{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T18:18:25Z","timestamp":1782584305828,"version":"3.54.5"},"reference-count":54,"publisher":"Impact Journals, LLC","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2021,12,31]]},"DOI":"10.18632\/aging.203778","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T18:36:19Z","timestamp":1639593379000},"page":"25903-25919","source":"Crossref","is-referenced-by-count":30,"title":["METTL14 benefits the mesenchymal stem cells in patients with steroid-associated osteonecrosis of the femoral head by regulating the m6A level of PTPN6"],"prefix":"10.18632","volume":"13","author":[{"given":"Cheng","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Henan Provincial People\u2032s Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Mini-invasive Spinal Surgery, Third Hospital of Henan Province, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Henan Provincial People\u2032s Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Henan Provincial People\u2032s Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Henan Provincial People\u2032s Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Henan Provincial People\u2032s Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1182\/blood-2015-05-643601","article-title":"Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia","volume":"12","author":"Carroll","year":"2015","journal-title":"Blood"},{"key":"2","doi-asserted-by":"publisher","first-page":"226","DOI":"10.12659\/msm.897044","article-title":"Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoblasts and Adipocytes and its Role in Treatment of Osteoporosis","volume":"2","author":"Wang","year":"2016","journal-title":"Med Sci Monit"},{"key":"3","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1038\/cdd.2015.168","article-title":"Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?","volume":"2","author":"Yang","year":"2016","journal-title":"Cell Death Differ"},{"key":"4","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jdermsci.2016.11.005","article-title":"Mesenchymal stem cells: The roles and functions in cutaneous wound healing and tumor growth","volume":"8","author":"Ishikawa","year":"2017","journal-title":"J Dermatol Sci"},{"key":"5","doi-asserted-by":"publisher","first-page":"937","DOI":"10.3727\/096368915X690288","article-title":"Mesenchymal Stem Cells and Their Clinical Applications in Osteoarthritis","volume":"2","author":"Ding","year":"2016","journal-title":"Cell Transplant"},{"key":"6","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1172\/JCI70050","article-title":"Bone marrow mesenchymal stem cells and TGF-\u03b2 signaling in bone remodeling","volume":"12","author":"Cao","year":"2014","journal-title":"J Clin Invest"},{"key":"7","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1007\/s00264-013-2059-2","article-title":"Role of mesenchymal stem cells in bone regeneration and fracture repair: a review","volume":"3","author":"Lu","year":"2013","journal-title":"Int Orthop"},{"key":"8","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1615\/CritRevEukaryotGeneExpr.2018023572","article-title":"Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells: Characterization, Differentiation, and Applications in Cartilage Tissue Engineering","volume":"2","author":"Xian","year":"2018","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"9","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1186\/s13287-019-1498-0","article-title":"The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor","volume":"1","author":"Xu","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"10","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1016\/j.biopha.2018.10.166","article-title":"MiR-217 promotes cell proliferation and osteogenic differentiation of BMSCs by targeting DKK1 in steroid-associated osteonecrosis","volume":"10","author":"Sun","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"11","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/s41419-020-2238-1","article-title":"P53 and Parkin co-regulate mitophagy in bone marrow mesenchymal stem cells to promote the repair of early steroid-induced osteonecrosis of the femoral head","volume":"1","author":"Xie","year":"2020","journal-title":"Cell Death Dis"},{"key":"12","doi-asserted-by":"publisher","first-page":"22599","DOI":"10.1038\/srep22599","article-title":"MiR-708 promotes steroid-induced osteonecrosis of femoral head, suppresses osteogenic differentiation by targeting SMAD3","volume":"6","author":"Feng","year":"2016","journal-title":"Sci Rep"},{"key":"13","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.yexmp.2012.06.003","article-title":"G-CSF\/SCF exert beneficial effects via anti-apoptosis in rabbits with steroid-associated osteonecrosis","volume":"9","author":"Liu","year":"2013","journal-title":"Exp Mol Pathol"},{"key":"14","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s00198-014-2809-z","article-title":"Icariin may benefit the mesenchymal stem cells of patients with steroid-associated osteonecrosis by ABCB1-promoter demethylation: a preliminary study","volume":"2","author":"Ye","year":"2015","journal-title":"Osteoporos Int"},{"key":"15","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nrm.2016.132","article-title":"Post-transcriptional gene regulation by mRNA modifications","volume":"1","author":"He","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"16","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1101\/gad.262766.115","article-title":"RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation","volume":"2","author":"He","year":"2015","journal-title":"Genes Dev"},{"key":"17","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1146\/annurev-cellbio-100616-060758","article-title":"Rethinking mA Readers, Writers, and Erasers","volume":"3","author":"Jaffrey","year":"2017","journal-title":"Annu Rev Cell Dev Biol"},{"key":"18","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.bbagrm.2018.10.014","article-title":"Mechanistic insights into mA RNA enzymes","volume":"186","author":"Roignant","year":"2019","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"key":"19","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s12943-019-1033-z","article-title":"The role of mA RNA methylation in human cancer","volume":"1","author":"Zhu","year":"2019","journal-title":"Mol Cancer"},{"key":"20","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.cell.2017.05.045","article-title":"Dynamic RNA Modifications in Gene Expression Regulation","volume":"16","author":"He","year":"2017","journal-title":"Cell"},{"key":"21","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrg3724","article-title":"Gene expression regulation mediated through reversible mA RNA methylation","volume":"1","author":"He","year":"2014","journal-title":"Nat Rev Genet"},{"key":"22","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency","volume":"16","author":"He","year":"2015","journal-title":"Cell"},{"key":"23","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1111\/jcmm.13491","article-title":"METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells","volume":"2","author":"Xu","year":"2018","journal-title":"J Cell Mol Med"},{"key":"24","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature12730","article-title":"N6-methyladenosine-dependent regulation of messenger RNA stability","volume":"50","author":"He","year":"2014","journal-title":"Nature"},{"key":"25","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/jnc.14481","article-title":"The m6A-epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity","volume":"14","author":"Anggono","year":"2018","journal-title":"J Neurochem"},{"key":"26","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s12943-018-0847-4","article-title":"Novel insights on mA RNA methylation in tumorigenesis: a double-edged sword","volume":"1","author":"Jia","year":"2018","journal-title":"Mol Cancer"},{"key":"27","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1002\/jcb.25967","article-title":"Regulatory Role of N-methyladenosine (mA) Methylation in RNA Processing and Human Diseases","volume":"11","author":"Ji","year":"2017","journal-title":"J Cell Biochem"},{"key":"28","doi-asserted-by":"publisher","first-page":"4772","DOI":"10.1038\/s41467-018-06898-4","article-title":"Mettl3-mediated mA RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis","volume":"9","author":"Ye","year":"2018","journal-title":"Nat Commun"},{"key":"29","doi-asserted-by":"publisher","first-page":"23361","DOI":"10.18632\/aging.203630","article-title":"piRNA-36741 regulates BMP2-mediated osteoblast differentiation via METTL3 controlled m6A modification","volume":"1","author":"Du","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"30","doi-asserted-by":"publisher","first-page":"5373","DOI":"10.1038\/s41467-021-25710-4","article-title":"TNF-\u03b1-mediated mA modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis","volume":"1","author":"Ye","year":"2021","journal-title":"Nat Commun"},{"key":"31","doi-asserted-by":"publisher","first-page":"21134","DOI":"10.18632\/aging.203377","article-title":"RNA N6-methyladenosine demethylase FTO promotes osteoporosis through demethylating Runx2 mRNA and inhibiting osteogenic differentiation","volume":"1","author":"Wang","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"32","doi-asserted-by":"publisher","first-page":"4029","DOI":"10.1007\/s00018-012-1067-5","article-title":"The tyrosine phosphatase SHP-1 negatively regulates cytotrophoblast proliferation in first-trimester human placenta by modulating EGFR activation","volume":"6","author":"Westwood","year":"2012","journal-title":"Cell Mol Life Sci"},{"key":"33","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12989-017-0234-0","article-title":"Suppression of PTPN6 exacerbates aluminum oxide nanoparticle-induced COPD-like lesions in mice through activation of STAT pathway","volume":"1","author":"Chen","year":"2017","journal-title":"Part Fibre Toxicol"},{"key":"34","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1002\/hep.26957","article-title":"Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPAR\u03b3","volume":"5","author":"Siminovitch","year":"2014","journal-title":"Hepatology"},{"key":"35","doi-asserted-by":"publisher","first-page":"5525","DOI":"10.3390\/ijms20225525","article-title":"The Regulation of Bone Metabolism and Disorders by Wnt Signaling","volume":"2","author":"Marumo","year":"2019","journal-title":"Int J Mol Sci"},{"key":"36","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1111\/joim.12368","article-title":"The WNT system: background and its role in bone","volume":"27","author":"Ohlsson","year":"2015","journal-title":"J Intern Med"},{"key":"37","doi-asserted-by":"publisher","first-page":"303","DOI":"10.14670\/HH-18-062","article-title":"Wnt signaling in physiological and pathological bone formation","volume":"3","author":"Kan","year":"2019","journal-title":"Histol Histopathol"},{"key":"38","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s13287-018-1018-7","article-title":"Stem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research","volume":"9","author":"Peng","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"39","doi-asserted-by":"publisher","first-page":"922","DOI":"10.3389\/fimmu.2019.00922","article-title":"A Review in Research Progress Concerning m6A Methylation and Immunoregulation","volume":"1","author":"Zhou","year":"2019","journal-title":"Front Immunol"},{"key":"40","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.stem.2017.11.016","article-title":"METTL14 Inhibits Hematopoietic Stem\/Progenitor Differentiation and Promotes Leukemogenesis via mRNA mA Modification","volume":"2","author":"Wunderlich","year":"2018","journal-title":"Cell Stem Cell"},{"key":"41","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1002\/hep.28885","article-title":"METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N-methyladenosine-dependent primary MicroRNA processing","volume":"6","author":"Sun","year":"2017","journal-title":"Hepatology"},{"key":"42","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2174\/187152011794941154","article-title":"SHP-1 in cell-cycle regulation","volume":"1","author":"Col\u00e1s","year":"2011","journal-title":"Anticancer Agents Med Chem"},{"key":"43","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.4049\/jimmunol.1200551","article-title":"Deficiency in hematopoietic phosphatase ptpn6\/Shp1 hyperactivates the innate immune system and impairs control of bacterial infections in zebrafish embryos","volume":"19","author":"Meijer","year":"2013","journal-title":"J Immunol"},{"key":"44","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.4049\/jimmunol.0901972","article-title":"SHP-1 deficient mast cells are hyperresponsive to stimulation and critical in initiating allergic inflammation in the lung","volume":"18","author":"Zhu","year":"2010","journal-title":"J Immunol"},{"key":"45","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1016\/j.celrep.2016.10.069","article-title":"SHP1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Differentiation","volume":"1","author":"Cao","year":"2016","journal-title":"Cell Rep"},{"key":"46","doi-asserted-by":"publisher","first-page":"dev146589","DOI":"10.1242\/dev.146589","article-title":"Wnt signaling in development and tissue homeostasis","volume":"14","author":"Angers","year":"2018","journal-title":"Development"},{"key":"47","doi-asserted-by":"publisher","first-page":"379","DOI":"10.2741\/4214","article-title":"Wnt and the Wnt signaling pathway in bone development and disease","volume":"1","author":"Chen","year":"2014","journal-title":"Front Biosci (Landmark Ed)"},{"key":"48","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"1","author":"He","year":"2009","journal-title":"Dev Cell"},{"key":"49","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/\u03b2-catenin signaling and disease","volume":"14","author":"Nusse","year":"2012","journal-title":"Cell"},{"key":"50","doi-asserted-by":"publisher","first-page":"216","DOI":"10.2174\/1574888x10666150519093429","article-title":"PPAR\u03b3 and Wnt Signaling in Adipogenic and Osteogenic Differentiation of Mesenchymal Stem Cells","volume":"1","author":"Xiao","year":"2016","journal-title":"Curr Stem Cell Res Ther"},{"key":"51","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s11914-014-0197-0","article-title":"The role of Wnt signaling and sclerostin in the pathogenesis of glucocorticoid-induced osteoporosis","volume":"1","author":"Peris","year":"2014","journal-title":"Curr Osteoporos Rep"},{"key":"52","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.fct.2013.02.003","article-title":"Dexamethasone alters epithelium proliferation and survival and suppresses Wnt\/\u03b2-catenin signaling in developing cleft palate","volume":"5","author":"Lu","year":"2013","journal-title":"Food Chem Toxicol"},{"key":"53","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.biocel.2011.11.013","article-title":"PPAR\u03b3 suppression inhibits adipogenesis but does not promote osteogenesis of human mesenchymal stem cells","volume":"4","author":"Xiang","year":"2012","journal-title":"Int J Biochem Cell Biol"},{"key":"54","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s12943-019-1053-8","article-title":"WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1","volume":"1","author":"Zheng","year":"2019","journal-title":"Mol Cancer"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T18:28:25Z","timestamp":1641407305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,15]]},"references-count":54,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2021,12,31]]}},"alternative-id":["203778","34910686"],"URL":"https:\/\/doi.org\/10.18632\/aging.203778","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,15]]}}}