{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T21:12:42Z","timestamp":1762809162950},"reference-count":35,"publisher":"Impact Journals, LLC","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,9,15]]},"DOI":"10.18632\/aging.203524","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T15:33:13Z","timestamp":1631633593000},"page":"21778-21790","source":"Crossref","is-referenced-by-count":9,"title":["Transfection of STAT3 overexpression plasmid mediated through recombinant lentivirus promotes differentiation of bone marrow mesenchymal stem cells into neural cells in fetal rats with spina bifida aperta"],"prefix":"10.18632","volume":"13","author":[{"given":"Mingyu","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiale","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine, The Fifth Hospital of Harbin, Harbin 150040, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbo","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tieling Central Hospital, Tieling 112000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jicheng","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunpeng","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Hospital of Jilin University, Changchun 130021, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1007\/s00381-013-2119-3","article-title":"Closed neural tube defects in children with caudal regression.","volume":"2","author":"McComb","year":"2013","journal-title":"Childs Nerv Syst"},{"key":"2","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1002\/bdr2.1682","article-title":"Preconception telomere length as a novel maternal biomarker to assess the risk of spina bifida in the offspring.","volume":"11","author":"Steegers-Theunissen","year":"2020","journal-title":"Birth Defects Res"},{"key":"3","doi-asserted-by":"publisher","first-page":"11208","DOI":"10.1002\/jcp.27771","article-title":"NEFLb impairs early nervous system development via regulation of neuron apoptosis in zebrafish.","volume":"23","author":"Li","year":"2019","journal-title":"J Cell Physiol"},{"key":"4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.neures.2018.11.007","article-title":"Apoptosis versus axon pruning: Molecular intersection of two distinct pathways for axon degeneration.","volume":"13","author":"Deshmukh","year":"2019","journal-title":"Neurosci Res"},{"key":"5","doi-asserted-by":"publisher","first-page":"219","DOI":"10.31486\/toj.18.0153","article-title":"Pneumococcal Meningitis Complicated by Spinal Cord Dysfunction and Acute Polyradiculopathy.","volume":"2","author":"Khalid","year":"2020","journal-title":"Ochsner J"},{"key":"6","doi-asserted-by":"publisher","first-page":"631","DOI":"10.14670\/HH-24.631","article-title":"Induction system of neural and muscle lineage cells from bone marrow stromal cells; a new strategy for tissue reconstruction in degenerative diseases.","volume":"2","author":"Dezawa","year":"2009","journal-title":"Histol Histopathol"},{"key":"7","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1177\/107327480401100217","article-title":"Stem cell transplantation in the fetus.","volume":"1","author":"B\u00e1rcena","year":"2004","journal-title":"Cancer Control"},{"key":"8","doi-asserted-by":"publisher","first-page":"22","DOI":"10.2174\/1574888X13666180913123424","article-title":"The Clinical Trials of Mesenchymal Stem Cell Therapy in Skin Diseases: An Update and Concise Review.","volume":"1","author":"Ardeshirylajimi","year":"2019","journal-title":"Curr Stem Cell Res Ther"},{"key":"9","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jcyt.2018.11.008","article-title":"Mesenchymal stromal cells from infants with simple polydactyly modulate immune responses more efficiently than adult mesenchymal stromal cells.","volume":"2","author":"Mezey","year":"2019","journal-title":"Cytotherapy"},{"key":"10","doi-asserted-by":"publisher","first-page":"5405","DOI":"10.1074\/jbc.M116.771964","article-title":"Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity.","volume":"29","author":"Baldwin","year":"2017","journal-title":"J Biol Chem"},{"key":"11","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.bbr.2018.12.013","article-title":"Mesenchymal stem cells therapy enhances the efficacy of pregabalin and prevents its motor impairment in paclitaxel-induced neuropathy in rats: Role of Notch1 receptor and JAK\/STAT signaling pathway.","volume":"36","author":"El-Abhar","year":"2019","journal-title":"Behav Brain Res"},{"key":"12","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3389\/fcell.2020.00079","article-title":"FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency.","volume":"8","author":"Li","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"13","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/s41586-019-1770-6","article-title":"Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.","volume":"57","author":"Kashkar","year":"2019","journal-title":"Nature"},{"key":"14","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.ceb.2020.02.004","article-title":"New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8.","volume":"6","author":"Pasparakis","year":"2020","journal-title":"Curr Opin Cell Biol"},{"key":"15","doi-asserted-by":"publisher","first-page":"112319","DOI":"10.1016\/j.jep.2019.112319","article-title":"Astragaloside IV alleviates ischemia reperfusion-induced apoptosis by inhibiting the activation of key factors in death receptor pathway and mitochondrial pathway.","volume":"24","author":"Yang","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"16","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13578-019-0312-0","article-title":"Combination chemotherapy of valproic acid (VPA) and gemcitabine regulates STAT3\/Bmi1 pathway to differentially potentiate the motility of pancreatic cancer cells.","volume":"9","author":"Yin","year":"2019","journal-title":"Cell Biosci"},{"key":"17","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/imr.12541","article-title":"Caspase-8: regulating life and death.","volume":"27","author":"Green","year":"2017","journal-title":"Immunol Rev"},{"key":"18","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3390\/cells9010217","article-title":"Role of JAK\/STAT3 Signaling in the Regulation of Metastasis, the Transition of Cancer Stem Cells, and Chemoresistance of Cancer by Epithelial-Mesenchymal Transition.","volume":"9","author":"Jin","year":"2020","journal-title":"Cells"},{"key":"19","doi-asserted-by":"publisher","first-page":"125775","DOI":"10.1016\/j.zool.2020.125775","article-title":"Characteristics of Mesenchymal Stem Cells Isolated from the Bone Marrow of Red Pandas.","volume":"14","author":"Hou","year":"2020","journal-title":"Zoology (Jena)"},{"key":"20","doi-asserted-by":"publisher","first-page":"227","DOI":"10.4103\/1673-5374.244778","article-title":"Mesenchymal stem cells and the neuronal microenvironment in the area of spinal cord injury.","volume":"1","author":"Rizvanov","year":"2019","journal-title":"Neural Regen Res"},{"key":"21","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.ijdevneu.2013.02.006","article-title":"Epigenetic regulation of neural stem cell fate during corticogenesis.","volume":"3","author":"Nakashima","year":"2013","journal-title":"Int J Dev Neurosci"},{"key":"22","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1002\/cne.20140","article-title":"STAT3 phosphorylation in injured axons before sensory and motor neuron nuclei: potential role for STAT3 as a retrograde signaling transcription factor.","volume":"47","author":"MacLennan","year":"2004","journal-title":"J Comp Neurol"},{"key":"23","doi-asserted-by":"publisher","first-page":"C487","DOI":"10.1152\/ajpcell.00112.2017","article-title":"Acute myotube protein synthesis regulation by IL-6-related cytokines.","volume":"31","author":"Carson","year":"2017","journal-title":"Am J Physiol Cell Physiol"},{"key":"24","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1006\/mcne.2000.0947","article-title":"Selective introduction of antisense oligonucleotides into single adult CNS progenitor cells using electroporation demonstrates the requirement of STAT3 activation for CNTF-induced gliogenesis.","volume":"1","author":"Eriksson","year":"2001","journal-title":"Mol Cell Neurosci"},{"key":"25","doi-asserted-by":"publisher","first-page":"10859","DOI":"10.1096\/fj.201900743R","article-title":"Silencing miR-21 induces polarization of astrocytes to the A2 phenotype and improves the formation of synapses by targeting glypican 6 via the signal transducer and activator of transcription-3 pathway after acute ischemic spinal cord injury.","volume":"3","author":"Ning","year":"2019","journal-title":"FASEB J"},{"key":"26","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.3390\/molecules25092020","article-title":"Preconditioning of Adipose-Derived Mesenchymal Stem-Like Cells with Eugenol Potentiates Their Migration and Proliferationand Therapeutic Abilities in Rat Hepatic Fibrosis.","volume":"2","author":"Yoshida","year":"2020","journal-title":"Molecules"},{"key":"27","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/sctm.17-0108","article-title":"Neurotrophically Induced Mesenchymal Progenitor Cells Derived from Induced Pluripotent Stem Cells Enhance Neuritogenesis via Neurotrophin and Cytokine Production.","volume":"7","author":"Tuan","year":"2018","journal-title":"Stem Cells Transl Med"},{"key":"28","doi-asserted-by":"publisher","first-page":"e39871","DOI":"10.1371\/journal.pone.0039871","article-title":"Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation.","volume":"7","author":"Horwood","year":"2012","journal-title":"PLoS One"},{"key":"29","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1080\/15384047.2016.1219820","article-title":"The histone deacetylase inhibitor romidepsin synergizes with lenalidomide and enhances tumor cell death in T-cell lymphoma cell lines.","volume":"1","author":"Sacchi","year":"2016","journal-title":"Cancer Biol Ther"},{"key":"30","doi-asserted-by":"publisher","first-page":"4957","DOI":"10.2147\/CMAR.S206175","article-title":"Negative regulators of STAT3 signaling pathway in cancers.","volume":"1","author":"Shu","year":"2019","journal-title":"Cancer Manag Res"},{"key":"31","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1126\/science.284.5413.479","article-title":"Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300.","volume":"28","author":"Taga","year":"1999","journal-title":"Science"},{"key":"32","doi-asserted-by":"publisher","first-page":"3023","DOI":"10.1046\/j.1432-1033.2002.02977.x","article-title":"Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor\/soluble CNTF-receptor and leukemia inhibitory factor.","volume":"26","author":"Rose-John","year":"2002","journal-title":"Eur J Biochem"},{"key":"33","doi-asserted-by":"publisher","first-page":"e212","DOI":"10.1038\/cddis.2011.93","article-title":"Caspase-8 activity has an essential role in CD95\/Fas-mediated MAPK activation.","volume":"2","author":"Lavrik","year":"2011","journal-title":"Cell Death Dis"},{"key":"34","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.4049\/jimmunol.165.5.2500","article-title":"Apoptosis induced by TGF-beta 1 in Burkitt\u2019s lymphoma cells is caspase 8 dependent but is death receptor independent.","volume":"16","author":"Allday","year":"2000","journal-title":"J Immunol"},{"key":"35","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00381-006-0289-y","article-title":"Retinoic acid-induced lumbosacral neural tube defects: myeloschisis and hamartoma.","volume":"2","author":"Wang","year":"2007","journal-title":"Childs Nerv Syst"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T14:53:17Z","timestamp":1632149597000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,14]]},"references-count":35,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2021,9,15]]}},"alternative-id":["203524","34520395"],"URL":"https:\/\/doi.org\/10.18632\/aging.203524","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,14]]}}}