{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:15:40Z","timestamp":1791688540633,"version":"4.3.4"},"reference-count":59,"publisher":"Impact Journals, LLC","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2022,8,31]]},"DOI":"10.18632\/aging.204248","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T10:10:56Z","timestamp":1661767856000},"page":"6829-6839","source":"Crossref","is-referenced-by-count":314,"title":["New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary"],"prefix":"10.18632","volume":"14","author":[{"given":"Tomas","family":"Schmauck-Medina","sequence":"first","affiliation":[{"name":"Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, L\u00f8renskog 1478, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Moli\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, L\u00f8renskog 1478, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Lautrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, L\u00f8renskog 1478, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, L\u00f8renskog 1478, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Chlopicki","sequence":"additional","affiliation":[{"name":"Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow 30-348, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Borland","family":"Madsen","sequence":"additional","affiliation":[{"name":"Center for Healthy Ageing, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2400, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, L\u00f8renskog 1478, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper","family":"Soendenbroe","sequence":"additional","affiliation":[{"name":"Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg, Copenhagen 2400, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els","family":"Mansell","sequence":"additional","affiliation":[{"name":"Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden"},{"name":"Stem Cell Laboratory, UCL Cancer Institute, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Bitsch","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Glostrup 2600, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiquan","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Healthy Ageing, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2400, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosef","family":"Shiloh","sequence":"additional","affiliation":[{"name":"The David and Inez Myers Laboratory of Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Tel Aviv University School of Medicine P.O.B 39040, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia L.","family":"Opresko","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA 15261, USA"},{"name":"UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Egly","sequence":"additional","affiliation":[{"name":"Department of Functional Genomics and Cancer, IGBMC, CNRS\/INSERM\/University of Strasbourg, Equipe labellis\u00e9e Ligue contre le Cancer, Strasbourg, France"},{"name":"College of Medicine, Center for Genomics and Precision Medicine, National Taiwan University, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kirkwood","sequence":"additional","affiliation":[{"name":"Center for Healthy Ageing, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2400, Denmark"},{"name":"UK National Innovation Centre for Ageing, The Catalyst, 3 Science Square, Newcastle University, Newcastle upon Tyne, NE4 5TG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Verdin","sequence":"additional","affiliation":[{"name":"Buck Institute for Research on Ageing, Novato, CA 94945, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilhelm A.","family":"Bohr","sequence":"additional","affiliation":[{"name":"Center for Healthy Ageing, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2400, Denmark"},{"name":"Section on DNA Repair, National Institute on Ageing, Baltimore, MD 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne S.","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinna","family":"Stevnsner","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Aarhus University, Aarhus 8000, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene Juel","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Center for Healthy Ageing, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2400, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evandro F.","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, L\u00f8renskog 1478, Norway"},{"name":"The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging.","volume":"15","author":"Kroemer","year":"2013","journal-title":"Cell"},{"key":"2","doi-asserted-by":"publisher","first-page":"101407","DOI":"10.1016\/j.arr.2021.101407","article-title":"The hoverfly and the wasp: A critique of the hallmarks of aging as a paradigm.","volume":"7","author":"de Magalh\u00e3es","year":"2021","journal-title":"Ageing Res Rev"},{"key":"3","doi-asserted-by":"publisher","first-page":"e13524","DOI":"10.1111\/acel.13524","article-title":"Biological mechanisms of aging predict age-related disease co-occurrence in patients.","volume":"2","author":"Partridge","year":"2022","journal-title":"Aging Cell"},{"key":"4","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","article-title":"Senolytics improve physical function and increase lifespan in old age.","volume":"2","author":"Verzosa","year":"2018","journal-title":"Nat Med"},{"key":"5","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.cell.2017.02.031","article-title":"Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.","volume":"16","author":"van Cappellen","year":"2017","journal-title":"Cell"},{"key":"6","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.","volume":"47","author":"van Deursen","year":"2011","journal-title":"Nature"},{"key":"7","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.ebiom.2018.12.052","article-title":"Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.","volume":"4","author":"Kirkland","year":"2019","journal-title":"EBioMedicine"},{"key":"8","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00439-019-02031-7","article-title":"Autophagy in aging and longevity.","volume":"13","author":"Lapierre","year":"2020","journal-title":"Hum Genet"},{"key":"9","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in healthy aging and disease.","volume":"1","author":"Kroemer","year":"2021","journal-title":"Nat Aging"},{"key":"10","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s41586-018-0162-7","article-title":"Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.","volume":"55","author":"Bhagat","year":"2018","journal-title":"Nature"},{"key":"11","doi-asserted-by":"publisher","first-page":"e57950","DOI":"10.7554\/eLife.57950","article-title":"Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses.","volume":"9","author":"Simon","year":"2020","journal-title":"Elife"},{"key":"12","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/s41580-018-0001-6","article-title":"The coming of age of chaperone-mediated autophagy.","volume":"1","author":"Cuervo","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"13","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.mad.2013.05.006","article-title":"Changes in splicing factor expression are associated with advancing age in man.","volume":"13","author":"Harries","year":"2013","journal-title":"Mech Ageing Dev"},{"key":"14","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12860-017-0147-7","article-title":"Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence.","volume":"1","author":"Harries","year":"2017","journal-title":"BMC Cell Biol"},{"key":"15","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.gendis.2019.10.011","article-title":"Alternative polyadenylation of mRNA and its role in cancer.","volume":"8","author":"Wang","year":"2019","journal-title":"Genes Dis"},{"key":"16","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.18632\/aging.101836","article-title":"Alternative polyadenylation dependent function of splicing factor SRSF3 contributes to cellular senescence.","volume":"1","author":"Ni","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"17","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/s42255-021-00348-0","article-title":"Gut microbiome pattern reflects healthy ageing and predicts survival in humans.","volume":"3","author":"Cauley","year":"2021","journal-title":"Nat Metab"},{"key":"18","doi-asserted-by":"publisher","first-page":"231","DOI":"10.18632\/aging.100872","article-title":"Reversal of phenotypes of cellular senescence by pan-mTOR inhibition.","volume":"8","author":"Cox","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"19","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s10522-012-9407-2","article-title":"p38 (MAPK) stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes.","volume":"1","author":"Davis","year":"2013","journal-title":"Biogerontology"},{"key":"20","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1164\/rccm.201812-2328OC","article-title":"Simvastatin Improves Neutrophil Function and Clinical Outcomes in Pneumonia. A Pilot Randomized Controlled Clinical Trial.","volume":"20","author":"Scott","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"21","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1101\/gad.331272.119","article-title":"Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence.","volume":"3","author":"Clark","year":"2020","journal-title":"Genes Dev"},{"key":"22","doi-asserted-by":"publisher","first-page":"12879","DOI":"10.1073\/pnas.0506001102","article-title":"Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.","volume":"10","author":"Collins","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"23","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1001\/jama.2018.3264","article-title":"Association of Lonafarnib Treatment vs No Treatment With Mortality Rate in Patients With Hutchinson-Gilford Progeria Syndrome.","volume":"31","author":"Kieran","year":"2018","journal-title":"JAMA"},{"key":"24","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1038\/s41563-018-0190-6","article-title":"Spatial confinement downsizes the inflammatory response of macrophages.","volume":"1","author":"Vogel","year":"2018","journal-title":"Nat Mater"},{"key":"25","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s11357-021-00469-0","article-title":"Diabetes mellitus correlates with increased biological age as indicated by clinical biomarkers.","volume":"4","author":"Aguayo-Mazzucato","year":"2022","journal-title":"Geroscience"},{"key":"26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12979-017-0112-5","article-title":"Ageing: from inflammation to cancer.","volume":"1","author":"Libra","year":"2018","journal-title":"Immun Ageing"},{"key":"27","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty.","volume":"1","author":"Fabbri","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"28","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.coi.2014.07.003","article-title":"The cross talk between microbiota and the immune system: metabolites take center stage.","volume":"3","author":"Elinav","year":"2014","journal-title":"Curr Opin Immunol"},{"key":"29","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/s0047-6374(01)00419-5","article-title":"Evolution of ageing.","volume":"12","author":"Kirkwood","year":"2002","journal-title":"Mech Ageing Dev"},{"key":"30","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/j.1558-5646.1957.tb02911.x","article-title":"Pleiotropy, Natural selection, and the evolution of senescence.","volume":"1","author":"Williams","year":"1957","journal-title":"Evolution"},{"key":"31","doi-asserted-by":"publisher","first-page":"111588","DOI":"10.1016\/j.exger.2021.111588","article-title":"Senolytics and the compression of late-life mortality.","volume":"15","author":"Kirkwood","year":"2021","journal-title":"Exp Gerontol"},{"key":"32","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.devcel.2014.11.012","article-title":"An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.","volume":"3","author":"Campisi","year":"2014","journal-title":"Dev Cell"},{"key":"33","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nature13193","article-title":"The role of senescent cells in ageing.","volume":"50","author":"van Deursen","year":"2014","journal-title":"Nature"},{"key":"34","article-title":"The Evolution of Aging.","volume":"3","author":"Flat","year":"2011","journal-title":"Nature Education Knowledge"},{"key":"35","doi-asserted-by":"publisher","first-page":"6697861","DOI":"10.1155\/2021\/6697861","article-title":"Intercellular Transfer of Mitochondria between Senescent Cells through Cytoskeleton-Supported Intercellular Bridges Requires mTOR and CDC42 Signalling.","volume":"202","author":"Cox","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"36","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nature08221","article-title":"Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.","volume":"46","author":"Miller","year":"2009","journal-title":"Nature"},{"key":"37","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.molcel.2019.04.024","article-title":"Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis.","volume":"7","author":"Opresko","year":"2019","journal-title":"Mol Cell"},{"key":"38","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/s41594-022-00790-y","article-title":"Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening.","volume":"2","author":"Opresko","year":"2022","journal-title":"Nat Struct Mol Biol"},{"key":"39","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: a new immune-metabolic viewpoint for age-related diseases.","volume":"1","author":"Santoro","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"40","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3390\/biomedicines9020192","article-title":"Immunomodulatory Role of Urolithin A on Metabolic Diseases.","volume":"9","author":"Chung","year":"2021","journal-title":"Biomedicines"},{"key":"41","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.cmet.2017.11.002","article-title":"NADIntermediates: The Biology and Therapeutic Potential of NMN and NR.","volume":"2","author":"Imai","year":"2018","journal-title":"Cell Metab"},{"key":"42","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NADmetabolism and its roles in cellular processes during ageing.","volume":"2","author":"Verdin","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"43","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1038\/s42255-020-00305-3","article-title":"Senescent cells promote tissue NADdecline during ageing via the activation of CD38+ macrophages.","volume":"2","author":"Iyer","year":"2020","journal-title":"Nat Metab"},{"key":"44","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.tcb.2014.11.002","article-title":"Protecting the mitochondrial powerhouse.","volume":"2","author":"Bohr","year":"2015","journal-title":"Trends Cell Biol"},{"key":"45","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.cell.2014.03.026","article-title":"Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)\/SIRT1 reduction.","volume":"15","author":"Bohr","year":"2014","journal-title":"Cell"},{"key":"46","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.molmed.2019.07.002","article-title":"Mitophagy and Neuroprotection.","volume":"2","author":"Fang","year":"2020","journal-title":"Trends Mol Med"},{"key":"47","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.stem.2020.09.018","article-title":"Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function.","volume":"2","author":"Enver","year":"2021","journal-title":"Cell Stem Cell"},{"key":"48","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.cmet.2019.09.001","article-title":"NADin Brain Aging and Neurodegenerative Disorders.","volume":"3","author":"Fang","year":"2019","journal-title":"Cell Metab"},{"key":"49","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/s41551-021-00819-5","article-title":"Amelioration of Alzheimer\u2019s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow.","volume":"6","author":"Xie","year":"2022","journal-title":"Nat Biomed Eng"},{"key":"50","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.neuint.2017.02.007","article-title":"Mitophagy in neurodegeneration and aging.","volume":"10","author":"Fang","year":"2017","journal-title":"Neurochem Int"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-022-02904-5","article-title":"P. edulis Extract Protects Against Amyloid-\u03b2 Toxicity in Alzheimer\u2019s Disease Models Through Maintenance of Mitochondrial Homeostasis via the FOXO3\/DAF-16 Pathway.","author":"Tencomnao","year":"2022","journal-title":"Mol Neurobiol"},{"key":"52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41514-019-0040-z","article-title":"Short-term NADsupplementation prevents hearing loss in mouse models of Cockayne syndrome.","volume":"6","author":"Bohr","year":"2020","journal-title":"NPJ Aging Mech Dis"},{"key":"53","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/s41598-020-57999-4","article-title":"Defective transcription of ATF3 responsive genes, a marker for Cockayne Syndrome.","volume":"1","author":"Egly","year":"2020","journal-title":"Sci Rep"},{"key":"54","doi-asserted-by":"publisher","first-page":"30498","DOI":"10.1073\/pnas.2006543117","article-title":"The Cockayne syndrome group A and B proteins are part of a ubiquitin-proteasome degradation complex regulating cell division.","volume":"11","author":"Proietti-De-Santis","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab306","article-title":"Temporal relationship between systemic endothelial dysfunction and alterations in erythrocyte function in a murine model of chronic heart failure.","author":"Wojnar-Lason","year":"2021","journal-title":"Cardiovasc Res"},{"key":"56","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1002\/nbm.3567","article-title":"Retrospectively gated MRI forassessment of endothelium-dependent vasodilatation and endothelial permeability in murine models of endothelial dysfunction.","volume":"2","author":"Chlopicki","year":"2016","journal-title":"NMR Biomed"},{"key":"57","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1177\/0271678X18818291","article-title":"Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain.","volume":"4","author":"Larsson","year":"2020","journal-title":"J Cereb Blood Flow Metab"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-022-00596-2","article-title":"Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men.","author":"Larsson","year":"2022","journal-title":"Geroscience"},{"key":"59","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1113\/JP282677","article-title":"Preserved stem cell content and innervation profile of elderly human skeletal muscle with lifelong recreational exercise.","volume":"60","author":"Mackey","year":"2022","journal-title":"J Physiol"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.204248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T10:43:04Z","timestamp":1662374584000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.204248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":59,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2022,8,31]]}},"alternative-id":["204248","36040386"],"URL":"https:\/\/doi.org\/10.18632\/aging.204248","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,29]]}}}