{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:20:11Z","timestamp":1792855211735,"version":"4.5.0"},"reference-count":65,"publisher":"Impact Journals, LLC","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2022,8,31]]},"DOI":"10.18632\/aging.204256","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T16:28:08Z","timestamp":1661876888000},"page":"6809-6828","source":"Crossref","is-referenced-by-count":55,"title":["LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K\/AKT\/mTOR axis"],"prefix":"10.18632","volume":"14","author":[{"given":"Sixuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangquan","family":"Liao","sequence":"additional","affiliation":[{"name":"National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Xiao","sequence":"additional","affiliation":[{"name":"National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Gu","sequence":"additional","affiliation":[{"name":"National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yang","sequence":"additional","affiliation":[{"name":"National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongliang","family":"Fu","sequence":"additional","affiliation":[{"name":"National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhang","family":"Du","sequence":"additional","affiliation":[{"name":"National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlun","family":"Li","sequence":"additional","affiliation":[{"name":"National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjing","family":"Shao","sequence":"additional","affiliation":[{"name":"National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3892\/br.2017.841","article-title":"Role of microRNAs in the pathogenesis of diabetic cardiomyopathy.","volume":"6","author":"Liu","year":"2017","journal-title":"Biomed Rep"},{"key":"2","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.bbrc.2012.09.058","article-title":"Recent advances in understanding the biochemical and molecular mechanism of diabetic cardiomyopathy.","volume":"42","author":"Su","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"3","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2147\/IJICMR.S21679","article-title":"The role of inflammation in diabetic cardiomyopathy.","volume":"4","author":"Reis","year":"2012","journal-title":"Int J Interferon Cytokine Mediat Res"},{"key":"4","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1210\/er.2003-0012","article-title":"Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications.","volume":"2","author":"Marwick","year":"2004","journal-title":"Endocr Rev"},{"key":"5","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.1016\/j.cellsig.2014.08.015","article-title":"Protein kinase RNA-like endoplasmic reticulum kinase (PERK)\/calcineurin signaling is a novel pathway regulating intracellular calcium accumulation which might be involved in ventricular arrhythmias in diabetic cardiomyopathy.","volume":"2","author":"Wang","year":"2014","journal-title":"Cell Signal"},{"key":"6","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s12933-015-0288-y","article-title":"Circulating interleukin-1\u03b2 promotes endoplasmic reticulum stress-induced myocytes apoptosis in diabetic cardiomyopathy via interleukin-1 receptor-associated kinase-2.","volume":"1","author":"Wang","year":"2015","journal-title":"Cardiovasc Diabetol"},{"key":"7","first-page":"161","article-title":"Research on the expression of Caspase 12 in rats with diabetic cardiomyopathy and the intervention of puerarin.","volume":"2","author":"Jian-Nong","year":"2012","journal-title":"J Crit Care Med"},{"key":"8","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1046\/j.1365-313x.1997.11020313.x","article-title":"The C-terminal HDEL sequence is sufficient for retention of secretory proteins in the endoplasmic reticulum (ER) but promotes vacuolar targeting of proteins that escape the ER.","volume":"1","author":"Faye","year":"1997","journal-title":"Plant J"},{"key":"9","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3389\/fimmu.2012.00240","article-title":"Obesity and endoplasmic reticulum (ER) stresses.","volume":"3","author":"Pandey","year":"2012","journal-title":"Front Immunol"},{"key":"10","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1210\/me.2011-1362","article-title":"Endoplasmic reticulum (ER) stress in cumulus-oocyte complexes impairs pentraxin-3 secretion, mitochondrial membrane potential (DeltaPsi m), and embryo development.","volume":"2","author":"Robker","year":"2012","journal-title":"Mol Endocrinol"},{"key":"11","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s00709-015-0842-1","article-title":"Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in plants.","volume":"25","author":"Jiang","year":"2016","journal-title":"Protoplasma"},{"key":"12","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.molmed.2012.06.010","article-title":"ER stress-induced inflammation: does it aid or impede disease progression?","volume":"1","author":"Agostinis","year":"2012","journal-title":"Trends Mol Med"},{"key":"13","doi-asserted-by":"publisher","first-page":"382","DOI":"10.3390\/ijms18020382","article-title":"Endoplasmic Reticulum (ER) Stress and Endocrine Disorders.","volume":"1","author":"Hasegawa","year":"2017","journal-title":"Int J Mol Sci"},{"key":"14","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.toxlet.2014.05.012","article-title":"Anacardic acid induces cell apoptosis associated with induction of ATF4-dependent endoplasmic reticulum stress.","volume":"22","author":"Liu","year":"2014","journal-title":"Toxicol Lett"},{"key":"15","doi-asserted-by":"publisher","first-page":"R92","DOI":"10.1152\/ajpregu.00169.2010","article-title":"UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4\/CHOP stimulation of TRB3 expression.","volume":"30","author":"Bordin","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"16","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1007\/s10753-020-01410-x","article-title":"Sufentanil Protects the Liver from Ischemia\/Reperfusion-Induced Inflammation and Apoptosis by Inhibiting ATF4-Induced TP53BP2 Expression.","volume":"4","author":"Chai","year":"2021","journal-title":"Inflammation"},{"key":"17","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1056\/NEJMoa011795","article-title":"CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma.","volume":"34","author":"Gisselbrecht","year":"2002","journal-title":"N Engl J Med"},{"key":"18","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.1093\/emboj\/17.13.3619","article-title":"Identification of novel stress-induced genes downstream of chop.","volume":"1","author":"Ron","year":"1998","journal-title":"EMBO J"},{"key":"19","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1128\/MCB.01394-14","article-title":"Novel long noncoding RNAs (lncRNAs) in myogenesis: a miR-31 overlapping lncRNA transcript controls myoblast differentiation.","volume":"3","author":"Bozzoni","year":"2015","journal-title":"Mol Cell Biol"},{"key":"20","doi-asserted-by":"publisher","first-page":"20911","DOI":"10.1074\/jbc.M117.799155","article-title":"CRISPR\/Cas-based screening of long non-coding RNAs (lncRNAs) in macrophages with an NF-\u03baB reporter.","volume":"29","author":"Carpenter","year":"2017","journal-title":"J Biol Chem"},{"key":"21","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1002\/1873-3468.12171","article-title":"LncRNA H19 functions as a competing endogenous RNA to regulate AQP3 expression by sponging miR-874 in the intestinal barrier.","volume":"59","author":"Xu","year":"2016","journal-title":"FEBS Lett"},{"key":"22","doi-asserted-by":"publisher","first-page":"53581","DOI":"10.18632\/oncotarget.18655","article-title":"lncRNA H19 mediates BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs) through Notch signaling.","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"23","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.18632\/oncotarget.13637","article-title":"LncRNA H19 inhibits autophagy by epigenetically silencing of DIRAS3 in diabetic cardiomyopathy.","volume":"8","author":"Shao","year":"2017","journal-title":"Oncotarget"},{"key":"24","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12933-021-01245-2","article-title":"MicroRNAs and long non-coding RNAs in the pathophysiological processes of diabetic cardiomyopathy: emerging biomarkers and potential therapeutics.","volume":"2","author":"Postula","year":"2021","journal-title":"Cardiovasc Diabetol"},{"key":"25","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s12872-018-0939-5","article-title":"Current status and strategies of long noncoding RNA research for diabetic cardiomyopathy.","volume":"1","author":"Ge","year":"2018","journal-title":"BMC Cardiovasc Disord"},{"key":"26","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.18632\/oncotarget.1913","article-title":"Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer.","volume":"5","author":"Liu","year":"2014","journal-title":"Oncotarget"},{"key":"27","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1016\/j.ctrv.2014.06.006","article-title":"Targeting the phosphatidylinositol 3-kinase (PI3K)\/AKT\/mammalian target of rapamycin (mTOR) pathway: an emerging treatment strategy for squamous cell lung carcinoma.","volume":"4","author":"Tolomeo","year":"2014","journal-title":"Cancer Treat Rev"},{"key":"28","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1200\/JCO.2011.36.1196","article-title":"PI3K\/AKT\/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations.","volume":"3","author":"Kurzrock","year":"2012","journal-title":"J Clin Oncol"},{"key":"29","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fonc.2014.00064","article-title":"Targeting PI3K\/Akt\/mTOR Signaling in Cancer.","volume":"4","author":"Mosca","year":"2014","journal-title":"Front Oncol"},{"key":"30","doi-asserted-by":"publisher","first-page":"964","DOI":"10.14348\/molcells.2018.0111","article-title":"Laminar Flow Inhibits ER Stress-Induced Endothelial Apoptosis through PI3K\/Akt-Dependent Signaling Pathway.","volume":"4","author":"Woo","year":"2018","journal-title":"Mol Cells"},{"key":"31","doi-asserted-by":"publisher","first-page":"596","DOI":"10.19540\/j.cnki.cjcmm.2018.0013","article-title":"[Effect of naringin on oxidative stress and endoplasmic reticulum stress in diabetic cardiomyopathy].","volume":"4","author":"Jin","year":"2018","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"32","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/s41419-018-0593-y","article-title":"Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N-acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress.","volume":"9","author":"Fang","year":"2018","journal-title":"Cell Death Dis"},{"key":"33","doi-asserted-by":"publisher","first-page":"4098","DOI":"10.3390\/ijms19124098","article-title":"PI3Kinases in Diabetes Mellitus and Its Related Complications.","volume":"1","author":"Carnevale","year":"2018","journal-title":"Int J Mol Sci"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Vashi, Patel. NRF2 in Cardiovascular Diseases: a Ray of Hope! J Cardiovasc Transl Res. 2021; 14:573-86. https:\/\/doi.org\/10.1007\/s12265-020-10083-8.","DOI":"10.1007\/s12265-020-10083-8"},{"key":"35","doi-asserted-by":"publisher","first-page":"145209","DOI":"10.1016\/j.gene.2020.145209","article-title":"Irisin improves insulin resistance by inhibiting autophagy through the PI3K\/Akt pathway in H9c2 cells.","volume":"76","author":"Wang","year":"2021","journal-title":"Gene"},{"key":"36","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.jcma.2018.02.002","article-title":"Anti-apoptotic effect of Suxiao Jiuxin Pills against hypoxia-induced injury through PI3K\/Akt\/GSK3\u03b2 pathway in HL-1 cardiomyocytes.","volume":"8","author":"Wang","year":"2018","journal-title":"J Chin Med Assoc"},{"key":"37","doi-asserted-by":"publisher","first-page":"20534","DOI":"10.18632\/aging.203435","article-title":"NLRP3 inflammasome activation contributes to the pathogenesis of cardiocytes aging.","volume":"1","author":"Zhuang","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"38","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.2337\/diabetes.50.6.1414","article-title":"IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress.","volume":"5","author":"Anversa","year":"2001","journal-title":"Diabetes"},{"key":"39","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s11154-010-9131-7","article-title":"Diabetic cardiomyopathy, causes and effects.","volume":"1","author":"Abel","year":"2010","journal-title":"Rev Endocr Metab Disord"},{"key":"40","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1159\/000481843","article-title":"H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation.","volume":"4","author":"Yin","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"41","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.jep.2016.08.029","article-title":"Protective effects of triptolide on TLR4 mediated autoimmune and inflammatory response induced myocardial fibrosis in diabetic cardiomyopathy.","volume":"19","author":"Chen","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"42","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.canlet.2015.05.027","article-title":"IDH1, a CHOP and C\/EBP\u03b2-responsive gene under ER stress, sensitizes human melanoma cells to hypoxia-induced apoptosis.","volume":"36","author":"Han","year":"2015","journal-title":"Cancer Lett"},{"key":"43","doi-asserted-by":"publisher","first-page":"3960","DOI":"10.1172\/JCI64583","article-title":"ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension.","volume":"12","author":"Davisson","year":"2012","journal-title":"J Clin Invest"},{"key":"44","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1007\/s11064-017-2333-6","article-title":"NGF Attenuates High Glucose-Induced ER Stress, Preventing Schwann Cell Apoptosis by Activating the PI3K\/Akt\/GSK3\u03b2 and ERK1\/2 Pathways.","volume":"4","author":"Xiao","year":"2017","journal-title":"Neurochem Res"},{"key":"45","doi-asserted-by":"publisher","first-page":"22502","DOI":"10.18632\/aging.203561","article-title":"Melatonin inhibits proliferation, migration, and invasion by inducing ROS-mediated apoptosis via suppression of the PI3K\/Akt\/mTOR signaling pathway in gallbladder cancer cells.","volume":"1","author":"Zhai","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"46","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nature11910","article-title":"Autophagosomes form at ER-mitochondria contact sites.","volume":"49","author":"Yoshimori","year":"2013","journal-title":"Nature"},{"key":"47","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.mcn.2012.07.011","article-title":"Mitochondria-associated ER membranes in Alzheimer disease.","volume":"5","author":"Area-Gomez","year":"2013","journal-title":"Mol Cell Neurosci"},{"key":"48","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/molehr\/gaz066","article-title":"Activation of endoplasmic reticulum stress mediates oxidative stress-induced apoptosis of granulosa cells in ovaries affected by endometrioma.","volume":"2","author":"Osuga","year":"2020","journal-title":"Mol Hum Reprod"},{"key":"49","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.leukres.2015.08.007","article-title":"Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress.","volume":"3","author":"Barredo","year":"2015","journal-title":"Leuk Res"},{"key":"50","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s12012-007-9004-9","article-title":"Myocardial Fas ligand expression increases susceptibility to AZT-induced cardiomyopathy.","volume":"7","author":"Bowles","year":"2007","journal-title":"Cardiovasc Toxicol"},{"key":"51","doi-asserted-by":"publisher","first-page":"48321","DOI":"10.18632\/oncotarget.15689","article-title":"In-depth proteomic profiling of left ventricular tissues in human end-stage dilated cardiomyopathy.","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"52","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1139\/bcb-2019-0434","article-title":"LncRNA MALAT1 regulates diabetic cardiac fibroblasts through the Hippo-YAP signaling pathway.","volume":"9","author":"Zhan","year":"2020","journal-title":"Biochem Cell Biol"},{"key":"53","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3892\/mmr.2021.11898","article-title":"lncRNA-MALAT1 promotes high glucose-induced H9C2 cardiomyocyte pyroptosis by downregulating miR-141-3p expression.","volume":"2","author":"Mou","year":"2021","journal-title":"Mol Med Rep"},{"key":"54","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/1475-2840-12-172","article-title":"Eplerenone attenuated cardiac steatosis, apoptosis and diastolic dysfunction in experimental type-II diabetes.","volume":"1","author":"Lorenzo","year":"2013","journal-title":"Cardiovasc Diabetol"},{"key":"55","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.jdiacomp.2008.02.009","article-title":"Cardioprotective effect of vitamin E: rescues of diabetes-induced cardiac malfunction, oxidative stress, and apoptosis in rat.","volume":"2","author":"Khademvatani","year":"2009","journal-title":"J Diabetes Complications"},{"key":"56","doi-asserted-by":"publisher","first-page":"16","DOI":"10.2174\/187153010790827957","article-title":"SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.","volume":"1","author":"Koya","year":"2010","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"57","first-page":"56","article-title":"Long non-coding RNA H19 promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by regulating microRNA-140-5p\/SATB2 axis.","volume":"4","author":"Wu","year":"2020","journal-title":"J Biosci"},{"key":"58","doi-asserted-by":"publisher","first-page":"4045","DOI":"10.1007\/s11010-021-04219-w","article-title":"Role of PI3K\/Akt signaling pathway in cardiac fibrosis.","volume":"47","author":"Massey","year":"2021","journal-title":"Mol Cell Biochem"},{"key":"59","doi-asserted-by":"publisher","first-page":"5063","DOI":"10.1111\/jcmm.14367","article-title":"Sulodexide attenuates endoplasmic reticulum stress induced by myocardial ischaemia\/reperfusion by activating the PI3K\/Akt pathway.","volume":"2","author":"Zhang","year":"2019","journal-title":"J Cell Mol Med"},{"key":"60","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.freeradbiomed.2015.05.027","article-title":"Endoplasmic reticulum stress and Nrf2 signaling in cardiovascular diseases.","volume":"8","author":"Fratta Pasini","year":"2015","journal-title":"Free Radic Biol Med"},{"key":"61","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1097\/SHK.0000000000001116","article-title":"Crocin Alleviates Myocardial Ischemia\/Reperfusion-Induced Endoplasmic Reticulum Stress via Regulation of miR-34a\/Sirt1\/Nrf2 Pathway.","volume":"5","author":"Gong","year":"2019","journal-title":"Shock"},{"key":"62","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.ecoenv.2018.06.046","article-title":"Luteolin-mediated PI3K\/AKT\/Nrf2 signaling pathway ameliorates inorganic mercury-induced cardiac injury.","volume":"16","author":"Zhang","year":"2018","journal-title":"Ecotoxicol Environ Saf"},{"key":"63","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1002\/ddr.21495","article-title":"The protective effect of kaempferol on heart via the regulation of Nrf2, NF-\u03ba\u03b2, and PI3K\/Akt\/GSK-3\u03b2 signaling pathways in isoproterenol-induced heart failure in diabetic rats.","volume":"8","author":"Han","year":"2019","journal-title":"Drug Dev Res"},{"key":"64","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions of the unfolded protein response.","volume":"2","author":"Kaufman","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"65","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.molcel.2017.06.017","article-title":"The Unfolded Protein Response and Cell Fate Control.","volume":"6","author":"Papa","year":"2018","journal-title":"Mol Cell"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.204256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T14:43:01Z","timestamp":1662388981000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.204256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,30]]},"references-count":65,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2022,8,31]]}},"alternative-id":["204256","36044268"],"URL":"https:\/\/doi.org\/10.18632\/aging.204256","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,30]]}}}