{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:16:29Z","timestamp":1787854589471,"version":"build-2784847793"},"reference-count":48,"publisher":"Impact Journals, LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"DOI":"10.18632\/aging.205139","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T20:28:52Z","timestamp":1697833732000},"source":"Crossref","is-referenced-by-count":4,"title":["Anti-cancer targets and molecular mechanisms of formononetin in treating osteosarcoma based on network pharmacology"],"prefix":"10.18632","author":[{"given":"Lizhi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Science and Education, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China"},{"name":"Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Medical Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Science and Education, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Weng","sequence":"additional","affiliation":[{"name":"The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Medical Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Medical Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Medical Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Institute of Ultrasound in Musculoskeletal Sports Medicine, Guangdong Second Provincial, General Hospital, Guangzhou, Guangdong, China"},{"name":"Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Medical Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2023,10,20]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13046-018-0689-3","article-title":"SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition.","volume":"3","author":"Zhu","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"key":"2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/mc.22873","article-title":"Notch pathway inhibition using DAPT, a \u03b3-secretase inhibitor (GSI), enhances the antitumor effect of cisplatin in resistant osteosarcoma.","volume":"5","author":"Gao","year":"2019","journal-title":"Mol Carcinog"},{"key":"3","doi-asserted-by":"publisher","first-page":"20116","DOI":"10.18632\/aging.203047","article-title":"LncRNA RUSC1-AS1 promotes osteosarcoma progression through regulating the miR-340-5p and PI3K\/AKT pathway.","volume":"1","author":"Huang","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1051\/sicotj\/2017028","article-title":"Osteosarcoma: a comprehensive review.","volume":"4","author":"Kulidjian","year":"2018","journal-title":"SICOT J"},{"key":"5","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1007\/s11914-023-00803-9","article-title":"Advances in Osteosarcoma.","volume":"2","author":"Heymann","year":"2023","journal-title":"Curr Osteoporos Rep"},{"key":"6","doi-asserted-by":"publisher","first-page":"115214","DOI":"10.1016\/j.jep.2022.115214","article-title":"Tanshinol suppresses osteosarcoma by specifically inducing apoptosis of U2-OS cells through p53-mediated mechanism.","volume":"29","author":"Efferth","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"7","doi-asserted-by":"publisher","first-page":"18191","DOI":"10.18632\/aging.203156","article-title":"Formononetin relieves the facilitating effect of lncRNA AFAP1-AS1-miR-195\/miR-545 axis on progression and chemo-resistance of triple-negative breast cancer.","volume":"1","author":"Chen","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"8","doi-asserted-by":"publisher","first-page":"7865015","DOI":"10.1155\/2022\/7865015","article-title":"In Vitro and In Vivo Wound Healing Activity ofBoiss. (Fabaceae).","volume":"202","author":"Vahedi","year":"2022","journal-title":"Adv Pharmacol Pharm Sci"},{"key":"9","doi-asserted-by":"publisher","first-page":"813","DOI":"10.3390\/ijms19030813","article-title":"Inhibition of Intracellular ROS Accumulation by Formononetin Attenuates Cisplatin-Mediated Apoptosis in LLC-PK1 Cells.","volume":"1","author":"Choi","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10","doi-asserted-by":"publisher","first-page":"3048532","DOI":"10.1155\/2018\/3048532","article-title":"Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway.","volume":"201","author":"Ding","year":"2018","journal-title":"Mediators Inflamm"},{"key":"11","doi-asserted-by":"publisher","first-page":"3813","DOI":"10.18632\/aging.204042","article-title":"Apoptosis-related genes-based prognostic signature for osteosarcoma.","volume":"1","author":"Zhang","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"12","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.sjbs.2020.11.048","article-title":"Isoflavones from black chickpea (L) sprouts with antioxidant and antiproliferative activity.","volume":"2","author":"Edith-Oliva","year":"2021","journal-title":"Saudi J Biol Sci"},{"key":"13","doi-asserted-by":"publisher","first-page":"108899","DOI":"10.1016\/j.jnutbio.2021.108899","article-title":"Formononetin represses cervical tumorigenesis by interfering with the activation of PD-L1 through MYC and STAT3 downregulation.","volume":"10","author":"Jin","year":"2022","journal-title":"J Nutr Biochem"},{"key":"14","doi-asserted-by":"publisher","first-page":"7721","DOI":"10.3892\/mmr.2018.8857","article-title":"Formononetin inhibits colon carcinoma cell growth and invasion by microRNA-149-mediated EphB3 downregulation and inhibition of PI3K\/AKT and STAT3 signaling pathways.","volume":"1","author":"Fan","year":"2018","journal-title":"Mol Med Rep"},{"key":"15","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/kjm2.12322","article-title":"Formononetin exhibits anticancer activity in gastric carcinoma cell and regulating miR-542-5p.","volume":"3","author":"Zhao","year":"2021","journal-title":"Kaohsiung J Med Sci"},{"key":"16","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.3892\/mmr.2020.11039","article-title":"Calycosin induces apoptosis in osteosarcoma cell line via ER\u03b2- mediated PI3K\/Akt signaling pathways.","volume":"2","author":"Bao","year":"2020","journal-title":"Mol Med Rep"},{"key":"17","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery.","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat Chem Biol"},{"key":"18","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.2147\/DDDT.S189088","article-title":"Systematic elucidation of the mechanism of geraniol via network pharmacology.","volume":"1","author":"Xu","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"19","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1016\/j.prp.2018.09.013","article-title":"Identification of potential drugs for diffuse large b-cell lymphoma based on bioinformatics and Connectivity Map database.","volume":"21","author":"Peng","year":"2018","journal-title":"Pathol Res Pract"},{"key":"20","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s40001-022-00699-8","article-title":"Mechanistic insight of the potential of geraniol against Alzheimer's disease.","volume":"2","author":"Rehman","year":"2022","journal-title":"Eur J Med Res"},{"key":"21","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1007\/s10529-022-03266-7","article-title":"Network pharmacological evaluation of strigolactones efficacy as potential inhibitors against therapeutic targets of hepatocellular carcinoma.","volume":"4","author":"Singh","year":"2022","journal-title":"Biotechnol Lett"},{"key":"22","doi-asserted-by":"publisher","first-page":"114615","DOI":"10.1016\/j.jep.2021.114615","article-title":"Network pharmacology-based approach to understand the effect and mechanism of Danshen against anemia.","volume":"28","author":"Fu","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"23","doi-asserted-by":"publisher","first-page":"26003","DOI":"10.18632\/aging.203786","article-title":"Network pharmacology reveals the potential mechanism of Baiying Qinghou decoction in treating laryngeal squamous cell carcinoma.","volume":"1","author":"Zhou","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"24","doi-asserted-by":"publisher","first-page":"3197402","DOI":"10.1155\/2022\/3197402","article-title":"Network Pharmacology Prediction: The Possible Mechanisms of Cinobufotalin against Osteosarcoma.","volume":"202","author":"Zhang","year":"2022","journal-title":"Comput Math Methods Med"},{"key":"25","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s13020-021-00520-4","article-title":"Aloin induced apoptosis by enhancing autophagic flux through the PI3K\/AKT axis in osteosarcoma.","volume":"1","author":"Wang","year":"2021","journal-title":"Chin Med"},{"key":"26","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1007\/s10103-018-2486-9","article-title":"The impact of photobiomodulation on osteoblast-like cell: a review.","volume":"3","author":"Fernandes","year":"2018","journal-title":"Lasers Med Sci"},{"key":"27","doi-asserted-by":"publisher","first-page":"3545","DOI":"10.3892\/or.2016.5158","article-title":"Anticancer effect of thalidomide in vitro on human osteosarcoma cells.","volume":"3","author":"Guo","year":"2016","journal-title":"Oncol Rep"},{"key":"28","doi-asserted-by":"publisher","first-page":"115433","DOI":"10.1016\/j.jep.2022.115433","article-title":"Cinobufagin inhibits tumor progression and reduces doxorubicin resistance by enhancing FOXO1-mediated transcription of FCGBP in osteosarcoma.","volume":"29","author":"Song","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"29","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jep.2018.04.014","article-title":"Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells.","volume":"22","author":"Li","year":"2018","journal-title":"J Ethnopharmacol"},{"key":"30","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s12672-017-0306-5","article-title":"The Impact of ESR1 Mutations on the Treatment of Metastatic Breast Cancer.","volume":"9","author":"Fuqua","year":"2018","journal-title":"Horm Cancer"},{"key":"31","doi-asserted-by":"publisher","first-page":"3714","DOI":"10.1002\/cncr.32345","article-title":"ESR1 mutations in breast cancer.","volume":"12","author":"Fuqua","year":"2019","journal-title":"Cancer"},{"key":"32","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1530\/EC-19-0398","article-title":"ESR1 polymorphism (rs2234693) influences femoral bone mass in patients with Turner syndrome.","volume":"8","author":"Jorge","year":"2019","journal-title":"Endocr Connect"},{"key":"33","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.gene.2019.05.060","article-title":"Estrogen receptor \u03b1 and \u03b2 gene polymorphism in relation to bone mineral density and lipid profile in Northeast Indian women.","volume":"71","author":"Khatkhatay","year":"2019","journal-title":"Gene"},{"key":"34","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13058-022-01520-4","article-title":"SETDB1 interactions with PELP1 contributes to breast cancer endocrine therapy resistance.","volume":"2","author":"Viswanadhapalli","year":"2022","journal-title":"Breast Cancer Res"},{"key":"35","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/jth.13604","article-title":"C-type lectin-like receptor 2 promotes hematogenous tumor metastasis and prothrombotic state in tumor-bearing mice.","volume":"1","author":"Suzuki-Inoue","year":"2017","journal-title":"J Thromb Haemost"},{"key":"36","doi-asserted-by":"publisher","first-page":"1533033819898728","DOI":"10.1177\/1533033819898728","article-title":"Circular RNAPromotes Osteosarcoma Migration and Invasion through\/miR-7\/EGFR Pathway.","volume":"1","author":"Yang","year":"2020","journal-title":"Technol Cancer Res Treat"},{"key":"37","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1080\/21655979.2021.2017679","article-title":"inhibits the growth of osteosarcoma cells via impeding Akt\/ERK\/EGFR signaling pathways.","volume":"1","author":"Liu","year":"2022","journal-title":"Bioengineered"},{"key":"38","doi-asserted-by":"publisher","first-page":"362","DOI":"10.3390\/ph15030362","article-title":"Tumor Suppressive Role of miR-342-5p and miR-491-5p in Human Osteosarcoma Cells.","volume":"1","author":"Galera","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"key":"39","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1038\/s41379-019-0302-0","article-title":"A combination of the immunohistochemical markers CK7 and SATB2 is highly sensitive and specific for distinguishing primary ovarian mucinous tumors from colorectal and appendiceal metastases.","volume":"3","author":"Zhang","year":"2019","journal-title":"Mod Pathol"},{"key":"40","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.2174\/1871520619666190705121614","article-title":"Dehydroandrographolide Inhibits Osteosarcoma Cell Growth and Metastasis by Targeting SATB2-mediated EMT.","volume":"1","author":"Wang","year":"2019","journal-title":"Anticancer Agents Med Chem"},{"key":"41","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1093\/carcin\/bgz020","article-title":"Deregulation of SATB2 in carcinogenesis with emphasis on miRNA-mediated control.","volume":"4","author":"Costa","year":"2019","journal-title":"Carcinogenesis"},{"key":"42","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s10238-017-0464-3","article-title":"SATB2 suppresses non-small cell lung cancer invasiveness by G9a.","volume":"1","author":"Han","year":"2018","journal-title":"Clin Exp Med"},{"key":"43","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.apsb.2018.08.003","article-title":"Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms.","volume":"9","author":"Sheng","year":"2019","journal-title":"Acta Pharm Sin B"},{"key":"44","doi-asserted-by":"publisher","first-page":"4040","DOI":"10.1158\/1078-0432.CCR-19-2460","article-title":"Discovery of Berberine that Targetedly Induces Autophagic Degradation of both BCR-ABL and BCR-ABL T315I through Recruiting LRSAM1 for Overcoming Imatinib Resistance.","volume":"2","author":"Fei","year":"2020","journal-title":"Clin Cancer Res"},{"key":"45","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1007\/s00018-016-2166-5","article-title":"Tumor-associated macrophages and anti-tumor therapies: complex links.","volume":"7","author":"Frapolli","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"46","doi-asserted-by":"publisher","first-page":"121686","DOI":"10.1016\/j.jhazmat.2019.121686","article-title":"Formation of di-cysteine acrolein adduct decreases cytotoxicity of acrolein by ROS alleviation and apoptosis intervention.","volume":"38","author":"Ou","year":"2020","journal-title":"J Hazard Mater"},{"key":"47","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1002\/cam4.2127","article-title":"Delineating the pattern of treatment for elderly locally advanced NSCLC and predicting outcomes by a validated model: A SEER based analysis.","volume":"8","author":"Yu","year":"2019","journal-title":"Cancer Med"},{"key":"48","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1158\/0008-5472.CAN-16-2098","article-title":"The p53\/p21 Complex Regulates Cancer Cell Invasion and Apoptosis by Targeting Bcl-2 Family Proteins.","volume":"7","author":"Um","year":"2017","journal-title":"Cancer Res"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T20:28:54Z","timestamp":1697833734000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,20]]},"references-count":48,"alternative-id":["205139"],"URL":"https:\/\/doi.org\/10.18632\/aging.205139","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,20]]}}}