{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T05:51:19Z","timestamp":1718776279636},"reference-count":96,"publisher":"Impact Journals, LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"DOI":"10.18632\/aging.204412","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T19:40:18Z","timestamp":1669923618000},"source":"Crossref","is-referenced-by-count":3,"title":["Identification of natural products and FDA-approved drugs for targeting cancer stem cell (CSC) propagation"],"prefix":"10.18632","author":[{"given":"Gloria","family":"Bonuccelli","sequence":"first","affiliation":[{"name":"Translational Medicine, School of Science, Engineering and Environment, Biomedical Research Centre, University of Salford, Greater Manchester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Sotgia","sequence":"additional","affiliation":[{"name":"Translational Medicine, School of Science, Engineering and Environment, Biomedical Research Centre, University of Salford, Greater Manchester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Lisanti","sequence":"additional","affiliation":[{"name":"Translational Medicine, School of Science, Engineering and Environment, Biomedical Research Centre, University of Salford, Greater Manchester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.molmed.2008.08.003","article-title":"Cancer stem cell markers in common cancers - therapeutic implications.","volume":"1","author":"Los","year":"2008","journal-title":"Trends Mol Med"},{"key":"2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4331\/wjbc.v6.i3.57","article-title":"DNA damage responses in cancer stem cells: Implications for cancer therapeutic strategies.","volume":"6","author":"Wang","year":"2015","journal-title":"World J Biol Chem"},{"key":"3","doi-asserted-by":"publisher","first-page":"4036","DOI":"10.3390\/ijms19124036","article-title":"Targeting Cancer Stem Cells to Overcome Chemoresistance.","volume":"1","author":"Janin","year":"2018","journal-title":"Int J Mol Sci"},{"key":"4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.semcancer.2017.02.011","article-title":"Cancer stem cells: The root of tumor recurrence and metastases.","volume":"4","author":"Dubrovska","year":"2017","journal-title":"Semin Cancer Biol"},{"key":"5","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.stem.2014.02.006","article-title":"Evolution of the cancer stem cell model.","volume":"1","author":"Dick","year":"2014","journal-title":"Cell Stem Cell"},{"key":"6","doi-asserted-by":"publisher","first-page":"96","DOI":"10.21037\/sci.2017.11.03","article-title":"Breast cancer stem cells-from origins to targeted therapy.","volume":"4","author":"Lim","year":"2017","journal-title":"Stem Cell Investig"},{"key":"7","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1042\/BCJ20170164","article-title":"Cancer stem cells (CSCs): metabolic strategies for their identification and eradication.","volume":"47","author":"Lisanti","year":"2018","journal-title":"Biochem J"},{"key":"8","doi-asserted-by":"publisher","first-page":"11029","DOI":"10.18632\/oncotarget.2789","article-title":"Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1\/2 inhibition.","volume":"5","author":"Sotgia","year":"2014","journal-title":"Oncotarget"},{"key":"9","doi-asserted-by":"publisher","first-page":"30453","DOI":"10.18632\/oncotarget.5852","article-title":"Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT\/FGF-driven anabolic signaling.","volume":"6","author":"Martinez-Outschoorn","year":"2015","journal-title":"Oncotarget"},{"key":"10","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.18632\/aging.101351","article-title":"Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration: Vitamin B2 (Riboflavin) in cancer therapy.","volume":"9","author":"Lisanti","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"11","doi-asserted-by":"publisher","first-page":"67457","DOI":"10.18632\/oncotarget.19084","article-title":"Mitoriboscins: Mitochondrial-based therapeutics targeting cancer stem cells (CSCs), bacteria and pathogenic yeast.","volume":"8","author":"Lisanti","year":"2017","journal-title":"Oncotarget"},{"key":"12","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/ijc.32616","article-title":"Oxidative phosphorylation as a potential therapeutic target for cancer therapy.","volume":"14","author":"Kroemer","year":"2020","journal-title":"Int J Cancer"},{"key":"13","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.18632\/aging.101483","article-title":"Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways.","volume":"1","author":"Lisanti","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"14","doi-asserted-by":"publisher","first-page":"20667","DOI":"10.18632\/oncotarget.15400","article-title":"NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting \u201cstemness\u201d.","volume":"8","author":"Lisanti","year":"2017","journal-title":"Oncotarget"},{"key":"15","doi-asserted-by":"publisher","first-page":"67269","DOI":"10.18632\/oncotarget.18428","article-title":"Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs).","volume":"8","author":"Lisanti","year":"2017","journal-title":"Oncotarget"},{"key":"16","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.bbabio.2018.03.018","article-title":"Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism.","volume":"185","author":"Lisanti","year":"2018","journal-title":"Biochim Biophys Acta Bioenerg"},{"key":"17","doi-asserted-by":"publisher","first-page":"615","DOI":"10.3389\/fonc.2019.00615","article-title":"Dodecyl-TPP Targets Mitochondria and Potently Eradicates Cancer Stem Cells (CSCs): Synergy With FDA-Approved Drugs and Natural Compounds (Vitamin C and Berberine).","volume":"9","author":"Lisanti","year":"2019","journal-title":"Front Oncol"},{"key":"18","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s10911-012-9255-3","article-title":"A detailed mammosphere assay protocol for the quantification of breast stem cell activity.","volume":"1","author":"Clarke","year":"2012","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"19","doi-asserted-by":"publisher","first-page":"14777","DOI":"10.18632\/oncotarget.4401","article-title":"Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells.","volume":"6","author":"Sotgia","year":"2015","journal-title":"Oncotarget"},{"key":"20","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1038\/nprot.2006.179","article-title":"Sulforhodamine B colorimetric assay for cytotoxicity screening.","volume":"1","author":"Kirtikara","year":"2006","journal-title":"Nat Protoc"},{"key":"21","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1177\/0192623312467522","article-title":"The chemopreventive capacity of quercetin to induce programmed cell death in hepatocarcinogenesis.","volume":"4","author":"Villa-Trevi\u00f1o","year":"2013","journal-title":"Toxicol Pathol"},{"key":"22","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.3892\/or.2015.3886","article-title":"Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential (Review).","volume":"3","author":"Xing","year":"2015","journal-title":"Oncol Rep"},{"key":"23","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3390\/biom9050174","article-title":"Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential.","volume":"9","author":"Sandhu","year":"2019","journal-title":"Biomolecules"},{"key":"24","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s11010-006-9307-3","article-title":"Induction of apoptosis by quercetin: different response of human chronic myeloid (K562) and acute lymphoblastic (HSB-2) leukemia cells.","volume":"29","author":"Bozzi","year":"2007","journal-title":"Mol Cell Biochem"},{"key":"25","doi-asserted-by":"publisher","first-page":"e0141370","DOI":"10.1371\/journal.pone.0141370","article-title":"Quercetin Suppresses Twist to Induce Apoptosis in MCF-7 Breast Cancer Cells.","volume":"1","author":"Sivasithambaram","year":"2015","journal-title":"PLoS One"},{"key":"26","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.cellimm.2016.08.011","article-title":"Quercetin attenuates atherosclerotic inflammation and adhesion molecule expression by modulating TLR-NF-\u03baB signaling pathway.","volume":"31","author":"Helen","year":"2016","journal-title":"Cell Immunol"},{"key":"27","doi-asserted-by":"publisher","first-page":"e0157251","DOI":"10.1371\/journal.pone.0157251","article-title":"Anti-Breast Cancer Potential of Quercetin via the Akt\/AMPK\/Mammalian Target of Rapamycin (mTOR) Signaling Cascade.","volume":"1","author":"Dharmawardhane","year":"2016","journal-title":"PLoS One"},{"key":"28","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ejmech.2017.09.001","article-title":"Anti-inflammatory effects of flavonoids in neurodegenerative disorders.","volume":"15","author":"Russo","year":"2018","journal-title":"Eur J Med Chem"},{"key":"29","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.3390\/ijms20133177","article-title":"The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism.","volume":"2","author":"Carrasco-Pozo","year":"2019","journal-title":"Int J Mol Sci"},{"key":"30","doi-asserted-by":"publisher","first-page":"172568","DOI":"10.1016\/j.ejphar.2019.172568","article-title":"Antitumor and apoptotic effects of quercetin on human melanoma cells involving JNK\/P38 MAPK signaling activation.","volume":"86","author":"Jung","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"31","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.cmet.2018.06.006","article-title":"Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling.","volume":"2","author":"Lozier","year":"2018","journal-title":"Cell Metab"},{"key":"32","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/0014-2999(92)90130-v","article-title":"Carvedilol, a new beta-adrenoceptor antagonist and vasodilator antihypertensive drug, inhibits superoxide release from human neutrophils.","volume":"21","author":"Feuerstein","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"33","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1006\/taap.2002.9532","article-title":"Carvedilol protects against doxorubicin-induced mitochondrial cardiomyopathy.","volume":"18","author":"Wallace","year":"2002","journal-title":"Toxicol Appl Pharmacol"},{"key":"34","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.3390\/ijms19092843","article-title":"Genus Plants: From Farm to Food Applications and Phytopharmacotherapy.","volume":"1","author":"Martins","year":"2018","journal-title":"Int J Mol Sci"},{"key":"35","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/s0021-9673(96)01067-9","article-title":"Identification of phenolic acids and inositols in balms and tissues from an Egyptian mummy.","volume":"76","author":"Tchapla","year":"1997","journal-title":"J Chromatogr A"},{"key":"36","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/jssc.200301607","article-title":"Characterisation of embalming materials of a mummy of the Ptolemaic era. Comparison with balms from mummies of different eras.","volume":"2","author":"Goursaud","year":"2004","journal-title":"J Sep Sci"},{"key":"37","doi-asserted-by":"publisher","first-page":"344","DOI":"10.3390\/biom9080344","article-title":"Tannins: Prospectives and Actual Industrial Applications.","volume":"9","author":"Pizzi","year":"2019","journal-title":"Biomolecules"},{"key":"38","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1093\/carcin\/bgi068","article-title":"Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes.","volume":"2","author":"Talalay","year":"2005","journal-title":"Carcinogenesis"},{"key":"39","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1080\/10715760801993076","article-title":"Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K\/Akt and Nrf2.","volume":"4","author":"Zhao","year":"2008","journal-title":"Free Radic Res"},{"key":"40","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1054\/mehy.1997.0647","article-title":"Azelaic acid: potential as a general antitumoural agent.","volume":"5","author":"Breathnach","year":"1999","journal-title":"Med Hypotheses"},{"key":"41","doi-asserted-by":"publisher","first-page":"S45","DOI":"10.1186\/1423-0127-17-S1-S45","article-title":"Effect of combination of taurine and azelaic acid on antimelanogenesis in murine melanoma cells.","volume":"1","author":"Kim","year":"2010","journal-title":"J Biomed Sci"},{"key":"42","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3389\/fphar.2017.00359","article-title":"Azelaic Acid Exerts Antileukemic Activity in Acute Myeloid Leukemia.","volume":"8","author":"Zhou","year":"2017","journal-title":"Front Pharmacol"},{"key":"43","first-page":"937","article-title":"Gas-liquid chromatographic determination of adipic acid in crackling candy and soft drinks.","volume":"6","author":"Iwaida","year":"1979","journal-title":"J Assoc Off Anal Chem"},{"key":"44","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.copbio.2017.03.006","article-title":"Metabolic engineering strategies to bio-adipic acid production.","volume":"4","author":"Peralta-Yahya","year":"2017","journal-title":"Curr Opin Biotechnol"},{"key":"45","doi-asserted-by":"publisher","first-page":"302875","DOI":"10.1155\/2012\/302875","article-title":"Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from Pellagra.","volume":"201","author":"Ramsden","year":"2012","journal-title":"Curr Gerontol Geriatr Res"},{"key":"46","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1136\/bmj.2.5098.713","article-title":"Effects of salts of nicotinic acid on serum cholesterol.","volume":"2","author":"Hoffer","year":"1958","journal-title":"Br Med J"},{"key":"47","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s13058-016-0712-6","article-title":"Cancer stem cell metabolism.","volume":"1","author":"Lisanti","year":"2016","journal-title":"Breast Cancer Res"},{"key":"48","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cmet.2017.05.016","article-title":"Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells.","volume":"2","author":"Chan","year":"2017","journal-title":"Cell Metab"},{"key":"49","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.semcancer.2019.09.002","article-title":"Dormant disseminated tumor cells and cancer stem\/progenitor-like cells: Similarities and opportunities.","volume":"6","author":"Barkan","year":"2020","journal-title":"Semin Cancer Biol"},{"key":"50","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.ctrv.2018.07.004","article-title":"Cancer stem cell in breast cancer therapeutic resistance.","volume":"6","author":"Li","year":"2018","journal-title":"Cancer Treat Rev"},{"key":"51","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.semcancer.2018.11.006","article-title":"Therapy resistance mediated by cancer stem cells.","volume":"5","author":"Skvortsova","year":"2018","journal-title":"Semin Cancer Biol"},{"key":"52","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1038\/s41388-018-0589-1","article-title":"Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.","volume":"3","author":"Kohno","year":"2019","journal-title":"Oncogene"},{"key":"53","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12943-016-0555-x","article-title":"Cancer stem cell metabolism: a potential target for cancer therapy.","volume":"1","author":"Dharmarajan","year":"2016","journal-title":"Mol Cancer"},{"key":"54","doi-asserted-by":"publisher","first-page":"dmm033464","DOI":"10.1242\/dmm.033464","article-title":"Metabolic traits of cancer stem cells.","volume":"1","author":"Lima","year":"2018","journal-title":"Dis Model Mech"},{"key":"55","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3389\/fonc.2018.00203","article-title":"Cancer Stem Cell Metabolism and Potential Therapeutic Targets.","volume":"8","author":"Anant","year":"2018","journal-title":"Front Oncol"},{"key":"56","doi-asserted-by":"publisher","first-page":"319","DOI":"10.5483\/bmbrep.2018.51.7.112","article-title":"Cancer stem cell metabolism: target for cancer therapy.","volume":"5","author":"Kim","year":"2018","journal-title":"BMB Rep"},{"key":"57","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1136\/bjsports-2016-097333","article-title":"Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.","volume":"5","author":"Hunter","year":"2018","journal-title":"Br J Sports Med"},{"key":"58","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1007\/s10552-011-9806-8","article-title":"Use of glucosamine and chondroitin and lung cancer risk in the VITamins And Lifestyle (VITAL) cohort.","volume":"2","author":"White","year":"2011","journal-title":"Cancer Causes Control"},{"key":"59","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/0304-4165(75)90074-4","article-title":"Inhibitory effect of D-glucosamine on glycolysis in bovine retina.","volume":"38","author":"Calvaruso","year":"1975","journal-title":"Biochim Biophys Acta"},{"key":"60","doi-asserted-by":"publisher","first-page":"3563","DOI":"10.1038\/ncomms4563","article-title":"D-Glucosamine supplementation extends life span of nematodes and of ageing mice.","volume":"5","author":"Platzer","year":"2014","journal-title":"Nat Commun"},{"key":"61","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1080\/13813450802033909","article-title":"Glucosamine inhibits the synthesis of glycosaminoglycan chains on vascular smooth muscle cell proteoglycans by depletion of ATP.","volume":"11","author":"Tannock","year":"2008","journal-title":"Arch Physiol Biochem"},{"key":"62","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s40001-015-0176-7","article-title":"Beneficial reward-to-risk action of glucosamine during pathogenesis of osteoarthritis.","volume":"2","author":"Jin","year":"2015","journal-title":"Eur J Med Res"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2017.1339813","article-title":"Sequential Therapy of Breast Cancer Cell Lines with Vitamin C and Quercetin Improves the Efficacy of Chemotherapeutic Drugs.","author":"Mostafavi-Pour","year":"2017","journal-title":"Nutr Cancer"},{"key":"64","doi-asserted-by":"publisher","first-page":"123","DOI":"10.4149\/BLL_2017_025","article-title":"Quercetin induces apoptosis and necroptosis in MCF-7 breast cancer cells.","volume":"11","author":"Khodadadi","year":"2017","journal-title":"Bratisl Lek Listy"},{"key":"65","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.jfda.2019.07.001","article-title":"Quercetin facilitates cell death and chemosensitivity through RAGE\/PI3K\/AKT\/mTOR axis in human pancreatic cancer cells.","volume":"2","author":"Yen","year":"2019","journal-title":"J Food Drug Anal"},{"key":"66","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1080\/01635581.2019.1670853","article-title":"The Effect of Resveratrol and Quercetin on Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem Cell.","volume":"7","author":"Vatansever","year":"2020","journal-title":"Nutr Cancer"},{"key":"67","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jphs.2019.03.005","article-title":"Quercetin suppresses the tumorigenesis of oral squamous cell carcinoma by regulating microRNA-22\/WNT1\/\u03b2-catenin axis.","volume":"14","author":"Liu","year":"2019","journal-title":"J Pharmacol Sci"},{"key":"68","doi-asserted-by":"publisher","first-page":"4509","DOI":"10.7150\/jca.31045","article-title":"Combination of quercetin and cisplatin enhances apoptosis in OSCC cells by downregulating xIAP through the NF-\u03baB pathway.","volume":"1","author":"Wang","year":"2019","journal-title":"J Cancer"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.12.014","article-title":"Quercetin and the mitochondria: A mechanistic view.","author":"Nabavi","year":"2016","journal-title":"Biotechnol Adv"},{"key":"70","doi-asserted-by":"publisher","first-page":"e15403","DOI":"10.1097\/MD.0000000000015403","article-title":"Clinical efficacy of carvedilol treatment for dilated cardiomyopathy: A meta-analysis of randomized controlled trials.","volume":"9","author":"Li","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"71","doi-asserted-by":"publisher","first-page":"109106","DOI":"10.1016\/j.biopha.2019.109106","article-title":"The cardioprotective effects of carvedilol on ischemia and reperfusion injury by AMPK signaling pathway.","volume":"11","author":"Zhu","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"72","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ahj.2017.03.010","article-title":"Lisinopril or Coreg CR in reducing cardiotoxicity in women with breast cancer receiving trastuzumab: A rationale and design of a randomized clinical trial.","volume":"18","author":"Krischer","year":"2017","journal-title":"Am Heart J"},{"key":"73","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1016\/j.jacc.2019.03.495","article-title":"Randomized Trial of Lisinopril Versus Carvedilol to Prevent Trastuzumab Cardiotoxicity in Patients With Breast Cancer.","volume":"7","author":"Munster","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"74","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.2174\/1389203720666190830163735","article-title":"A Mitochondrial Approach to Cardiovascular Risk and Disease.","volume":"2","author":"Oliveira","year":"2019","journal-title":"Curr Pharm Des"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.137664","article-title":"Carvedilol suppresses migration and invasion of malignant breast cells by inactivating Src involving cAMP\/PKA and PKC\u03b4 signaling pathway.","author":"Zhigang","year":"2014","journal-title":"J Cancer Res Ther"},{"key":"76","doi-asserted-by":"publisher","first-page":"811","DOI":"10.3892\/or.2018.6873","article-title":"Carvedilol suppresses malignant proliferation of mammary epithelial cells through inhibition of the ROS-mediated PI3K\/AKT signaling pathway.","volume":"4","author":"Gao","year":"2019","journal-title":"Oncol Rep"},{"key":"77","first-page":"891","article-title":"Ciprofloxacin mediated cell growth inhibition, S\/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line.","volume":"6","author":"Sarkar","year":"2000","journal-title":"Clin Cancer Res"},{"key":"78","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.pharep.2017.07.007","article-title":"Ciprofloxacin-mediated induction of S-phase cell cycle arrest and apoptosis in COLO829 melanoma cells.","volume":"7","author":"Buszman","year":"2018","journal-title":"Pharmacol Rep"},{"key":"79","doi-asserted-by":"publisher","first-page":"9625","DOI":"10.1093\/nar\/gky793","article-title":"Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2.","volume":"4","author":"Goffart","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"80","doi-asserted-by":"publisher","first-page":"97","DOI":"10.4161\/cbt.5.1.2347","article-title":"Cytotoxicity of a natural anthraquinone (Aloin) against human breast cancer cell lines with and without ErbB-2: topoisomerase IIalpha coamplification.","volume":"5","author":"Rio","year":"2006","journal-title":"Cancer Biol Ther"},{"key":"81","doi-asserted-by":"publisher","first-page":"5759","DOI":"10.3892\/mmr.2017.7379","article-title":"Aloin promotes A549 cell apoptosis via the reactive oxygen species-mitogen activated protein kinase signaling pathway and p53 phosphorylation.","volume":"1","author":"Wang","year":"2017","journal-title":"Mol Med Rep"},{"key":"82","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1111\/jcmm.13015","article-title":"Tannic acid inhibits EGFR\/STAT1\/3 and enhances p38\/STAT1 signalling axis in breast cancer cells.","volume":"2","author":"Yang","year":"2017","journal-title":"J Cell Mol Med"},{"key":"83","first-page":"735","article-title":"The chlorophyllin-induced cell cycle arrest and apoptosis in human breast cancer MCF-7 cells is associated with ERK deactivation and Cyclin D1 depletion.","volume":"1","author":"Ooi","year":"2005","journal-title":"Int J Mol Med"},{"key":"84","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.etap.2016.07.006","article-title":"Nano-encapsulated chlorophyllin significantly delays progression of lung cancer both inandmodels through activation of mitochondrial signaling cascades and drug-DNA interaction.","volume":"4","author":"Khuda-Bukhsh","year":"2016","journal-title":"Environ Toxicol Pharmacol"},{"key":"85","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1515\/znb-1970-0514","article-title":"Light amplified inhibition of oxidative phosphorylation by chlorophyllins in rat liver mitochondria.","volume":"2","author":"Frimmer","year":"1970","journal-title":"Z Naturforsch B"},{"key":"86","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1080\/10611860701349315","article-title":"Characteristics and anti-proliferative activity of azelaic acid and its derivatives entrapped in bilayer vesicles in cancer cell lines.","volume":"1","author":"Manosroi","year":"2007","journal-title":"J Drug Target"},{"key":"87","first-page":"964","article-title":"Azelaic Acid: Evidence-based Update on Mechanism of Action and Clinical Application.","volume":"1","author":"Rosen","year":"2015","journal-title":"J Drugs Dermatol"},{"key":"88","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0006-2952(84)90376-9","article-title":"Antimitochondrial effect of saturated medium chain length (C8-C13) dicarboxylic acids.","volume":"3","author":"Serlupi-Crescenzi","year":"1984","journal-title":"Biochem Pharmacol"},{"key":"89","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.biochi.2018.02.013","article-title":"Cymbopogon citratus and Cymbopogon giganteus essential oils have cytotoxic effects on tumor cell cultures. Identification of citral as a new putative anti-proliferative molecule.","volume":"15","author":"Lobaccaro","year":"2018","journal-title":"Biochimie"},{"key":"90","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3389\/fmicb.2018.00239","article-title":"A Damaged Oxidative Phosphorylation Mechanism Is Involved in the Antifungal Activity of Citral against","volume":"9","author":"Zhang","year":"2018","journal-title":"Front Microbiol"},{"key":"91","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1038\/s41598-018-38214-x","article-title":"cytotoxicity and anticancer effects of citral nanostructured lipid carrier on MDA MBA-231 human breast cancer cells.","volume":"9","author":"Alitheen","year":"2019","journal-title":"Sci Rep"},{"key":"92","doi-asserted-by":"publisher","first-page":"5962832","DOI":"10.1155\/2016\/5962832","article-title":"Protective Effect of D-Limonene against Oxidative Stress-Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway.","volume":"201","author":"Liu","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"93","doi-asserted-by":"publisher","first-page":"683","DOI":"10.17179\/excli2019-1431","article-title":"Up-regulation of miR-381 inhibits NAD+ salvage pathway and promotes apoptosis in breast cancer cells.","volume":"1","author":"Mobaser","year":"2019","journal-title":"EXCLI J"},{"key":"94","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1080\/15384101.2018.1515551","article-title":"A mitochondrial based oncology platform for targeting cancer stem cells (CSCs): MITO-ONC-RX.","volume":"1","author":"Lisanti","year":"2018","journal-title":"Cell Cycle"},{"key":"95","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.3389\/fonc.2020.01528","article-title":"A Myristoyl Amide Derivative of Doxycycline Potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis, Without Retaining Antibiotic Activity.","volume":"1","author":"Lisanti","year":"2020","journal-title":"Front Oncol"},{"key":"96","doi-asserted-by":"publisher","first-page":"452","DOI":"10.3389\/fonc.2018.00452","article-title":"Doxycycline, an Inhibitor of Mitochondrial Biogenesis, Effectively Reduces Cancer Stem Cells (CSCs) in Early Breast Cancer Patients: A Clinical Pilot Study.","volume":"8","author":"Naccarato","year":"2018","journal-title":"Front Oncol"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.204412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T19:40:26Z","timestamp":1669923626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.204412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":96,"alternative-id":["204412"],"URL":"https:\/\/doi.org\/10.18632\/aging.204412","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,1]]}}}