{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:37:33Z","timestamp":1772131053917,"version":"3.50.1"},"reference-count":31,"publisher":"Impact Journals, LLC","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,9,15]]},"DOI":"10.18632\/aging.203418","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T19:09:04Z","timestamp":1629400144000},"page":"20886-20895","source":"Crossref","is-referenced-by-count":9,"title":["The potential role of abnormal angiotensin-converting enzyme 2 expression correlated with immune infiltration after SARS-CoV-2 infection in the prognosis of breast cancer"],"prefix":"10.18632","volume":"13","author":[{"given":"Yufeng","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsheng","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofei","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/S0140-6736(16)31891-8","article-title":"Breast cancer.","volume":"38","author":"Gnant","year":"2017","journal-title":"Lancet"},{"key":"2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40659-017-0140-9","article-title":"Awareness and current knowledge of breast cancer.","volume":"5","author":"Khan","year":"2017","journal-title":"Biol Res"},{"key":"3","first-page":"401M","article-title":"Precision Medicine in Breast Cancer.","volume":"8","author":"Odle","year":"2017","journal-title":"Radiol Technol"},{"key":"4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.pmbts.2017.07.002","article-title":"Breast Cancer Epidemiology, Prevention, and Screening.","volume":"15","author":"Shokar","year":"2017","journal-title":"Prog Mol Biol Transl Sci"},{"key":"5","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1158\/1078-0432.CCR-16-3001","article-title":"Breast Cancer Immunotherapy: Facts and Hopes.","volume":"2","author":"Emens","year":"2018","journal-title":"Clin Cancer Res"},{"key":"6","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.cpet.2018.02.004","article-title":"Molecular Classification of Breast Cancer.","volume":"1","author":"Chin","year":"2018","journal-title":"PET Clin"},{"key":"7","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s12013-014-0459-6","article-title":"Breast Cancer: Epidemiology and Etiology.","volume":"7","author":"Zhao","year":"2015","journal-title":"Cell Biochem Biophys"},{"key":"8","doi-asserted-by":"publisher","first-page":"271","DOI":"10.2214\/AJR.17.18708","article-title":"Biomarkers and Imaging of Breast Cancer.","volume":"21","author":"Leung","year":"2018","journal-title":"AJR Am J Roentgenol"},{"key":"9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.21037\/cco.2018.05.05","article-title":"Immunotherapy for metastatic breast cancer.","volume":"7","author":"Sugie","year":"2018","journal-title":"Chin Clin Oncol"},{"key":"10","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1080\/22221751.2020.1747363","article-title":"Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.","volume":"9","author":"Zhang","year":"2020","journal-title":"Emerg Microbes Infect"},{"key":"11","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1080\/22221751.2020.1729071","article-title":"Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.","volume":"9","author":"Zhou","year":"2020","journal-title":"Emerg Microbes Infect"},{"key":"12","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1080\/01652176.2020.1727993","article-title":"Emerging novel coronavirus (2019-nCoV)-current scenario, evolutionary perspective based on genome analysis and recent developments.","volume":"4","author":"Chaicumpa","year":"2020","journal-title":"Vet Q"},{"key":"13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40121-020-00295-5","article-title":"Coronavirus: Update Related to the Current Outbreak of COVID-19.","volume":"9","author":"Stefanati","year":"2020","journal-title":"Infect Dis Ther"},{"key":"14","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1080\/22221751.2020.1739565","article-title":"Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26.","volume":"9","author":"Wilce","year":"2020","journal-title":"Emerg Microbes Infect"},{"key":"15","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1159\/000486585","article-title":"The Role of Immune Escape and Immune Cell Infiltration in Breast Cancer.","volume":"1","author":"Seliger","year":"2018","journal-title":"Breast Care (Basel)"},{"key":"16","first-page":"375","article-title":"Immune targeting in breast cancer.","volume":"2","author":"Emens","year":"2015","journal-title":"Oncology (Williston Park)"},{"key":"17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s12282-016-0698-z","article-title":"Immune infiltrates in the breast cancer microenvironment: detection, characterization and clinical implication.","volume":"2","author":"Nielsen","year":"2017","journal-title":"Breast Cancer"},{"key":"18","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/978-3-319-70197-4_10","article-title":"Immune Checkpoint Blockade for Breast Cancer.","volume":"17","author":"Nanda","year":"2018","journal-title":"Cancer Treat Res"},{"key":"19","doi-asserted-by":"publisher","first-page":"503","DOI":"10.26402\/jpp.2019.4.02","article-title":"Angiotensin 1-7 formation in breast tissue is attenuated in breast cancer - a study on the metabolism of angiotensinogen in breast cancer cell lines.","volume":"7","author":"Olszanecki","year":"2019","journal-title":"J Physiol Pharmacol"},{"key":"20","doi-asserted-by":"publisher","first-page":"R653","DOI":"10.1530\/ERC-19-0314","article-title":"Mechanisms linking the renin-angiotensin system, obesity, and breast cancer.","volume":"2","author":"Moustaid-Moussa","year":"2019","journal-title":"Endocr Relat Cancer"},{"key":"21","doi-asserted-by":"publisher","first-page":"4597","DOI":"10.21873\/anticanres.13639","article-title":"Renin-Angiotensin Inhibition in Combating Malignancy: A Review.","volume":"3","author":"Gavras","year":"2019","journal-title":"Anticancer Res"},{"key":"22","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s13046-019-1156-5","article-title":"ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa\/VEGFR2\/ERK pathway.","volume":"3","author":"Lin","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"23","doi-asserted-by":"publisher","first-page":"88475","DOI":"10.18632\/oncotarget.19290","article-title":"Angiotensin-(1-7) counteracts the transforming effects triggered by angiotensin II in breast cancer cells.","volume":"8","author":"Schere-Levy","year":"2017","journal-title":"Oncotarget"},{"key":"24","doi-asserted-by":"publisher","first-page":"18640","DOI":"10.18632\/oncotarget.15553","article-title":"The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma.","volume":"8","author":"Alorro","year":"2017","journal-title":"Oncotarget"},{"key":"25","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1097\/CEJ.0000000000000269","article-title":"The effect of angiotensin system inhibitors (angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) on cancer recurrence and survival: a meta-analysis.","volume":"2","author":"Seong","year":"2017","journal-title":"Eur J Cancer Prev"},{"key":"26","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.canlet.2016.04.006","article-title":"Downregulation of ACE2\/Ang-(1-7)\/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry.","volume":"37","author":"Zou","year":"2016","journal-title":"Cancer Lett"},{"key":"27","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1179\/1973947815Y.0000000055","article-title":"Angiotensin II receptor antagonist olmesartan and NF-kappaB inhibitor as cytotoxic and apoptotic agents in MCF-7 human cell line.","volume":"2","author":"Mousavi","year":"2016","journal-title":"J Chemother"},{"key":"28","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s13277-014-2713-3","article-title":"Effect of angiotensin receptor blockade on prevention and reversion of tamoxifen-resistant phenotype in MCF-7 cells.","volume":"3","author":"Arabsolghar","year":"2015","journal-title":"Tumour Biol"},{"key":"29","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1593\/neo.07112","article-title":"Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles.","volume":"9","author":"Chinnaiyan","year":"2007","journal-title":"Neoplasia"},{"key":"30","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1158\/0008-5472.CAN-17-0307","article-title":"TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells.","volume":"7","author":"Liu","year":"2017","journal-title":"Cancer Res"},{"key":"31","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s10549-009-0674-9","article-title":"An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients.","volume":"12","author":"Szallasi","year":"2010","journal-title":"Breast Cancer Res Treat"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T14:49:44Z","timestamp":1632149384000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,19]]},"references-count":31,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2021,9,15]]}},"alternative-id":["203418","34413267"],"URL":"https:\/\/doi.org\/10.18632\/aging.203418","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,19]]}}}