{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:03:03Z","timestamp":1768482183618,"version":"3.49.0"},"reference-count":42,"publisher":"Impact Journals, LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2022,1,15]]},"DOI":"10.18632\/aging.203768","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:51:30Z","timestamp":1641343890000},"page":"286-296","source":"Crossref","is-referenced-by-count":8,"title":["Yes-associated protein reacts differently in vascular smooth muscle cells under different intensities of mechanical stretch"],"prefix":"10.18632","volume":"14","author":[{"given":"Xinhao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangdang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lujun","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoqun","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanzhong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yigong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanshe","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Instrument Science and Optoelectronic Engineering, Beihang University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1161\/01.CIR.0000154569.08857.7A","article-title":"Thoracic and abdominal aortic aneurysms.","volume":"11","author":"Isselbacher","year":"2005","journal-title":"Circulation"},{"key":"2","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1161\/CIRCULATIONAHA.104.511717","article-title":"Hyperplastic cellular remodeling of the media in ascending thoracic aortic aneurysms.","volume":"11","author":"Tellides","year":"2005","journal-title":"Circulation"},{"key":"3","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.ajhg.2009.04.007","article-title":"Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease.","volume":"8","author":"Dalman","year":"2009","journal-title":"Am J Hum Genet"},{"key":"4","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1093\/cvr\/cvs274","article-title":"Cyclic stretch-induced thrombin generation by rat vascular smooth muscle cells is mediated by the integrin \u03b1v\u03b23 pathway.","volume":"9","author":"Lacolley","year":"2012","journal-title":"Cardiovasc Res"},{"key":"5","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1039\/c2lc20896b","article-title":"A silicone-based stretchable micropost array membrane for monitoring live-cell subcellular cytoskeletal response.","volume":"1","author":"Fu","year":"2012","journal-title":"Lab Chip"},{"key":"6","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/nature10316","article-title":"Dynamic molecular processes mediate cellular mechanotransduction.","volume":"47","author":"Schwartz","year":"2011","journal-title":"Nature"},{"key":"7","doi-asserted-by":"publisher","first-page":"40","DOI":"10.7555\/JBR.28.20130130","article-title":"Mechanisms simultaneously regulate smooth muscle proliferation and differentiation.","volume":"2","author":"Chen","year":"2014","journal-title":"J Biomed Res"},{"key":"8","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.yjmcc.2014.11.003","article-title":"Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-\u03b2 signaling.","volume":"7","author":"Hardiman","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"9","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.3892\/mmr.2014.2984","article-title":"Cyclic stretch induces human bladder smooth muscle cell proliferationthrough muscarinic receptors.","volume":"1","author":"Wang","year":"2015","journal-title":"Mol Med Rep"},{"key":"10","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1007\/s10753-017-0653-y","article-title":"Biomechanical Stretch Induces Inflammation, Proliferation, and Migration by Activating NFAT5 in Arterial Smooth Muscle Cells.","volume":"4","author":"Yu","year":"2017","journal-title":"Inflammation"},{"key":"11","doi-asserted-by":"publisher","first-page":"e13346","DOI":"10.14814\/phy2.13346","article-title":"Pressure and stretch differentially affect proliferation of renal proximal tubular cells.","volume":"5","author":"N\u00f8rregaard","year":"2017","journal-title":"Physiol Rep"},{"key":"12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13221-015-0032-0","article-title":"Variability in vascular smooth muscle cell stretch-induced responses in 2D culture.","volume":"7","author":"Verma","year":"2015","journal-title":"Vasc Cell"},{"key":"13","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.tcb.2015.05.002","article-title":"YAP and TAZ: a nexus for Hippo signaling and beyond.","volume":"2","author":"Guan","year":"2015","journal-title":"Trends Cell Biol"},{"key":"14","doi-asserted-by":"publisher","first-page":"3907","DOI":"10.1242\/dev.070987","article-title":"Hippo pathway regulation by cell morphology and stress fibers.","volume":"13","author":"Sasaki","year":"2011","journal-title":"Development"},{"key":"15","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/nrm3416","article-title":"Transduction of mechanical and cytoskeletal cues by YAP and TAZ.","volume":"1","author":"Piccolo","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"16","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1016\/j.cub.2014.07.034","article-title":"Regulation of YAP by mechanical strain through Jnk and Hippo signaling.","volume":"2","author":"Irvine","year":"2014","journal-title":"Curr Biol"},{"key":"17","doi-asserted-by":"publisher","first-page":"E507","DOI":"10.21037\/jtd.2017.03.179","article-title":"The emerging role of YAP\/TAZ in mechanotransduction.","volume":"9","author":"Krams","year":"2017","journal-title":"J Thorac Dis"},{"key":"18","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/nrc2070","article-title":"The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network.","volume":"7","author":"Tapon","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"19","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.devcel.2010.09.011","article-title":"The hippo signaling pathway in development and cancer.","volume":"1","author":"Pan","year":"2010","journal-title":"Dev Cell"},{"key":"20","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1101\/gad.1909210","article-title":"The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.","volume":"2","author":"Guan","year":"2010","journal-title":"Genes Dev"},{"key":"21","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction.","volume":"47","author":"Piccolo","year":"2011","journal-title":"Nature"},{"key":"22","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1093\/abbs\/gmu109","article-title":"Hippo signaling in stress response and homeostasis maintenance.","volume":"4","author":"Yuan","year":"2015","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"23","doi-asserted-by":"publisher","first-page":"3957","DOI":"10.1242\/dev.157917","article-title":"Rho differentially regulates the Hippo pathway by modulating the interaction between Amot and Nf2 in the blastocyst.","volume":"14","author":"Chen","year":"2017","journal-title":"Development"},{"key":"24","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.ydbio.2014.06.023","article-title":"Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst.","volume":"39","author":"Alarcon","year":"2014","journal-title":"Dev Biol"},{"key":"25","doi-asserted-by":"publisher","first-page":"314395","DOI":"10.1155\/2012\/314395","article-title":"Inhibitory Effect of Ginsenoside Rg1 on Vascular Smooth Muscle Cell Proliferation Induced by PDGF-BB Is Involved in Nitric Oxide Formation.","volume":"201","author":"Huang","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"key":"26","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1161\/CIRCRESAHA.110.221846","article-title":"Short communication: vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging.","volume":"10","author":"Vatner","year":"2010","journal-title":"Circ Res"},{"key":"27","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1093\/cvr\/cvs135","article-title":"The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles.","volume":"9","author":"Michel","year":"2012","journal-title":"Cardiovasc Res"},{"key":"28","doi-asserted-by":"publisher","first-page":"6333","DOI":"10.1038\/ncomms7333","article-title":"Cyclic stretching of soft substrates induces spreading and growth.","volume":"6","author":"Sheetz","year":"2015","journal-title":"Nat Commun"},{"key":"29","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s12079-015-0305-7","article-title":"Signs of stress on soft surfaces : A commentary on: Cui, Y., F.M. Hameed, B. Yang, K. Lee, C.Q. Pan, S. Park, and M. Sheetz. 2015. Cyclic stretching of soft substrates induces spreading and growth. Nat Commun. 6:6333.","volume":"9","author":"Hinz","year":"2015","journal-title":"J Cell Commun Signal"},{"key":"30","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1007\/s00424-017-2025-8","article-title":"Stressed podocytes-mechanical forces, sensors, signaling and response.","volume":"46","author":"Endlich","year":"2017","journal-title":"Pflugers Arch"},{"key":"31","first-page":"4632","article-title":"YAP1 up-regulation inhibits apoptosis of aortic dissection vascular smooth muscle cells.","volume":"2","author":"Zhang","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"32","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/s0092-8674(03)00557-9","article-title":"The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.","volume":"11","author":"Hariharan","year":"2003","journal-title":"Cell"},{"key":"33","doi-asserted-by":"publisher","first-page":"e36562","DOI":"10.1371\/journal.pone.0036562","article-title":"Regulation of neuronal cell death by c-Abl-Hippo\/MST2 signaling pathway.","volume":"7","author":"Yuan","year":"2012","journal-title":"PLoS One"},{"key":"34","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.1158\/0008-5472.CAN-12-3793","article-title":"YAP\/TEAD-mediated transcription controls cellular senescence.","volume":"7","author":"Yuan","year":"2013","journal-title":"Cancer Res"},{"key":"35","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1111\/cas.13138","article-title":"Verteporfin suppresses cell survival, angiogenesis and vasculogenic mimicry of pancreatic ductal adenocarcinoma via disrupting the YAP-TEAD complex.","volume":"10","author":"Li","year":"2017","journal-title":"Cancer Sci"},{"key":"36","doi-asserted-by":"publisher","first-page":"12039","DOI":"10.1523\/JNEUROSCI.0486-14.2014","article-title":"BMP2-SMAD signaling represses the proliferation of embryonic neural stem cells through YAP.","volume":"3","author":"Yuan","year":"2014","journal-title":"J Neurosci"},{"key":"37","doi-asserted-by":"publisher","first-page":"5117","DOI":"10.1038\/onc.2012.5","article-title":"YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes.","volume":"3","author":"Sekido","year":"2012","journal-title":"Oncogene"},{"key":"38","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/cdd.2011.87","article-title":"Transcription factor TEAD4 regulates expression of myogenin and the unfolded protein response genes during C2C12 cell differentiation.","volume":"1","author":"Davidson","year":"2012","journal-title":"Cell Death Differ"},{"key":"39","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1167\/iovs.12-11007","article-title":"Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ.","volume":"5","author":"Russell","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"40","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.exer.2013.05.014","article-title":"Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells.","volume":"11","author":"Russell","year":"2013","journal-title":"Exp Eye Res"},{"key":"41","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","article-title":"Matrix crosslinking forces tumor progression by enhancing integrin signaling.","volume":"13","author":"Weaver","year":"2009","journal-title":"Cell"},{"key":"42","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix elasticity directs stem cell lineage specification.","volume":"12","author":"Discher","year":"2006","journal-title":"Cell"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T23:13:45Z","timestamp":1642720425000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,4]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1,15]]}},"alternative-id":["203768","34983026"],"URL":"https:\/\/doi.org\/10.18632\/aging.203768","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,4]]}}}