{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:28:17Z","timestamp":1788931697623,"version":"build-2803163510"},"reference-count":64,"publisher":"Impact Journals, LLC","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2022,9,14]]},"DOI":"10.18632\/aging.204266","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:24:15Z","timestamp":1662769455000},"page":"7014-7025","source":"Crossref","is-referenced-by-count":35,"title":["Probiotics treatment for Parkinson disease: a systematic review and meta-analysis of clinical trials"],"prefix":"10.18632","volume":"14","author":[{"given":"Chien-Tai","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Neurology, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan"},{"name":"Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsai-Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Nursing, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan"},{"name":"Center for Nursing and Healthcare Research in Clinical Practice Application, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan"},{"name":"Cochrane Taiwan, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"S656","DOI":"10.1002\/mds.22672","article-title":"When does Parkinson's disease begin?","volume":"2","author":"Tolosa","year":"2009","journal-title":"Mov Disord"},{"key":"2","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/S1474-4422(15)00007-1","article-title":"Gastrointestinal dysfunction in Parkinson\u2019s disease.","volume":"1","author":"Pfeiffer","year":"2015","journal-title":"Lancet Neurol"},{"key":"3","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s00401-010-0664-3","article-title":"Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders.","volume":"11","author":"Walker","year":"2010","journal-title":"Acta Neuropathol"},{"key":"4","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1002\/mds.25776","article-title":"Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders.","volume":"2","author":"Ribalta","year":"2014","journal-title":"Mov Disord"},{"key":"5","doi-asserted-by":"publisher","first-page":"7935820","DOI":"10.1155\/2019\/7935820","article-title":"Atrophic Myenteric and Submucosal Neurons Are Observed in Parkinson\u2019s Disease.","volume":"201","author":"Englund","year":"2019","journal-title":"Parkinsons Dis"},{"key":"6","doi-asserted-by":"publisher","first-page":"S331","DOI":"10.3233\/JPD-191729","article-title":"Inflammatory Bowel Diseases and Parkinson\u2019s Disease.","volume":"9","author":"Brudek","year":"2019","journal-title":"J Parkinsons Dis"},{"key":"7","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1212\/WNL.0000000000003961","article-title":"Vagotomy and Parkinson disease: A Swedish register-based matched-cohort study.","volume":"8","author":"Wirdefeldt","year":"2017","journal-title":"Neurology"},{"key":"8","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/ana.24448","article-title":"Vagotomy and subsequent risk of Parkinson\u2019s disease.","volume":"7","author":"S\u00f8rensen","year":"2015","journal-title":"Ann Neurol"},{"key":"9","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1002\/mds.25522","article-title":"The role of small intestinal bacterial overgrowth in Parkinson's disease.","volume":"2","author":"Gigante","year":"2013","journal-title":"Mov Disord"},{"key":"10","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1002\/mds.23566","article-title":"Prevalence of small intestinal bacterial overgrowth in Parkinson's disease.","volume":"2","author":"Gasbarrini","year":"2011","journal-title":"Mov Disord"},{"key":"11","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41531-021-00156-z","article-title":"Meta-analysis of the Parkinson\u2019s disease gut microbiome suggests alterations linked to intestinal inflammation.","volume":"7","author":"Narbad","year":"2021","journal-title":"NPJ Parkinsons Dis"},{"key":"12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/JAD-161141","article-title":"The Gut Microbiota and Alzheimer\u2019s Disease.","volume":"5","author":"Zhao","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"13","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/s41435-021-00126-8","article-title":"The aging gut microbiome and its impact on host immunity.","volume":"2","author":"Noti","year":"2021","journal-title":"Genes Immun"},{"key":"14","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.chom.2020.07.013","article-title":"The Gut Microbiota and Unhealthy Aging: Disentangling Cause from Consequence.","volume":"2","author":"Bowdish","year":"2020","journal-title":"Cell Host Microbe"},{"key":"15","doi-asserted-by":"publisher","first-page":"484","DOI":"10.3945\/an.116.014407","article-title":"Mechanisms of Action of Probiotics and the Gastrointestinal Microbiota on Gut Motility and Constipation.","volume":"8","author":"Whelan","year":"2017","journal-title":"Adv Nutr"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000252","article-title":"Diet, microbiota, and colorectal cancer.","author":"T\u00f6z\u00fcn","year":"2014","journal-title":"J Clin Gastroenterol"},{"key":"17","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/ni.2608","article-title":"Control of pathogens and pathobionts by the gut microbiota.","volume":"1","author":"N\u00fa\u00f1ez","year":"2013","journal-title":"Nat Immunol"},{"key":"18","doi-asserted-by":"publisher","first-page":"7577","DOI":"10.1007\/s13197-015-1921-1","article-title":"Probiotics, prebiotics and synbiotics- a review.","volume":"5","author":"Vakil","year":"2015","journal-title":"J Food Sci Technol"},{"key":"19","doi-asserted-by":"publisher","first-page":"631254","DOI":"10.3389\/fmicb.2021.631254","article-title":"Role of Probiotics, Prebiotics, and Synbiotics in the Elderly: Insights Into Their Applications.","volume":"1","author":"Binetti","year":"2021","journal-title":"Front Microbiol"},{"key":"20","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1038\/ajg.2014.202","article-title":"Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis.","volume":"10","author":"Moayyedi","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"21","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/mds.27602","article-title":"Update on treatments for nonmotor symptoms of Parkinson\u2019s disease-an evidence-based medicine review.","volume":"3","author":"Sampaio","year":"2019","journal-title":"Mov Disord"},{"key":"22","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/s41575-020-0339-z","article-title":"Parkinson disease and the gut: new insights into pathogenesis and clinical relevance.","volume":"1","author":"Camilleri","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"23","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1212\/WNL.0000000000003127","article-title":"Probiotics and prebiotic fiber for constipation associated with Parkinson disease: An RCT.","volume":"8","author":"Cereda","year":"2016","journal-title":"Neurology"},{"key":"24","first-page":"117","article-title":"Use of probiotics for the treatment of constipation in Parkinson\u2019s disease patients.","volume":"5","author":"Barichella","year":"2011","journal-title":"Minerva Gastroenterol Dietol"},{"key":"25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12929-018-0493-6","article-title":"Probiotics, prebiotics and amelioration of diseases.","volume":"2","author":"Lai","year":"2019","journal-title":"J Biomed Sci"},{"key":"26","doi-asserted-by":"publisher","first-page":"e132055","DOI":"10.1172\/jci.insight.132055","article-title":"A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota\/taurine\/tight junction axis.","volume":"5","author":"Yadav","year":"2020","journal-title":"JCI Insight"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001064","article-title":"Influence of Probiotics Administration on Gut Microbiota Core: A Review on the Effects on Appetite Control, Glucose, and Lipid Metabolism.","author":"Carnevali","year":"2018","journal-title":"J Clin Gastroenterol"},{"key":"28","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jclinepi.2009.06.006","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.","volume":"6","author":"Moher","year":"2009","journal-title":"J Clin Epidemiol"},{"key":"29","unstructured":"Higgins, Thomas, Chandler, Cumpston, Li, Page, Welch (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.2. Cochrane. 2021. https:\/\/training.cochrane.org\/handbook."},{"key":"30","doi-asserted-by":"publisher","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions.","volume":"35","author":"Churchill","year":"2016","journal-title":"BMJ"},{"key":"31","doi-asserted-by":"publisher","first-page":"650053","DOI":"10.3389\/fnut.2021.650053","article-title":"The Add-On Effect ofPS128 in Patients With Parkinson's Disease: A Pilot Study.","volume":"8","author":"Tsai","year":"2021","journal-title":"Front Nutr"},{"key":"32","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.clnu.2018.05.018","article-title":"Clinical and metabolic response to probiotic administration in people with Parkinson\u2019s disease: A randomized, double-blind, placebo-controlled trial.","volume":"3","author":"Asemi","year":"2019","journal-title":"Clin Nutr"},{"key":"33","doi-asserted-by":"publisher","first-page":"e0244680","DOI":"10.1371\/journal.pone.0244680","article-title":"Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson\u2019s disease: A randomised controlled trial.","volume":"1","author":"Ibrahim","year":"2020","journal-title":"PLoS One"},{"key":"34","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.2147\/CIA.S106284","article-title":"Nonmotor gastrointestinal disorders in older patients with Parkinson\u2019s disease: is there hope?","volume":"1","author":"Reisz","year":"2016","journal-title":"Clin Interv Aging"},{"key":"35","first-page":"289","article-title":"The Effects of Probiotic Supplementation on Gene Expression Related to Inflammation, Insulin and Lipid in Patients with Parkinson\u2019s Disease: A Randomized, Double-blind, PlaceboControlled Trial.","volume":"2","author":"Asemi","year":"2018","journal-title":"Arch Iran Med"},{"key":"36","doi-asserted-by":"publisher","first-page":"e772","DOI":"10.1212\/WNL.0000000000010998","article-title":"Probiotics for Constipation in Parkinson Disease: A Randomized Placebo-Controlled Study.","volume":"9","author":"Lang","year":"2021","journal-title":"Neurology"},{"key":"37","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1126\/science.aac8469","article-title":"Gut microbiota and aging.","volume":"35","author":"Jeffery","year":"2015","journal-title":"Science"},{"key":"38","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","article-title":"Interaction between microbiota and immunity in health and disease.","volume":"3","author":"Elinav","year":"2020","journal-title":"Cell Res"},{"key":"39","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1007\/s00467-016-3392-7","article-title":"Gut microbiome and kidney disease: a bidirectional relationship.","volume":"3","author":"Shatat","year":"2017","journal-title":"Pediatr Nephrol"},{"key":"40","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s40364-020-00211-6","article-title":"Bidirectional interaction between intestinal microbiome and cancer: opportunities for therapeutic interventions.","volume":"8","author":"Lim","year":"2020","journal-title":"Biomark Res"},{"key":"41","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1097\/WCO.0000000000000112","article-title":"Premotor and nonmotor features of Parkinson's disease.","volume":"2","author":"Postuma","year":"2014","journal-title":"Curr Opin Neurol"},{"key":"42","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/j.parkreldis.2014.09.026","article-title":"Risk of Parkinson\u2019s disease following severe constipation: a nationwide population-based cohort study.","volume":"2","author":"Wu","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"key":"43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40478-016-0408-2","article-title":"Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson\u2019s disease.","volume":"5","author":"Wedel","year":"2017","journal-title":"Acta Neuropathol Commun"},{"key":"44","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.neuroscience.2008.02.074","article-title":"Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: autonomic pathway implicated in Parkinson\u2019s disease?","volume":"15","author":"Powley","year":"2008","journal-title":"Neuroscience"},{"key":"45","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41531-020-0112-6","article-title":"Characterizing dysbiosis of gut microbiome in PD: evidence for overabundance of opportunistic pathogens.","volume":"6","author":"Payami","year":"2020","journal-title":"NPJ Parkinsons Dis"},{"key":"46","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1002\/mds.28119","article-title":"Meta-Analysis of Gut Dysbiosis in Parkinson\u2019s Disease.","volume":"3","author":"Ohno","year":"2020","journal-title":"Mov Disord"},{"key":"47","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson\u2019s Disease.","volume":"16","author":"Shannon","year":"2016","journal-title":"Cell"},{"key":"48","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1002\/mds.23732","article-title":"Etiology and pathogenesis of Parkinson's disease.","volume":"2","author":"Jenner","year":"2011","journal-title":"Mov Disord"},{"key":"49","doi-asserted-by":"publisher","first-page":"729194","DOI":"10.1155\/2014\/729194","article-title":"Metabolic syndrome: an important risk factor for Parkinson's disease.","volume":"201","author":"Tian","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"50","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40035-015-0042-0","article-title":"Neuroinflammation in Parkinson\u2019s disease and its potential as therapeutic target.","volume":"4","author":"Zhou","year":"2015","journal-title":"Transl Neurodegener"},{"key":"51","doi-asserted-by":"publisher","first-page":"436813","DOI":"10.4061\/2011\/436813","article-title":"Parkinson\u2019s disease and systemic inflammation.","volume":"201","author":"Tarelli","year":"2011","journal-title":"Parkinsons Dis"},{"key":"52","doi-asserted-by":"publisher","first-page":"604","DOI":"10.3390\/cells10030604","article-title":"Cytokine Profile in Plasma Extracellular Vesicles of Parkinson\u2019s Disease and the Association with Cognitive Function.","volume":"1","author":"Hong","year":"2021","journal-title":"Cells"},{"key":"53","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12974-019-1528-y","article-title":"Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson\u2019s disease.","volume":"1","author":"Wu","year":"2019","journal-title":"J Neuroinflammation"},{"key":"54","doi-asserted-by":"publisher","first-page":"363","DOI":"10.5056\/jnm19044","article-title":"Parkinson\u2019s Disease: The Emerging Role of Gut Dysbiosis, Antibiotics, Probiotics, and Fecal Microbiota Transplantation.","volume":"2","author":"Nair","year":"2019","journal-title":"J Neurogastroenterol Motil"},{"key":"55","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1002\/mds.28551","article-title":"Type 2 Diabetes as a Determinant of Parkinson\u2019s Disease Risk and Progression.","volume":"3","author":"Noyce","year":"2021","journal-title":"Mov Disord"},{"key":"56","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1002\/acn3.51343","article-title":"Effect of diabetes control status on the progression of Parkinson\u2019s disease: A prospective study.","volume":"8","author":"Shang","year":"2021","journal-title":"Ann Clin Transl Neurol"},{"key":"57","doi-asserted-by":"publisher","first-page":"564641","DOI":"10.3389\/fcell.2020.564641","article-title":"Altered Insulin Receptor Substrate 1 Phosphorylation in Blood Neuron-Derived Extracellular Vesicles From Patients With Parkinson\u2019s Disease.","volume":"8","author":"Hong","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"58","doi-asserted-by":"publisher","first-page":"740","DOI":"10.3390\/cells9030740","article-title":"Insulin Resistance Promotes Parkinson\u2019s Disease through Aberrant Expression of \u03b1-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.","volume":"9","author":"Bamodu","year":"2020","journal-title":"Cells"},{"key":"59","doi-asserted-by":"publisher","first-page":"127","DOI":"10.5217\/ir.2016.14.2.127","article-title":"Pathogenic role of the gut microbiota in gastrointestinal diseases.","volume":"1","author":"Kamada","year":"2016","journal-title":"Intest Res"},{"key":"60","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1177\/1756283X12459294","article-title":"Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation.","volume":"6","author":"Versalovic","year":"2013","journal-title":"Therap Adv Gastroenterol"},{"key":"61","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1093\/nutrit\/nuy056","article-title":"Yogurt and other fermented foods as sources of health-promoting bacteria.","volume":"7","author":"Hutkins","year":"2018","journal-title":"Nutr Rev"},{"key":"62","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.cgh.2018.08.067","article-title":"Influence of Early Life, Diet, and the Environment on the Microbiome.","volume":"1","author":"Gupta","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"63","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota-gut-brain communication.","volume":"1","author":"Verbeke","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"64","doi-asserted-by":"publisher","first-page":"454","DOI":"10.3389\/fcimb.2019.00454","article-title":"How Probiotics Affect the Microbiota.","volume":"9","author":"Cani","year":"2020","journal-title":"Front Cell Infect Microbiol"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.204266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:24:00Z","timestamp":1663719840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.204266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,9]]},"references-count":64,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2022,9,14]]}},"alternative-id":["204266","36084951"],"URL":"https:\/\/doi.org\/10.18632\/aging.204266","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,9]]}}}