{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T18:44:12Z","timestamp":1775501052160,"version":"3.50.1"},"reference-count":87,"publisher":"Impact Journals, LLC","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2024,2,28]]},"DOI":"10.18632\/aging.205553","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T21:48:01Z","timestamp":1708120081000},"page":"3694-3715","source":"Crossref","is-referenced-by-count":9,"title":["PMAIP1, a novel diagnostic and potential therapeutic biomarker in osteoporosis"],"prefix":"10.18632","volume":"16","author":[{"given":"Tao","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Orthopaedics of Jiangxi Province, Nanchang, Jiangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics of Jiangxi Province, Nanchang, Jiangxi, China"},{"name":"Department of Osteoporosis, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peichuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics of Jiangxi Province, Nanchang, Jiangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Jia","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics of Jiangxi Province, Nanchang, Jiangxi, China"},{"name":"Department of Osteoporosis, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangminghao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Osteoporosis, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics of Jiangxi Province, Nanchang, Jiangxi, China"},{"name":"Department of Osteoporosis, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Ding","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics of Jiangxi Province, Nanchang, Jiangxi, China"},{"name":"Department of Orthopaedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaokun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Osteoporosis, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingwen","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics of Jiangxi Province, Nanchang, Jiangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianlong","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics of Jiangxi Province, Nanchang, Jiangxi, China"},{"name":"Department of Orthopaedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xigao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics of Jiangxi Province, Nanchang, Jiangxi, China"},{"name":"Department of Osteoporosis, The Second Affiliated Hospital of Nanchang University, Nanchang, China"},{"name":"Department of Orthopaedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"h3783","DOI":"10.1136\/bmj.h3783","article-title":"Bisphosphonates for the prevention and treatment of osteoporosis.","volume":"35","author":"Kennel","year":"2015","journal-title":"BMJ"},{"key":"2","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s00198-017-4308-5","article-title":"Risk of venous thromboembolism among users of different anti-osteoporosis drugs: a population-based cohort analysis including over 200,000 participants from Spain and the UK.","volume":"2","author":"Prieto-Alhambra","year":"2018","journal-title":"Osteoporos Int"},{"key":"3","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","article-title":"Disorders of bone remodeling.","volume":"6","author":"McDonald","year":"2011","journal-title":"Annu Rev Pathol"},{"key":"4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s001980170152","article-title":"Lifetime and five-year age-specific risks of first and subsequent osteoporotic fractures in postmenopausal women.","volume":"1","author":"Prince","year":"2001","journal-title":"Osteoporos Int"},{"key":"5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s11739-018-1874-2","article-title":"Guidelines for the management of osteoporosis and fragility fractures.","volume":"1","author":"Rossini","year":"2019","journal-title":"Intern Emerg Med"},{"key":"6","doi-asserted-by":"publisher","first-page":"ITC17","DOI":"10.7326\/AITC201708010","article-title":"Osteoporosis.","volume":"16","author":"Crandall","year":"2017","journal-title":"Ann Intern Med"},{"key":"7","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1359\/JBMR.050304","article-title":"Predictive value of BMD for hip and other fractures.","volume":"2","author":"O\u2019Neill","year":"2005","journal-title":"J Bone Miner Res"},{"key":"8","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1111\/joim.12369","article-title":"Osteoporosis: the evolution of a diagnosis.","volume":"27","author":"Cummings","year":"2015","journal-title":"J Intern Med"},{"key":"9","doi-asserted-by":"publisher","first-page":"7260","DOI":"10.1073\/pnas.87.18.7260","article-title":"Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.","volume":"8","author":"Suda","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1359\/jbmr.1998.13.5.763","article-title":"A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men.","volume":"1","author":"Melton LJ","year":"1998","journal-title":"J Bone Miner Res"},{"key":"11","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.1210\/jcem.83.7.4924","article-title":"Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen.","volume":"8","author":"Riggs","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"12","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1210\/edrv.23.3.0465","article-title":"Sex steroids and the construction and conservation of the adult skeleton.","volume":"2","author":"Melton LJ","year":"2002","journal-title":"Endocr Rev"},{"key":"13","doi-asserted-by":"publisher","first-page":"16069","DOI":"10.1038\/nrdp.2016.69","article-title":"Postmenopausal osteoporosis.","volume":"2","author":"Cummings","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"14","doi-asserted-by":"publisher","first-page":"S65","DOI":"10.1016\/0378-5122(96)01015-8","article-title":"Estrogen and bone metabolism.","volume":"2","author":"H\u00e4rk\u00f6nen","year":"1996","journal-title":"Maturitas"},{"key":"15","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1210\/jc.2011-2332","article-title":"Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives.","volume":"9","author":"Hesse","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"16","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1210\/jcem.82.5.3946","article-title":"Effects of age and estrogen status on serum parathyroid hormone levels and biochemical markers of bone turnover in women: a population-based study.","volume":"8","author":"Riggs","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"17","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1152\/physrev.00014.2015","article-title":"Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.","volume":"9","author":"Carmeliet","year":"2016","journal-title":"Physiol Rev"},{"key":"18","doi-asserted-by":"publisher","first-page":"7142","DOI":"10.3748\/wjg.v21.i23.7142","article-title":"Molecular aspects of intestinal calcium absorption.","volume":"2","author":"Tolosa de Talamoni","year":"2015","journal-title":"World J Gastroenterol"},{"key":"19","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1210\/endo.140.2.6673","article-title":"Stimulation of osteoclast formation by 1,25-dihydroxyvitamin D requires its binding to vitamin D receptor (VDR) in osteoblastic cells: studies using VDR knockout mice.","volume":"14","author":"Fujita","year":"1999","journal-title":"Endocrinology"},{"key":"20","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1002\/cphy.c140071","article-title":"PTH and Vitamin D.","volume":"6","author":"Lederer","year":"2016","journal-title":"Compr Physiol"},{"key":"21","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.3389\/fimmu.2019.02925","article-title":"TNF-\u03b1 Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation.","volume":"1","author":"Mizoguchi","year":"2019","journal-title":"Front Immunol"},{"key":"22","doi-asserted-by":"publisher","first-page":"13692","DOI":"10.1021\/acsnano.1c04974","article-title":"Near-Infrared Light and Upconversion Nanoparticle Defined Nitric Oxide-Based Osteoporosis Targeting Therapy.","volume":"1","author":"Wang","year":"2021","journal-title":"ACS Nano"},{"key":"23","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1056\/NEJM199502023320506","article-title":"Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis.","volume":"33","author":"Jilka","year":"1995","journal-title":"N Engl J Med"},{"key":"24","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/s8756-3282(98)00077-5","article-title":"Cytokines, bone remodeling, and estrogen deficiency: a 1998 update.","volume":"2","author":"Jilka","year":"1998","journal-title":"Bone"},{"key":"25","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1126\/science.288.5468.1053","article-title":"Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.","volume":"28","author":"Tanaka","year":"2000","journal-title":"Science"},{"key":"26","doi-asserted-by":"publisher","first-page":"48292","DOI":"10.1074\/jbc.M308785200","article-title":"The molecular mechanism of Noxa-induced mitochondrial dysfunction in p53-mediated cell death.","volume":"27","author":"Kim","year":"2003","journal-title":"J Biol Chem"},{"key":"27","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/s1074-7613(03)00234-6","article-title":"The structure of a Bcl-xL\/Bim fragment complex: implications for Bim function.","volume":"1","author":"Kappler","year":"2003","journal-title":"Immunity"},{"key":"28","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrm3722","article-title":"Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.","volume":"1","author":"Adams","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"29","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1007\/s10495-013-0868-9","article-title":"Mouse Noxa uses only the C-terminal BH3-domain to inactivate Mcl-1.","volume":"1","author":"H\u00e4cker","year":"2013","journal-title":"Apoptosis"},{"key":"30","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.molcel.2004.12.030","article-title":"Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.","volume":"1","author":"Huang","year":"2005","journal-title":"Mol Cell"},{"key":"31","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1038\/ncb1499","article-title":"Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies.","volume":"8","author":"Cheng","year":"2006","journal-title":"Nat Cell Biol"},{"key":"32","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.bbrc.2011.06.040","article-title":"The role of the BH3-only protein Noxa in bone homeostasis.","volume":"41","author":"Takayanagi","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"33","doi-asserted-by":"publisher","first-page":"115494","DOI":"10.1016\/j.bone.2020.115494","article-title":"Novel gene Merlot inhibits differentiation and promotes apoptosis of osteoclasts.","volume":"13","author":"Takami","year":"2020","journal-title":"Bone"},{"key":"34","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"affy--analysis of Affymetrix GeneChip data at the probe level.","volume":"2","author":"Irizarry","year":"2004","journal-title":"Bioinformatics"},{"key":"35","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies.","volume":"4","author":"Smyth","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"36","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: Database for Annotation, Visualization, and Integrated Discovery.","volume":"4","author":"Lempicki","year":"2003","journal-title":"Genome Biol"},{"key":"37","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.","volume":"1","author":"Chanda","year":"2019","journal-title":"Nat Commun"},{"key":"38","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.","volume":"10","author":"Mesirov","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"39","doi-asserted-by":"publisher","first-page":"W110","DOI":"10.1093\/nar\/gkw345","article-title":"miEAA: microRNA enrichment analysis and annotation.","volume":"4","author":"Keller","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"40","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1186\/gb-2008-9-s1-s4","article-title":"GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function.","volume":"9","author":"Morris","year":"2008","journal-title":"Genome Biol"},{"key":"41","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/bioinformatics\/btq675","article-title":"Cytoscape 2.8: new features for data integration and network visualization.","volume":"2","author":"Ideker","year":"2011","journal-title":"Bioinformatics"},{"key":"42","doi-asserted-by":"publisher","first-page":"e1003731","DOI":"10.1371\/journal.pcbi.1003731","article-title":"iRegulon: from a gene list to a gene regulatory network using large motif and track collections.","volume":"1","author":"Fiers","year":"2014","journal-title":"PLoS Comput Biol"},{"key":"43","doi-asserted-by":"publisher","first-page":"D1068","DOI":"10.1093\/nar\/gkx1143","article-title":"DGIdb 3.0: a redesign and expansion of the drug-gene interaction database.","volume":"4","author":"Griffith","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"44","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s001980050224","article-title":"Interim report and recommendations of the World Health Organization Task-Force for Osteoporosis.","volume":"1","author":"Dequeker","year":"1999","journal-title":"Osteoporos Int"},{"key":"45","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future.","volume":"37","author":"Hofbauer","year":"2011","journal-title":"Lancet"},{"key":"46","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/S0140-6736(98)09075-8","article-title":"Mortality after all major types of osteoporotic fracture in men and women: an observational study.","volume":"35","author":"Eisman","year":"1999","journal-title":"Lancet"},{"key":"47","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1016\/j.bone.2005.11.024","article-title":"Osteoporosis: a still increasing prevalence.","volume":"3","author":"Burlet","year":"2006","journal-title":"Bone"},{"key":"48","doi-asserted-by":"publisher","first-page":"16041","DOI":"10.1038\/boneres.2016.41","article-title":"Vitamin D, calcium homeostasis and aging.","volume":"4","author":"Christakos","year":"2016","journal-title":"Bone Res"},{"key":"49","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.2215\/CJN.05910809","article-title":"Calcium metabolism in health and disease.","volume":"5","author":"Peacock","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"50","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0143-4160(93)90048-b","article-title":"Extracellular Ca2+ sensing by the osteoclast.","volume":"1","author":"Shankar","year":"1993","journal-title":"Cell Calcium"},{"key":"51","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1006\/bbrc.2000.2229","article-title":"High extracellular calcium concentrations directly stimulate osteoclast apoptosis.","volume":"26","author":"Brazier","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"52","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1083\/jcb.111.6.2543","article-title":"Osteoclast cytosolic calcium, regulated by voltage-gated calcium channels and extracellular calcium, controls podosome assembly and bone resorption.","volume":"11","author":"Teti","year":"1990","journal-title":"J Cell Biol"},{"key":"53","doi-asserted-by":"publisher","first-page":"21351","DOI":"10.1074\/jbc.M010921200","article-title":"Sustained activation of the extracellular signal-regulated kinase pathway is required for extracellular calcium stimulation of human osteoblast proliferation.","volume":"27","author":"Slatopolsky","year":"2001","journal-title":"J Biol Chem"},{"key":"54","doi-asserted-by":"publisher","first-page":"5140","DOI":"10.1073\/pnas.0306141101","article-title":"Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones.","volume":"10","author":"Riccardi","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"55","doi-asserted-by":"publisher","first-page":"3184","DOI":"10.3390\/nu5083184","article-title":"Iron and zinc nutrition in the economically-developed world: a review.","volume":"5","author":"Szymlek-Gay","year":"2013","journal-title":"Nutrients"},{"key":"56","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1515\/cclm-2012-0868","article-title":"Trace elements and bone health.","volume":"5","author":"Matucha","year":"2013","journal-title":"Clin Chem Lab Med"},{"key":"57","first-page":"1276","article-title":"The effects of zinc supplementation on serum zinc, alkaline phosphatase activity and fracture healing of bones.","volume":"2","author":"Ostadrahimi","year":"2008","journal-title":"Saudi Med J"},{"key":"58","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3892\/ijmm.8.4.433","article-title":"Increase in bone growth factors with healing rat fractures: the enhancing effect of zinc.","volume":"8","author":"Yamaguchi","year":"2001","journal-title":"Int J Mol Med"},{"key":"59","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/1478-811X-11-74","article-title":"Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway.","volume":"1","author":"Lee","year":"2013","journal-title":"Cell Commun Signal"},{"key":"60","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/BF01075720","article-title":"Effect of beta-alanyl-L-histidinato zinc on differentiation of osteoblastic MC3T3-E1 cells: increases in alkaline phosphatase activity and protein concentration.","volume":"13","author":"Yamaguchi","year":"1994","journal-title":"Mol Cell Biochem"},{"key":"61","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/BF00925737","article-title":"Stimulatory effect of beta-alanyl-L-histidinato zinc on cell proliferation is dependent on protein synthesis in osteoblastic MC3T3-E1 cells.","volume":"12","author":"Yamaguchi","year":"1993","journal-title":"Mol Cell Biochem"},{"key":"62","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/ageing\/24.4.303","article-title":"Zinc, biochemical markers of nutrition, and type I osteoporosis.","volume":"2","author":"Rico","year":"1995","journal-title":"Age Ageing"},{"key":"63","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.cell.2018.01.029","article-title":"The Human Transcription Factors.","volume":"17","author":"Weirauch","year":"2018","journal-title":"Cell"},{"key":"64","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1186\/gb-2009-10-3-r29","article-title":"TFCat: the curated catalog of mouse and human transcription factors.","volume":"1","author":"Sladek","year":"2009","journal-title":"Genome Biol"},{"key":"65","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/s1097-2765(01)00392-6","article-title":"Recognition of specific DNA sequences.","volume":"8","author":"Wolberger","year":"2001","journal-title":"Mol Cell"},{"key":"66","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1101\/gad.1424806","article-title":"Sensors and signals: a coactivator\/corepressor\/epigenetic code for integrating signal-dependent programs of transcriptional response.","volume":"2","author":"Glass","year":"2006","journal-title":"Genes Dev"},{"key":"67","doi-asserted-by":"publisher","first-page":"3040","DOI":"10.1093\/nar\/gkh624","article-title":"How do site-specific DNA-binding proteins find their targets?","volume":"3","author":"Marko","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"68","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.0105-2896.2009.00849.x","article-title":"Transcriptional regulation of bone and joint remodeling by NFAT.","volume":"23","author":"Aliprantis","year":"2010","journal-title":"Immunol Rev"},{"key":"69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbrc.2008.10.146","article-title":"NF-kappaB functions in osteoclasts.","volume":"37","author":"Alles","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"70","doi-asserted-by":"publisher","first-page":"18245","DOI":"10.1074\/jbc.M610701200","article-title":"NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1.","volume":"28","author":"Boyce","year":"2007","journal-title":"J Biol Chem"},{"key":"71","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1038\/cdd.2014.71","article-title":"Lhx2 regulates bone remodeling in mice by modulating RANKL signaling in osteoclasts.","volume":"2","author":"Kim","year":"2014","journal-title":"Cell Death Differ"},{"key":"72","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.1474-9728.2004.00127.x","article-title":"Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma\/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta\/BMP signaling pathways.","volume":"3","author":"Lecka-Czernik","year":"2004","journal-title":"Aging Cell"},{"key":"73","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1172\/JCI77716","article-title":"MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation.","volume":"12","author":"Luo","year":"2015","journal-title":"J Clin Invest"},{"key":"74","doi-asserted-by":"publisher","first-page":"11524","DOI":"10.1002\/jcp.27815","article-title":"A novel long noncoding RNA AK016739 inhibits osteoblast differentiation and bone formation.","volume":"23","author":"Qian","year":"2019","journal-title":"J Cell Physiol"},{"key":"75","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.bbrc.2019.09.058","article-title":"LncRNA MSC-AS1 promotes osteogenic differentiation and alleviates osteoporosis through sponging microRNA-140-5p to upregulate BMP2.","volume":"51","author":"Huang","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"76","doi-asserted-by":"publisher","first-page":"105719","DOI":"10.1016\/j.biocel.2020.105719","article-title":"Circular RNA hsa_circ_0076906 competes with OGN for miR-1305 biding site to alleviate the progression of osteoporosis.","volume":"12","author":"Hu","year":"2020","journal-title":"Int J Biochem Cell Biol"},{"key":"77","doi-asserted-by":"publisher","first-page":"43191","DOI":"10.1038\/srep43191","article-title":"miR-21 deficiency inhibits osteoclast function and prevents bone loss in mice.","volume":"7","author":"Jin","year":"2017","journal-title":"Sci Rep"},{"key":"78","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nm1025","article-title":"PPARs and the complex journey to obesity.","volume":"1","author":"Wang","year":"2004","journal-title":"Nat Med"},{"key":"79","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nm.3159","article-title":"PPAR\u03b3 signaling and metabolism: the good, the bad and the future.","volume":"1","author":"Evans","year":"2013","journal-title":"Nat Med"},{"key":"80","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1038\/nm1672","article-title":"PPAR-gamma regulates osteoclastogenesis in mice.","volume":"1","author":"Evans","year":"2007","journal-title":"Nat Med"},{"key":"81","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1172\/JCI19900","article-title":"PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors.","volume":"11","author":"Kawaguchi","year":"2004","journal-title":"J Clin Invest"},{"key":"82","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/nm.3146","article-title":"PPAR\u03b2\/\u03b4 governs Wnt signaling and bone turnover.","volume":"1","author":"Engelke","year":"2013","journal-title":"Nat Med"},{"key":"83","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.bbrc.2019.10.048","article-title":"Fenofibrate induces PPAR\u03b1 and BMP2 expression to stimulate osteoblast differentiation.","volume":"52","author":"Koh","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"84","doi-asserted-by":"publisher","first-page":"3371","DOI":"10.1158\/1078-0432.CCR-19-1900","article-title":"5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis.","volume":"2","author":"Phillips","year":"2020","journal-title":"Clin Cancer Res"},{"key":"85","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1756-9966-33-3","article-title":"Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells.","volume":"3","author":"Su","year":"2014","journal-title":"J Exp Clin Cancer Res"},{"key":"86","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.omtn.2019.07.026","article-title":"Silencing lncRNA LOC101928963 Inhibits Proliferation and Promotes Apoptosis in Spinal Cord Glioma Cells by Binding to PMAIP1.","volume":"1","author":"Liu","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"87","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s40659-019-0244-5","article-title":"TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells.","volume":"5","author":"Kim","year":"2019","journal-title":"Biol Res"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T16:01:17Z","timestamp":1709654477000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,16]]},"references-count":87,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,2,28]]}},"alternative-id":["205553","38372699"],"URL":"https:\/\/doi.org\/10.18632\/aging.205553","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,16]]}}}