{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:23:16Z","timestamp":1784690596876,"version":"3.55.0"},"reference-count":34,"publisher":"Impact Journals, LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"DOI":"10.18632\/aging.205593","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T17:10:43Z","timestamp":1708708243000},"source":"Crossref","is-referenced-by-count":5,"title":["Probucol protects against brain damage caused by intra-neural pyroptosis in rats with vascular dementia through inhibition of the Syk\/Ros pathway"],"prefix":"10.18632","author":[{"given":"Jingyi","family":"Zhu","sequence":"first","affiliation":[{"name":"Graduate School, Hebei North University, Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Kou","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenling","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate School, Hebei North University, Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchun","family":"Fan","sequence":"additional","affiliation":[{"name":"Graduate School, Hebei North University, Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Graduate School, Hebei North University, Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lexiu","family":"Deng","sequence":"additional","affiliation":[{"name":"Graduate School, Hebei North University, Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Guan","sequence":"additional","affiliation":[{"name":"Graduate School, Hebei North University, Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuandi","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate School, Hebei North University, Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1161\/ATVBAHA.119.311908","article-title":"Epidemiology of Vascular Dementia.","volume":"3","author":"Ikram","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.3390\/ijms20102405","article-title":"Vascular Cognitive Impairment: Information from Animal Models on the Pathogenic Mechanisms of Cognitive Deficits.","volume":"2","author":"Angelucci","year":"2019","journal-title":"Int J Mol Sci"},{"key":"3","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.7150\/thno.68304","article-title":"Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment.","volume":"1","author":"Arumugam","year":"2022","journal-title":"Theranostics"},{"key":"4","doi-asserted-by":"publisher","first-page":"4544","DOI":"10.1038\/s41380-020-00971-5","article-title":"AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia.","volume":"2","author":"Jo","year":"2021","journal-title":"Mol Psychiatry"},{"key":"5","doi-asserted-by":"publisher","first-page":"107422","DOI":"10.1016\/j.intimp.2021.107422","article-title":"Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis.","volume":"9","author":"Fu","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"6","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1089\/ars.2012.5129","article-title":"NADPH oxidase 1, a novel molecular source of ROS in hippocampal neuronal death in vascular dementia.","volume":"2","author":"Lee","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"7","doi-asserted-by":"publisher","first-page":"948","DOI":"10.4103\/1673-5374.250568","article-title":"Nicotinamide adenine dinucleotide phosphate oxidase activation and neuronal death after ischemic stroke.","volume":"1","author":"Ding","year":"2019","journal-title":"Neural Regen Res"},{"key":"8","doi-asserted-by":"publisher","first-page":"61","DOI":"10.4103\/2394-8108.186256","article-title":"Pyruvate dehydrogenase complex in cerebral ischemia-reperfusion injury.","volume":"2","author":"Ding","year":"2016","journal-title":"Brain Circ"},{"key":"9","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1111\/cns.13384","article-title":"Caspase-1 inhibition prevents neuronal death by targeting the canonical inflammasome pathway of pyroptosis in a murine model of cerebral ischemia.","volume":"2","author":"Wang","year":"2020","journal-title":"CNS Neurosci Ther"},{"key":"10","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation.","volume":"2","author":"He","year":"2019","journal-title":"Int J Mol Sci"},{"key":"11","doi-asserted-by":"publisher","first-page":"488","DOI":"10.3389\/fncel.2018.00488","article-title":"Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response.","volume":"1","author":"Boza-Serrano","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"12","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","article-title":"Microglia Function in the Central Nervous System During Health and Neurodegeneration.","volume":"3","author":"Butovsky","year":"2017","journal-title":"Annu Rev Immunol"},{"key":"13","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1089\/ars.2020.8257","article-title":"Loop Between NLRP3 Inflammasome and Reactive Oxygen Species.","volume":"3","author":"Takahashi","year":"2022","journal-title":"Antioxid Redox Signal"},{"key":"14","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nri2765","article-title":"The SYK tyrosine kinase: a crucial player in diverse biological functions.","volume":"1","author":"Tybulewicz","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"15","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.4049\/jimmunol.1700258","article-title":"Dectin-1 Activation duringPhagocytosis Prompts Syk-Dependent Reactive Oxygen Species Production To Trigger Inflammasome Assembly and Restriction of Parasite Replication.","volume":"19","author":"Zamboni","year":"2017","journal-title":"J Immunol"},{"key":"16","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s10020-022-00503-7","article-title":"Probucol promotes osteoblasts differentiation and prevents osteoporosis development through reducing oxidative stress.","volume":"2","author":"Wei","year":"2022","journal-title":"Mol Med"},{"key":"17","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/aps.2016.51","article-title":"Probucol inhibits LPS-induced microglia activation and ameliorates brain ischemic injury in normal and hyperlipidemic mice.","volume":"3","author":"Shin","year":"2016","journal-title":"Acta Pharmacol Sin"},{"key":"18","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.neuroscience.2014.10.019","article-title":"Probucol mitigates streptozotocin-induced cognitive and biochemical changes in mice.","volume":"28","author":"Farina","year":"2015","journal-title":"Neuroscience"},{"key":"19","doi-asserted-by":"publisher","first-page":"e67658","DOI":"10.1371\/journal.pone.0067658","article-title":"Probucol increases striatal glutathione peroxidase activity and protects against 3-nitropropionic acid-induced pro-oxidative damage in rats.","volume":"8","author":"Farina","year":"2013","journal-title":"PLoS One"},{"key":"20","doi-asserted-by":"publisher","first-page":"112266","DOI":"10.1016\/j.biopha.2021.112266","article-title":"Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment.","volume":"14","author":"Meng","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"21","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s12640-021-00458-3","article-title":"Protective Effects of Probucol on Different Brain Cells Exposed to Manganese.","volume":"4","author":"Remor","year":"2022","journal-title":"Neurotox Res"},{"key":"22","doi-asserted-by":"publisher","first-page":"2832","DOI":"10.7150\/thno.37119","article-title":"Upregulation of neuronal PGC-1\u03b1 ameliorates cognitive impairment induced by chronic cerebral hypoperfusion.","volume":"1","author":"Hao","year":"2020","journal-title":"Theranostics"},{"key":"23","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1124\/jpet.116.237503","article-title":"Oxidative Stress and the Central Nervous System.","volume":"36","author":"Salim","year":"2017","journal-title":"J Pharmacol Exp Ther"},{"key":"24","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1002\/ana.21511","article-title":"Glucose and NADPH oxidase drive neuronal superoxide formation in stroke.","volume":"6","author":"Swanson","year":"2008","journal-title":"Ann Neurol"},{"key":"25","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.freeradbiomed.2011.03.025","article-title":"NADPH-oxidase activation and cognition in Alzheimer disease progression.","volume":"5","author":"Scheff","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"26","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1146\/annurev-immunol-042617-053010","article-title":"Apoptosis and Clearance of Apoptotic Cells.","volume":"3","author":"Nagata","year":"2018","journal-title":"Annu Rev Immunol"},{"key":"27","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00395-017-0663-9","article-title":"Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases.","volume":"11","author":"Wang","year":"2017","journal-title":"Basic Res Cardiol"},{"key":"28","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.jneuroim.2018.04.004","article-title":"The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia.","volume":"32","author":"Touil-Boukoffa","year":"2018","journal-title":"J Neuroimmunol"},{"key":"29","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.neuint.2019.01.003","article-title":"Valproic acid attenuates global cerebral ischemia\/reperfusion injury in gerbils via anti-pyroptosis pathways.","volume":"12","author":"Yang","year":"2019","journal-title":"Neurochem Int"},{"key":"30","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fnins.2020.00028","article-title":"Transcranial Direct Current Stimulation Ameliorates Cognitive Impairment via Modulating Oxidative Stress, Inflammation, and Autophagy in a Rat Model of Vascular Dementia.","volume":"1","author":"Luo","year":"2020","journal-title":"Front Neurosci"},{"key":"31","doi-asserted-by":"publisher","first-page":"e2595","DOI":"10.1371\/journal.pntd.0002595","article-title":"NLRP3 inflammasome activation by Paracoccidioides brasiliensis.","volume":"7","author":"Bocca","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"32","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature07965","article-title":"Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.","volume":"45","author":"Ruland","year":"2009","journal-title":"Nature"},{"key":"33","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s40478-020-01045-x","article-title":"Nilvadipine suppresses inflammation via inhibition of P-SYK and restores spatial memory deficits in a mouse model of repetitive mild TBI.","volume":"8","author":"Crawford","year":"2020","journal-title":"Acta Neuropathol Commun"},{"key":"34","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12974-019-1693-z","article-title":"Dectin-1\/Syk signaling triggers neuroinflammation after ischemic stroke in mice.","volume":"1","author":"Zu","year":"2020","journal-title":"J Neuroinflammation"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T17:10:45Z","timestamp":1708708245000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":34,"alternative-id":["205593"],"URL":"https:\/\/doi.org\/10.18632\/aging.205593","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,23]]}}}