZBTB2 And SP1.","volume":"9","author":"Hua","year":"2018","journal-title":"J Cancer"},{"key":"12","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.3892\/ol.2020.11260","article-title":"Long-chain non-coding RNA GACAT1 promotes development and progression of breast cancer by targeting microRNA-875-3p.","volume":"1","author":"Qiu","year":"2020","journal-title":"Oncol Lett"},{"key":"13","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.gene.2017.01.024","article-title":"LncRNA, TUG1 regulates the oral squamous cell carcinoma progression possibly via interacting with Wnt\/\u03b2-catenin signaling.","volume":"60","author":"Wang","year":"2017","journal-title":"Gene"},{"key":"14","doi-asserted-by":"publisher","first-page":"16120","DOI":"10.1002\/jcb.28893","article-title":"LncRNA PAPAS promotes oral squamous cell carcinoma by upregulating transforming growth factor-\u03b21.","volume":"12","author":"Jiang","year":"2019","journal-title":"J Cell Biochem"},{"key":"15","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1007\/s13277-013-0916-7","article-title":"Long noncoding RNA AC096655.1-002 has been officially named as gastric cancer-associated transcript 1, GACAT1.","volume":"3","author":"Guo","year":"2013","journal-title":"Tumour Biol"},{"key":"16","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nature10888","article-title":"The microcosmos of cancer.","volume":"48","author":"Lowe","year":"2012","journal-title":"Nature"},{"key":"17","volume-title":"MicroRNAs in Cancer.","author":"Marchat","year":"2013"},{"key":"18","doi-asserted-by":"publisher","first-page":"5481","DOI":"10.1007\/s11033-011-1350-9","article-title":"miR-21 inhibitor sensitizes human OSCC cells to cisplatin.","volume":"3","author":"Wang","year":"2012","journal-title":"Mol Biol Rep"},{"key":"19","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.oraloncology.2009.12.005","article-title":"miR-24 up-regulation in oral carcinoma: positive association from clinical andanalysis.","volume":"4","author":"Chang","year":"2010","journal-title":"Oral Oncol"},{"key":"20","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3892\/or.2016.4891","article-title":"miR-24 promotes the proliferation, migration and invasion in human tongue squamous cell carcinoma by targeting FBXW7.","volume":"3","author":"Zheng","year":"2016","journal-title":"Oncol Rep"},{"key":"21","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.ajpath.2019.10.010","article-title":"miR-149Suppresses Liver Cancer Progression by Down-Regulating Tumor Necrosis Factor Receptor 1-Associated Death Domain Protein Expression.","volume":"19","author":"Wang","year":"2020","journal-title":"Am J Pathol"},{"key":"22","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1002\/ijc.24827","article-title":"Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma.","volume":"12","author":"Jung","year":"2010","journal-title":"Int J Cancer"},{"key":"23","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1073\/pnas.1112500109","article-title":"Isoprenoid biosynthesis is required for miRNA function and affects membrane association of ARGONAUTE 1 in Arabidopsis.","volume":"10","author":"Voinnet","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"24","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.26355\/eurrev_201903_17389","article-title":"LncRNA LACAT1 promotes proliferation of oral squamous cell carcinoma cells by inhibiting microRNA-4301.","volume":"2","author":"Xu","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"25","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s13577-020-00411-0","article-title":"LncRNA DANCR regulates the growth and metastasis of oral squamous cell carcinoma cells via altering miR-216a-5p expression.","volume":"3","author":"Zhang","year":"2020","journal-title":"Hum Cell"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T16:11:16Z","timestamp":1630944676000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,30]]},"references-count":25,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2021,8,31]]}},"alternative-id":["203416","34460438"],"URL":"https:\/\/doi.org\/10.18632\/aging.203416","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,30]]}}}