{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:32:19Z","timestamp":1768253539505,"version":"3.49.0"},"reference-count":43,"publisher":"Impact Journals, LLC","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,10,15]]},"DOI":"10.18632\/aging.203583","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T16:58:29Z","timestamp":1633021109000},"page":"22898-22911","source":"Crossref","is-referenced-by-count":16,"title":["Downregulation of KIF2C and TEKT2 is associated with male infertility and testicular carcinoma"],"prefix":"10.18632","volume":"13","author":[{"given":"Haiming","family":"Cao","sequence":"first","affiliation":[{"name":"The Urology Department, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi","family":"Wan","sequence":"additional","affiliation":[{"name":"The Urology Department, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"The Urology Department, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyin","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Li","sequence":"additional","affiliation":[{"name":"The Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianquan","family":"Hou","sequence":"additional","affiliation":[{"name":"The Urology Department, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.fertnstert.2017.06.005","article-title":"The International Glossary on Infertility and Fertility Care, 2017.","volume":"10","author":"van der Poel","year":"2017","journal-title":"Fertil Steril"},{"key":"2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.clinbiochem.2018.03.012","article-title":"Fertility and infertility: Definition and epidemiology.","volume":"6","author":"Wyns","year":"2018","journal-title":"Clin Biochem"},{"key":"3","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1016\/B978-0-323-18907-1.00141-4","volume-title":"Endocrinology: Adult and Pediatric (7th ed)","author":"Weir","year":"2016"},{"key":"4","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1093\/humrep\/dex214","article-title":"A prognosis-based approach to infertility: understanding the role of time.","volume":"3","author":"ESHRE Capri Workshop Group","year":"2017","journal-title":"Hum Reprod"},{"key":"5","first-page":"129","article-title":"Fallopian tubes--literature review of anatomy and etiology in female infertility.","volume":"8","author":"Ispas","year":"2015","journal-title":"J Med Life"},{"key":"6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.4103\/0974-1208.170370","article-title":"Trends of male factor infertility, an important cause of infertility: A review of literature.","volume":"8","author":"Singh","year":"2015","journal-title":"J Hum Reprod Sci"},{"key":"7","first-page":"513","article-title":"An epidemiologic survey on the causes of infertility in patients referred to infertility center in Fatemieh Hospital in Hamadan.","volume":"1","author":"Roshanaei","year":"2015","journal-title":"Iran J Reprod Med"},{"key":"8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","article-title":"A unique view on male infertility around the globe.","volume":"1","author":"Chyatte","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"9","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/s41585-018-0003-3","article-title":"Genetics of male infertility.","volume":"1","author":"Riera-Escamilla","year":"2018","journal-title":"Nat Rev Urol"},{"key":"10","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/S2213-8587(16)30040-7","article-title":"Novel concepts in the aetiology of male reproductive impairment.","volume":"5","author":"Oates","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"key":"11","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.beem.2010.08.006","article-title":"Male infertility: pathogenesis and clinical diagnosis.","volume":"2","author":"Krausz","year":"2011","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"12","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.3892\/mmr.2018.9112","article-title":"System analysis of teratozoospermia mRNA profile based on integrated bioinformatics tools.","volume":"1","author":"Yu","year":"2018","journal-title":"Mol Med Rep"},{"key":"13","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/j.fertnstert.2013.07.1999","article-title":"Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.","volume":"10","author":"Kurpisz","year":"2013","journal-title":"Fertil Steril"},{"key":"14","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1093\/humupd\/dmx021","article-title":"The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance-challenges and future research opportunities.","volume":"2","author":"Tournaye","year":"2017","journal-title":"Hum Reprod Update"},{"key":"15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2147\/ijgm.s241099","article-title":"Some of the Factors Involved in Male Infertility: A Prospective Review.","volume":"1","author":"Khodadadian","year":"2020","journal-title":"Int J Gen Med"},{"key":"16","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1111\/andr.12704","article-title":"Sequence analysis of 37 candidate genes for male infertility: challenges in variant assessment and validating genes.","volume":"8","author":"T\u00fcttelmann","year":"2020","journal-title":"Andrology"},{"key":"17","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1111\/aji.12149","article-title":"The gene expression analysis of paracrine\/autocrine factors in patients with spermatogenetic failure compared with normal spermatogenesis.","volume":"7","author":"Kurpisz","year":"2013","journal-title":"Am J Reprod Immunol"},{"key":"18","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1093\/molehr\/gal097","article-title":"A new paradigm for profiling testicular gene expression during normal and disturbed human spermatogenesis.","volume":"1","author":"Spiess","year":"2007","journal-title":"Mol Hum Reprod"},{"key":"19","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.1091\/mbc.e07-02-0110","article-title":"The kinesin-13 proteins Kif2a, Kif2b, and Kif2c\/MCAK have distinct roles during mitosis in human cells.","volume":"1","author":"Compton","year":"2007","journal-title":"Mol Biol Cell"},{"key":"20","doi-asserted-by":"publisher","first-page":"935","DOI":"10.18632\/oncotarget.416","article-title":"Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.","volume":"2","author":"Yuan","year":"2011","journal-title":"Oncotarget"},{"key":"21","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.mrfmmm.2010.11.002","article-title":"Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation.","volume":"71","author":"Chen","year":"2011","journal-title":"Mutat Res"},{"key":"22","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1126\/science.1088845","article-title":"Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains.","volume":"30","author":"Kanaar","year":"2004","journal-title":"Science"},{"key":"23","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/nsmb.3387","article-title":"Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes.","volume":"2","author":"Legube","year":"2017","journal-title":"Nat Struct Mol Biol"},{"key":"24","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1073\/pnas.1117849108","article-title":"Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells.","volume":"10","author":"Costes","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"25","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1126\/science.1237150","article-title":"Spatial dynamics of chromosome translocations in living cells.","volume":"34","author":"Misteli","year":"2013","journal-title":"Science"},{"key":"26","doi-asserted-by":"publisher","first-page":"8912","DOI":"10.1523\/JNEUROSCI.18-21-08912.1998","article-title":"Expression of ciliary tektins in brain and sensory development.","volume":"1","author":"Linck","year":"1998","journal-title":"J Neurosci"},{"key":"27","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1073\/pnas.85.8.2643","article-title":"Evidence for tektins in centrioles and axonemal microtubules.","volume":"8","author":"Linck","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"28","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1078\/0171-9335-00097","article-title":"The spatial and temporal expression of Tekt1, a mouse tektin C homologue, during spermatogenesis suggest that it is involved in the development of the sperm tail basal body and axoneme.","volume":"7","author":"H\u00f6\u00f6g","year":"2000","journal-title":"Eur J Cell Biol"},{"key":"29","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/s1096-4959(02)00153-7","article-title":"Cloning and characterization of testis-specific tektin in Bombyx mori.","volume":"13","author":"Koga","year":"2002","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"30","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/s0014-5793(99)00967-9","article-title":"Molecular cloning of haploid germ cell-specific tektin cDNA and analysis of the protein in mouse testis.","volume":"45","author":"Nishimune","year":"1999","journal-title":"FEBS Lett"},{"key":"31","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1016\/s1357-2725(01)00089-9","article-title":"Cloning and characterization of a novel human TEKTIN1 gene.","volume":"3","author":"Mao","year":"2001","journal-title":"Int J Biochem Cell Biol"},{"key":"32","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1095\/biolreprod66.1.241","article-title":"Tektin B1 demonstrates flagellar localization in human sperm.","volume":"6","author":"Herr","year":"2002","journal-title":"Biol Reprod"},{"key":"33","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/cm.970020724","article-title":"Tektin filaments: chemically unique filaments of sperm flagellar microtubules.","volume":"8","author":"Langevin","year":"1982","journal-title":"Prog Clin Biol Res"},{"key":"34","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1006\/jmbi.1996.0170","article-title":"Structural comparison of tektins and evidence for their determination of complex spacings in flagellar microtubules.","volume":"25","author":"Linck","year":"1996","journal-title":"J Mol Biol"},{"key":"35","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1073\/pnas.0610286104","article-title":"All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility.","volume":"10","author":"Clapham","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"36","doi-asserted-by":"publisher","first-page":"7958","DOI":"10.1128\/MCB.24.18.7958-7964.2004","article-title":"Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function.","volume":"2","author":"Nishimune","year":"2004","journal-title":"Mol Cell Biol"},{"key":"37","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.cryobiol.2013.05.007","article-title":"Effect of cryopreservation on human sperm messenger RNAs crucial for fertilization and early embryo development.","volume":"6","author":"Robles","year":"2013","journal-title":"Cryobiology"},{"key":"38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1477-7827-7-13","article-title":"Altered microRNA expression in patients with non-obstructive azoospermia.","volume":"7","author":"Sun","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"key":"39","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1093\/humrep\/det099","article-title":"Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p.","volume":"2","author":"Shen","year":"2013","journal-title":"Hum Reprod"},{"key":"40","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.fertnstert.2014.07.001","article-title":"Panel of five microRNAs as potential biomarkers for the diagnosis and assessment of male infertility.","volume":"10","author":"Meese","year":"2014","journal-title":"Fertil Steril"},{"key":"41","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/andr.12573","article-title":"Expressions of miR-525-3p and its target gene SEMG1 in the spermatozoa of patients with asthenozoospermia.","volume":"7","author":"Liu","year":"2019","journal-title":"Andrology"},{"key":"42","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.12659\/msm.897340","article-title":"Up-Regulation of microRNA-210 is Associated with Spermatogenesis by Targeting IGF2 in Male Infertility.","volume":"2","author":"Zhang","year":"2016","journal-title":"Med Sci Monit"},{"key":"43","doi-asserted-by":"publisher","first-page":"e12297","DOI":"10.1111\/cpr.12297","article-title":"Reduced microRNA-188-3p expression contributes to apoptosis of spermatogenic cells in patients with azoospermia.","volume":"5","author":"Sun","year":"2017","journal-title":"Cell Prolif"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T14:49:13Z","timestamp":1634827753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,30]]},"references-count":43,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2021,10,15]]}},"alternative-id":["203583","34591790"],"URL":"https:\/\/doi.org\/10.18632\/aging.203583","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,30]]}}}