{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T14:13:52Z","timestamp":1764080032623},"reference-count":52,"publisher":"Impact Journals, LLC","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2024,7,15]]},"DOI":"10.18632\/aging.205927","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T17:15:47Z","timestamp":1720458947000},"page":"10813-10831","source":"Crossref","is-referenced-by-count":1,"title":["An immune biomarker associated with EMT serves as a predictor for prognosis and drug response in bladder cancer"],"prefix":"10.18632","volume":"16","author":[{"given":"Yike","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Ultrasonography, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, China"},{"name":"Second College of Clinical Medicine, Nanchang University, Nanchang, Jiangxi 330000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zichuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Second College of Clinical Medicine, Nanchang University, Nanchang, Jiangxi 330000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Second College of Clinical Medicine, Nanchang University, Nanchang, Jiangxi 330000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanrui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Second College of Clinical Medicine, Nanchang University, Nanchang, Jiangxi 330000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minqin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Second College of Clinical Medicine, Nanchang University, Nanchang, Jiangxi 330000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xitong","family":"Geng","sequence":"additional","affiliation":[{"name":"Second College of Clinical Medicine, Nanchang University, Nanchang, Jiangxi 330000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanting","family":"Zhu","sequence":"additional","affiliation":[{"name":"Second College of Clinical Medicine, Nanchang University, Nanchang, Jiangxi 330000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhan","family":"Huang","sequence":"additional","affiliation":[{"name":"Second College of Clinical Medicine, Nanchang University, Nanchang, Jiangxi 330000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyang","family":"Gong","sequence":"additional","affiliation":[{"name":"Second College of Clinical Medicine, Nanchang University, Nanchang, Jiangxi 330000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangyun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023.","volume":"7","author":"Jemal","year":"2023","journal-title":"CA Cancer J Clin"},{"key":"2","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.urolonc.2021.01.015","article-title":"Locoregional recurrence after cystectomy in muscle invasive bladder cancer: Implications for adjuvant radiotherapy.","volume":"3","author":"Salunkhe","year":"2021","journal-title":"Urol Oncol"},{"key":"3","first-page":"235","article-title":"Management of muscle-invasive bladder cancer.","volume":"6","author":"Jentzmik","year":"2013","journal-title":"Minerva Urol Nefrol"},{"key":"4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/978-3-319-93339-9_8","article-title":"Molecular Prognostication in Bladder Cancer.","volume":"17","author":"Daneshmand","year":"2018","journal-title":"Cancer Treat Res"},{"key":"5","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1038\/ncomms3612","article-title":"Inferring tumour purity and stromal and immune cell admixture from expression data.","volume":"4","author":"Stemke-Hale","year":"2013","journal-title":"Nat Commun"},{"key":"6","doi-asserted-by":"publisher","first-page":"592","DOI":"10.18632\/aging.101415","article-title":"Mining TCGA database for genes of prognostic value in glioblastoma microenvironment.","volume":"1","author":"Liu","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00262-020-02649-x","article-title":"Tumour microenvironment (TME) characterization identified prognosis and immunotherapy response in muscle-invasive bladder cancer (MIBC).","volume":"7","author":"Tian","year":"2021","journal-title":"Cancer Immunol Immunother"},{"key":"8","doi-asserted-by":"publisher","first-page":"150","DOI":"10.2741\/E853","article-title":"Epithelial-to-mesenchymal transition: Event and core associates in bladder cancer.","volume":"1","author":"Singh","year":"2019","journal-title":"Front Biosci (Elite Ed)"},{"key":"9","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.3389\/fonc.2019.01533","article-title":"Screening and Identifying Immune-Related Cells and Genes in the Tumor Microenvironment of Bladder Urothelial Carcinoma: Based on TCGA Database and Bioinformatics.","volume":"9","author":"Tian","year":"2020","journal-title":"Front Oncol"},{"key":"10","doi-asserted-by":"publisher","first-page":"260","DOI":"10.4252\/wjsc.v8.i8.260","article-title":"Epithelial plasticity in urothelial carcinoma: Current advancements and future challenges.","volume":"8","author":"Garg","year":"2016","journal-title":"World J Stem Cells"},{"key":"11","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1158\/1078-0432.CCR-09-1405","article-title":"Activation of WD repeat and high-mobility group box DNA binding protein 1 in pulmonary and esophageal carcinogenesis.","volume":"1","author":"Daigo","year":"2010","journal-title":"Clin Cancer Res"},{"key":"12","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3389\/fonc.2020.00461","article-title":"WDHD1 Leads to Cisplatin Resistance by Promoting MAPRE2 Ubiquitination in Lung Adenocarcinoma.","volume":"1","author":"Cheng","year":"2020","journal-title":"Front Oncol"},{"key":"13","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.dld.2018.08.021","article-title":"MicroRNA-494-dependent WDHDI inhibition suppresses epithelial-mesenchymal transition, tumor growth and metastasis in cholangiocarcinoma.","volume":"5","author":"Huang","year":"2019","journal-title":"Dig Liver Dis"},{"key":"14","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/s41419-020-03210-5","article-title":"WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer.","volume":"1","author":"Ewing","year":"2020","journal-title":"Cell Death Dis"},{"key":"15","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1186\/s12967-019-2065-2","article-title":"Identification of key DNA methylation-driven genes in prostate adenocarcinoma: an integrative analysis of TCGA methylation data.","volume":"1","author":"Xue","year":"2019","journal-title":"J Transl Med"},{"key":"16","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1186\/s12967-020-02512-8","article-title":"Comprehensive profiling of immune-related genes in soft tissue sarcoma patients.","volume":"1","author":"Zhao","year":"2020","journal-title":"J Transl Med"},{"key":"17","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1186\/s12967-023-04411-0","article-title":"Weighted gene coexpression network analysis and machine learning reveal oncogenome associated microbiome plays an important role in tumor immunity and prognosis in pan-cancer.","volume":"2","author":"Yu","year":"2023","journal-title":"J Transl Med"},{"key":"18","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1186\/s12967-022-03562-w","article-title":"Identification of immune-related key genes in the peripheral blood of ischaemic stroke patients using a weighted gene coexpression network analysis and machine learning.","volume":"2","author":"Liu","year":"2022","journal-title":"J Transl Med"},{"key":"19","doi-asserted-by":"publisher","first-page":"D956","DOI":"10.1093\/nar\/gkx1090","article-title":"LinkedOmics: analyzing multi-omics data within and across 32 cancer types.","volume":"4","author":"Zhang","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"20","doi-asserted-by":"publisher","first-page":"W98","DOI":"10.1093\/nar\/gkx247","article-title":"GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses.","volume":"4","author":"Zhang","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"21","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1186\/s12967-023-04180-w","article-title":"Inflammatory and interferon gene expression signatures in patients with mitochondrial disease.","volume":"2","author":"McGuire","year":"2023","journal-title":"J Transl Med"},{"key":"22","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1186\/s12967-023-04112-8","article-title":"Comprehensive single-cell transcriptomic and proteomic analysis reveals NK cell exhaustion and unique tumor cell evolutionary trajectory in non-keratinizing nasopharyngeal carcinoma.","volume":"2","author":"Tao","year":"2023","journal-title":"J Transl Med"},{"key":"23","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1158\/0008-5472.CAN-17-0307","article-title":"TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells.","volume":"7","author":"Liu","year":"2017","journal-title":"Cancer Res"},{"key":"24","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1093\/bioinformatics\/btz210","article-title":"TISIDB: an integrated repository portal for tumor-immune system interactions.","volume":"3","author":"Zhang","year":"2019","journal-title":"Bioinformatics"},{"key":"25","doi-asserted-by":"publisher","first-page":"bbac558","DOI":"10.1093\/bib\/bbac558","article-title":"GSCA: an integrated platform for gene set cancer analysis at genomic, pharmacogenomic and immunogenomic levels.","volume":"2","author":"Guo","year":"2023","journal-title":"Brief Bioinform"},{"key":"26","doi-asserted-by":"publisher","first-page":"D1138","DOI":"10.1093\/nar\/gkaa891","article-title":"Comparative Toxicogenomics Database (CTD): update 2021.","volume":"4","author":"Mattingly","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"27","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.1016\/j.devcel.2021.11.006","article-title":"Distinct contributions of partial and full EMT to breast cancer malignancy.","volume":"5","author":"Christofori","year":"2021","journal-title":"Dev Cell"},{"key":"28","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13287-023-03239-1","article-title":"Tumor stemness score to estimate epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSCs) characterization and to predict the prognosis and immunotherapy response in bladder urothelial carcinoma.","volume":"1","author":"Yan","year":"2023","journal-title":"Stem Cell Res Ther"},{"key":"29","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition.","volume":"11","author":"Weinberg","year":"2009","journal-title":"J Clin Invest"},{"key":"30","doi-asserted-by":"publisher","first-page":"e1380765","DOI":"10.1080\/2162402X.2017.1380765","article-title":"Tumor-associated macrophages remodeling EMT and predicting survival in colorectal carcinoma.","volume":"7","author":"Lai","year":"2017","journal-title":"Oncoimmunology"},{"key":"31","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.canlet.2017.01.041","article-title":"Crosstalk between stromal cells and cancer cells in pancreatic cancer: New insights into stromal biology.","volume":"39","author":"Hu","year":"2017","journal-title":"Cancer Lett"},{"key":"32","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1126\/science.1090922","article-title":"TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia.","volume":"30","author":"Moses","year":"2004","journal-title":"Science"},{"key":"33","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/s41419-018-0922-1","article-title":"HGF-mediated crosstalk between cancer-associated fibroblasts and MET-unamplified gastric cancer cells activates coordinated tumorigenesis and metastasis.","volume":"9","author":"Zhang","year":"2018","journal-title":"Cell Death Dis"},{"key":"34","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s13046-023-02742-w","article-title":"TRAF2 promotes M2-polarized tumor-associated macrophage infiltration, angiogenesis and cancer progression by inhibiting autophagy in clear cell renal cell carcinoma.","volume":"4","author":"Gong","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"key":"35","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/s41568-019-0235-4","article-title":"CD8T cell states in human cancer: insights from single-cell analysis.","volume":"2","author":"Schumacher","year":"2020","journal-title":"Nat Rev Cancer"},{"key":"36","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.immuni.2022.12.008","article-title":"Microenvironment-driven metabolic adaptations guiding CD8T cell anti-tumor immunity.","volume":"5","author":"Ho","year":"2023","journal-title":"Immunity"},{"key":"37","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells.","volume":"3","author":"Rinn","year":"2014","journal-title":"Nat Biotechnol"},{"key":"38","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1016\/j.jocn.2010.03.031","article-title":"CD8+ T-cell infiltrate in newly diagnosed glioblastoma is associated with long-term survival.","volume":"1","author":"Parsa","year":"2010","journal-title":"J Clin Neurosci"},{"key":"39","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1245\/s10434-009-0585-3","article-title":"T cell infiltrate predicts long-term survival following resection of colorectal cancer liver metastases.","volume":"1","author":"DeMatteo","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"40","doi-asserted-by":"publisher","first-page":"1070383","DOI":"10.3389\/fmolb.2022.1070383","article-title":"Tumor microenvironment and epithelial-mesenchymal transition in bladder cancer: Cytokines in the game?","volume":"9","author":"Correia","year":"2023","journal-title":"Front Mol Biosci"},{"key":"41","doi-asserted-by":"publisher","first-page":"3236384","DOI":"10.1155\/2021\/3236384","article-title":"Identification of a Prognosis-Related Risk Signature for Bladder Cancer to Predict Survival and Immune Landscapes.","volume":"202","author":"Bi","year":"2021","journal-title":"J Immunol Res"},{"key":"42","doi-asserted-by":"publisher","first-page":"103374","DOI":"10.1016\/j.critrevonc.2021.103374","article-title":"TMB or not TMB as a biomarker: That is the question.","volume":"16","author":"Weiss","year":"2021","journal-title":"Crit Rev Oncol Hematol"},{"key":"43","doi-asserted-by":"publisher","first-page":"558","DOI":"10.3390\/cancers13030558","article-title":"PD-L1, TMB, MSI, and Other Predictors of Response to Immune Checkpoint Inhibitors in Biliary Tract Cancer.","volume":"1","author":"Brandi","year":"2021","journal-title":"Cancers (Basel)"},{"key":"44","doi-asserted-by":"publisher","first-page":"eabg2752","DOI":"10.1126\/science.abg2752","article-title":"CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses.","volume":"37","author":"Korenfeld","year":"2023","journal-title":"Science"},{"key":"45","doi-asserted-by":"publisher","first-page":"D955","DOI":"10.1093\/nar\/gks1111","article-title":"Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells.","volume":"4","author":"Haber","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"46","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s00280-011-1620-1","article-title":"Pilot study of PD-0325901 in previously treated patients with advanced melanoma, breast cancer, and colon cancer.","volume":"6","author":"Ricart","year":"2011","journal-title":"Cancer Chemother Pharmacol"},{"key":"47","doi-asserted-by":"publisher","first-page":"6839","DOI":"10.1158\/0008-5472.CAN-09-0679","article-title":"RDEA119\/BAY 869766: a potent, selective, allosteric inhibitor of MEK1\/2 for the treatment of cancer.","volume":"6","author":"Quart","year":"2009","journal-title":"Cancer Res"},{"key":"48","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1002\/ijc.25304","article-title":"BRAF mutation-selective inhibition of thyroid cancer cells by the novel MEK inhibitor RDEA119 and genetic-potentiated synergism with the mTOR inhibitor temsirolimus.","volume":"12","author":"Xing","year":"2010","journal-title":"Int J Cancer"},{"key":"49","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1186\/1471-2407-10-515","article-title":"Antitumour activity of a potent MEK inhibitor RDEA119\/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts.","volume":"1","author":"Hedley","year":"2010","journal-title":"BMC Cancer"},{"key":"50","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/S0140-6736(21)02175-9","article-title":"Trametinib versus standard of care in patients with recurrent low-grade serous ovarian cancer (GOG 281\/LOGS): an international, randomised, open-label, multicentre, phase 2\/3 trial.","volume":"39","author":"O'Malley","year":"2022","journal-title":"Lancet"},{"key":"51","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1056\/NEJMoa1912735","article-title":"Selumetinib in Children with Inoperable Plexiform Neurofibromas.","volume":"38","author":"Pichard","year":"2020","journal-title":"N Engl J Med"},{"key":"52","unstructured":"LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Selumetinib. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2021."}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T14:31:31Z","timestamp":1721917891000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.205927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,8]]},"references-count":52,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,7,15]]}},"alternative-id":["205927","38980253"],"URL":"https:\/\/doi.org\/10.18632\/aging.205927","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,8]]}}}