{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:40:06Z","timestamp":1771566006314,"version":"3.50.1"},"reference-count":32,"publisher":"Impact Journals, LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"DOI":"10.18632\/aging.205808","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T17:29:36Z","timestamp":1715189376000},"source":"Crossref","is-referenced-by-count":4,"title":["4-hydroxysesamin protects rat with right ventricular failure due to pulmonary hypertension by inhibiting JNK\/p38 MAPK signaling"],"prefix":"10.18632","author":[{"given":"Lingnan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular, Affiliated Hospital of Hebei University, Baoding 071000, Hebei, China"},{"name":"Department of Cardiovascular Sciences, Hebei Medical University, Shijiazhuang 050017, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinshun","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, The Second Hospital of Hebei Medicine University, Shijiazhuang 050000, Hebei, China"},{"name":"Department of Cardiovascular Sciences, Hebei Medical University, Shijiazhuang 050017, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"104168","DOI":"10.1016\/j.lpm.2023.104168","article-title":"Pulmonary arterial hypertension.","volume":"5","author":"Humbert","year":"2023","journal-title":"Presse Med"},{"key":"2","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1016\/S2589-7500(22)00187-X","article-title":"Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study.","volume":"5","author":"Hingorani","year":"2023","journal-title":"Lancet Digit Health"},{"key":"3","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1093\/eurheartj\/ehac395","article-title":"Hypertension management in patients with cardiovascular comorbidities.","volume":"4","author":"Weber","year":"2023","journal-title":"Eur Heart J"},{"key":"4","doi-asserted-by":"publisher","first-page":"210220","DOI":"10.1183\/16000617.0220-2021","article-title":"Recent advances in the management of pulmonary hypertension with interstitial lung disease.","volume":"3","author":"Harari","year":"2022","journal-title":"Eur Respir Rev"},{"key":"5","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1002\/ehf2.14233","article-title":"Adaptive versus maladaptive right ventricular remodelling.","volume":"1","author":"Tello","year":"2023","journal-title":"ESC Heart Fail"},{"key":"6","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension.","volume":"4","author":"Giannakoulas","year":"2022","journal-title":"Eur Heart J"},{"key":"7","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/S2213-2600(23)00264-3","article-title":"Treatment of pulmonary arterial hypertension: recent progress and a look to the future.","volume":"1","author":"Weatherald","year":"2023","journal-title":"Lancet Respir Med"},{"key":"8","doi-asserted-by":"publisher","first-page":"4079","DOI":"10.3390\/nu14194079","article-title":"Sesame (L.): A Comprehensive Review of Nutritional Value, Phytochemical Composition, Health Benefits, Development of Food, and Industrial Applications.","volume":"1","author":"Meng","year":"2022","journal-title":"Nutrients"},{"key":"9","doi-asserted-by":"publisher","first-page":"109637","DOI":"10.1016\/j.cbpc.2023.109637","article-title":"Sesamin lacks zebrafish embryotoxicity but exhibits evidence of anti-angiogenesis, anti-oxidant and anti-inflammatory activities.","volume":"26","author":"Pimtong","year":"2023","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"10","doi-asserted-by":"publisher","first-page":"11615","DOI":"10.3390\/ijms231911615","article-title":"The Protective Effects of Sesamin against Cyclophosphamide-Induced Nephrotoxicity through Modulation of Oxidative Stress, Inflammatory-Cytokines and Apoptosis in Rats.","volume":"2","author":"Alam","year":"2022","journal-title":"Int J Mol Sci"},{"key":"11","doi-asserted-by":"publisher","first-page":"106759","DOI":"10.1016\/j.intimp.2020.106759","article-title":"Inhibition of programmed death ligand 1 (PD-L1) expression in breast cancer cells by sesamin.","volume":"8","author":"Phitak","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"12","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.7150\/ijms.48955","article-title":"Sesamin inhibits cervical cancer cell proliferation by promoting p53\/PTEN-mediated apoptosis.","volume":"1","author":"Kao","year":"2020","journal-title":"Int J Med Sci"},{"key":"13","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.3390\/molecules25143119","article-title":"Self-Nanoemulsifying Drug Delivery Systems for Enhancing Solubility, Permeability, and Bioavailability of Sesamin.","volume":"2","author":"Wu","year":"2020","journal-title":"Molecules"},{"key":"14","doi-asserted-by":"publisher","first-page":"121607","DOI":"10.1016\/j.lfs.2023.121607","article-title":"Ginsenoside Rh1 ameliorates the asthma and allergic inflammation via inhibiting Akt, MAPK, and NF-\u03baB signaling pathways in vitro and in vivo.","volume":"32","author":"Son","year":"2023","journal-title":"Life Sci"},{"key":"15","doi-asserted-by":"publisher","first-page":"2432416","DOI":"10.1155\/2019\/2432416","article-title":"Sesamin Enhances Nrf2-Mediated Protective Defense against Oxidative Stress and Inflammation in Colitis via AKT and ERK Activation.","volume":"201","author":"Jin","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"16","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.jsps.2020.08.018","article-title":"Health benefits of sesamin on cardiovascular disease and its associated risk factors.","volume":"2","author":"Manjikian","year":"2020","journal-title":"Saudi Pharm J"},{"key":"17","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ccl.2021.08.005","article-title":"Lung Disease-Related Pulmonary Hypertension.","volume":"4","author":"Nathan","year":"2022","journal-title":"Cardiol Clin"},{"key":"18","doi-asserted-by":"publisher","first-page":"1181987","DOI":"10.3389\/fimmu.2023.1181987","article-title":"Interleukin-6 and pulmonary hypertension: from physiopathology to therapy.","volume":"1","author":"Jiang","year":"2023","journal-title":"Front Immunol"},{"key":"19","doi-asserted-by":"publisher","first-page":"20220650","DOI":"10.1515\/biol-2022-0650","article-title":"TNF-\u03b1 and IL-8 levels are positively correlated with hypobaric hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats.","volume":"1","author":"Wan","year":"2023","journal-title":"Open Life Sci"},{"key":"20","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1161\/ATVBAHA.121.317168","article-title":"Caspase-8 Promotes Pulmonary Hypertension by Activating Macrophage-Associated Inflammation and IL-1\u03b2 (Interleukin 1\u03b2) Production.","volume":"4","author":"Liu","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"21","doi-asserted-by":"publisher","first-page":"106562","DOI":"10.1016\/j.vph.2019.05.002","article-title":"Inflammation in pulmonary artery hypertension.","volume":"118","author":"Node","year":"2019","journal-title":"Vascul Pharmacol"},{"key":"22","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/s1015-9584(09)60176-7","article-title":"Induction of higher expression of IL-beta and TNF-alpha, lower expression of IL-10 and cyclic guanosine monophosphate by pulmonary arterial hypertension following cardiopulmonary bypass.","volume":"2","author":"Jian","year":"2002","journal-title":"Asian J Surg"},{"key":"23","doi-asserted-by":"publisher","first-page":"ITC49","DOI":"10.7326\/AITC202104200","article-title":"Pulmonary Hypertension.","volume":"17","author":"Mandel","year":"2021","journal-title":"Ann Intern Med"},{"key":"24","doi-asserted-by":"publisher","first-page":"12671","DOI":"10.1039\/d1fo02913d","article-title":"Sesamin attenuates PM-induced cardiovascular injury by inhibiting ferroptosis in rats.","volume":"1","author":"Ma","year":"2021","journal-title":"Food Funct"},{"key":"25","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1080\/13880209.2020.1787469","article-title":"Sesamin attenuates intestinal injury in sepsis via the HMGB1\/TLR4\/IL-33 signalling pathway.","volume":"5","author":"Yang","year":"2020","journal-title":"Pharm Biol"},{"key":"26","doi-asserted-by":"publisher","first-page":"e0123662","DOI":"10.1371\/journal.pone.0123662","article-title":"Hyperplastic Growth of Pulmonary Artery Smooth Muscle Cells from Subjects with Pulmonary Arterial Hypertension Is Activated through JNK and p38 MAPK.","volume":"1","author":"Polgar","year":"2015","journal-title":"PLoS One"},{"key":"27","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.3390\/biom11121801","article-title":"Andrographolide Attenuates Established Pulmonary Hypertension via Rescue of Vascular Remodeling.","volume":"1","author":"Chen","year":"2021","journal-title":"Biomolecules"},{"key":"28","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1111\/jocd.15951","article-title":"Sesamin attenuates UVA-induced keratinocyte injury via inhibiting ASK-1-JNK\/p38 MAPK pathways.","volume":"2","author":"Cao","year":"2024","journal-title":"J Cosmet Dermatol"},{"key":"29","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1039\/d0fo00950d","article-title":"Sesamin protects against DSS-induced colitis in mice by inhibiting NF-\u03baB and MAPK signaling pathways.","volume":"1","author":"Yi","year":"2021","journal-title":"Food Funct"},{"key":"30","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.tcb.2021.05.001","article-title":"Cyclin E in normal physiology and disease states.","volume":"3","author":"Sicinski","year":"2021","journal-title":"Trends Cell Biol"},{"key":"31","doi-asserted-by":"publisher","first-page":"e22744","DOI":"10.1096\/fj.202201219RR","article-title":"LDHA deficiency inhibits trophoblast proliferation via the PI3K\/AKT\/FOXO1\/CyclinD1 signaling pathway in unexplained recurrent spontaneous abortion.","volume":"3","author":"Liu","year":"2023","journal-title":"FASEB J"},{"key":"32","doi-asserted-by":"publisher","first-page":"570","DOI":"10.3390\/biom10040570","article-title":"Human PCNA Structure, Function and Interactions.","volume":"1","author":"Blanco","year":"2020","journal-title":"Biomolecules"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T17:29:40Z","timestamp":1715189380000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,8]]},"references-count":32,"alternative-id":["205808"],"URL":"https:\/\/doi.org\/10.18632\/aging.205808","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,8]]}}}