{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:00:25Z","timestamp":1791910825289,"version":"4.3.4"},"reference-count":37,"publisher":"Impact Journals, LLC","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2024,2,28]]},"DOI":"10.18632\/aging.205519","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T14:47:21Z","timestamp":1708440441000},"page":"3185-3199","source":"Crossref","is-referenced-by-count":11,"title":["The high expression of TOP2A and MELK induces the occurrence of psoriasis"],"prefix":"10.18632","volume":"16","author":[{"given":"Xinhua","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Dermatology, China Aerospace Science and Industry Corporation 731 Hospital, Beijing 100074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erjia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, China Aerospace Science and Industry Corporation 731 Hospital, Beijing 100074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, China Aerospace Science and Industry Corporation 731 Hospital, Beijing 100074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1111\/ijd.14032","article-title":"Stress and psoriasis.","volume":"5","author":"Halioua","year":"2018","journal-title":"Int J Dermatol"},{"key":"2","doi-asserted-by":"publisher","first-page":"170","DOI":"10.7861\/clinmed.2021-0257","article-title":"Psoriasis: a brief overview.","volume":"2","author":"Barker","year":"2021","journal-title":"Clin Med (Lond)"},{"key":"3","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1016\/j.jid.2022.01.014","article-title":"From Empirical to Pathogenesis-Based Treatments for Psoriasis.","volume":"14","author":"van de Kerkhof","year":"2022","journal-title":"J Invest Dermatol"},{"key":"4","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1111\/bjd.18245","article-title":"Management of psoriasis as a systemic disease: what is the evidence?","volume":"18","author":"Korman","year":"2020","journal-title":"Br J Dermatol"},{"key":"5","first-page":"97","article-title":"Current Developments in the Immunology of Psoriasis.","volume":"9","author":"Muhammad","year":"2020","journal-title":"Yale J Biol Med"},{"key":"6","doi-asserted-by":"publisher","first-page":"4347","DOI":"10.3390\/ijms20184347","article-title":"Risk Factors for the Development of Psoriasis.","volume":"2","author":"Ohtsuki","year":"2019","journal-title":"Int J Mol Sci"},{"key":"7","doi-asserted-by":"publisher","first-page":"7488","DOI":"10.3390\/ijms21207488","article-title":"New Treatment Addressing the Pathogenesis of Psoriasis.","volume":"2","author":"Mabuchi","year":"2020","journal-title":"Int J Mol Sci"},{"key":"8","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis.","volume":"39","author":"Barker","year":"2021","journal-title":"Lancet"},{"key":"9","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.3390\/genes14081619","article-title":"Genetic and Epigenetic Mechanisms of Psoriasis.","volume":"1","author":"Puig","year":"2023","journal-title":"Genes (Basel)"},{"key":"10","doi-asserted-by":"publisher","first-page":"adv00030","DOI":"10.2340\/00015555-3384","article-title":"Psoriasis and Genetics.","volume":"10","author":"Barker","year":"2020","journal-title":"Acta Derm Venereol"},{"key":"11","first-page":"428","article-title":"Human leukocyte antigens as psoriasis inheritance and susceptibility markers.","volume":"5","author":"Szczerkowska-Dobosz","year":"2005","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"12","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/j.1468-3083.2006.02008.x","article-title":"Psoriasis vulgaris and human leukocyte antigens.","volume":"2","author":"Porto","year":"2007","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"13","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s10020-022-00592-4","article-title":"TOP2A deficiency leads to human recurrent spontaneous abortion and growth retardation of mouse pre-implantation embryos.","volume":"2","author":"Liu","year":"2022","journal-title":"Mol Med"},{"key":"14","doi-asserted-by":"publisher","first-page":"8089","DOI":"10.3390\/ijms24098089","article-title":"Differential Effects of Overexpression of Wild Type and Kinase-Dead MELK in Fibroblasts and Keratinocytes, Potential Implications for Skin Wound Healing and Cancer.","volume":"2","author":"Kubiak","year":"2023","journal-title":"Int J Mol Sci"},{"key":"15","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.jbiosc.2022.08.004","article-title":"Bioinformatics in bioscience and bioengineering: Recent advances, applications, and perspectives.","volume":"13","author":"Horinouchi","year":"2022","journal-title":"J Biosci Bioeng"},{"key":"16","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1038\/s41587-021-01108-x","article-title":"Nanopore sequencing technology, bioinformatics and applications.","volume":"3","author":"Au","year":"2021","journal-title":"Nat Biotechnol"},{"key":"17","doi-asserted-by":"publisher","first-page":"15286","DOI":"10.3390\/ijms232315286","article-title":"Identification of Novel Hub Genes Associated with Psoriasis Using Integrated Bioinformatics Analysis.","volume":"2","author":"Jin","year":"2022","journal-title":"Int J Mol Sci"},{"key":"18","first-page":"6","article-title":"Update on the pathophysiology of psoriasis.","volume":"10","author":"Weinberg","year":"2018","journal-title":"Cutis"},{"key":"19","doi-asserted-by":"publisher","first-page":"4983","DOI":"10.3390\/ijms22094983","article-title":"Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics.","volume":"2","author":"S\u00e1nchez-L\u00f3pez","year":"2021","journal-title":"Int J Mol Sci"},{"key":"20","doi-asserted-by":"publisher","first-page":"eadd4920","DOI":"10.1126\/sciadv.add4920","article-title":"Untangling the roles of TOP2A and TOP2B in transcription and cancer.","volume":"8","author":"Wilson","year":"2022","journal-title":"Sci Adv"},{"key":"21","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3390\/biology10030190","article-title":"Why Should DNA Topoisomerase I Have a Scaffold Activity?","volume":"1","author":"Camilloni","year":"2021","journal-title":"Biology (Basel)"},{"key":"22","doi-asserted-by":"publisher","first-page":"12967","DOI":"10.1080\/21655979.2021.2012069","article-title":"Type IIA topoisomerase (TOP2A) triggers epithelial-mesenchymal transition and facilitates HCC progression by regulating Snail expression.","volume":"1","author":"Ren","year":"2021","journal-title":"Bioengineered"},{"key":"23","doi-asserted-by":"publisher","first-page":"589","DOI":"10.7150\/jca.64017","article-title":"TOP2A promotes proliferation and metastasis of hepatocellular carcinoma regulated by miR-144-3p.","volume":"1","author":"Xu","year":"2022","journal-title":"J Cancer"},{"key":"24","doi-asserted-by":"publisher","first-page":"733","DOI":"10.4149\/neo_2015_087","article-title":"Identification of potential therapeutic targets for melanoma using gene expression analysis.","volume":"6","author":"Tao","year":"2015","journal-title":"Neoplasma"},{"key":"25","doi-asserted-by":"publisher","first-page":"103169","DOI":"10.1016\/j.autrev.2022.103169","article-title":"Psoriasis: Interplay between dysbiosis and host immune system.","volume":"2","author":"Gupta","year":"2022","journal-title":"Autoimmun Rev"},{"key":"26","doi-asserted-by":"publisher","first-page":"5665","DOI":"10.1002\/cam4.1816","article-title":"Maternal embryonic leucine zipper kinase: A novel biomarker and a potential therapeutic target of cervical cancer.","volume":"7","author":"Chen","year":"2018","journal-title":"Cancer Med"},{"key":"27","doi-asserted-by":"publisher","first-page":"239","DOI":"10.21037\/atm.2020.03.46","article-title":"Cloning, tissue distribution, expression pattern, and function of porcine maternal embryonic leucine zipper kinase.","volume":"8","author":"Tan","year":"2020","journal-title":"Ann Transl Med"},{"key":"28","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.18632\/oncotarget.790","article-title":"Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer.","volume":"3","author":"Matsuo","year":"2012","journal-title":"Oncotarget"},{"key":"29","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1083\/jcb.200412115","article-title":"Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.","volume":"17","author":"Sofroniew","year":"2005","journal-title":"J Cell Biol"},{"key":"30","doi-asserted-by":"publisher","first-page":"483","DOI":"10.4161\/cib.4.4.15669","article-title":"Cortical localization of maternal embryonic leucine zipper kinase (MELK) implicated in cytokinesis in early xenopus embryos.","volume":"4","author":"Tassan","year":"2011","journal-title":"Commun Integr Biol"},{"key":"31","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1158\/2767-9764.CRC-22-0330","article-title":"Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer.","volume":"3","author":"Browning","year":"2023","journal-title":"Cancer Res Commun"},{"key":"32","doi-asserted-by":"publisher","first-page":"5520","DOI":"10.1038\/s41388-018-0333-x","article-title":"Inhibition of maternal embryonic leucine zipper kinase with OTSSP167 displays potent anti-leukemic effects in chronic lymphocytic leukemia.","volume":"3","author":"Wang","year":"2018","journal-title":"Oncogene"},{"key":"33","doi-asserted-by":"publisher","first-page":"103335","DOI":"10.1016\/j.sjbs.2022.103335","article-title":"Computational exploration of maternal embryonic leucine zipper kinase (MELK) as a cancer drug target.","volume":"2","author":"Makki Almansour","year":"2022","journal-title":"Saudi J Biol Sci"},{"key":"34","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.3892\/or.2020.7686","article-title":"Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in osteosarcoma.","volume":"4","author":"Li","year":"2020","journal-title":"Oncol Rep"},{"key":"35","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3892\/ol.2020.12010","article-title":"Maternal embryonic leucine zipper kinase: A novel biomarker and a potential therapeutic target in lung adenocarcinoma.","volume":"2","author":"Xiao","year":"2020","journal-title":"Oncol Lett"},{"key":"36","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41419-020-03344-6","article-title":"Discovery of a new molecule inducing melanoma cell death: dual AMPK\/MELK targeting for novel melanoma therapies.","volume":"1","author":"Hofman","year":"2021","journal-title":"Cell Death Dis"},{"key":"37","doi-asserted-by":"publisher","first-page":"3973","DOI":"10.18632\/aging.204059","article-title":"Comprehensive analysis to identify noncoding RNAs mediated upregulation of maternal embryonic leucine zipper kinase (MELK) correlated with poor prognosis in hepatocellular carcinoma.","volume":"1","author":"Zhu","year":"2022","journal-title":"Aging (Albany NY)"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T16:00:23Z","timestamp":1709654423000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,2,28]]}},"alternative-id":["205519","38382096"],"URL":"https:\/\/doi.org\/10.18632\/aging.205519","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,20]]}}}