{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:42:27Z","timestamp":1777387347352,"version":"3.51.4"},"reference-count":36,"publisher":"Impact Journals, LLC","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,10,31]]},"DOI":"10.18632\/aging.203646","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T01:32:21Z","timestamp":1635039141000},"page":"23739-23756","source":"Crossref","is-referenced-by-count":24,"title":["Loganin substantially ameliorates molecular deficits, pathologies and cognitive impairment in a mouse model of Alzheimer\u2019s disease"],"prefix":"10.18632","volume":"13","author":[{"given":"Lulin","family":"Nie","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020\u20132024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiwu","family":"He","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020\u20132024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China"},{"name":"School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengzhu","family":"Xie","sequence":"additional","affiliation":[{"name":"Shenzhen Center for Chronic Disease Control and Prevention, Shenzhen 518020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shifeng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shupeng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020\u20132024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China"},{"name":"Department of Pathophysiology, Guangzhou Medical University, Guangzhou 510182, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020\u20132024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China"},{"name":"College of Public Health, University of South China, Hengyang 421001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020\u20132024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020\u20132024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020\u20132024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangyu","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shenzhen People\u2019s Hospital, Second Clinical College, Jinan University, Shenzhen 518020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xifei","family":"Yang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020\u20132024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2021,10,23]]},"reference":[{"key":"1","first-page":"1","article-title":"World Alzheimer Report 2018. The state of the art of dementia research: New frontiers.","author":"Patterson","year":"2018","journal-title":"Alzheimer\u2019s Disease International"},{"key":"2","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","article-title":"Amyloid-\u03b2 and tau: the trigger and bullet in Alzheimer disease pathogenesis.","volume":"7","author":"Bloom","year":"2014","journal-title":"JAMA Neurol"},{"key":"3","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.tins.2017.04.002","article-title":"Synaptic Impairment in Alzheimer\u2019s Disease: A Dysregulated Symphony.","volume":"4","author":"LaFerla","year":"2017","journal-title":"Trends Neurosci"},{"key":"4","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease.","volume":"1","author":"Finsen","year":"2015","journal-title":"Lancet Neurol"},{"key":"5","doi-asserted-by":"publisher","first-page":"7403","DOI":"10.3390\/molecules15107403","article-title":"The pharmacological effects of morroniside and loganin isolated from Liuweidihuang Wan, on MC3T3-E1 cells.","volume":"1","author":"Wang","year":"2010","journal-title":"Molecules"},{"key":"6","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1002\/jcb.25749","article-title":"Unexpected Neuroprotective Effects of Loganin on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurotoxicity and Cell Death in Zebrafish.","volume":"11","author":"Shen","year":"2017","journal-title":"J Cell Biochem"},{"key":"7","doi-asserted-by":"publisher","first-page":"3495","DOI":"10.1002\/jcb.26010","article-title":"Neuroprotective Effects of Loganin on MPTP-Induced Parkinson\u2019s Disease Mice: Neurochemistry, Glial Reaction and Autophagy Studies.","volume":"11","author":"Shen","year":"2017","journal-title":"J Cell Biochem"},{"key":"8","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.ejphar.2015.09.019","article-title":"Loganin protects against pancreatitis by inhibiting NF-\u03baB activation.","volume":"76","author":"Park","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"9","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1002\/cbin.11060","article-title":"Loganin prevents BV-2 microglia cells from A\u03b2-induced inflammation via regulating TLR4\/TRAF6\/NF-\u03baB axis.","volume":"4","author":"Liu","year":"2018","journal-title":"Cell Biol Int"},{"key":"10","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1039\/c5fo00055f","article-title":"Neuroprotective effect of loganin against A\u03b225-35-induced injury via the NF-\u03baB-dependent signaling pathway in PC12 cells.","volume":"6","author":"Jun","year":"2015","journal-title":"Food Funct"},{"key":"11","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.physbeh.2016.12.043","article-title":"Loganin enhances long-term potentiation and recovers scopolamine-induced learning and memory impairments.","volume":"17","author":"Park","year":"2017","journal-title":"Physiol Behav"},{"key":"12","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ejphar.2009.06.062","article-title":"Loganin improves learning and memory impairments induced by scopolamine in mice.","volume":"61","author":"Jang","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"13","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/978-1-4939-7231-9_17","article-title":"2D-DIGE in Proteomics.","volume":"165","author":"Renaut","year":"2017","journal-title":"Methods Mol Biol"},{"key":"14","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jalz.2016.11.007","article-title":"Recent publications from the Alzheimer\u2019s Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials.","volume":"1","author":"Shaw","year":"2017","journal-title":"Alzheimers Dement"},{"key":"15","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1556\/2060.105.2018.1.8","article-title":"Impact of loganin on pro-inflammatory cytokines and depression- and anxiety-like behaviors in male diabetic rats.","volume":"10","author":"Babri","year":"2018","journal-title":"Physiol Int"},{"key":"16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.5681\/apb.2013.015","article-title":"Effect of Acute Administration of loganin on Spatial Memory in Diabetic Male Rats.","volume":"3","author":"Mohaddes","year":"2013","journal-title":"Adv Pharm Bull"},{"key":"17","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/B978-0-12-802395-2.00023-7","article-title":"Alzheimer disease.","volume":"14","author":"Duyckaerts","year":"2017","journal-title":"Handb Clin Neurol"},{"key":"18","doi-asserted-by":"publisher","first-page":"491","DOI":"10.3892\/mmr.2015.4496","article-title":"Catalpol preserves neural function and attenuates the pathology of Alzheimer\u2019s disease in mice.","volume":"1","author":"Hua","year":"2016","journal-title":"Mol Med Rep"},{"key":"19","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/bpa.12116","article-title":"Geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via GSK3\u03b2 pathway in streptozotocin-induced Alzheimer rat model.","volume":"2","author":"Li","year":"2014","journal-title":"Brain Pathol"},{"key":"20","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ejmech.2019.03.009","article-title":"Therapeutic potentials of plant iridoids in Alzheimer\u2019s and Parkinson\u2019s diseases: A review.","volume":"16","author":"Dinda","year":"2019","journal-title":"Eur J Med Chem"},{"key":"21","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1080\/14786419.2012.718774","article-title":"\u03b2-Secretase (BACE1) inhibitory property of loganin isolated from Corni fructus.","volume":"2","author":"Jun","year":"2013","journal-title":"Nat Prod Res"},{"key":"22","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.1749-6632.2000.tb06370.x","article-title":"Inherent abnormalities in energy metabolism in Alzheimer disease. Interaction with cerebrovascular compromise.","volume":"90","author":"Gibson","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"23","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2016.04.200","article-title":"Energy metabolism and inflammation in brain aging and Alzheimer\u2019s disease.","volume":"10","author":"Cadenas","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"24","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neuroscience.2017.06.034","article-title":"Newly Developed Drugs for Alzheimer\u2019s Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission.","volume":"37","author":"Hroudov\u00e1","year":"2018","journal-title":"Neuroscience"},{"key":"25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.ejmech.2019.01.085","article-title":"Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment.","volume":"16","author":"Zhou","year":"2019","journal-title":"Eur J Med Chem"},{"key":"26","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1111\/j.1471-4159.2009.06397.x","article-title":"Multifunctional roles of enolase in Alzheimer\u2019s disease brain: beyond altered glucose metabolism.","volume":"11","author":"Lange","year":"2009","journal-title":"J Neurochem"},{"key":"27","doi-asserted-by":"publisher","first-page":"156795","DOI":"10.1155\/2012\/156795","article-title":"\u03b1-Enolase, a multifunctional protein: its role on pathophysiological situations.","volume":"201","author":"L\u00f3pez-Alemany","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"28","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1007\/s12035-014-9053-6","article-title":"Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer\u2019s Disease: Understanding the Therapeutics Strategies.","volume":"5","author":"Tyagi","year":"2016","journal-title":"Mol Neurobiol"},{"key":"29","doi-asserted-by":"publisher","first-page":"E4648","DOI":"10.1073\/pnas.1704698114","article-title":"Selective lowering of synapsins induced by oligomeric \u03b1-synuclein exacerbates memory deficits.","volume":"11","author":"Lesn\u00e9","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"30","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s00204-018-2163-6","article-title":"Proteomic alterations of brain subcellular organelles caused by low-dose copper exposure: implication for Alzheimer\u2019s disease.","volume":"9","author":"Yang","year":"2018","journal-title":"Arch Toxicol"},{"key":"31","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.nbd.2018.02.006","article-title":"Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age.","volume":"11","author":"Honer","year":"2018","journal-title":"Neurobiol Dis"},{"key":"32","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/s0092-8674(01)00192-1","article-title":"Complexins regulate a late step in Ca-dependent neurotransmitter release.","volume":"10","author":"Rosenmund","year":"2001","journal-title":"Cell"},{"key":"33","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.jalz.2016.02.010","article-title":"Neuroinflammation in Alzheimer\u2019s disease: Current evidence and future directions.","volume":"1","author":"Edison","year":"2016","journal-title":"Alzheimers Dement"},{"key":"34","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1159\/000008054","article-title":"The 14-3-3 protein detectable in the cerebrospinal fluid of patients with prion-unrelated neurological diseases is expressed constitutively in neurons and glial cells in culture.","volume":"4","author":"Kuroda","year":"1999","journal-title":"Eur Neurol"},{"key":"35","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s12035-019-01754-y","article-title":"Downregulation of 14-3-3 Proteins in Alzheimer\u2019s Disease.","volume":"5","author":"Sarkar","year":"2020","journal-title":"Mol Neurobiol"},{"key":"36","doi-asserted-by":"publisher","first-page":"6473506","DOI":"10.1155\/2017\/6473506","article-title":"Ginsenoside Rg1 Ameliorates Behavioral Abnormalities and Modulates the Hippocampal Proteomic Change in Triple Transgenic Mice of Alzheimer\u2019s Disease.","volume":"201","author":"Yang","year":"2017","journal-title":"Oxid Med Cell Longev"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T14:57:56Z","timestamp":1636124276000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,23]]},"references-count":36,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2021,10,31]]}},"alternative-id":["203646","34689137"],"URL":"https:\/\/doi.org\/10.18632\/aging.203646","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,23]]}}}