{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:04:48Z","timestamp":1788444288204,"version":"build-2803163510"},"reference-count":29,"publisher":"Impact Journals, LLC","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2023,5,15]]},"DOI":"10.18632\/aging.204713","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T15:43:43Z","timestamp":1683819823000},"page":"3791-3806","source":"Crossref","is-referenced-by-count":3,"title":["microRNA-497 slows esophageal cancer development and reverses chemotherapy resistance through its target QKI"],"prefix":"10.18632","volume":"15","author":[{"given":"Yun-Xia","family":"Xie","sequence":"first","affiliation":[{"name":"Academy of Medical Science, Zhengzhou University, Zhengzhou 450000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hao","family":"Zhou","sequence":"additional","affiliation":[{"name":"BGI College and Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Wen","family":"Liu","sequence":"additional","affiliation":[{"name":"Academy of Medical Science, Zhengzhou University, Zhengzhou 450000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou University, Zhengzhou 450000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou University, Zhengzhou 450000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Ke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Academy of Medical Science, Zhengzhou University, Zhengzhou 450000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Liang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, City University of Hong Kong, Hong Kong 999077, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Ge","family":"Qiu","sequence":"additional","affiliation":[{"name":"Academy of Medical Science, Zhengzhou University, Zhengzhou 450000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Academy of Medical Science, Zhengzhou University, Zhengzhou 450000, China"},{"name":"BGI College and Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Hua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Academy of Medical Science, Zhengzhou University, Zhengzhou 450000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.","volume":"7","author":"Bray","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"2","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.asjsur.2016.10.005","article-title":"Esophageal cancer: Risk factors, genetic association, and treatment.","volume":"4","author":"Yu","year":"2018","journal-title":"Asian J Surg"},{"key":"3","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1097\/SLA.0000000000002118","article-title":"Clinical and Prognostic Features of Patients With Esophageal Cancer and Multiple Primary Cancers: A Retrospective Single-institution Study.","volume":"26","author":"Baba","year":"2018","journal-title":"Ann Surg"},{"key":"4","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1080\/14728222.2022.2036718","article-title":"Esophageal cancer: emerging therapeutics.","volume":"2","author":"Ajani","year":"2022","journal-title":"Expert Opin Ther Targets"},{"key":"5","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1038\/s41419-018-1176-7","article-title":"Hypoxia-mediated mitochondria apoptosis inhibition induces temozolomide treatment resistance through miR-26a\/Bad\/Bax axis.","volume":"9","author":"Jiang","year":"2018","journal-title":"Cell Death Dis"},{"key":"6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12943-018-0830-0","article-title":"Estrogen-induced miR-196a elevation promotes tumor growth and metastasis via targeting SPRED1 in breast cancer.","volume":"1","author":"Jiang","year":"2018","journal-title":"Mol Cancer"},{"key":"7","doi-asserted-by":"publisher","first-page":"e19139","DOI":"10.1371\/journal.pone.0019139","article-title":"MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1\u03b1 expression.","volume":"6","author":"Jiang","year":"2011","journal-title":"PLoS One"},{"key":"8","doi-asserted-by":"publisher","first-page":"107157","DOI":"10.18632\/oncotarget.22362","article-title":"Insulin-like growth factor-I induces chemoresistence to docetaxel by inhibiting miR-143 in human prostate cancer.","volume":"8","author":"Jiang","year":"2017","journal-title":"Oncotarget"},{"key":"9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/jmcb\/mjs049","article-title":"A regulatory circuit of miR-148a\/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1.","volume":"5","author":"Liu","year":"2013","journal-title":"J Mol Cell Biol"},{"key":"10","doi-asserted-by":"publisher","first-page":"643","DOI":"10.3389\/fonc.2020.00643","article-title":"MiR-200b Inhibits Tumor Growth and Chemoresistance via Targeting p70S6K1 in Lung Cancer.","volume":"1","author":"Wang","year":"2020","journal-title":"Front Oncol"},{"key":"11","doi-asserted-by":"publisher","first-page":"840","DOI":"10.3389\/fcell.2020.00840","article-title":"Regulation of MicroRNA-497-Targeting AKT2 Influences Tumor Growth and Chemoresistance to Cisplatin in Lung Cancer.","volume":"8","author":"Jiang","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"12","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.1016\/j.febslet.2014.07.021","article-title":"Hypoxia-induced miR-497 decreases glioma cell sensitivity to TMZ by inhibiting apoptosis.","volume":"58","author":"Lou","year":"2014","journal-title":"FEBS Lett"},{"key":"13","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1261\/rna.038422.113","article-title":"Quaking and PTB control overlapping splicing regulatory networks during muscle cell differentiation.","volume":"1","author":"Ares","year":"2013","journal-title":"RNA"},{"key":"14","doi-asserted-by":"publisher","first-page":"e99016","DOI":"10.15252\/embj.201899016","article-title":"miR-200\/375 control epithelial plasticity-associated alternative splicing by repressing the RNA-binding protein Quaking.","volume":"3","author":"Lawrence","year":"2018","journal-title":"EMBO J"},{"key":"15","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/gene.10060","article-title":"Quaking is essential for blood vessel development.","volume":"3","author":"Justice","year":"2002","journal-title":"Genesis"},{"key":"16","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.yjmcc.2014.07.010","article-title":"QKI deficiency promotes FoxO1 mediated nitrosative stress and endoplasmic reticulum stress contributing to increased vulnerability to ischemic injury in diabetic heart.","volume":"7","author":"Ma","year":"2014","journal-title":"J Mol Cell Cardiol"},{"key":"17","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.cell.2015.02.014","article-title":"The RNA binding protein quaking regulates formation of circRNAs.","volume":"16","author":"Goodall","year":"2015","journal-title":"Cell"},{"key":"18","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1007\/s00210-019-01772-6","article-title":"Inhibition of miR-574-5p suppresses cell growth and metastasis and enhances chemosensitivity by targeting RNA binding protein QKI in cervical cancer cells.","volume":"39","author":"Ju","year":"2020","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"19","doi-asserted-by":"publisher","first-page":"24037","DOI":"10.18632\/aging.203665","article-title":"MiRNA-30e downregulation increases cancer cell proliferation, invasion and tumor growth through targeting RPS6KB1.","volume":"1","author":"Liu","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"20","doi-asserted-by":"publisher","first-page":"e1008592","DOI":"10.1371\/journal.pgen.1008592","article-title":"DNA methylation-mediated repression of exosomal miR-652-5p expression promotes oesophageal squamous cell carcinoma aggressiveness by targeting PARG and VEGF pathways.","volume":"1","author":"Sun","year":"2020","journal-title":"PLoS Genet"},{"key":"21","doi-asserted-by":"publisher","first-page":"985","DOI":"10.3892\/ijo.2012.1537","article-title":"Identification of novel molecular targets regulated by tumor suppressive miR-375 induced by histone acetylation in esophageal squamous cell carcinoma.","volume":"4","author":"Nishino","year":"2012","journal-title":"Int J Oncol"},{"key":"22","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13045-020-00937-8","article-title":"EZH2: a novel target for cancer treatment.","volume":"1","author":"Guo","year":"2020","journal-title":"J Hematol Oncol"},{"key":"23","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1093\/nar\/gkr730","article-title":"MiR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angiogenesis.","volume":"4","author":"Jiang","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"24","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.bbrc.2018.04.188","article-title":"MiR-502 mediates esophageal cancer cell TE1 proliferation by promoting AKT phosphorylation.","volume":"50","author":"Hu","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"25","doi-asserted-by":"publisher","first-page":"114606","DOI":"10.1016\/j.taap.2019.114606","article-title":"Arsenic-induced metabolic shift triggered by the loss of miR-199a-5p through Sp1-dependent DNA methylation.","volume":"37","author":"Jiang","year":"2019","journal-title":"Toxicol Appl Pharmacol"},{"key":"26","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12943-021-01343-5","article-title":"Epigenetic silencing of miR-144\/451a cluster contributes to HCC progression via paracrine HGF\/MIF-mediated TAM remodeling.","volume":"2","author":"Liu","year":"2021","journal-title":"Mol Cancer"},{"key":"27","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.gene.2017.10.018","article-title":"Epigenetic regulation of miR-200 as the potential strategy for the therapy against triple-negative breast cancer.","volume":"64","author":"Pal-Bhadra","year":"2018","journal-title":"Gene"},{"key":"28","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1111\/1759-7714.13950","article-title":"miR-493 by regulating of c-Jun targets Wnt5a\/PD-L1-inducing esophageal cancer cell development.","volume":"1","author":"Li","year":"2021","journal-title":"Thorac Cancer"},{"key":"29","doi-asserted-by":"publisher","first-page":"2577","DOI":"10.1038\/onc.2016.414","article-title":"Downregulation of miR-218 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer by targeting Slug\/ZEB2 signaling.","volume":"3","author":"Peiper","year":"2017","journal-title":"Oncogene"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.204713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T12:21:06Z","timestamp":1684758066000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.204713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,11]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,5,15]]}},"alternative-id":["204713","37171386"],"URL":"https:\/\/doi.org\/10.18632\/aging.204713","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,11]]}}}