{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:27:30Z","timestamp":1777584450764,"version":"3.51.4"},"reference-count":45,"publisher":"Impact Journals, LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"DOI":"10.18632\/aging.204944","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T15:20:05Z","timestamp":1691594405000},"source":"Crossref","is-referenced-by-count":9,"title":["Hmgcs2 regulates M2 polarization of macrophages to repair myocardial injury induced by sepsis"],"prefix":"10.18632","author":[{"given":"Xiao-Zheng","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning, PR China"},{"name":"Department of Cardiovascular Surgery, General Hospital of Northern Theater Command of China Medical University, Laboratory of Rescue Center of Severe Wound and Trauma PLA, Shenyang 110016, Liaoning, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Feng","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, Guangdong, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Xiao","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, General Hospital of Northern Theater Command of China Medical University, Laboratory of Rescue Center of Severe Wound and Trauma PLA, Shenyang 110016, Liaoning, PR China"},{"name":"Shenyang Medical College, Shenyang 110034, Liaoning, PR China"},{"name":"Department of Cardiovascular Surgery, The Second Affiliated Hospital of Shenyang Medical College, The Veterans General Hospital of Liaoning, Shenyang 110001, Liaoning, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"997853","DOI":"10.3389\/fimmu.2022.997853","article-title":"Diagnostic value of RDW for the prediction of mortality in adult sepsis patients: A systematic review and meta-analysis.","volume":"1","author":"Ma","year":"2022","journal-title":"Front Immunol"},{"key":"2","doi-asserted-by":"publisher","first-page":"8471","DOI":"10.1038\/s41598-021-88231-6","article-title":"Therapeutic effects and outcomes of rescue high-frequency oscillatory ventilation for premature infants with severe refractory respiratory failure.","volume":"1","author":"Tsai","year":"2021","journal-title":"Sci Rep"},{"key":"3","doi-asserted-by":"publisher","first-page":"9367","DOI":"10.1080\/21655979.2021.2001913","article-title":"Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction.","volume":"1","author":"Huang","year":"2021","journal-title":"Bioengineered"},{"key":"4","doi-asserted-by":"publisher","first-page":"174644","DOI":"10.1016\/j.ejphar.2021.174644","article-title":"Syringaresinol attenuates sepsis-induced cardiac dysfunction by inhibiting inflammation and pyroptosis in mice.","volume":"91","author":"Cong","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"5","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.kint.2021.07.022","article-title":"Ketone bodies: back to a place in the sun.","volume":"10","author":"Kume","year":"2021","journal-title":"Kidney Int"},{"key":"6","doi-asserted-by":"publisher","first-page":"158813","DOI":"10.1016\/j.bbalip.2020.158813","article-title":"Ketone metabolism in the failing heart.","volume":"186","author":"Ketema","year":"2020","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"7","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","article-title":"Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.","volume":"2","author":"Crawford","year":"2017","journal-title":"Cell Metab"},{"key":"8","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1194\/jlr.M023382","article-title":"Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver.","volume":"5","author":"Burgess","year":"2012","journal-title":"J Lipid Res"},{"key":"9","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s10753-018-0890-8","article-title":"Review: the Role and Mechanisms of Macrophage Autophagy in Sepsis.","volume":"4","author":"Zhang","year":"2019","journal-title":"Inflammation"},{"key":"10","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3109\/10408363.2013.764490","article-title":"Biomarkers of sepsis.","volume":"5","author":"Faix","year":"2013","journal-title":"Crit Rev Clin Lab Sci"},{"key":"11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.immuni.2017.11.026","article-title":"Chanzyme TRPM7 Mediates the CaInflux Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.","volume":"4","author":"Desai","year":"2018","journal-title":"Immunity"},{"key":"12","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.3389\/fimmu.2019.01084","article-title":"Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages.","volume":"1","author":"Ley","year":"2019","journal-title":"Front Immunol"},{"key":"13","doi-asserted-by":"publisher","first-page":"16045","DOI":"10.1038\/nrdp.2016.45","article-title":"Sepsis and septic shock.","volume":"2","author":"Vincent","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"14","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s12866-018-1227-3","article-title":"Gold nanoparticles attenuates bacterial sepsis in cecal ligation and puncture mouse model through the induction of M2 macrophage polarization.","volume":"1","author":"Leelahavanichkul","year":"2018","journal-title":"BMC Microbiol"},{"key":"15","doi-asserted-by":"publisher","first-page":"9089610","DOI":"10.1155\/2016\/9089610","article-title":"The Alternative Faces of Macrophage Generate Osteoclasts.","volume":"201","author":"Zito","year":"2016","journal-title":"Biomed Res Int"},{"key":"16","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.3389\/fimmu.2019.01462","article-title":"The Metabolic Signature of Macrophage Responses.","volume":"1","author":"Castegna","year":"2019","journal-title":"Front Immunol"},{"key":"17","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cyto.2018.02.002","article-title":"Melanoma exosomes promote mixed M1 and M2 macrophage polarization.","volume":"10","author":"Hood","year":"2018","journal-title":"Cytokine"},{"key":"18","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.","volume":"1","author":"Anders","year":"2014","journal-title":"Genome Biol"},{"key":"19","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters.","volume":"1","author":"He","year":"2012","journal-title":"OMICS"},{"key":"20","doi-asserted-by":"publisher","first-page":"173090","DOI":"10.1016\/j.ejphar.2020.173090","article-title":"Macrophage M1\/M2 polarization.","volume":"87","author":"Weidong","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"21","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.4049\/jimmunol.1601515","article-title":"Akt Signaling Pathway in Macrophage Activation and M1\/M2 Polarization.","volume":"19","author":"Tsatsanis","year":"2017","journal-title":"J Immunol"},{"key":"22","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jgar.2017.06.013","article-title":"Sepsis and septic shock: New definitions, new diagnostic and therapeutic approaches.","volume":"1","author":"Pagliano","year":"2017","journal-title":"J Glob Antimicrob Resist"},{"key":"23","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1097\/01.NAJ.0000530223.33211.f5","article-title":"CE: Managing Sepsis and Septic Shock: Current Guidelines and Definitions.","volume":"11","author":"Bridges","year":"2018","journal-title":"Am J Nurs"},{"key":"24","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1056\/NEJMoa1703058","article-title":"Time to Treatment and Mortality during Mandated Emergency Care for Sepsis.","volume":"37","author":"Levy","year":"2017","journal-title":"N Engl J Med"},{"key":"25","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/SHK.0000000000000272","article-title":"Impaired heart rate regulation and depression of cardiac chronotropic and dromotropic function in polymicrobial sepsis.","volume":"4","author":"Williams","year":"2015","journal-title":"Shock"},{"key":"26","doi-asserted-by":"publisher","first-page":"5622","DOI":"10.3390\/molecules25235622","article-title":"Cardioprotective Effect of Tangeretin by Inhibiting PTEN\/AKT\/mTOR Axis in Experimental Sepsis-Induced Myocardial Dysfunction.","volume":"2","author":"Sreeharsha","year":"2020","journal-title":"Molecules"},{"key":"27","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1056\/NEJMoa1214865","article-title":"Treatment of anemia with darbepoetin alfa in systolic heart failure.","volume":"36","author":"van Veldhuisen","year":"2013","journal-title":"N Engl J Med"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2011.06.017","article-title":"Ventricular dysfunction and dilation in severe sepsis and septic shock: relation to endothelial function and mortality.","volume":"2","author":"Biolo","year":"2012","journal-title":"J Crit Care"},{"key":"29","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.chest.2020.09.274","article-title":"Right Ventricular Dysfunction in Early Sepsis and Septic Shock.","volume":"15","author":"Grissom","year":"2021","journal-title":"Chest"},{"key":"30","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1016\/j.chest.2020.11.054","article-title":"Sepsis-Induced Myocardial Dysfunction: \"Right Ventricular Dysfunction\" or \"Biventricular Dysfunction\"?","volume":"15","author":"Karamchandani","year":"2021","journal-title":"Chest"},{"key":"31","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.cell.2019.07.048","article-title":"Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet.","volume":"17","author":"Bauer-Rowe","year":"2019","journal-title":"Cell"},{"key":"32","doi-asserted-by":"publisher","first-page":"983401","DOI":"10.1155\/2014\/983401","article-title":"BHBA suppresses LPS-induced inflammation in BV-2 cells by inhibiting NF-\u03baB activation.","volume":"201","author":"Liu","year":"2014","journal-title":"Mediators Inflamm"},{"key":"33","doi-asserted-by":"publisher","first-page":"eabc8433","DOI":"10.1126\/science.abc8433","article-title":"Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.","volume":"37","author":"Garcia","year":"2021","journal-title":"Science"},{"key":"34","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/s13287-019-1352-4","article-title":"Mesenchymal stromal cell-derived nanovesicles ameliorate bacterial outer membrane vesicle-induced sepsis via IL-10.","volume":"1","author":"L\u00f6tvall","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"35","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.4049\/jimmunol.2001131","article-title":"NK Cell-Derived IL-10 Supports Host Survival during Sepsis.","volume":"20","author":"Badovinac","year":"2021","journal-title":"J Immunol"},{"key":"36","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.3389\/fimmu.2020.01731","article-title":"Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment.","volume":"1","author":"Xu","year":"2020","journal-title":"Front Immunol"},{"key":"37","doi-asserted-by":"publisher","first-page":"6779","DOI":"10.2147\/IJN.S215055","article-title":"SPIONs enhances IL-10-producing macrophages to relieve sepsis via Cav1-Notch1\/HES1-mediated autophagy.","volume":"1","author":"Hou","year":"2019","journal-title":"Int J Nanomedicine"},{"key":"38","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1146\/annurev-immunol-032414-112220","article-title":"Macrophages: development and tissue specialization.","volume":"3","author":"Jung","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"39","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage Polarization.","volume":"7","author":"Murray","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"40","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1146\/annurev-physiol-022516-034348","article-title":"Macrophages and the Recovery from Acute and Chronic Inflammation.","volume":"7","author":"Mosser","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"41","doi-asserted-by":"publisher","first-page":"815347","DOI":"10.3389\/fnagi.2022.815347","article-title":"Microglia Polarization From M1 to M2 in Neurodegenerative Diseases.","volume":"1","author":"Yin","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"42","doi-asserted-by":"publisher","first-page":"22460","DOI":"10.18632\/oncotarget.13006","article-title":"HMGCS2 enhances invasion and metastasis via direct interaction with PPAR\u03b1 to activate Src signaling in colorectal cancer and oral cancer.","volume":"8","author":"Lin","year":"2017","journal-title":"Oncotarget"},{"key":"43","doi-asserted-by":"publisher","first-page":"101494","DOI":"10.1016\/j.molmet.2022.101494","article-title":"Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis.","volume":"6","author":"Kim","year":"2022","journal-title":"Mol Metab"},{"key":"44","doi-asserted-by":"publisher","first-page":"99762","DOI":"10.1172\/jci.insight.99762","article-title":"Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome.","volume":"3","author":"Crawford","year":"2018","journal-title":"JCI Insight"},{"key":"45","doi-asserted-by":"publisher","first-page":"103959","DOI":"10.1016\/j.ebiom.2022.103959","article-title":"Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis.","volume":"7","author":"Lu","year":"2022","journal-title":"EBioMedicine"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.204944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T15:20:08Z","timestamp":1691594408000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.204944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,9]]},"references-count":45,"alternative-id":["204944"],"URL":"https:\/\/doi.org\/10.18632\/aging.204944","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,9]]}}}