{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:26:37Z","timestamp":1787023597165,"version":"build-2736575974"},"reference-count":50,"publisher":"Impact Journals, LLC","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,10,15]]},"DOI":"10.18632\/aging.203615","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T20:40:50Z","timestamp":1633898450000},"page":"22690-22709","source":"Crossref","is-referenced-by-count":18,"title":["Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease"],"prefix":"10.18632","volume":"13","author":[{"given":"Esmeralda","family":"Castelblanco","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau and Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona 08041, Spain"},{"name":"Department of Internal Medicine, Endocrinology, Metabolism and Lipid Research Division, Washington University School of Medicine, St Louis, MO 63110, USA"},{"name":"DAP-Cat Group, Unitat de Suport a la Recerca Barcelona, Fundaci\u00f3 Institut Universitari per a la recerca a l\u2019Atenci\u00f3 Prim\u00e0ria de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona 08006, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R.","family":"Sarrias","sequence":"additional","affiliation":[{"name":"Institute for Health Science Research Germans Trias i Pujol (IGTP) and Center for Biomedical Research on Liver and Digestive Diseases (CIBEREHD), Madrid 28029, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c0ngels","family":"Betriu","sequence":"additional","affiliation":[{"name":"Vascular and Renal Translational Research Group, Biomedical Research Institute of Lleida, (IRBLleida), Lleida 25198, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta","family":"Soldevila","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Health Sciences Research Institute and University Hospital Germans Trias i Pujol, Badalona 08916, Spain"},{"name":"Center for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona 08907, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Barranco-Altirriba","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau and Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona 08041, Spain"},{"name":"B2SLab, Department of Systems Engineering, Automation and Industrial Informatics, Polytechnic University of Catalonia, Barcelona 08034, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Franch-Nadal","sequence":"additional","affiliation":[{"name":"DAP-Cat Group, Unitat de Suport a la Recerca Barcelona, Fundaci\u00f3 Institut Universitari per a la recerca a l\u2019Atenci\u00f3 Prim\u00e0ria de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona 08006, Spain"},{"name":"Department of Medicine, Barcelona Autonomous University (UAB), Bellaterra 08193, Spain"},{"name":"Primary Health Care Center Raval Sud, Ger\u00e8ncia d\u2019Atenci\u00f3 Primaria, Institut Catal\u00e0 de la Salut, Barcelona 08001, Spain"},{"name":"Center for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona 08907, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Valdivielso","sequence":"additional","affiliation":[{"name":"Vascular and Renal Translational Research Group, Biomedical Research Institute of Lleida, (IRBLleida), Lleida 25198, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelino","family":"Bermudez-Lopez","sequence":"additional","affiliation":[{"name":"Vascular and Renal Translational Research Group, Biomedical Research Institute of Lleida, (IRBLleida), Lleida 25198, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per-Henrik","family":"Groop","sequence":"additional","affiliation":[{"name":"Folkh\u00e4lsan Institute of Genetics, Folkh\u00e4lsan Research Center, Helsinki 00290, Finland"},{"name":"Abdominal Center Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00280, Finland"},{"name":"Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki 00100, Finland"},{"name":"Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Vascular and Renal Translational Research Group, Biomedical Research Institute of Lleida, (IRBLleida), Lleida 25198, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Health Sciences Research Institute and University Hospital Germans Trias i Pujol, Badalona 08916, Spain"},{"name":"Department of Medicine, Barcelona Autonomous University (UAB), Bellaterra 08193, Spain"},{"name":"Center for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona 08907, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didac","family":"Mauricio","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau and Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona 08041, Spain"},{"name":"DAP-Cat Group, Unitat de Suport a la Recerca Barcelona, Fundaci\u00f3 Institut Universitari per a la recerca a l\u2019Atenci\u00f3 Prim\u00e0ria de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona 08006, Spain"},{"name":"Faculty of Medicine, University of Vic \u2013 Central University of Catalonia (UVic\/UCC), Vic 08500, Spain"},{"name":"Center for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona 08907, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2021,10,10]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.","volume":"35","author":"Hsu","year":"2004","journal-title":"N Engl J Med"},{"key":"2","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1159\/000321845","article-title":"Lipid disorders and their relevance to outcomes in chronic kidney disease.","volume":"3","author":"Norris","year":"2011","journal-title":"Blood Purif"},{"key":"3","doi-asserted-by":"publisher","first-page":"592","DOI":"10.3390\/jcm8050592","article-title":"The rs1126616 Single Nucleotide Polymorphism of the Osteopontin Gene Is Independently Associated with Cardiovascular Events in a Chronic Kidney Disease Cohort.","volume":"8","author":"Valdivielso","year":"2019","journal-title":"J Clin Med"},{"key":"4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.atherosclerosis.2018.01.011","article-title":"Combination of biomarkers of vascular calcification and sTWEAK to predict cardiovascular events in chronic kidney disease.","volume":"27","author":"Blanco-Colio","year":"2018","journal-title":"Atherosclerosis"},{"key":"5","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1007\/s00125-015-3548-1","article-title":"Blood pressure level and risk of major cardiovascular events and all-cause of mortality in patients with type 2 diabetes and renal impairment: an observational study from the Swedish National Diabetes Register.","volume":"5","author":"Svensson","year":"2015","journal-title":"Diabetologia"},{"key":"6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1476-511X-13-135","article-title":"Markers of increased cardiovascular risk in patients with chronic kidney disease.","volume":"1","author":"Rysz","year":"2014","journal-title":"Lipids Health Dis"},{"key":"7","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.2215\/CJN.10441015","article-title":"Biomarkers of Cardiovascular Disease and Mortality Risk in Patients with Advanced CKD.","volume":"1","author":"Qureshi","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"8","doi-asserted-by":"publisher","first-page":"e50","DOI":"10.1016\/j.jacc.2010.09.001","article-title":"2010 ACCF\/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines.","volume":"5","author":"Smith","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"9","doi-asserted-by":"publisher","first-page":"6151","DOI":"10.1074\/jbc.272.10.6151","article-title":"Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins.","volume":"27","author":"Aruffo","year":"1997","journal-title":"J Biol Chem"},{"key":"10","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1080\/15548627.2015.1017183","article-title":"The human CD5L\/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses.","volume":"1","author":"Sarrias","year":"2015","journal-title":"Autophagy"},{"key":"11","doi-asserted-by":"publisher","first-page":"e79670","DOI":"10.1371\/journal.pone.0079670","article-title":"The scavenger protein apoptosis inhibitor of macrophages (AIM) potentiates the antimicrobial response against Mycobacterium tuberculosis by enhancing autophagy.","volume":"8","author":"Sarrias","year":"2013","journal-title":"PLoS One"},{"key":"12","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/j.1471-4159.2009.05801.x","article-title":"CD36: a multi-modal target for acute stroke therapy.","volume":"10","author":"Kim","year":"2009","journal-title":"J Neurochem"},{"key":"13","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.atherosclerosis.2006.07.015","article-title":"Continued inhibition of atherosclerotic lesion development in long term Western diet fed CD36o\/apoEo mice.","volume":"19","author":"Febbraio","year":"2007","journal-title":"Atherosclerosis"},{"key":"14","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/cvr\/cvm093","article-title":"Absence of CD36 protects against atherosclerosis in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor A I\/II.","volume":"7","author":"Febbraio","year":"2008","journal-title":"Cardiovasc Res"},{"key":"15","doi-asserted-by":"publisher","first-page":"710","DOI":"10.3390\/jcm8050710","article-title":"Circulating Soluble CD36 is Similar in Type 1 and Type 2 Diabetes Mellitus versus Non-Diabetic Subjects.","volume":"8","author":"Mauricio","year":"2019","journal-title":"J Clin Med"},{"key":"16","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1189\/jlb.1212660","article-title":"Human scavenger protein AIM increases foam cell formation and CD36-mediated oxLDL uptake.","volume":"9","author":"Sarrias","year":"2014","journal-title":"J Leukoc Biol"},{"key":"17","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.1253\/circj.cj-11-0891","article-title":"AIMing at metabolic syndrome. -Towards the development of novel therapies for metabolic diseases via apoptosis inhibitor of macrophage (AIM).-.","volume":"7","author":"Arai","year":"2011","journal-title":"Circ J"},{"key":"18","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.2337\/dc10-0460","article-title":"Increased CD36 expression signals monocyte activation among patients with type 2 diabetes.","volume":"3","author":"Zager","year":"2010","journal-title":"Diabetes Care"},{"key":"19","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/j.1365-2796.2011.02442.x","article-title":"Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population.","volume":"27","author":"Beck-Nielsen","year":"2012","journal-title":"J Intern Med"},{"key":"20","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1016\/j.cca.2010.09.009","article-title":"Serum soluble CD36, assessed by a novel monoclonal antibody-based sandwich ELISA, predicts cardiovascular mortality in dialysis patients.","volume":"41","author":"Anderstam","year":"2010","journal-title":"Clin Chim Acta"},{"key":"21","doi-asserted-by":"publisher","first-page":"642","DOI":"10.3892\/br.2016.622","article-title":"Soluble cluster of differentiation 36 concentrations are not associated with cardiovascular risk factors in middle-aged subjects.","volume":"4","author":"Lincz","year":"2016","journal-title":"Biomed Rep"},{"key":"22","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.arcped.2018.01.008","article-title":"CD36 gene polymorphism and plasma sCD36 as the risk factor in higher cholesterolemia.","volume":"2","author":"Chlubek","year":"2018","journal-title":"Arch Pediatr"},{"key":"23","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.cmet.2005.02.002","article-title":"A role for the apoptosis inhibitory factor AIM\/Spalpha\/Api6 in atherosclerosis development.","volume":"1","author":"Miyazaki","year":"2005","journal-title":"Cell Metab"},{"key":"24","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1189\/jlb.3RU0215-074R","article-title":"AIM\/CD5L: a key protein in the control of immune homeostasis and inflammatory disease.","volume":"9","author":"Sarrias","year":"2015","journal-title":"J Leukoc Biol"},{"key":"25","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.cmet.2010.04.013","article-title":"Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.","volume":"1","author":"Febbraio","year":"2010","journal-title":"Cell Metab"},{"key":"26","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1097\/MOL.0b013e32832fa5c4","article-title":"Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome.","volume":"2","author":"Brown","year":"2009","journal-title":"Curr Opin Lipidol"},{"key":"27","doi-asserted-by":"publisher","first-page":"12072","DOI":"10.1073\/pnas.1101841108","article-title":"Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue.","volume":"10","author":"Miyazaki","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"28","doi-asserted-by":"publisher","first-page":"e0187894","DOI":"10.1371\/journal.pone.0187894","article-title":"Apoptosis inhibitor of macrophage depletion decreased M1 macrophage accumulation and the incidence of cardiac rupture after myocardial infarction in mice.","volume":"1","author":"Minamino","year":"2017","journal-title":"PLoS One"},{"key":"29","doi-asserted-by":"publisher","first-page":"e002863","DOI":"10.1161\/JAHA.115.002863","article-title":"Deletion of Apoptosis Inhibitor of Macrophage (AIM)\/CD5L Attenuates the Inflammatory Response and Infarct Size in Acute Myocardial Infarction.","volume":"5","author":"Node","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"30","doi-asserted-by":"publisher","first-page":"620","DOI":"10.3389\/fphys.2020.00620","article-title":"CD5L, Macrophage Apoptosis Inhibitor, Was Identified in Epicardial Fat-Secretome and Regulated by Isoproterenol From Patients With Heart Failure.","volume":"1","author":"Eiras","year":"2020","journal-title":"Front Physiol"},{"key":"31","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.jinf.2019.12.003","article-title":"Assessment of serum CD5L as a biomarker to distinguish etiology and predict mortality in adults with pneumonia.","volume":"8","author":"Cao","year":"2020","journal-title":"J Infect"},{"key":"32","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.chest.2019.04.134","article-title":"Assessment of Apoptosis Inhibitor of Macrophage\/CD5L as a Biomarker to Predict Mortality in the Critically Ill With Sepsis.","volume":"15","author":"Cao","year":"2019","journal-title":"Chest"},{"key":"33","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.healun.2019.11.004","article-title":"Plasma CD5L and non-invasive diagnosis of acute heart rejection.","volume":"3","author":"Rosell\u00f3-Llet\u00ed","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"34","doi-asserted-by":"publisher","first-page":"398","DOI":"10.3109\/00365513.2015.1031693","article-title":"Is plasma soluble CD36 associated with cardiovascular risk factors in early onset coronary artery disease patients?","volume":"7","author":"Ra\u0107","year":"2015","journal-title":"Scand J Clin Lab Invest"},{"key":"35","doi-asserted-by":"publisher","first-page":"9582","DOI":"10.26355\/eurrev_201911_19453","article-title":"Correlations of degree of coronary artery stenosis with blood lipid, CRP, Hcy, GGT, SCD36 and fibrinogen levels in elderly patients with coronary heart disease.","volume":"2","author":"Bai","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"36","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3390\/toxins10100384","article-title":"The Impact of Uremic Toxicity Induced Inflammatory Response on the Cardiovascular Burden in Chronic Kidney Disease.","volume":"1","author":"P\u00e9coits-Filho","year":"2018","journal-title":"Toxins (Basel)"},{"key":"37","doi-asserted-by":"publisher","first-page":"722","DOI":"10.3390\/nu11040722","article-title":"Lipid Accumulation and Chronic Kidney Disease.","volume":"1","author":"Wang","year":"2019","journal-title":"Nutrients"},{"key":"38","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1371\/journal.pmed.0020045","article-title":"Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy.","volume":"2","author":"B\u00f6ttinger","year":"2005","journal-title":"PLoS Med"},{"key":"39","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.3390\/jcm9061700","article-title":"The Circulating Fatty Acid Transporter Soluble CD36 Is Not Associated with Carotid Atherosclerosis in Subjects with Type 1 and Type 2 Diabetes Mellitus.","volume":"9","author":"Mauricio","year":"2020","journal-title":"J Clin Med"},{"key":"40","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1515\/cclm-2011-0950","article-title":"Lack of consistency between two commercial ELISAs and against an in-house ELISA for the detection of CD36 in human plasma.","volume":"5","author":"Handberg","year":"2012","journal-title":"Clin Chem Lab Med"},{"key":"41","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.2337\/dc06-0248","article-title":"Glomerular filtration rate, cardiorenal end points, and all-cause mortality in type 2 diabetic patients.","volume":"2","author":"Tong","year":"2006","journal-title":"Diabetes Care"},{"key":"42","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1681\/ASN.2012070718","article-title":"Kidney disease and increased mortality risk in type 2 diabetes.","volume":"2","author":"de Boer","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"43","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1471-2369-10-17","article-title":"Age-related associations of hypertension and diabetes mellitus with chronic kidney disease.","volume":"1","author":"Muntner","year":"2009","journal-title":"BMC Nephrol"},{"key":"44","doi-asserted-by":"publisher","first-page":"120","DOI":"10.2337\/diacare.2.2.120","article-title":"Diabetes and glucose tolerance as risk factors for cardiovascular disease: the Framingham study.","volume":"2","author":"McGee","year":"1979","journal-title":"Diabetes Care"},{"key":"45","doi-asserted-by":"publisher","first-page":"e0186665","DOI":"10.1371\/journal.pone.0186665","article-title":"Factors predicting cardiovascular events in chronic kidney disease patients. Role of subclinical atheromatosis extent assessed by vascular ultrasound.","volume":"1","author":"Fernandez","year":"2017","journal-title":"PLoS One"},{"key":"46","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12933-019-0897-y","article-title":"Subclinical atherosclerosis burden predicts cardiovascular events in individuals with diabetes and chronic kidney disease.","volume":"1","author":"Mauricio","year":"2019","journal-title":"Cardiovasc Diabetol"},{"key":"47","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1471-2369-11-14","article-title":"Predicting cardiovascular disease morbidity and mortality in chronic kidney disease in Spain.","volume":"1","author":"Fern\u00e1ndez","year":"2010","journal-title":"The rationale and design of NEFRONA: a prospective, multicenter, observational cohort study. BMC Nephrol"},{"key":"48","doi-asserted-by":"publisher","first-page":"287","DOI":"10.2215\/CJN.01240215","article-title":"Predictors of Subclinical Atheromatosis Progression over 2 Years in Patients with Different Stages of CKD.","volume":"1","author":"Valdivielso","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"49","doi-asserted-by":"publisher","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation.","volume":"13","author":"Roth","year":"1999","journal-title":"Modification of Diet in Renal Disease Study Group. Ann Intern Med"},{"key":"50","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.atherosclerosis.2018.07.018","article-title":"Prevalence and progression of subclinical atherosclerosis in patients with chronic kidney disease and diabetes.","volume":"27","author":"Mauricio","year":"2018","journal-title":"Atherosclerosis"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T10:48:23Z","timestamp":1634813303000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,10]]},"references-count":50,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2021,10,15]]}},"alternative-id":["203615","34629330"],"URL":"https:\/\/doi.org\/10.18632\/aging.203615","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,10]]}}}