{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:14:42Z","timestamp":1791465282148,"version":"4.3.4"},"reference-count":102,"publisher":"Impact Journals, LLC","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2022,2,15]]},"DOI":"10.18632\/aging.203880","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T15:21:06Z","timestamp":1644247266000},"page":"1549-1561","source":"Crossref","is-referenced-by-count":60,"title":["Cholesterol metabolism in aging simultaneously altered in liver and nervous system"],"prefix":"10.18632","volume":"14","author":[{"given":"Val\u00e9ria Sutti","family":"Nunes","sequence":"first","affiliation":[{"name":"Laboratorio de Lipides (LIM10), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Bazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"da Silva Ferreira","sequence":"additional","affiliation":[{"name":"Laboratorio de Lipides (LIM10), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Bazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eder Carlos Rocha","family":"Quint\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratorio de Lipides (LIM10), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Bazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.arr.2014.12.001","article-title":"Aging and dyslipidemia: a review of potential mechanisms.","volume":"1","author":"Li","year":"2015","journal-title":"Ageing Res Rev"},{"key":"2","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3109\/07853890.2010.546363","article-title":"Prognostic significance of serum cholesterol, lathosterol, and sitosterol in old age; a 17-year population study.","volume":"4","author":"Miettinen","year":"2011","journal-title":"Ann Med"},{"key":"3","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s40266-018-00632-x","article-title":"Drug Therapy of Dyslipidemia in the Elderly.","volume":"3","author":"Aronow","year":"2019","journal-title":"Drugs Aging"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20153810","article-title":"Lipid and Lipid Raft Alteration in Aging and Neurodegenerative Diseases: A Window for the Development of New Biomarkers.","volume":"2","author":"Mar\u00edn","year":"2019","journal-title":"Int J Mol Sci"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00104","article-title":"Lipid rafts: a signaling platform linking cholesterol metabolism to synaptic deficits in autism spectrum disorders.","volume":"8","author":"Wang","year":"2014","journal-title":"Front Behav Neurosci"},{"key":"6","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1111\/j.1471-4159.2010.07079.x","article-title":"Regulation of tyrosine kinase B activity by the Cyp46\/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging.","volume":"11","author":"Martin","year":"2011","journal-title":"J Neurochem"},{"key":"7","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1146\/annurev-pharmtox-010715-103233","article-title":"Oxysterols: Old Tale, New Twists.","volume":"5","author":"Brown","year":"2016","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"8","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41580-019-0190-7","article-title":"Mechanisms and regulation of cholesterol homeostasis.","volume":"2","author":"Song","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1073\/pnas.79.9.3037","article-title":"Mevalonic acid in human plasma: relationship of concentration and circadian rhythm to cholesterol synthesis rates in man.","volume":"7","author":"Ahrens","year":"1982","journal-title":"Proc Natl Acad Sci USA"},{"key":"10","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/MOL.0b013e328306a043","article-title":"The value of HDL genetics.","volume":"1","author":"Kuivenhoven","year":"2008","journal-title":"Curr Opin Lipidol"},{"key":"11","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/s0092-8674(00)80213-5","article-title":"The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.","volume":"8","author":"Goldstein","year":"1997","journal-title":"Cell"},{"key":"12","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.arr.2014.09.006","article-title":"Involvement of oxysterols in age-related diseases and ageing processes.","volume":"1","author":"Lizard","year":"2014","journal-title":"Ageing Res Rev"},{"key":"13","doi-asserted-by":"publisher","first-page":"110","DOI":"10.2174\/0929867327666200316142659","article-title":"A Comprehensive Review on Oxysterols and Related Diseases.","volume":"2","author":"Bj\u00f8rklund","year":"2021","journal-title":"Curr Med Chem"},{"key":"14","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.1111\/febs.15727","article-title":"Cholesterol metabolism pathways - are the intermediates more important than the products?","volume":"28","author":"Griffiths","year":"2021","journal-title":"FEBS J"},{"key":"15","doi-asserted-by":"publisher","first-page":"303","DOI":"10.2174\/1567205014666170505101426","article-title":"Lipid Biomarkers in Alzheimer\u2019s Disease.","volume":"1","author":"Lizard","year":"2018","journal-title":"Curr Alzheimer Res"},{"key":"16","doi-asserted-by":"crossref","DOI":"10.36255\/exonpublications.gliomas.2021","volume-title":"Gliomas","author":"Debinski","year":"2021"},{"key":"17","first-page":"1155","article-title":"Impact of age on the metabolism of VLDL, IDL, and LDL apolipoprotein B-100 in men.","volume":"3","author":"Schaefer","year":"1995","journal-title":"J Lipid Res"},{"key":"18","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1007\/s11745-001-0845-y","article-title":"Plasma kinetics of a cholesterol-rich emulsion in young, middle-aged, and elderly subjects.","volume":"3","author":"Maranh\u00e3o","year":"2001","journal-title":"Lipids"},{"key":"19","doi-asserted-by":"publisher","first-page":"748","DOI":"10.14336\/AD.2017.1003","article-title":"Removal of Chylomicron Remnants from the Bloodstream is Delayed in Aged Subjects.","volume":"9","author":"Maranh\u00e3o","year":"2018","journal-title":"Aging Dis"},{"key":"20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2009.12.027","article-title":"The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight.","volume":"21","author":"Nieuwdorp","year":"2010","journal-title":"Atherosclerosis"},{"key":"21","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.tibs.2006.12.008","article-title":"Molecular biology of PCSK9: its role in LDL metabolism.","volume":"3","author":"Hobbs","year":"2007","journal-title":"Trends Biochem Sci"},{"key":"22","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1007\/BF00400918","article-title":"Glycated low density lipoprotein catabolism is increased in rabbits with alloxan-induced diabetes mellitus.","volume":"3","author":"Erkelens","year":"1992","journal-title":"Diabetologia"},{"key":"23","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0005-2760(82)90237-5","article-title":"Glycosylation of LDL decreases its ability to interact with high-affinity receptors of human fibroblastsand decreases its clearance from rabbit plasma","volume":"71","author":"Cottam","year":"1982","journal-title":"Biochim Biophys Acta"},{"key":"24","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1194\/jlr.M600167-JLR200","article-title":"Age-related impairment of HDL-mediated cholesterol efflux.","volume":"4","author":"Khalil","year":"2007","journal-title":"J Lipid Res"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9050487","article-title":"The Susceptibility to Diet-Induced Atherosclerosis Is Exacerbated with Aging in C57B1\/6 Mice.","volume":"9","author":"Khalil","year":"2021","journal-title":"Biomedicines"},{"key":"26","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1161\/01.atv.0000013312.32196.49","article-title":"Oxysterols: friends, foes, or just fellow passengers?","volume":"2","author":"Diczfalusy","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"27","doi-asserted-by":"publisher","first-page":"199","DOI":"10.2174\/156652407780059168","article-title":"Enzymes in the conversion of cholesterol into bile acids.","volume":"7","author":"Wikvall","year":"2007","journal-title":"Curr Mol Med"},{"key":"28","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1194\/jlr.M500024-JLR200","article-title":"Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain.","volume":"4","author":"Bj\u00f6rkhem","year":"2005","journal-title":"J Lipid Res"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00119","article-title":"Oxidized cholesterol as the driving force behind the development of Alzheimer\u2019s disease.","volume":"7","author":"Leonarduzzi","year":"2015","journal-title":"Front Aging Neurosci"},{"key":"30","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.bbr.2014.10.018","article-title":"27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice.","volume":"27","author":"Bj\u00f6rkhem","year":"2015","journal-title":"Behav Brain Res"},{"key":"31","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1084\/jem.20160534","article-title":"27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP\/GLUT4 system dysregulation.","volume":"21","author":"Cedazo-M\u00ednguez","year":"2017","journal-title":"J Exp Med"},{"key":"32","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/j.1750-3639.2008.00174.x","article-title":"Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat dietand by 27-hydroxycholesterol","volume":"1","author":"Cedazo-M\u00ednguez","year":"2009","journal-title":"Brain Pathol"},{"key":"33","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/j.1365-2362.2007.01808.x","article-title":"Age-related changes in bile acid synthesis and hepatic nuclear receptor expression.","volume":"3","author":"Carulli","year":"2007","journal-title":"Eur J Clin Invest"},{"key":"34","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1093\/gerona\/glr124","article-title":"Aging is associated with a shift of fatty metabolism toward lipogenesis.","volume":"6","author":"Vollmar","year":"2011","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"35","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.mad.2004.11.010","article-title":"Dietary restriction counteracts age-related changes in cholesterol metabolism in the rat.","volume":"12","author":"Dessi","year":"2005","journal-title":"Mech Ageing Dev"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12895","article-title":"Reactive oxygen species-induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging.","volume":"1","author":"Jun","year":"2019","journal-title":"Aging Cell"},{"key":"37","doi-asserted-by":"publisher","first-page":"G269","DOI":"10.1152\/ajpgi.00172.2005","article-title":"Role of intestinal sterol transporters Abcg5, Abcg8, and Npc1l1 in cholesterol absorption in mice: gender and age effects.","volume":"29","author":"Wang","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"38","doi-asserted-by":"publisher","first-page":"3238","DOI":"10.3748\/wjg.v27.i23.3238","article-title":"Clinical indicators for progression of nonalcoholic steatohepatitis to cirrhosis.","volume":"2","author":"Bansal","year":"2021","journal-title":"World J Gastroenterol"},{"key":"39","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.jhep.2010.05.037","article-title":"Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity.","volume":"5","author":"Yki-J\u00e4rvinen","year":"2011","journal-title":"J Hepatol"},{"key":"40","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.cmet.2012.04.004","article-title":"Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease.","volume":"1","author":"Sanyal","year":"2012","journal-title":"Cell Metab"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00467","article-title":"Disturbances in Cholesterol Homeostasis and Non-alcoholic Fatty Liver Diseases.","volume":"7","author":"Alrefai","year":"2020","journal-title":"Front Med (Lausanne)"},{"key":"42","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1002\/hep.21763","article-title":"A lipidomic analysis of nonalcoholic fatty liver disease.","volume":"4","author":"Sanyal","year":"2007","journal-title":"Hepatology"},{"key":"43","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1007\/s11745-013-3836-9","article-title":"Aging induces tissue-specific changes in cholesterol metabolism in rat brain and liver.","volume":"4","author":"Kanazir","year":"2013","journal-title":"Lipids"},{"key":"44","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1161\/01.ATV.0000120374.59826.1b","article-title":"Brain cholesterol: long secret life behind a barrier.","volume":"2","author":"Meaney","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"45","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1194\/jlr.R400004-JLR200","article-title":"Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal.","volume":"4","author":"Turley","year":"2004","journal-title":"J Lipid Res"},{"key":"46","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/nature04399","article-title":"Role of cholesterol and lipid organization in disease.","volume":"43","author":"Tabas","year":"2005","journal-title":"Nature"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00382","article-title":"Intracellular Cholesterol Trafficking and Impact in Neurodegeneration.","volume":"1","author":"Fernandez-Checa","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"48","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.freeradbiomed.2016.10.008","article-title":"Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson\u2019s disease.","volume":"10","author":"Vejux","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"49","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.tins.2011.06.005","article-title":"Emerging roles for cholesterol in Huntington\u2019s disease.","volume":"3","author":"Cattaneo","year":"2011","journal-title":"Trends Neurosci"},{"key":"50","doi-asserted-by":"publisher","first-page":"747","DOI":"10.2174\/1389450116666150330114850","article-title":"Statins and epilepsy: preclinical studies, clinical trials and statin-anticonvulsant drug interactions.","volume":"1","author":"Russo","year":"2015","journal-title":"Curr Drug Targets"},{"key":"51","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1146\/annurev.biochem.78.072407.103859","article-title":"Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain.","volume":"7","author":"Kotti","year":"2009","journal-title":"Annu Rev Biochem"},{"key":"52","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.steroids.2015.02.007","article-title":"24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8.","volume":"9","author":"Noguchi","year":"2015","journal-title":"Steroids"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.524","article-title":"Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1.","volume":"5","author":"Noguchi","year":"2014","journal-title":"Cell Death Dis"},{"key":"54","doi-asserted-by":"publisher","first-page":"24666","DOI":"10.1074\/jbc.M111.236273","article-title":"24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis.","volume":"28","author":"Noguchi","year":"2011","journal-title":"J Biol Chem"},{"key":"55","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1111\/bph.13007","article-title":"Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel.","volume":"17","author":"Mennerick","year":"2015","journal-title":"Br J Pharmacol"},{"key":"56","doi-asserted-by":"publisher","first-page":"17290","DOI":"10.1523\/JNEUROSCI.2619-13.2013","article-title":"The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors.","volume":"3","author":"Zorumski","year":"2013","journal-title":"J Neurosci"},{"key":"57","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.neulet.2010.03.078","article-title":"Effects of cholesterol oxidation products on exocytosis.","volume":"47","author":"Ong","year":"2010","journal-title":"Neurosci Lett"},{"key":"58","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.redox.2013.11.007","article-title":"Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death.","volume":"2","author":"Noguchi","year":"2013","journal-title":"Redox Biol"},{"key":"59","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1111\/jnc.15228","article-title":"24S-hydroxycholesterol: Cellular effects and variations in brain diseases.","volume":"15","author":"Sodero","year":"2021","journal-title":"J Neurochem"},{"key":"60","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.plipres.2011.11.004","article-title":"Lipid changes in the aged brain: effect on synaptic function and neuronal survival.","volume":"5","author":"Dotti","year":"2012","journal-title":"Prog Lipid Res"},{"key":"61","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neurobiolaging.2018.02.022","article-title":"\u201cLipid raft aging\u201d in the human frontal cortex during nonpathological aging: gender influences and potential implications in Alzheimer\u2019s disease.","volume":"6","author":"Mar\u00edn","year":"2018","journal-title":"Neurobiol Aging"},{"key":"62","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/j.1471-4159.1990.tb01889.x","article-title":"Lipid compositions of different regions of the human brain during aging.","volume":"5","author":"Dallner","year":"1990","journal-title":"J Neurochem"},{"key":"63","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1091\/mbc.e07-09-0897","article-title":"Cholesterol loss enhances TrkB signaling in hippocampal neurons aging","volume":"1","author":"Dotti","year":"2008","journal-title":"Mol Biol Cell"},{"key":"64","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1046\/j.1471-4159.1994.63051802.x","article-title":"Membrane lipids of adult human brain: lipid composition of frontal and temporal lobe in subjects of age 20 to 100 years.","volume":"6","author":"Olsson","year":"1994","journal-title":"J Neurochem"},{"key":"65","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1016\/j.bbamem.2008.07.028","article-title":"Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid beta-protein fibrillogenesis.","volume":"177","author":"Yanagisawa","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"66","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.neulet.2006.04.034","article-title":"Cholesterol synthesis rate in human hippocampus declines with aging.","volume":"40","author":"L\u00fctjohann","year":"2006","journal-title":"Neurosci Lett"},{"key":"67","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1161\/01.ATV.0000148704.72481.28","article-title":"24(S),25-epoxycholesterol--a potential friend.","volume":"2","author":"Diczfalusy","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"68","doi-asserted-by":"publisher","first-page":"9799","DOI":"10.1073\/pnas.93.18.9799","article-title":"Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation.","volume":"9","author":"Bj\u00f6rkhem","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"69","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1046\/j.1471-4159.1996.66041717.x","article-title":"Increasing age alters transbilayer fluidity and cholesterol asymmetry in synaptic plasma membranes of mice.","volume":"6","author":"Wood","year":"1996","journal-title":"J Neurochem"},{"key":"70","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1023\/a:1007501306623","article-title":"Effect of long-term feeding with acetyl-L-carnitine on the age-related changes in rat brain lipid composition: a study by 31P NMR spectroscopy.","volume":"2","author":"Conti","year":"2000","journal-title":"Neurochem Res"},{"key":"71","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1161\/CIR.0b013e318282ab8f","article-title":"Executive summary: heart disease and stroke statistics--2013 update: a report from the American Heart Association.","volume":"12","author":"Gillespie","year":"2013","journal-title":"Circulation"},{"key":"72","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","article-title":"Alzheimer disease in the United States (2010-2050) estimated using the 2010 census.","volume":"8","author":"Evans","year":"2013","journal-title":"Neurology"},{"key":"73","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1007\/s11011-017-9999-y","article-title":"Sex-specific nonlinear associations between serum lipids and different domains of cognitive function in middle to older age individuals.","volume":"3","author":"Xiao","year":"2017","journal-title":"Metab Brain Dis"},{"key":"74","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1111\/jgs.15581","article-title":"Serum Cholesterol and Incident Alzheimer\u2019s Disease: Findings from the Adult Changes in Thought Study.","volume":"6","author":"Larson","year":"2018","journal-title":"J Am Geriatr Soc"},{"key":"75","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1037\/neu0000002","article-title":"Nonlinear longitudinal trajectories of cholesterol and neuropsychological function.","volume":"2","author":"Zonderman","year":"2014","journal-title":"Neuropsychology"},{"key":"76","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1037\/neu0000298","article-title":"Nonlinear associations between plasma cholesterol levels and neuropsychological function.","volume":"3","author":"Waldstein","year":"2016","journal-title":"Neuropsychology"},{"key":"77","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1093\/hmg\/ddx155","article-title":"APOE \u03b54\/\u03b54 diminishes neurotrophic function of human iPSC-derived astrocytes.","volume":"2","author":"Bu","year":"2017","journal-title":"Hum Mol Genet"},{"key":"78","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s10863-018-9757-9","article-title":"Decreased content, rate of synthesis and export of cholesterol in the brain of apoE knockout mice.","volume":"5","author":"Quint\u00e3o","year":"2018","journal-title":"J Bioenerg Biomembr"},{"key":"79","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.bbrc.2014.01.153","article-title":"Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse.","volume":"44","author":"Griffiths","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"80","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.neuroscience.2010.04.026","article-title":"The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice.","volume":"16","author":"Martins","year":"2010","journal-title":"Neuroscience"},{"key":"81","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1002\/hep.22371","article-title":"Cognitive impairment in primary biliary cirrhosis: symptom impact and potential etiology.","volume":"4","author":"Jones","year":"2008","journal-title":"Hepatology"},{"key":"82","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1002\/hep.22752","article-title":"Liver disease as a risk factor for cognitive decline and dementia: an under-recognized issue.","volume":"4","author":"Ozdogan","year":"2009","journal-title":"Hepatology"},{"key":"83","doi-asserted-by":"publisher","first-page":"14185","DOI":"10.3748\/wjg.v20.i39.14185","article-title":"Nonalcoholic fatty liver disease and aging: epidemiology to management.","volume":"2","author":"Loria","year":"2014","journal-title":"World J Gastroenterol"},{"key":"84","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1212\/WNL.0000000000002498","article-title":"Nonalcoholic fatty liver disease is associated with cognitive function in adults.","volume":"8","author":"Lazo","year":"2016","journal-title":"Neurology"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174169","article-title":"Reduced brain activity in female patients with non-alcoholic fatty liver disease as measured by near-infrared spectroscopy.","volume":"1","author":"Ohira","year":"2017","journal-title":"PLoS One"},{"key":"86","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1001\/jamaneurol.2017.3229","article-title":"Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study.","volume":"7","author":"Seshadri","year":"2018","journal-title":"JAMA Neurol"},{"key":"87","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1111\/liv.14161","article-title":"Non-alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle-aged adults: The Framingham Study.","volume":"3","author":"Seshadri","year":"2019","journal-title":"Liver Int"},{"key":"88","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/nrgastro.2013.171","article-title":"The global NAFLD epidemic.","volume":"1","author":"Sanyal","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"89","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/j.1365-2036.2011.04724.x","article-title":"Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults.","volume":"3","author":"Younossi","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"90","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.cld.2012.05.008","article-title":"The cardiovascular link to nonalcoholic fatty liver disease: a critical analysis.","volume":"1","author":"Fuchs","year":"2012","journal-title":"Clin Liver Dis"},{"key":"91","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/0895-4356(88)90080-7","article-title":"CARDIA: study design, recruitment, and some characteristics of the examined subjects.","volume":"4","author":"Savage","year":"1988","journal-title":"J Clin Epidemiol"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01681-0","article-title":"Non-alcoholic fatty liver disease and cognitive function in middle-aged adults: the CARDIA study.","volume":"2","author":"Sidney","year":"2021","journal-title":"BMC Gastroenterol"},{"key":"93","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1177\/0004563218817798","article-title":"Bile acids and the metabolic syndrome.","volume":"5","author":"Bloom","year":"2019","journal-title":"Ann Clin Biochem"},{"key":"94","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1152\/physrev.00010.2008","article-title":"Role of bile acids and bile acid receptors in metabolic regulation.","volume":"8","author":"Staels","year":"2009","journal-title":"Physiol Rev"},{"key":"95","doi-asserted-by":"publisher","first-page":"S58","DOI":"10.5604\/01.3001.0010.5498","article-title":"Bile Acids in Nonalcoholic Fatty Liver Disease: New Concepts and Therapeutic Advances.","volume":"1","author":"M\u00e9ndez-S\u00e1nchez","year":"2017","journal-title":"Ann Hepatol"},{"key":"96","doi-asserted-by":"publisher","first-page":"13493","DOI":"10.3748\/wjg.v20.i37.13493","article-title":"Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease.","volume":"2","author":"Ji","year":"2014","journal-title":"World J Gastroenterol"},{"key":"97","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1111\/liv.14802","article-title":"Fibroblast Growth Factor 19: Potential modulation of hepatic metabolism for the treatment of non-alcoholic fatty liver disease.","volume":"4","author":"Emerson","year":"2021","journal-title":"Liver Int"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.3390\/cells9092014","article-title":"A Translational Mouse Model for NASH with Advanced Fibrosis and Atherosclerosis Expressing Key Pathways of Human Pathology.","volume":"9","author":"Kleemann","year":"2020","journal-title":"Cells"},{"key":"99","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1016\/j.numecd.2021.03.020","article-title":"Metabolic syndrome and the risk of late onset Alzheimer\u2019s disease: An updated review and meta-analysis.","volume":"3","author":"Zuliani","year":"2021","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003615","article-title":"Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study.","volume":"1","author":"Resnick","year":"2021","journal-title":"PLoS Med"},{"key":"101","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1002\/med.21653","article-title":"Expert insights: The potential role of the gut microbiome-bile acid-brain axis in the development and progression of Alzheimer\u2019s disease and hepatic encephalopathy.","volume":"4","author":"Li","year":"2020","journal-title":"Med Res Rev"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220254","article-title":"Proprotein convertase subtilisin\/kexin type 9 (PCSK9) in Alzheimer\u2019s disease: A genetic and proteomic multi-cohort study.","volume":"1","author":"Poirier","year":"2019","journal-title":"PLoS One"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:37:41Z","timestamp":1645461461000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.203880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,7]]},"references-count":102,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,2,15]]}},"alternative-id":["203880","35130181"],"URL":"https:\/\/doi.org\/10.18632\/aging.203880","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,7]]}}}