{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:30:39Z","timestamp":1778509839359,"version":"3.51.4"},"reference-count":36,"publisher":"Impact Journals, LLC","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2024,6,15]]},"DOI":"10.18632\/aging.205902","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T11:44:46Z","timestamp":1717674286000},"page":"9846-9858","source":"Crossref","is-referenced-by-count":6,"title":["LncRNA MIR181A2HG inhibits keratinocytes proliferation through miR-223-3p\/SOX6 axis"],"prefix":"10.18632","volume":"16","author":[{"given":"Mingzhao","family":"Li","sequence":"first","affiliation":[{"name":"School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin 541199, Guangxi, P.R. China"},{"name":"Key Laboratory of Biochemistry and Molecular Biology (Guilin Medical University), Education Department of Guangxi Zhuang Autonomous Region, Guilin 541199, Guangxi, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutian","family":"Niu","sequence":"additional","affiliation":[{"name":"School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin 541199, Guangxi, P.R. China"},{"name":"Key Laboratory of Biochemistry and Molecular Biology (Guilin Medical University), Education Department of Guangxi Zhuang Autonomous Region, Guilin 541199, Guangxi, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin 541199, Guangxi, P.R. China"},{"name":"Key Laboratory of Biochemistry and Molecular Biology (Guilin Medical University), Education Department of Guangxi Zhuang Autonomous Region, Guilin 541199, Guangxi, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangru","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital of Guilin Medical University, Guilin 541199, Guangxi, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingbo","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin 541199, Guangxi, P.R. China"},{"name":"Key Laboratory of Biochemistry and Molecular Biology (Guilin Medical University), Education Department of Guangxi Zhuang Autonomous Region, Guilin 541199, Guangxi, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoqin","family":"Gan","sequence":"additional","affiliation":[{"name":"School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin 541199, Guangxi, P.R. China"},{"name":"Key Laboratory of Biochemistry and Molecular Biology (Guilin Medical University), Education Department of Guangxi Zhuang Autonomous Region, Guilin 541199, Guangxi, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengpeng","family":"Yue","sequence":"additional","affiliation":[{"name":"School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin 541199, Guangxi, P.R. China"},{"name":"Key Laboratory of Biochemistry and Molecular Biology (Guilin Medical University), Education Department of Guangxi Zhuang Autonomous Region, Guilin 541199, Guangxi, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jintao","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin 541199, Guangxi, P.R. China"},{"name":"Key Laboratory of Biochemistry and Molecular Biology (Guilin Medical University), Education Department of Guangxi Zhuang Autonomous Region, Guilin 541199, Guangxi, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis.","volume":"39","author":"Barker","year":"2021","journal-title":"Lancet"},{"key":"2","doi-asserted-by":"publisher","first-page":"e133","DOI":"10.1016\/j.jid.2019.08.437","article-title":"Psoriasis: Past, Present, and Future.","volume":"13","author":"Voorhees","year":"2019","journal-title":"J Invest Dermatol"},{"key":"3","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.3390\/ijms20061475","article-title":"Psoriasis Pathogenesis and Treatment.","volume":"2","author":"Sch\u00e4kel","year":"2019","journal-title":"Int J Mol Sci"},{"key":"4","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.clindermatol.2017.09.005","article-title":"Psoriasis and the metabolic syndrome.","author":"Targher","year":"2018","journal-title":"Clin Dermatol"},{"key":"5","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41419-022-04523-3","article-title":"Advances in the pathogenesis of psoriasis: from keratinocyte perspective.","volume":"1","author":"Guo","year":"2022","journal-title":"Cell Death Dis"},{"key":"6","doi-asserted-by":"publisher","first-page":"13241","DOI":"10.1096\/fj.201900642R","article-title":"Keratinocyte exosomes activate neutrophils and enhance skin inflammation in psoriasis.","volume":"3","author":"Wang","year":"2019","journal-title":"FASEB J"},{"key":"7","doi-asserted-by":"publisher","first-page":"4347","DOI":"10.3390\/ijms20184347","article-title":"Risk Factors for the Development of Psoriasis.","volume":"2","author":"Ohtsuki","year":"2019","journal-title":"Int J Mol Sci"},{"key":"8","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s00335-021-09901-4","article-title":"Significance of lncRNA abundance to function.","volume":"3","author":"Lal","year":"2022","journal-title":"Mamm Genome"},{"key":"9","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1080\/08916934.2021.2001802","article-title":"LncRNA MALAT-1 regulates the growth of interleukin-22-stimulated keratinocytes via the miR-330-5p\/S100A7 axis.","volume":"5","author":"Wang","year":"2022","journal-title":"Autoimmunity"},{"key":"10","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1007\/s00424-016-1803-z","article-title":"PRINS, a primate-specific long non-coding RNA, plays a role in the keratinocyte stress response and psoriasis pathogenesis.","volume":"46","author":"Kem\u00e9ny","year":"2016","journal-title":"Pflugers Arch"},{"key":"11","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40659-018-0181-8","article-title":"Knockdown of lncRNA MIR31HG inhibits cell proliferation in human HaCaT keratinocytes.","volume":"5","author":"Qin","year":"2018","journal-title":"Biol Res"},{"key":"12","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1111\/1523-1747.ep12555613","article-title":"Effect of retinoids on hyperproliferation-associated keratins K6 and K16 in cultured human keratinocytes: a quantitative analysis.","volume":"9","author":"Mischke","year":"1990","journal-title":"J Invest Dermatol"},{"key":"13","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/j.1365-2133.1995.tb02696.x","article-title":"Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasisand","volume":"13","author":"Riddle","year":"1995","journal-title":"Br J Dermatol"},{"key":"14","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/BF00371784","article-title":"Normal psoriatic epidermis expression of hyperproliferation-associated keratins.","volume":"28","author":"Mischke","year":"1991","journal-title":"Arch Dermatol Res"},{"key":"15","doi-asserted-by":"publisher","first-page":"4011","DOI":"10.3892\/etm.2019.8035","article-title":"Construction of a lncRNA-miRNA-mRNA network to determine the regulatory roles of lncRNAs in psoriasis.","volume":"1","author":"Shi","year":"2019","journal-title":"Exp Ther Med"},{"key":"16","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis.","volume":"38","author":"Sch\u00f6n","year":"2015","journal-title":"Lancet"},{"key":"17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/sj.gene.6364351","article-title":"Psoriasis: genetic associations and immune system changes.","volume":"8","author":"Bowcock","year":"2007","journal-title":"Genes Immun"},{"key":"18","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.jaad.2006.08.040","article-title":"Prevalence of cardiovascular risk factors in patients with psoriasis.","volume":"5","author":"Gelfand","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"19","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00403-006-0703-z","article-title":"Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis.","volume":"29","author":"Weichenthal","year":"2006","journal-title":"Arch Dermatol Res"},{"key":"20","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000495291","article-title":"Psoriasis: Keratinocytes or Immune Cells - Which Is the Trigger?","volume":"23","author":"Del Marmol","year":"2019","journal-title":"Dermatology"},{"key":"21","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12860-019-0229-9","article-title":"LncRNA MEG3 influences the proliferation and apoptosis of psoriasis epidermal cells by targeting miR-21\/caspase-8.","volume":"2","author":"Tang","year":"2019","journal-title":"BMC Mol Cell Biol"},{"key":"22","doi-asserted-by":"publisher","first-page":"101803","DOI":"10.1016\/j.mcp.2022.101803","article-title":"LncRNA AGXT2L1-2:2 facilitates keratinocytes proliferation and inhibits apoptosis by interacting with estrogen-related receptor alpha in psoriasis.","volume":"6","author":"Xu","year":"2022","journal-title":"Mol Cell Probes"},{"key":"23","doi-asserted-by":"publisher","first-page":"9991175","DOI":"10.1155\/2021\/9991175","article-title":"The lncRNA H19\/miR-766-3p\/S1PR3 Axis Contributes to the Hyperproliferation of Keratinocytes and Skin Inflammation in Psoriasis via the AKT\/mTOR Pathway.","volume":"202","author":"Sun","year":"2021","journal-title":"Mediators Inflamm"},{"key":"24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jdermsci.2021.11.007","article-title":"N6-methyladenosine-modified long non-coding RNA AGAP2-AS1 promotes psoriasis pathogenesis via miR-424-5p\/AKT3 axis.","volume":"10","author":"Peng","year":"2022","journal-title":"J Dermatol Sci"},{"key":"25","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1111\/j.1365-2133.2011.10497.x","article-title":"microRNA-mediated keratinocyte hyperproliferation in psoriasis vulgaris.","volume":"16","author":"Ihn","year":"2011","journal-title":"Br J Dermatol"},{"key":"26","doi-asserted-by":"publisher","first-page":"4025","DOI":"10.1093\/hmg\/ddr331","article-title":"Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome.","volume":"2","author":"Bowcock","year":"2011","journal-title":"Hum Mol Genet"},{"key":"27","doi-asserted-by":"publisher","first-page":"2805645","DOI":"10.1155\/2022\/2805645","article-title":"miR-223-3p Regulates NLRP3 to Inhibit Proliferation and Promote Apoptosis of ONG Cells.","volume":"202","author":"Wang","year":"2022","journal-title":"Comput Math Methods Med"},{"key":"28","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1093\/abbs\/gmz151","article-title":"miR-223-3p promotes cell proliferation and invasion by targeting Arid1a in gastric cancer.","volume":"5","author":"Sheng","year":"2020","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"29","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.21037\/jtd-22-82","article-title":"MiR-223-3p affects myocardial inflammation and apoptosis following myocardial infarction via targeting FBXW7.","volume":"1","author":"Hao","year":"2022","journal-title":"J Thorac Dis"},{"key":"30","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jdermsci.2014.05.005","article-title":"MicroRNA-223 and miR-143 are important systemic biomarkers for disease activity in psoriasis.","volume":"7","author":"Skov","year":"2014","journal-title":"J Dermatol Sci"},{"key":"31","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/cmi.2011.27","article-title":"MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function.","volume":"8","author":"Mi","year":"2011","journal-title":"Cell Mol Immunol"},{"key":"32","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1038\/nature06607","article-title":"Regulation of progenitor cell proliferation and granulocyte function by microRNA-223.","volume":"45","author":"Camargo","year":"2008","journal-title":"Nature"},{"key":"33","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.lfs.2019.05.045","article-title":"MiR-223 regulates proliferation and apoptosis of IL-22-stimulated HaCat human keratinocyte cell lines via the PTEN\/Akt pathway.","volume":"23","author":"Yang","year":"2019","journal-title":"Life Sci"},{"key":"34","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s11010-015-2607-8","article-title":"Sox6 suppression induces RA-dependent apoptosis mediated by BMP-4 expression during neuronal differentiation in P19 cells.","volume":"41","author":"Miyake","year":"2016","journal-title":"Mol Cell Biochem"},{"key":"35","doi-asserted-by":"publisher","first-page":"19052","DOI":"10.1074\/jbc.M700460200","article-title":"SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation.","volume":"28","author":"Sakai","year":"2007","journal-title":"J Biol Chem"},{"key":"36","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.jaci.2020.02.007","article-title":"Belinostat resolves skin barrier defects in atopic dermatitis by targeting the dysregulated miR-335:SOX6 axis.","volume":"14","author":"Sampath","year":"2020","journal-title":"J Allergy Clin Immunol"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T10:51:48Z","timestamp":1718880708000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,6]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,6,15]]}},"alternative-id":["205902","38848163"],"URL":"https:\/\/doi.org\/10.18632\/aging.205902","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,6]]}}}