{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T19:12:56Z","timestamp":1768677176110,"version":"3.49.0"},"reference-count":25,"publisher":"Impact Journals, LLC","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2023,12,15]]},"DOI":"10.18632\/aging.205305","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T14:01:55Z","timestamp":1702476115000},"page":"14323-14332","source":"Crossref","is-referenced-by-count":6,"title":["Specific knockout of notch-1 attenuates non-alcoholic fatty liver disease by promoting SHP2 phosphorylation"],"prefix":"10.18632","volume":"15","author":[{"given":"Qian","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonggang","family":"Lu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Hebei General Hospital, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"585582","DOI":"10.3389\/fphar.2020.585582","article-title":"Hepatoprotective Effect and Molecular Mechanisms of Hengshun Aromatic Vinegar on Non-Alcoholic Fatty Liver Disease.","volume":"1","author":"Xu","year":"2020","journal-title":"Front Pharmacol"},{"key":"2","doi-asserted-by":"publisher","first-page":"575772","DOI":"10.3389\/fphar.2020.575772","article-title":"Veratrilla baillonii Franch Could Alleviate Lipid Accumulation in LO2 Cells by Regulating Oxidative, Inflammatory, and Lipid Metabolic Signaling Pathways.","volume":"1","author":"Zhao","year":"2020","journal-title":"Front Pharmacol"},{"key":"3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.15280\/jlm.2015.5.1.7","article-title":"Comorbidities and Metabolic Derangement of NAFLD.","volume":"5","author":"Cho","year":"2015","journal-title":"J Lifestyle Med"},{"key":"4","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.3390\/cells9071638","article-title":"Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease.","volume":"9","author":"Wahli","year":"2020","journal-title":"Cells"},{"key":"5","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1002\/hep.30645","article-title":"MicroRNA-223 Ameliorates Nonalcoholic Steatohepatitis and Cancer by Targeting Multiple Inflammatory and Oncogenic Genes in Hepatocytes.","volume":"7","author":"Gao","year":"2019","journal-title":"Hepatology"},{"key":"6","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3390\/cells8050457","article-title":"Bone Morphogenetic Protein-8B Expression is Induced in Steatotic Hepatocytes and Promotes Hepatic Steatosis and Inflammation In Vitro.","volume":"8","author":"Hellerbrand","year":"2019","journal-title":"Cells"},{"key":"7","first-page":"42","article-title":"Non-Alcoholic Fatty Liver Disease, an Overview.","volume":"1","author":"Nd","year":"2019","journal-title":"Integr Med (Encinitas)"},{"key":"8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3978\/j.issn.2304-3881.2015.01.02","article-title":"Immunoregulation by lipids during the development of non-alcoholic steatohepatitis.","volume":"4","author":"Streetz","year":"2015","journal-title":"Hepatobiliary Surg Nutr"},{"key":"9","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1002\/cpt.1701","article-title":"Acetaminophen-Induced Liver Damage in Hepatic Steatosis.","volume":"10","author":"Franc\u00e9s","year":"2020","journal-title":"Clin Pharmacol Ther"},{"key":"10","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1080\/00365521.2016.1278458","article-title":"Exosomes participate in the carcinogenesis and the malignant behavior of gastric cancer.","volume":"5","author":"Ming","year":"2017","journal-title":"Scand J Gastroenterol"},{"key":"11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3389\/fneur.2017.00057","article-title":"Increased Circulating Exosomal miRNA-223 Is Associated with Acute Ischemic Stroke.","volume":"8","author":"Yang","year":"2017","journal-title":"Front Neurol"},{"key":"12","doi-asserted-by":"publisher","first-page":"e0205496","DOI":"10.1371\/journal.pone.0205496","article-title":"Harmonization of exosome isolation from culture supernatants for optimized proteomics analysis.","volume":"1","author":"Pietrowska","year":"2018","journal-title":"PLoS One"},{"key":"13","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/j.1600-0897.2010.00822.x","article-title":"The role of placental exosomes in reproduction.","volume":"6","author":"Baranov","year":"2010","journal-title":"Am J Reprod Immunol"},{"key":"14","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.livres.2018.01.001","article-title":"Extracellular vesicles in non-alcoholic and alcoholic fatty liver diseases.","volume":"2","author":"Feldstein","year":"2018","journal-title":"Liver Res"},{"key":"15","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3389\/fphar.2017.00187","article-title":"Notch Signaling in Ischemic Damage and Fibrosis: Evidence and Clues from the Heart.","volume":"8","author":"Bani","year":"2017","journal-title":"Front Pharmacol"},{"key":"16","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.peptides.2016.12.014","article-title":"Increased FNDC5\/Irisin expression in human hepatocellular carcinoma.","volume":"8","author":"Basta","year":"2017","journal-title":"Peptides"},{"key":"17","doi-asserted-by":"publisher","first-page":"8050","DOI":"10.3390\/ijms21218050","article-title":"Contribution of Autophagy-Notch1-Mediated NLRP3 Inflammasome Activation to Chronic Inflammation and Fibrosis in Keloid Fibroblasts.","volume":"2","author":"Kim","year":"2020","journal-title":"Int J Mol Sci"},{"key":"18","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1002\/hep.28508","article-title":"Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans.","volume":"6","author":"Gores","year":"2016","journal-title":"Hepatology"},{"key":"19","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1038\/labinvest.2016.75","article-title":"Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation.","volume":"9","author":"Duong","year":"2016","journal-title":"Lab Invest"},{"key":"20","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1038\/s41467-017-02351-0","article-title":"Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis.","volume":"8","author":"Xu","year":"2017","journal-title":"Nat Commun"},{"key":"21","doi-asserted-by":"publisher","first-page":"4084566","DOI":"10.1155\/2021\/4084566","article-title":"Mangiferin Ameliorates HFD-Induced NAFLD through Regulation of the AMPK and NLRP3 Inflammasome Signal Pathways.","volume":"202","author":"Xiaopo","year":"2021","journal-title":"J Immunol Res"},{"key":"22","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1111\/bph.14938","article-title":"Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3\/NF-\u03baB pathway in mice.","volume":"17","author":"Qi","year":"2020","journal-title":"Br J Pharmacol"},{"key":"23","doi-asserted-by":"publisher","first-page":"6670495","DOI":"10.1155\/2021\/6670495","article-title":"Inhibiting ATP6V0D2 Aggravates Liver Ischemia-Reperfusion Injury by Promoting NLRP3 Activation via Impairing Autophagic Flux Independent of Notch1\/Hes1.","volume":"202","author":"Pu","year":"2021","journal-title":"J Immunol Res"},{"key":"24","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1038\/s41423-019-0318-x","article-title":"Jagged1-mediated myeloid Notch1 signaling activates HSF1\/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury.","volume":"1","author":"Ke","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"25","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1007\/s12026-017-8913-3","article-title":"Blockade of Notch signaling promotes acetaminophen-induced liver injury.","volume":"6","author":"Ke","year":"2017","journal-title":"Immunol Res"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T16:20:52Z","timestamp":1703089252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":25,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2023,12,15]]}},"alternative-id":["205305","38095642"],"URL":"https:\/\/doi.org\/10.18632\/aging.205305","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,13]]}}}